Amino acid dipepetide frequency for Candidatus Kinetoplastibacterium sorsogonicusi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.371AlaAla: 3.371 ± 0.16
0.67AlaCys: 0.67 ± 0.058
2.108AlaAsp: 2.108 ± 0.095
2.378AlaGlu: 2.378 ± 0.116
2.054AlaPhe: 2.054 ± 0.082
3.043AlaGly: 3.043 ± 0.121
0.899AlaHis: 0.899 ± 0.059
6.383AlaIle: 6.383 ± 0.184
4.257AlaLys: 4.257 ± 0.171
4.9AlaLeu: 4.9 ± 0.163
1.254AlaMet: 1.254 ± 0.092
3.273AlaAsn: 3.273 ± 0.11
1.358AlaPro: 1.358 ± 0.076
1.362AlaGln: 1.362 ± 0.074
2.023AlaArg: 2.023 ± 0.129
3.268AlaSer: 3.268 ± 0.112
2.293AlaThr: 2.293 ± 0.11
2.576AlaVal: 2.576 ± 0.123
0.463AlaTrp: 0.463 ± 0.043
1.609AlaTyr: 1.609 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
0.566CysAla: 0.566 ± 0.057
0.139CysCys: 0.139 ± 0.027
0.629CysAsp: 0.629 ± 0.055
0.539CysGlu: 0.539 ± 0.051
0.607CysPhe: 0.607 ± 0.05
0.872CysGly: 0.872 ± 0.069
0.243CysHis: 0.243 ± 0.033
1.335CysIle: 1.335 ± 0.066
0.949CysLys: 0.949 ± 0.071
1.083CysLeu: 1.083 ± 0.08
0.256CysMet: 0.256 ± 0.035
0.984CysAsn: 0.984 ± 0.062
0.427CysPro: 0.427 ± 0.048
0.342CysGln: 0.342 ± 0.034
0.27CysArg: 0.27 ± 0.038
0.769CysSer: 0.769 ± 0.056
0.481CysThr: 0.481 ± 0.048
0.535CysVal: 0.535 ± 0.049
0.099CysTrp: 0.099 ± 0.021
0.409CysTyr: 0.409 ± 0.038
0.0CysXaa: 0.0 ± 0.0
Asp
2.418AspAla: 2.418 ± 0.109
0.508AspCys: 0.508 ± 0.046
2.257AspAsp: 2.257 ± 0.112
2.72AspGlu: 2.72 ± 0.102
2.738AspPhe: 2.738 ± 0.107
2.513AspGly: 2.513 ± 0.123
0.908AspHis: 0.908 ± 0.054
7.763AspIle: 7.763 ± 0.227
4.041AspLys: 4.041 ± 0.13
5.228AspLeu: 5.228 ± 0.136
1.124AspMet: 1.124 ± 0.07
3.834AspAsn: 3.834 ± 0.154
1.641AspPro: 1.641 ± 0.094
1.447AspGln: 1.447 ± 0.088
1.654AspArg: 1.654 ± 0.085
3.219AspSer: 3.219 ± 0.115
1.973AspThr: 1.973 ± 0.098
2.616AspVal: 2.616 ± 0.103
0.468AspTrp: 0.468 ± 0.055
2.059AspTyr: 2.059 ± 0.079
0.0AspXaa: 0.0 ± 0.0
Glu
2.666GluAla: 2.666 ± 0.113
0.512GluCys: 0.512 ± 0.049
2.333GluAsp: 2.333 ± 0.114
3.012GluGlu: 3.012 ± 0.139
2.481GluPhe: 2.481 ± 0.11
2.32GluGly: 2.32 ± 0.111
0.931GluHis: 0.931 ± 0.065
7.35GluIle: 7.35 ± 0.201
5.457GluLys: 5.457 ± 0.144
5.3GluLeu: 5.3 ± 0.149
1.191GluMet: 1.191 ± 0.07
4.549GluAsn: 4.549 ± 0.146
1.241GluPro: 1.241 ± 0.08
1.564GluGln: 1.564 ± 0.073
1.87GluArg: 1.87 ± 0.112
3.336GluSer: 3.336 ± 0.124
2.126GluThr: 2.126 ± 0.11
2.414GluVal: 2.414 ± 0.115
0.503GluTrp: 0.503 ± 0.046
2.212GluTyr: 2.212 ± 0.09
0.0GluXaa: 0.0 ± 0.0
Phe
2.212PheAla: 2.212 ± 0.106
0.755PheCys: 0.755 ± 0.052
2.733PheAsp: 2.733 ± 0.126
2.329PheGlu: 2.329 ± 0.105
2.423PhePhe: 2.423 ± 0.145
2.679PheGly: 2.679 ± 0.109
1.083PheHis: 1.083 ± 0.081
5.489PheIle: 5.489 ± 0.175
3.16PheLys: 3.16 ± 0.119
4.823PheLeu: 4.823 ± 0.203
1.007PheMet: 1.007 ± 0.066
3.772PheAsn: 3.772 ± 0.146
1.367PhePro: 1.367 ± 0.068
1.349PheGln: 1.349 ± 0.075
1.34PheArg: 1.34 ± 0.081
3.902PheSer: 3.902 ± 0.133
1.834PheThr: 1.834 ± 0.079
2.05PheVal: 2.05 ± 0.129
0.387PheTrp: 0.387 ± 0.046
1.902PheTyr: 1.902 ± 0.114
0.0PheXaa: 0.0 ± 0.0
Gly
3.304GlyAla: 3.304 ± 0.15
0.782GlyCys: 0.782 ± 0.064
2.526GlyAsp: 2.526 ± 0.107
2.616GlyGlu: 2.616 ± 0.115
2.657GlyPhe: 2.657 ± 0.116
3.641GlyGly: 3.641 ± 0.184
1.29GlyHis: 1.29 ± 0.082
6.999GlyIle: 6.999 ± 0.184
4.509GlyLys: 4.509 ± 0.15
5.093GlyLeu: 5.093 ± 0.154
1.389GlyMet: 1.389 ± 0.084
2.864GlyAsn: 2.864 ± 0.106
1.497GlyPro: 1.497 ± 0.079
1.605GlyGln: 1.605 ± 0.075
2.185GlyArg: 2.185 ± 0.109
3.772GlySer: 3.772 ± 0.14
2.81GlyThr: 2.81 ± 0.136
3.088GlyVal: 3.088 ± 0.135
0.499GlyTrp: 0.499 ± 0.046
2.221GlyTyr: 2.221 ± 0.118
0.0GlyXaa: 0.0 ± 0.0
His
1.182HisAla: 1.182 ± 0.067
0.247HisCys: 0.247 ± 0.035
0.895HisAsp: 0.895 ± 0.066
0.944HisGlu: 0.944 ± 0.054
0.836HisPhe: 0.836 ± 0.058
1.331HisGly: 1.331 ± 0.075
0.391HisHis: 0.391 ± 0.05
2.558HisIle: 2.558 ± 0.122
1.618HisLys: 1.618 ± 0.086
1.659HisLeu: 1.659 ± 0.091
0.45HisMet: 0.45 ± 0.044
1.74HisAsn: 1.74 ± 0.1
0.926HisPro: 0.926 ± 0.073
0.521HisGln: 0.521 ± 0.043
0.719HisArg: 0.719 ± 0.057
1.115HisSer: 1.115 ± 0.071
0.751HisThr: 0.751 ± 0.052
0.899HisVal: 0.899 ± 0.057
0.13HisTrp: 0.13 ± 0.023
0.715HisTyr: 0.715 ± 0.061
0.0HisXaa: 0.0 ± 0.0
Ile
6.347IleAla: 6.347 ± 0.205
1.6IleCys: 1.6 ± 0.082
7.844IleAsp: 7.844 ± 0.174
7.269IleGlu: 7.269 ± 0.181
5.826IlePhe: 5.826 ± 0.19
6.756IleGly: 6.756 ± 0.202
2.153IleHis: 2.153 ± 0.095
13.315IleIle: 13.315 ± 0.292
11.049IleLys: 11.049 ± 0.25
12.191IleLeu: 12.191 ± 0.254
2.396IleMet: 2.396 ± 0.115
11.157IleAsn: 11.157 ± 0.28
4.199IlePro: 4.199 ± 0.126
3.016IleGln: 3.016 ± 0.116
3.439IleArg: 3.439 ± 0.126
10.339IleSer: 10.339 ± 0.231
4.949IleThr: 4.949 ± 0.151
5.696IleVal: 5.696 ± 0.159
0.949IleTrp: 0.949 ± 0.078
4.401IleTyr: 4.401 ± 0.144
0.0IleXaa: 0.0 ± 0.0
Lys
3.228LysAla: 3.228 ± 0.127
0.67LysCys: 0.67 ± 0.061
4.356LysAsp: 4.356 ± 0.165
4.805LysGlu: 4.805 ± 0.147
4.235LysPhe: 4.235 ± 0.143
3.156LysGly: 3.156 ± 0.124
1.551LysHis: 1.551 ± 0.089
11.665LysIle: 11.665 ± 0.259
8.393LysLys: 8.393 ± 0.246
8.375LysLeu: 8.375 ± 0.203
1.879LysMet: 1.879 ± 0.102
10.24LysAsn: 10.24 ± 0.263
2.027LysPro: 2.027 ± 0.092
2.342LysGln: 2.342 ± 0.1
2.594LysArg: 2.594 ± 0.123
5.48LysSer: 5.48 ± 0.15
3.434LysThr: 3.434 ± 0.127
3.362LysVal: 3.362 ± 0.12
0.701LysTrp: 0.701 ± 0.065
4.235LysTyr: 4.235 ± 0.143
0.0LysXaa: 0.0 ± 0.0
Leu
4.85LeuAla: 4.85 ± 0.159
1.106LeuCys: 1.106 ± 0.078
5.412LeuAsp: 5.412 ± 0.147
6.015LeuGlu: 6.015 ± 0.185
4.329LeuPhe: 4.329 ± 0.178
5.489LeuGly: 5.489 ± 0.152
2.009LeuHis: 2.009 ± 0.103
10.398LeuIle: 10.398 ± 0.26
8.056LeuLys: 8.056 ± 0.216
9.759LeuLeu: 9.759 ± 0.25
1.937LeuMet: 1.937 ± 0.096
7.629LeuAsn: 7.629 ± 0.216
3.65LeuPro: 3.65 ± 0.138
2.697LeuGln: 2.697 ± 0.095
3.547LeuArg: 3.547 ± 0.133
8.591LeuSer: 8.591 ± 0.212
3.965LeuThr: 3.965 ± 0.136
4.351LeuVal: 4.351 ± 0.147
0.719LeuTrp: 0.719 ± 0.055
3.358LeuTyr: 3.358 ± 0.132
0.0LeuXaa: 0.0 ± 0.0
Met
1.052MetAla: 1.052 ± 0.084
0.198MetCys: 0.198 ± 0.031
0.85MetAsp: 0.85 ± 0.059
0.949MetGlu: 0.949 ± 0.06
0.827MetPhe: 0.827 ± 0.061
1.191MetGly: 1.191 ± 0.073
0.602MetHis: 0.602 ± 0.054
2.203MetIle: 2.203 ± 0.1
2.009MetLys: 2.009 ± 0.104
2.185MetLeu: 2.185 ± 0.107
0.539MetMet: 0.539 ± 0.049
1.866MetAsn: 1.866 ± 0.082
1.002MetPro: 1.002 ± 0.066
0.89MetGln: 0.89 ± 0.067
0.877MetArg: 0.877 ± 0.068
1.803MetSer: 1.803 ± 0.082
0.922MetThr: 0.922 ± 0.074
1.016MetVal: 1.016 ± 0.071
0.148MetTrp: 0.148 ± 0.027
0.571MetTyr: 0.571 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
3.043AsnAla: 3.043 ± 0.115
0.971AsnCys: 0.971 ± 0.076
3.888AsnAsp: 3.888 ± 0.13
3.655AsnGlu: 3.655 ± 0.142
4.495AsnPhe: 4.495 ± 0.168
3.74AsnGly: 3.74 ± 0.149
1.623AsnHis: 1.623 ± 0.081
13.189AsnIle: 13.189 ± 0.335
8.289AsnLys: 8.289 ± 0.233
7.849AsnLeu: 7.849 ± 0.278
1.744AsnMet: 1.744 ± 0.089
8.824AsnAsn: 8.824 ± 0.271
2.347AsnPro: 2.347 ± 0.098
2.36AsnGln: 2.36 ± 0.112
2.54AsnArg: 2.54 ± 0.112
4.999AsnSer: 4.999 ± 0.134
3.327AsnThr: 3.327 ± 0.126
3.327AsnVal: 3.327 ± 0.127
0.746AsnTrp: 0.746 ± 0.058
3.201AsnTyr: 3.201 ± 0.123
0.0AsnXaa: 0.0 ± 0.0
Pro
1.259ProAla: 1.259 ± 0.075
0.391ProCys: 0.391 ± 0.043
1.56ProAsp: 1.56 ± 0.08
1.897ProGlu: 1.897 ± 0.096
1.443ProPhe: 1.443 ± 0.086
2.0ProGly: 2.0 ± 0.103
0.553ProHis: 0.553 ± 0.052
3.978ProIle: 3.978 ± 0.133
2.414ProLys: 2.414 ± 0.099
2.666ProLeu: 2.666 ± 0.108
0.593ProMet: 0.593 ± 0.047
2.463ProAsn: 2.463 ± 0.103
0.733ProPro: 0.733 ± 0.056
0.737ProGln: 0.737 ± 0.063
0.827ProArg: 0.827 ± 0.064
2.045ProSer: 2.045 ± 0.098
1.421ProThr: 1.421 ± 0.084
1.605ProVal: 1.605 ± 0.076
0.36ProTrp: 0.36 ± 0.04
1.295ProTyr: 1.295 ± 0.077
0.0ProXaa: 0.0 ± 0.0
Gln
1.65GlnAla: 1.65 ± 0.076
0.256GlnCys: 0.256 ± 0.032
1.376GlnAsp: 1.376 ± 0.083
1.776GlnGlu: 1.776 ± 0.102
1.241GlnPhe: 1.241 ± 0.075
1.308GlnGly: 1.308 ± 0.081
0.526GlnHis: 0.526 ± 0.048
3.538GlnIle: 3.538 ± 0.118
2.531GlnLys: 2.531 ± 0.126
2.715GlnLeu: 2.715 ± 0.12
0.643GlnMet: 0.643 ± 0.052
2.203GlnAsn: 2.203 ± 0.119
0.611GlnPro: 0.611 ± 0.061
0.922GlnGln: 0.922 ± 0.069
0.98GlnArg: 0.98 ± 0.068
1.843GlnSer: 1.843 ± 0.097
1.137GlnThr: 1.137 ± 0.075
1.259GlnVal: 1.259 ± 0.078
0.279GlnTrp: 0.279 ± 0.037
1.25GlnTyr: 1.25 ± 0.081
0.0GlnXaa: 0.0 ± 0.0
Arg
1.839ArgAla: 1.839 ± 0.083
0.364ArgCys: 0.364 ± 0.037
1.609ArgAsp: 1.609 ± 0.076
1.987ArgGlu: 1.987 ± 0.106
1.537ArgPhe: 1.537 ± 0.091
1.978ArgGly: 1.978 ± 0.106
0.652ArgHis: 0.652 ± 0.055
3.709ArgIle: 3.709 ± 0.126
2.675ArgLys: 2.675 ± 0.107
3.349ArgLeu: 3.349 ± 0.139
0.764ArgMet: 0.764 ± 0.054
2.414ArgAsn: 2.414 ± 0.102
1.128ArgPro: 1.128 ± 0.081
1.047ArgGln: 1.047 ± 0.07
1.524ArgArg: 1.524 ± 0.098
2.216ArgSer: 2.216 ± 0.116
1.488ArgThr: 1.488 ± 0.09
1.695ArgVal: 1.695 ± 0.097
0.247ArgTrp: 0.247 ± 0.035
1.371ArgTyr: 1.371 ± 0.076
0.0ArgXaa: 0.0 ± 0.0
Ser
3.331SerAla: 3.331 ± 0.118
0.782SerCys: 0.782 ± 0.059
3.416SerAsp: 3.416 ± 0.116
3.475SerGlu: 3.475 ± 0.135
3.21SerPhe: 3.21 ± 0.109
4.778SerGly: 4.778 ± 0.155
1.353SerHis: 1.353 ± 0.076
8.977SerIle: 8.977 ± 0.223
6.338SerLys: 6.338 ± 0.19
7.269SerLeu: 7.269 ± 0.199
1.659SerMet: 1.659 ± 0.092
5.979SerAsn: 5.979 ± 0.165
1.83SerPro: 1.83 ± 0.089
2.009SerGln: 2.009 ± 0.089
2.387SerArg: 2.387 ± 0.095
5.224SerSer: 5.224 ± 0.17
2.953SerThr: 2.953 ± 0.125
2.913SerVal: 2.913 ± 0.109
0.629SerTrp: 0.629 ± 0.059
2.868SerTyr: 2.868 ± 0.11
0.0SerXaa: 0.0 ± 0.0
Thr
2.194ThrAla: 2.194 ± 0.11
0.477ThrCys: 0.477 ± 0.043
2.068ThrAsp: 2.068 ± 0.086
2.009ThrGlu: 2.009 ± 0.091
1.659ThrPhe: 1.659 ± 0.078
2.837ThrGly: 2.837 ± 0.12
0.85ThrHis: 0.85 ± 0.06
5.107ThrIle: 5.107 ± 0.141
3.147ThrLys: 3.147 ± 0.132
4.185ThrLeu: 4.185 ± 0.134
0.917ThrMet: 0.917 ± 0.056
3.196ThrAsn: 3.196 ± 0.099
1.524ThrPro: 1.524 ± 0.094
1.133ThrGln: 1.133 ± 0.071
1.497ThrArg: 1.497 ± 0.092
2.913ThrSer: 2.913 ± 0.11
1.942ThrThr: 1.942 ± 0.113
2.212ThrVal: 2.212 ± 0.099
0.378ThrTrp: 0.378 ± 0.045
1.407ThrTyr: 1.407 ± 0.08
0.0ThrXaa: 0.0 ± 0.0
Val
2.751ValAla: 2.751 ± 0.12
0.494ValCys: 0.494 ± 0.041
2.72ValAsp: 2.72 ± 0.118
2.576ValGlu: 2.576 ± 0.126
1.834ValPhe: 1.834 ± 0.085
2.976ValGly: 2.976 ± 0.134
1.029ValHis: 1.029 ± 0.068
5.295ValIle: 5.295 ± 0.156
3.506ValLys: 3.506 ± 0.143
4.378ValLeu: 4.378 ± 0.145
1.016ValMet: 1.016 ± 0.068
3.282ValAsn: 3.282 ± 0.119
1.456ValPro: 1.456 ± 0.087
1.191ValGln: 1.191 ± 0.077
1.744ValArg: 1.744 ± 0.098
3.434ValSer: 3.434 ± 0.114
2.18ValThr: 2.18 ± 0.109
2.45ValVal: 2.45 ± 0.143
0.342ValTrp: 0.342 ± 0.038
1.349ValTyr: 1.349 ± 0.08
0.0ValXaa: 0.0 ± 0.0
Trp
0.382TrpAla: 0.382 ± 0.038
0.148TrpCys: 0.148 ± 0.023
0.364TrpAsp: 0.364 ± 0.044
0.427TrpGlu: 0.427 ± 0.042
0.414TrpPhe: 0.414 ± 0.045
0.351TrpGly: 0.351 ± 0.042
0.243TrpHis: 0.243 ± 0.034
1.034TrpIle: 1.034 ± 0.071
0.692TrpLys: 0.692 ± 0.055
1.182TrpLeu: 1.182 ± 0.083
0.265TrpMet: 0.265 ± 0.034
0.679TrpAsn: 0.679 ± 0.059
0.229TrpPro: 0.229 ± 0.031
0.292TrpGln: 0.292 ± 0.04
0.328TrpArg: 0.328 ± 0.036
0.459TrpSer: 0.459 ± 0.048
0.27TrpThr: 0.27 ± 0.04
0.369TrpVal: 0.369 ± 0.042
0.076TrpTrp: 0.076 ± 0.016
0.292TrpTyr: 0.292 ± 0.039
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.897TyrAla: 1.897 ± 0.106
0.463TyrCys: 0.463 ± 0.046
2.185TyrAsp: 2.185 ± 0.086
1.991TyrGlu: 1.991 ± 0.096
1.749TyrPhe: 1.749 ± 0.087
2.387TyrGly: 2.387 ± 0.101
0.737TyrHis: 0.737 ± 0.052
4.608TyrIle: 4.608 ± 0.135
3.641TyrLys: 3.641 ± 0.135
3.677TyrLeu: 3.677 ± 0.14
0.67TyrMet: 0.67 ± 0.063
3.21TyrAsn: 3.21 ± 0.135
1.047TyrPro: 1.047 ± 0.072
1.214TyrGln: 1.214 ± 0.085
1.25TyrArg: 1.25 ± 0.074
2.657TyrSer: 2.657 ± 0.122
1.394TyrThr: 1.394 ± 0.086
1.573TyrVal: 1.573 ± 0.088
0.373TyrTrp: 0.373 ± 0.049
1.389TyrTyr: 1.389 ± 0.083
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 670 proteins (222456 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski