Amino acid dipepetide frequency for Legionella sp. km772

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.021AlaAla: 7.021 ± 0.113
1.06AlaCys: 1.06 ± 0.036
3.411AlaAsp: 3.411 ± 0.062
4.608AlaGlu: 4.608 ± 0.081
3.22AlaPhe: 3.22 ± 0.061
4.961AlaGly: 4.961 ± 0.106
2.022AlaHis: 2.022 ± 0.043
6.037AlaIle: 6.037 ± 0.098
5.039AlaLys: 5.039 ± 0.073
10.246AlaLeu: 10.246 ± 0.106
2.009AlaMet: 2.009 ± 0.051
3.581AlaAsn: 3.581 ± 0.056
2.643AlaPro: 2.643 ± 0.056
4.178AlaGln: 4.178 ± 0.073
3.441AlaArg: 3.441 ± 0.064
5.16AlaSer: 5.16 ± 0.075
3.876AlaThr: 3.876 ± 0.068
4.726AlaVal: 4.726 ± 0.075
0.838AlaTrp: 0.838 ± 0.027
2.779AlaTyr: 2.779 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.887CysAla: 0.887 ± 0.033
0.174CysCys: 0.174 ± 0.016
0.536CysAsp: 0.536 ± 0.022
0.592CysGlu: 0.592 ± 0.026
0.631CysPhe: 0.631 ± 0.027
0.821CysGly: 0.821 ± 0.031
0.336CysHis: 0.336 ± 0.019
0.796CysIle: 0.796 ± 0.031
0.558CysLys: 0.558 ± 0.026
1.317CysLeu: 1.317 ± 0.041
0.26CysMet: 0.26 ± 0.017
0.457CysAsn: 0.457 ± 0.022
0.489CysPro: 0.489 ± 0.027
0.494CysGln: 0.494 ± 0.024
0.463CysArg: 0.463 ± 0.025
0.884CysSer: 0.884 ± 0.038
0.674CysThr: 0.674 ± 0.031
0.659CysVal: 0.659 ± 0.021
0.143CysTrp: 0.143 ± 0.012
0.498CysTyr: 0.498 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.492AspAla: 3.492 ± 0.06
0.526AspCys: 0.526 ± 0.023
2.286AspAsp: 2.286 ± 0.05
3.483AspGlu: 3.483 ± 0.07
2.349AspPhe: 2.349 ± 0.054
2.49AspGly: 2.49 ± 0.059
0.913AspHis: 0.913 ± 0.03
3.204AspIle: 3.204 ± 0.052
3.408AspLys: 3.408 ± 0.057
5.35AspLeu: 5.35 ± 0.069
0.956AspMet: 0.956 ± 0.031
2.321AspAsn: 2.321 ± 0.053
1.963AspPro: 1.963 ± 0.045
1.585AspGln: 1.585 ± 0.046
1.745AspArg: 1.745 ± 0.044
2.998AspSer: 2.998 ± 0.056
1.971AspThr: 1.971 ± 0.052
2.699AspVal: 2.699 ± 0.055
0.623AspTrp: 0.623 ± 0.023
2.148AspTyr: 2.148 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
4.734GluAla: 4.734 ± 0.085
0.551GluCys: 0.551 ± 0.027
2.526GluAsp: 2.526 ± 0.055
4.464GluGlu: 4.464 ± 0.092
2.327GluPhe: 2.327 ± 0.052
3.139GluGly: 3.139 ± 0.066
1.82GluHis: 1.82 ± 0.052
3.997GluIle: 3.997 ± 0.073
4.206GluLys: 4.206 ± 0.073
7.533GluLeu: 7.533 ± 0.105
1.402GluMet: 1.402 ± 0.039
2.569GluAsn: 2.569 ± 0.057
1.931GluPro: 1.931 ± 0.051
4.065GluGln: 4.065 ± 0.074
3.07GluArg: 3.07 ± 0.06
3.188GluSer: 3.188 ± 0.059
2.765GluThr: 2.765 ± 0.059
3.591GluVal: 3.591 ± 0.072
0.581GluTrp: 0.581 ± 0.025
1.762GluTyr: 1.762 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.578PheAla: 3.578 ± 0.069
0.649PheCys: 0.649 ± 0.031
2.158PheAsp: 2.158 ± 0.048
2.028PheGlu: 2.028 ± 0.051
2.475PhePhe: 2.475 ± 0.063
2.39PheGly: 2.39 ± 0.059
0.92PheHis: 0.92 ± 0.031
3.577PheIle: 3.577 ± 0.074
2.613PheLys: 2.613 ± 0.049
4.656PheLeu: 4.656 ± 0.081
0.962PheMet: 0.962 ± 0.032
2.52PheAsn: 2.52 ± 0.048
1.688PhePro: 1.688 ± 0.044
1.425PheGln: 1.425 ± 0.036
1.392PheArg: 1.392 ± 0.038
3.631PheSer: 3.631 ± 0.073
2.398PheThr: 2.398 ± 0.048
2.292PheVal: 2.292 ± 0.059
0.537PheTrp: 0.537 ± 0.024
1.785PheTyr: 1.785 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
4.4GlyAla: 4.4 ± 0.092
0.773GlyCys: 0.773 ± 0.032
2.667GlyAsp: 2.667 ± 0.051
3.171GlyGlu: 3.171 ± 0.053
3.123GlyPhe: 3.123 ± 0.078
3.928GlyGly: 3.928 ± 0.086
1.464GlyHis: 1.464 ± 0.046
4.494GlyIle: 4.494 ± 0.085
3.661GlyLys: 3.661 ± 0.071
6.86GlyLeu: 6.86 ± 0.101
1.608GlyMet: 1.608 ± 0.046
2.338GlyAsn: 2.338 ± 0.059
1.653GlyPro: 1.653 ± 0.039
2.509GlyGln: 2.509 ± 0.048
2.431GlyArg: 2.431 ± 0.049
3.861GlySer: 3.861 ± 0.075
3.138GlyThr: 3.138 ± 0.068
4.041GlyVal: 4.041 ± 0.068
0.79GlyTrp: 0.79 ± 0.03
2.425GlyTyr: 2.425 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
1.812HisAla: 1.812 ± 0.05
0.392HisCys: 0.392 ± 0.021
1.088HisAsp: 1.088 ± 0.032
1.325HisGlu: 1.325 ± 0.039
1.315HisPhe: 1.315 ± 0.041
1.451HisGly: 1.451 ± 0.041
0.936HisHis: 0.936 ± 0.043
1.467HisIle: 1.467 ± 0.041
1.222HisLys: 1.222 ± 0.034
3.138HisLeu: 3.138 ± 0.067
0.471HisMet: 0.471 ± 0.023
0.917HisAsn: 0.917 ± 0.03
1.347HisPro: 1.347 ± 0.043
1.345HisGln: 1.345 ± 0.04
1.049HisArg: 1.049 ± 0.033
1.706HisSer: 1.706 ± 0.043
1.067HisThr: 1.067 ± 0.029
1.202HisVal: 1.202 ± 0.035
0.372HisTrp: 0.372 ± 0.019
1.307HisTyr: 1.307 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.281IleAla: 6.281 ± 0.08
0.722IleCys: 0.722 ± 0.03
3.983IleAsp: 3.983 ± 0.063
4.71IleGlu: 4.71 ± 0.096
2.606IlePhe: 2.606 ± 0.058
4.3IleGly: 4.3 ± 0.081
1.786IleHis: 1.786 ± 0.043
5.133IleIle: 5.133 ± 0.087
5.083IleLys: 5.083 ± 0.093
6.682IleLeu: 6.682 ± 0.092
1.393IleMet: 1.393 ± 0.046
4.386IleAsn: 4.386 ± 0.069
3.326IlePro: 3.326 ± 0.061
2.832IleGln: 2.832 ± 0.057
2.768IleArg: 2.768 ± 0.057
4.965IleSer: 4.965 ± 0.076
3.908IleThr: 3.908 ± 0.057
3.723IleVal: 3.723 ± 0.077
0.6IleTrp: 0.6 ± 0.023
2.126IleTyr: 2.126 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
5.191LysAla: 5.191 ± 0.088
0.375LysCys: 0.375 ± 0.018
2.994LysAsp: 2.994 ± 0.061
4.772LysGlu: 4.772 ± 0.074
1.542LysPhe: 1.542 ± 0.043
3.251LysGly: 3.251 ± 0.065
1.492LysHis: 1.492 ± 0.042
4.592LysIle: 4.592 ± 0.073
4.941LysLys: 4.941 ± 0.08
6.27LysLeu: 6.27 ± 0.089
1.484LysMet: 1.484 ± 0.039
3.598LysAsn: 3.598 ± 0.059
2.852LysPro: 2.852 ± 0.055
3.483LysGln: 3.483 ± 0.059
2.824LysArg: 2.824 ± 0.052
3.547LysSer: 3.547 ± 0.055
3.877LysThr: 3.877 ± 0.068
3.298LysVal: 3.298 ± 0.057
0.535LysTrp: 0.535 ± 0.022
1.7LysTyr: 1.7 ± 0.044
0.0LysXaa: 0.0 ± 0.0
Leu
10.066LeuAla: 10.066 ± 0.117
1.458LeuCys: 1.458 ± 0.042
5.21LeuAsp: 5.21 ± 0.086
6.314LeuGlu: 6.314 ± 0.109
5.262LeuPhe: 5.262 ± 0.088
6.834LeuGly: 6.834 ± 0.093
2.442LeuHis: 2.442 ± 0.058
8.58LeuIle: 8.58 ± 0.106
7.065LeuLys: 7.065 ± 0.093
12.46LeuLeu: 12.46 ± 0.176
2.753LeuMet: 2.753 ± 0.056
6.162LeuAsn: 6.162 ± 0.08
4.949LeuPro: 4.949 ± 0.076
4.298LeuGln: 4.298 ± 0.079
4.367LeuArg: 4.367 ± 0.083
8.765LeuSer: 8.765 ± 0.113
6.196LeuThr: 6.196 ± 0.085
6.474LeuVal: 6.474 ± 0.086
1.094LeuTrp: 1.094 ± 0.035
3.358LeuTyr: 3.358 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
1.984MetAla: 1.984 ± 0.044
0.192MetCys: 0.192 ± 0.015
1.161MetAsp: 1.161 ± 0.037
1.152MetGlu: 1.152 ± 0.034
0.714MetPhe: 0.714 ± 0.029
1.478MetGly: 1.478 ± 0.04
0.561MetHis: 0.561 ± 0.028
1.519MetIle: 1.519 ± 0.048
1.484MetLys: 1.484 ± 0.035
2.361MetLeu: 2.361 ± 0.051
0.666MetMet: 0.666 ± 0.025
1.342MetAsn: 1.342 ± 0.037
1.071MetPro: 1.071 ± 0.034
1.078MetGln: 1.078 ± 0.037
1.117MetArg: 1.117 ± 0.034
1.589MetSer: 1.589 ± 0.041
1.333MetThr: 1.333 ± 0.036
1.408MetVal: 1.408 ± 0.043
0.161MetTrp: 0.161 ± 0.014
0.525MetTyr: 0.525 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.8AsnAla: 3.8 ± 0.069
0.561AsnCys: 0.561 ± 0.026
2.156AsnAsp: 2.156 ± 0.049
3.146AsnGlu: 3.146 ± 0.056
1.862AsnPhe: 1.862 ± 0.041
2.679AsnGly: 2.679 ± 0.067
1.215AsnHis: 1.215 ± 0.034
3.09AsnIle: 3.09 ± 0.058
3.531AsnLys: 3.531 ± 0.069
5.085AsnLeu: 5.085 ± 0.075
0.91AsnMet: 0.91 ± 0.028
2.809AsnAsn: 2.809 ± 0.061
2.667AsnPro: 2.667 ± 0.048
2.644AsnGln: 2.644 ± 0.058
1.863AsnArg: 1.863 ± 0.042
3.358AsnSer: 3.358 ± 0.07
2.633AsnThr: 2.633 ± 0.057
2.239AsnVal: 2.239 ± 0.053
0.612AsnTrp: 0.612 ± 0.025
2.035AsnTyr: 2.035 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
2.953ProAla: 2.953 ± 0.056
0.402ProCys: 0.402 ± 0.021
1.98ProAsp: 1.98 ± 0.048
2.979ProGlu: 2.979 ± 0.056
1.766ProPhe: 1.766 ± 0.041
2.489ProGly: 2.489 ± 0.052
1.039ProHis: 1.039 ± 0.031
2.926ProIle: 2.926 ± 0.056
2.325ProLys: 2.325 ± 0.058
4.561ProLeu: 4.561 ± 0.072
0.918ProMet: 0.918 ± 0.028
2.002ProAsn: 2.002 ± 0.052
1.604ProPro: 1.604 ± 0.05
1.956ProGln: 1.956 ± 0.045
1.401ProArg: 1.401 ± 0.04
2.963ProSer: 2.963 ± 0.057
2.147ProThr: 2.147 ± 0.049
2.695ProVal: 2.695 ± 0.059
0.486ProTrp: 0.486 ± 0.023
1.476ProTyr: 1.476 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
4.378GlnAla: 4.378 ± 0.062
0.548GlnCys: 0.548 ± 0.026
1.878GlnAsp: 1.878 ± 0.045
3.039GlnGlu: 3.039 ± 0.075
2.123GlnPhe: 2.123 ± 0.045
2.87GlnGly: 2.87 ± 0.059
1.246GlnHis: 1.246 ± 0.042
3.141GlnIle: 3.141 ± 0.057
2.93GlnLys: 2.93 ± 0.065
5.694GlnLeu: 5.694 ± 0.095
1.007GlnMet: 1.007 ± 0.034
2.017GlnAsn: 2.017 ± 0.062
1.447GlnPro: 1.447 ± 0.041
3.045GlnGln: 3.045 ± 0.065
2.053GlnArg: 2.053 ± 0.045
2.602GlnSer: 2.602 ± 0.057
2.262GlnThr: 2.262 ± 0.042
2.784GlnVal: 2.784 ± 0.055
0.643GlnTrp: 0.643 ± 0.023
1.494GlnTyr: 1.494 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
3.097ArgAla: 3.097 ± 0.068
0.499ArgCys: 0.499 ± 0.027
2.052ArgAsp: 2.052 ± 0.048
2.559ArgGlu: 2.559 ± 0.059
2.076ArgPhe: 2.076 ± 0.041
2.202ArgGly: 2.202 ± 0.048
1.041ArgHis: 1.041 ± 0.03
3.079ArgIle: 3.079 ± 0.059
2.293ArgLys: 2.293 ± 0.047
4.972ArgLeu: 4.972 ± 0.082
0.991ArgMet: 0.991 ± 0.033
1.692ArgAsn: 1.692 ± 0.04
1.475ArgPro: 1.475 ± 0.041
1.862ArgGln: 1.862 ± 0.046
1.879ArgArg: 1.879 ± 0.049
2.344ArgSer: 2.344 ± 0.054
2.078ArgThr: 2.078 ± 0.05
2.599ArgVal: 2.599 ± 0.065
0.505ArgTrp: 0.505 ± 0.025
1.696ArgTyr: 1.696 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
5.071SerAla: 5.071 ± 0.085
0.93SerCys: 0.93 ± 0.041
2.9SerAsp: 2.9 ± 0.055
3.472SerGlu: 3.472 ± 0.06
3.28SerPhe: 3.28 ± 0.062
4.223SerGly: 4.223 ± 0.071
1.661SerHis: 1.661 ± 0.041
4.868SerIle: 4.868 ± 0.07
3.679SerLys: 3.679 ± 0.051
8.389SerLeu: 8.389 ± 0.111
1.645SerMet: 1.645 ± 0.044
2.944SerAsn: 2.944 ± 0.063
2.979SerPro: 2.979 ± 0.057
2.955SerGln: 2.955 ± 0.052
2.561SerArg: 2.561 ± 0.052
5.117SerSer: 5.117 ± 0.084
3.715SerThr: 3.715 ± 0.068
3.615SerVal: 3.615 ± 0.062
0.808SerTrp: 0.808 ± 0.029
2.517SerTyr: 2.517 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
4.217ThrAla: 4.217 ± 0.069
0.531ThrCys: 0.531 ± 0.025
2.287ThrAsp: 2.287 ± 0.047
2.761ThrGlu: 2.761 ± 0.059
1.804ThrPhe: 1.804 ± 0.048
3.407ThrGly: 3.407 ± 0.065
1.515ThrHis: 1.515 ± 0.046
3.922ThrIle: 3.922 ± 0.064
2.73ThrLys: 2.73 ± 0.047
6.113ThrLeu: 6.113 ± 0.094
1.142ThrMet: 1.142 ± 0.032
2.31ThrAsn: 2.31 ± 0.052
2.784ThrPro: 2.784 ± 0.058
2.516ThrGln: 2.516 ± 0.058
2.089ThrArg: 2.089 ± 0.051
3.421ThrSer: 3.421 ± 0.061
3.128ThrThr: 3.128 ± 0.065
3.329ThrVal: 3.329 ± 0.073
0.558ThrTrp: 0.558 ± 0.023
1.754ThrTyr: 1.754 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
4.704ValAla: 4.704 ± 0.084
0.664ValCys: 0.664 ± 0.028
3.116ValAsp: 3.116 ± 0.06
3.269ValGlu: 3.269 ± 0.071
2.714ValPhe: 2.714 ± 0.057
3.639ValGly: 3.639 ± 0.067
1.32ValHis: 1.32 ± 0.041
4.236ValIle: 4.236 ± 0.068
3.337ValLys: 3.337 ± 0.061
6.492ValLeu: 6.492 ± 0.092
1.428ValMet: 1.428 ± 0.045
2.922ValAsn: 2.922 ± 0.052
2.18ValPro: 2.18 ± 0.051
2.14ValGln: 2.14 ± 0.051
2.35ValArg: 2.35 ± 0.051
4.007ValSer: 4.007 ± 0.073
2.897ValThr: 2.897 ± 0.056
3.897ValVal: 3.897 ± 0.082
0.568ValTrp: 0.568 ± 0.027
1.908ValTyr: 1.908 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.658TrpAla: 0.658 ± 0.026
0.139TrpCys: 0.139 ± 0.012
0.542TrpAsp: 0.542 ± 0.027
0.525TrpGlu: 0.525 ± 0.023
0.564TrpPhe: 0.564 ± 0.025
0.715TrpGly: 0.715 ± 0.031
0.307TrpHis: 0.307 ± 0.019
0.708TrpIle: 0.708 ± 0.028
0.511TrpLys: 0.511 ± 0.023
1.511TrpLeu: 1.511 ± 0.041
0.281TrpMet: 0.281 ± 0.018
0.479TrpAsn: 0.479 ± 0.02
0.43TrpPro: 0.43 ± 0.021
0.711TrpGln: 0.711 ± 0.027
0.528TrpArg: 0.528 ± 0.025
0.768TrpSer: 0.768 ± 0.033
0.503TrpThr: 0.503 ± 0.024
0.676TrpVal: 0.676 ± 0.026
0.156TrpTrp: 0.156 ± 0.013
0.401TrpTyr: 0.401 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.53TyrAla: 2.53 ± 0.05
0.523TyrCys: 0.523 ± 0.024
1.58TyrAsp: 1.58 ± 0.047
1.851TyrGlu: 1.851 ± 0.041
1.922TyrPhe: 1.922 ± 0.046
2.068TyrGly: 2.068 ± 0.048
0.892TyrHis: 0.892 ± 0.03
1.951TyrIle: 1.951 ± 0.045
2.005TyrLys: 2.005 ± 0.047
4.421TyrLeu: 4.421 ± 0.072
0.61TyrMet: 0.61 ± 0.026
1.529TyrAsn: 1.529 ± 0.043
1.589TyrPro: 1.589 ± 0.046
2.078TyrGln: 2.078 ± 0.048
1.601TyrArg: 1.601 ± 0.038
2.451TyrSer: 2.451 ± 0.052
1.751TyrThr: 1.751 ± 0.05
1.84TyrVal: 1.84 ± 0.048
0.501TyrTrp: 0.501 ± 0.024
1.467TyrTyr: 1.467 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3061 proteins (969520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski