Amino acid dipepetide frequency for Agathobaculum butyriciproducens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.118AlaAla: 12.118 ± 0.185	1.432AlaCys: 1.432 ± 0.043	6.086AlaAsp: 6.086 ± 0.1	7.024AlaGlu: 7.024 ± 0.103	3.488AlaPhe: 3.488 ± 0.067	7.142AlaGly: 7.142 ± 0.101	1.748AlaHis: 1.748 ± 0.049	5.243AlaIle: 5.243 ± 0.087	5.028AlaLys: 5.028 ± 0.077	9.359AlaLeu: 9.359 ± 0.134	2.769AlaMet: 2.769 ± 0.061	2.819AlaAsn: 2.819 ± 0.069	3.148AlaPro: 3.148 ± 0.067	3.643AlaGln: 3.643 ± 0.073	4.27AlaArg: 4.27 ± 0.079	4.313AlaSer: 4.313 ± 0.084	3.9AlaThr: 3.9 ± 0.086	8.203AlaVal: 8.203 ± 0.123	0.725AlaTrp: 0.725 ± 0.033	2.969AlaTyr: 2.969 ± 0.073	0.0AlaXaa: 0.0 ± 0.0
Cys	1.663CysAla: 1.663 ± 0.05	0.324CysCys: 0.324 ± 0.022	0.977CysAsp: 0.977 ± 0.037	1.04CysGlu: 1.04 ± 0.039	0.658CysPhe: 0.658 ± 0.033	1.871CysGly: 1.871 ± 0.057	0.291CysHis: 0.291 ± 0.018	0.99CysIle: 0.99 ± 0.038	0.769CysLys: 0.769 ± 0.031	1.166CysLeu: 1.166 ± 0.043	0.423CysMet: 0.423 ± 0.022	0.464CysAsn: 0.464 ± 0.026	0.689CysPro: 0.689 ± 0.035	0.351CysGln: 0.351 ± 0.024	0.95CysArg: 0.95 ± 0.032	0.951CysSer: 0.951 ± 0.038	0.958CysThr: 0.958 ± 0.035	1.171CysVal: 1.171 ± 0.039	0.112CysTrp: 0.112 ± 0.013	0.504CysTyr: 0.504 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	5.493AspAla: 5.493 ± 0.086	0.997AspCys: 0.997 ± 0.043	3.154AspAsp: 3.154 ± 0.074	4.681AspGlu: 4.681 ± 0.094	2.481AspPhe: 2.481 ± 0.063	5.203AspGly: 5.203 ± 0.1	0.924AspHis: 0.924 ± 0.034	3.727AspIle: 3.727 ± 0.077	3.312AspLys: 3.312 ± 0.071	4.658AspLeu: 4.658 ± 0.082	1.735AspMet: 1.735 ± 0.047	2.06AspAsn: 2.06 ± 0.058	2.13AspPro: 2.13 ± 0.053	1.278AspGln: 1.278 ± 0.04	2.942AspArg: 2.942 ± 0.071	3.186AspSer: 3.186 ± 0.073	3.764AspThr: 3.764 ± 0.076	3.735AspVal: 3.735 ± 0.076	0.695AspTrp: 0.695 ± 0.03	2.388AspTyr: 2.388 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	5.31GluAla: 5.31 ± 0.089	0.76GluCys: 0.76 ± 0.028	3.698GluAsp: 3.698 ± 0.08	4.456GluGlu: 4.456 ± 0.093	2.119GluPhe: 2.119 ± 0.059	3.798GluGly: 3.798 ± 0.072	1.569GluHis: 1.569 ± 0.051	4.407GluIle: 4.407 ± 0.085	4.794GluLys: 4.794 ± 0.09	6.416GluLeu: 6.416 ± 0.105	2.151GluMet: 2.151 ± 0.052	3.595GluAsn: 3.595 ± 0.075	2.091GluPro: 2.091 ± 0.064	3.641GluGln: 3.641 ± 0.083	4.041GluArg: 4.041 ± 0.078	2.884GluSer: 2.884 ± 0.064	3.623GluThr: 3.623 ± 0.072	3.989GluVal: 3.989 ± 0.071	0.57GluTrp: 0.57 ± 0.025	2.393GluTyr: 2.393 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.817PheAla: 3.817 ± 0.071	0.796PheCys: 0.796 ± 0.033	2.651PheAsp: 2.651 ± 0.062	2.279PheGlu: 2.279 ± 0.06	1.597PhePhe: 1.597 ± 0.053	3.214PheGly: 3.214 ± 0.075	0.788PheHis: 0.788 ± 0.034	2.048PheIle: 2.048 ± 0.058	1.533PheLys: 1.533 ± 0.052	3.355PheLeu: 3.355 ± 0.082	0.927PheMet: 0.927 ± 0.038	1.258PheAsn: 1.258 ± 0.043	1.38PhePro: 1.38 ± 0.044	1.016PheGln: 1.016 ± 0.037	1.947PheArg: 1.947 ± 0.052	2.703PheSer: 2.703 ± 0.063	2.438PheThr: 2.438 ± 0.058	2.725PheVal: 2.725 ± 0.057	0.376PheTrp: 0.376 ± 0.024	1.326PheTyr: 1.326 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	6.47GlyAla: 6.47 ± 0.117	1.428GlyCys: 1.428 ± 0.05	3.83GlyAsp: 3.83 ± 0.08	4.663GlyGlu: 4.663 ± 0.084	2.956GlyPhe: 2.956 ± 0.055	5.87GlyGly: 5.87 ± 0.119	1.442GlyHis: 1.442 ± 0.044	5.08GlyIle: 5.08 ± 0.09	5.109GlyLys: 5.109 ± 0.094	6.333GlyLeu: 6.333 ± 0.101	2.519GlyMet: 2.519 ± 0.059	2.506GlyAsn: 2.506 ± 0.057	1.394GlyPro: 1.394 ± 0.064	2.248GlyGln: 2.248 ± 0.055	3.624GlyArg: 3.624 ± 0.073	4.346GlySer: 4.346 ± 0.109	4.957GlyThr: 4.957 ± 0.097	5.6GlyVal: 5.6 ± 0.089	0.832GlyTrp: 0.832 ± 0.034	3.067GlyTyr: 3.067 ± 0.07	0.0GlyXaa: 0.0 ± 0.0
His	1.707HisAla: 1.707 ± 0.048	0.38HisCys: 0.38 ± 0.023	1.106HisAsp: 1.106 ± 0.04	1.273HisGlu: 1.273 ± 0.041	0.882HisPhe: 0.882 ± 0.036	1.565HisGly: 1.565 ± 0.048	0.558HisHis: 0.558 ± 0.075	1.428HisIle: 1.428 ± 0.043	0.949HisLys: 0.949 ± 0.038	1.696HisLeu: 1.696 ± 0.054	0.581HisMet: 0.581 ± 0.025	0.739HisAsn: 0.739 ± 0.029	1.056HisPro: 1.056 ± 0.034	0.537HisGln: 0.537 ± 0.028	1.096HisArg: 1.096 ± 0.039	1.062HisSer: 1.062 ± 0.037	1.157HisThr: 1.157 ± 0.036	1.119HisVal: 1.119 ± 0.042	0.205HisTrp: 0.205 ± 0.016	0.761HisTyr: 0.761 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.358IleAla: 6.358 ± 0.095	1.118IleCys: 1.118 ± 0.04	3.773IleAsp: 3.773 ± 0.075	4.102IleGlu: 4.102 ± 0.08	2.096IlePhe: 2.096 ± 0.062	4.809IleGly: 4.809 ± 0.096	1.079IleHis: 1.079 ± 0.038	3.572IleIle: 3.572 ± 0.079	2.774IleLys: 2.774 ± 0.073	5.229IleLeu: 5.229 ± 0.092	1.481IleMet: 1.481 ± 0.05	2.144IleAsn: 2.144 ± 0.056	2.707IlePro: 2.707 ± 0.061	1.649IleGln: 1.649 ± 0.041	3.335IleArg: 3.335 ± 0.068	3.703IleSer: 3.703 ± 0.069	3.886IleThr: 3.886 ± 0.073	4.487IleVal: 4.487 ± 0.076	0.493IleTrp: 0.493 ± 0.025	1.918IleTyr: 1.918 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.916LysAla: 4.916 ± 0.09	0.622LysCys: 0.622 ± 0.027	2.899LysAsp: 2.899 ± 0.071	3.584LysGlu: 3.584 ± 0.087	1.569LysPhe: 1.569 ± 0.044	3.383LysGly: 3.383 ± 0.083	0.978LysHis: 0.978 ± 0.034	3.289LysIle: 3.289 ± 0.059	3.962LysLys: 3.962 ± 0.089	4.906LysLeu: 4.906 ± 0.073	1.766LysMet: 1.766 ± 0.048	2.575LysAsn: 2.575 ± 0.055	2.362LysPro: 2.362 ± 0.067	2.308LysGln: 2.308 ± 0.056	3.027LysArg: 3.027 ± 0.07	2.815LysSer: 2.815 ± 0.056	3.665LysThr: 3.665 ± 0.086	3.371LysVal: 3.371 ± 0.069	0.464LysTrp: 0.464 ± 0.027	1.955LysTyr: 1.955 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	8.312LeuAla: 8.312 ± 0.115	1.96LeuCys: 1.96 ± 0.06	5.301LeuAsp: 5.301 ± 0.082	5.22LeuGlu: 5.22 ± 0.094	3.732LeuPhe: 3.732 ± 0.101	6.33LeuGly: 6.33 ± 0.102	2.12LeuHis: 2.12 ± 0.056	5.075LeuIle: 5.075 ± 0.099	4.404LeuLys: 4.404 ± 0.077	9.432LeuLeu: 9.432 ± 0.174	2.457LeuMet: 2.457 ± 0.058	3.438LeuAsn: 3.438 ± 0.071	4.309LeuPro: 4.309 ± 0.082	2.951LeuGln: 2.951 ± 0.06	5.297LeuArg: 5.297 ± 0.116	6.394LeuSer: 6.394 ± 0.108	6.408LeuThr: 6.408 ± 0.107	5.488LeuVal: 5.488 ± 0.096	0.793LeuTrp: 0.793 ± 0.032	3.103LeuTyr: 3.103 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	2.612MetAla: 2.612 ± 0.049	0.362MetCys: 0.362 ± 0.021	1.737MetAsp: 1.737 ± 0.051	1.814MetGlu: 1.814 ± 0.049	0.931MetPhe: 0.931 ± 0.038	1.94MetGly: 1.94 ± 0.058	0.549MetHis: 0.549 ± 0.03	1.593MetIle: 1.593 ± 0.049	1.921MetLys: 1.921 ± 0.048	2.995MetLeu: 2.995 ± 0.067	0.832MetMet: 0.832 ± 0.032	1.368MetAsn: 1.368 ± 0.041	1.315MetPro: 1.315 ± 0.038	1.349MetGln: 1.349 ± 0.043	1.512MetArg: 1.512 ± 0.044	1.654MetSer: 1.654 ± 0.053	1.86MetThr: 1.86 ± 0.051	1.777MetVal: 1.777 ± 0.052	0.17MetTrp: 0.17 ± 0.013	0.724MetTyr: 0.724 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.675AsnAla: 3.675 ± 0.075	0.558AsnCys: 0.558 ± 0.029	2.045AsnAsp: 2.045 ± 0.066	2.18AsnGlu: 2.18 ± 0.063	1.23AsnPhe: 1.23 ± 0.042	3.636AsnGly: 3.636 ± 0.105	0.728AsnHis: 0.728 ± 0.03	2.611AsnIle: 2.611 ± 0.067	1.791AsnLys: 1.791 ± 0.055	3.215AsnLeu: 3.215 ± 0.073	1.045AsnMet: 1.045 ± 0.035	1.435AsnAsn: 1.435 ± 0.055	1.866AsnPro: 1.866 ± 0.048	1.073AsnGln: 1.073 ± 0.033	1.946AsnArg: 1.946 ± 0.059	1.942AsnSer: 1.942 ± 0.056	2.292AsnThr: 2.292 ± 0.066	2.473AsnVal: 2.473 ± 0.059	0.36AsnTrp: 0.36 ± 0.023	1.312AsnTyr: 1.312 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	3.516ProAla: 3.516 ± 0.075	0.55ProCys: 0.55 ± 0.029	2.744ProAsp: 2.744 ± 0.064	3.439ProGlu: 3.439 ± 0.08	1.589ProPhe: 1.589 ± 0.051	2.261ProGly: 2.261 ± 0.053	0.877ProHis: 0.877 ± 0.035	2.166ProIle: 2.166 ± 0.055	1.949ProLys: 1.949 ± 0.05	3.276ProLeu: 3.276 ± 0.065	1.073ProMet: 1.073 ± 0.039	1.476ProAsn: 1.476 ± 0.049	1.167ProPro: 1.167 ± 0.043	1.444ProGln: 1.444 ± 0.038	1.604ProArg: 1.604 ± 0.048	2.026ProSer: 2.026 ± 0.052	2.101ProThr: 2.101 ± 0.058	3.2ProVal: 3.2 ± 0.063	0.323ProTrp: 0.323 ± 0.026	1.402ProTyr: 1.402 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	3.312GlnAla: 3.312 ± 0.082	0.46GlnCys: 0.46 ± 0.027	1.667GlnAsp: 1.667 ± 0.042	2.228GlnGlu: 2.228 ± 0.064	1.223GlnPhe: 1.223 ± 0.037	1.988GlnGly: 1.988 ± 0.052	0.687GlnHis: 0.687 ± 0.03	2.11GlnIle: 2.11 ± 0.053	2.045GlnLys: 2.045 ± 0.058	3.183GlnLeu: 3.183 ± 0.071	1.175GlnMet: 1.175 ± 0.033	1.617GlnAsn: 1.617 ± 0.044	1.435GlnPro: 1.435 ± 0.05	1.748GlnGln: 1.748 ± 0.058	1.93GlnArg: 1.93 ± 0.058	2.058GlnSer: 2.058 ± 0.051	2.245GlnThr: 2.245 ± 0.054	2.099GlnVal: 2.099 ± 0.048	0.365GlnTrp: 0.365 ± 0.023	1.331GlnTyr: 1.331 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	4.609ArgAla: 4.609 ± 0.082	0.802ArgCys: 0.802 ± 0.035	2.838ArgAsp: 2.838 ± 0.066	4.049ArgGlu: 4.049 ± 0.084	2.191ArgPhe: 2.191 ± 0.058	3.289ArgGly: 3.289 ± 0.073	1.019ArgHis: 1.019 ± 0.035	3.403ArgIle: 3.403 ± 0.072	3.119ArgLys: 3.119 ± 0.071	5.155ArgLeu: 5.155 ± 0.09	1.815ArgMet: 1.815 ± 0.043	1.829ArgAsn: 1.829 ± 0.054	1.886ArgPro: 1.886 ± 0.057	2.146ArgGln: 2.146 ± 0.056	3.548ArgArg: 3.548 ± 0.08	2.656ArgSer: 2.656 ± 0.058	2.965ArgThr: 2.965 ± 0.071	3.552ArgVal: 3.552 ± 0.073	0.535ArgTrp: 0.535 ± 0.025	1.913ArgTyr: 1.913 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.541SerAla: 5.541 ± 0.104	0.808SerCys: 0.808 ± 0.036	3.476SerAsp: 3.476 ± 0.076	3.557SerGlu: 3.557 ± 0.067	2.384SerPhe: 2.384 ± 0.057	5.05SerGly: 5.05 ± 0.086	1.087SerHis: 1.087 ± 0.035	3.425SerIle: 3.425 ± 0.063	2.576SerLys: 2.576 ± 0.062	4.863SerLeu: 4.863 ± 0.086	1.678SerMet: 1.678 ± 0.049	1.833SerAsn: 1.833 ± 0.058	1.94SerPro: 1.94 ± 0.062	1.639SerGln: 1.639 ± 0.049	3.061SerArg: 3.061 ± 0.07	3.261SerSer: 3.261 ± 0.094	3.091SerThr: 3.091 ± 0.066	4.329SerVal: 4.329 ± 0.089	0.53SerTrp: 0.53 ± 0.027	1.992SerTyr: 1.992 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	6.658ThrAla: 6.658 ± 0.114	0.785ThrCys: 0.785 ± 0.035	3.905ThrAsp: 3.905 ± 0.08	3.843ThrGlu: 3.843 ± 0.075	2.153ThrPhe: 2.153 ± 0.061	5.105ThrGly: 5.105 ± 0.103	1.117ThrHis: 1.117 ± 0.041	3.577ThrIle: 3.577 ± 0.075	2.513ThrLys: 2.513 ± 0.067	5.733ThrLeu: 5.733 ± 0.085	1.563ThrMet: 1.563 ± 0.04	1.77ThrAsn: 1.77 ± 0.054	2.83ThrPro: 2.83 ± 0.063	1.706ThrGln: 1.706 ± 0.048	2.72ThrArg: 2.72 ± 0.059	2.929ThrSer: 2.929 ± 0.074	3.206ThrThr: 3.206 ± 0.071	5.475ThrVal: 5.475 ± 0.112	0.433ThrTrp: 0.433 ± 0.022	1.911ThrTyr: 1.911 ± 0.065	0.0ThrXaa: 0.0 ± 0.0
Val	5.468ValAla: 5.468 ± 0.089	1.414ValCys: 1.414 ± 0.05	3.841ValAsp: 3.841 ± 0.089	4.096ValGlu: 4.096 ± 0.081	3.017ValPhe: 3.017 ± 0.07	4.55ValGly: 4.55 ± 0.094	1.325ValHis: 1.325 ± 0.041	4.334ValIle: 4.334 ± 0.077	3.712ValLys: 3.712 ± 0.072	7.421ValLeu: 7.421 ± 0.121	1.911ValMet: 1.911 ± 0.051	2.561ValAsn: 2.561 ± 0.056	2.922ValPro: 2.922 ± 0.061	2.579ValGln: 2.579 ± 0.061	3.868ValArg: 3.868 ± 0.073	4.841ValSer: 4.841 ± 0.077	4.61ValThr: 4.61 ± 0.109	4.801ValVal: 4.801 ± 0.093	0.628ValTrp: 0.628 ± 0.029	2.416ValTyr: 2.416 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.718TrpAla: 0.718 ± 0.04	0.179TrpCys: 0.179 ± 0.014	0.503TrpAsp: 0.503 ± 0.029	0.579TrpGlu: 0.579 ± 0.028	0.399TrpPhe: 0.399 ± 0.026	0.633TrpGly: 0.633 ± 0.031	0.221TrpHis: 0.221 ± 0.017	0.456TrpIle: 0.456 ± 0.024	0.577TrpLys: 0.577 ± 0.032	0.917TrpLeu: 0.917 ± 0.04	0.245TrpMet: 0.245 ± 0.019	0.476TrpAsn: 0.476 ± 0.027	0.227TrpPro: 0.227 ± 0.016	0.385TrpGln: 0.385 ± 0.021	0.517TrpArg: 0.517 ± 0.024	0.54TrpSer: 0.54 ± 0.026	0.488TrpThr: 0.488 ± 0.028	0.514TrpVal: 0.514 ± 0.027	0.089TrpTrp: 0.089 ± 0.011	0.362TrpTyr: 0.362 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.153TyrAla: 3.153 ± 0.075	0.587TyrCys: 0.587 ± 0.027	2.313TyrAsp: 2.313 ± 0.057	2.199TyrGlu: 2.199 ± 0.05	1.479TyrPhe: 1.479 ± 0.047	2.636TyrGly: 2.636 ± 0.071	0.752TyrHis: 0.752 ± 0.037	2.18TyrIle: 2.18 ± 0.048	1.579TyrLys: 1.579 ± 0.048	3.214TyrLeu: 3.214 ± 0.072	0.868TyrMet: 0.868 ± 0.035	1.451TyrAsn: 1.451 ± 0.048	1.33TyrPro: 1.33 ± 0.041	1.214TyrGln: 1.214 ± 0.041	2.082TyrArg: 2.082 ± 0.047	1.856TyrSer: 1.856 ± 0.053	2.32TyrThr: 2.32 ± 0.07	2.207TyrVal: 2.207 ± 0.048	0.33TyrTrp: 0.33 ± 0.022	1.47TyrTyr: 1.47 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2545 proteins (787198 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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