Amino acid dipepetide frequency for Luteimonas aestuarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.765AlaAla: 17.765 ± 0.175	1.389AlaCys: 1.389 ± 0.04	7.586AlaAsp: 7.586 ± 0.097	6.918AlaGlu: 6.918 ± 0.103	4.434AlaPhe: 4.434 ± 0.071	11.531AlaGly: 11.531 ± 0.111	2.777AlaHis: 2.777 ± 0.051	5.698AlaIle: 5.698 ± 0.067	2.999AlaLys: 2.999 ± 0.079	15.665AlaLeu: 15.665 ± 0.175	3.699AlaMet: 3.699 ± 0.069	2.87AlaAsn: 2.87 ± 0.058	6.361AlaPro: 6.361 ± 0.083	4.976AlaGln: 4.976 ± 0.084	10.524AlaArg: 10.524 ± 0.123	6.865AlaSer: 6.865 ± 0.069	6.835AlaThr: 6.835 ± 0.093	8.81AlaVal: 8.81 ± 0.102	2.261AlaTrp: 2.261 ± 0.06	2.555AlaTyr: 2.555 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.069CysAla: 1.069 ± 0.032	0.133CysCys: 0.133 ± 0.014	0.499CysAsp: 0.499 ± 0.023	0.418CysGlu: 0.418 ± 0.018	0.26CysPhe: 0.26 ± 0.017	0.882CysGly: 0.882 ± 0.031	0.247CysHis: 0.247 ± 0.017	0.365CysIle: 0.365 ± 0.02	0.155CysLys: 0.155 ± 0.01	0.757CysLeu: 0.757 ± 0.026	0.166CysMet: 0.166 ± 0.014	0.194CysAsn: 0.194 ± 0.014	0.393CysPro: 0.393 ± 0.021	0.218CysGln: 0.218 ± 0.015	0.627CysArg: 0.627 ± 0.027	0.427CysSer: 0.427 ± 0.021	0.439CysThr: 0.439 ± 0.02	0.692CysVal: 0.692 ± 0.024	0.122CysTrp: 0.122 ± 0.012	0.181CysTyr: 0.181 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	10.227AspAla: 10.227 ± 0.138	0.437AspCys: 0.437 ± 0.02	4.206AspAsp: 4.206 ± 0.07	3.492AspGlu: 3.492 ± 0.066	2.019AspPhe: 2.019 ± 0.047	6.607AspGly: 6.607 ± 0.087	1.233AspHis: 1.233 ± 0.035	2.497AspIle: 2.497 ± 0.055	1.371AspLys: 1.371 ± 0.041	5.538AspLeu: 5.538 ± 0.077	1.256AspMet: 1.256 ± 0.036	1.325AspAsn: 1.325 ± 0.04	3.652AspPro: 3.652 ± 0.054	1.535AspGln: 1.535 ± 0.036	4.5AspArg: 4.5 ± 0.077	2.377AspSer: 2.377 ± 0.052	2.989AspThr: 2.989 ± 0.055	4.712AspVal: 4.712 ± 0.068	1.192AspTrp: 1.192 ± 0.036	1.606AspTyr: 1.606 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.415GluAla: 7.415 ± 0.106	0.362GluCys: 0.362 ± 0.02	2.776GluAsp: 2.776 ± 0.06	2.359GluGlu: 2.359 ± 0.059	1.684GluPhe: 1.684 ± 0.038	4.362GluGly: 4.362 ± 0.063	1.342GluHis: 1.342 ± 0.035	2.408GluIle: 2.408 ± 0.054	1.333GluLys: 1.333 ± 0.045	5.578GluLeu: 5.578 ± 0.092	1.119GluMet: 1.119 ± 0.037	1.072GluAsn: 1.072 ± 0.033	2.516GluPro: 2.516 ± 0.056	2.299GluGln: 2.299 ± 0.053	5.416GluArg: 5.416 ± 0.075	2.503GluSer: 2.503 ± 0.048	2.651GluThr: 2.651 ± 0.052	3.865GluVal: 3.865 ± 0.062	0.762GluTrp: 0.762 ± 0.028	1.152GluTyr: 1.152 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.553PheAla: 4.553 ± 0.077	0.311PheCys: 0.311 ± 0.017	2.962PheAsp: 2.962 ± 0.062	2.026PheGlu: 2.026 ± 0.044	1.163PhePhe: 1.163 ± 0.042	3.416PheGly: 3.416 ± 0.065	0.761PheHis: 0.761 ± 0.031	1.25PheIle: 1.25 ± 0.038	0.728PheLys: 0.728 ± 0.029	2.961PheLeu: 2.961 ± 0.061	0.643PheMet: 0.643 ± 0.025	1.019PheAsn: 1.019 ± 0.034	1.485PhePro: 1.485 ± 0.039	0.885PheGln: 0.885 ± 0.029	2.286PheArg: 2.286 ± 0.045	1.837PheSer: 1.837 ± 0.042	1.705PheThr: 1.705 ± 0.043	2.607PheVal: 2.607 ± 0.054	0.477PheTrp: 0.477 ± 0.023	0.747PheTyr: 0.747 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.266GlyAla: 9.266 ± 0.115	0.801GlyCys: 0.801 ± 0.026	5.512GlyAsp: 5.512 ± 0.084	5.065GlyGlu: 5.065 ± 0.076	3.571GlyPhe: 3.571 ± 0.062	7.652GlyGly: 7.652 ± 0.111	2.159GlyHis: 2.159 ± 0.052	4.261GlyIle: 4.261 ± 0.057	2.725GlyLys: 2.725 ± 0.051	8.57GlyLeu: 8.57 ± 0.101	2.381GlyMet: 2.381 ± 0.049	2.539GlyAsn: 2.539 ± 0.061	3.119GlyPro: 3.119 ± 0.053	2.885GlyGln: 2.885 ± 0.057	6.64GlyArg: 6.64 ± 0.083	4.55GlySer: 4.55 ± 0.079	4.812GlyThr: 4.812 ± 0.084	6.649GlyVal: 6.649 ± 0.087	1.691GlyTrp: 1.691 ± 0.042	2.38GlyTyr: 2.38 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	3.481HisAla: 3.481 ± 0.069	0.263HisCys: 0.263 ± 0.016	1.554HisAsp: 1.554 ± 0.039	1.145HisGlu: 1.145 ± 0.032	0.786HisPhe: 0.786 ± 0.026	2.494HisGly: 2.494 ± 0.058	0.613HisHis: 0.613 ± 0.024	0.739HisIle: 0.739 ± 0.025	0.448HisLys: 0.448 ± 0.022	2.154HisLeu: 2.154 ± 0.048	0.427HisMet: 0.427 ± 0.022	0.481HisAsn: 0.481 ± 0.02	1.533HisPro: 1.533 ± 0.041	0.594HisGln: 0.594 ± 0.024	1.872HisArg: 1.872 ± 0.044	0.903HisSer: 0.903 ± 0.032	0.911HisThr: 0.911 ± 0.032	1.864HisVal: 1.864 ± 0.036	0.413HisTrp: 0.413 ± 0.019	0.603HisTyr: 0.603 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.531IleAla: 6.531 ± 0.071	0.313IleCys: 0.313 ± 0.019	3.571IleAsp: 3.571 ± 0.061	2.95IleGlu: 2.95 ± 0.047	0.973IlePhe: 0.973 ± 0.031	4.084IleGly: 4.084 ± 0.074	0.855IleHis: 0.855 ± 0.03	1.187IleIle: 1.187 ± 0.036	0.911IleLys: 0.911 ± 0.037	2.995IleLeu: 2.995 ± 0.054	0.499IleMet: 0.499 ± 0.025	1.131IleAsn: 1.131 ± 0.035	1.998IlePro: 1.998 ± 0.04	0.996IleGln: 0.996 ± 0.032	2.792IleArg: 2.792 ± 0.058	1.866IleSer: 1.866 ± 0.049	2.022IleThr: 2.022 ± 0.05	3.414IleVal: 3.414 ± 0.06	0.389IleTrp: 0.389 ± 0.02	0.758IleTyr: 0.758 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.154LysAla: 3.154 ± 0.073	0.118LysCys: 0.118 ± 0.01	1.29LysAsp: 1.29 ± 0.045	0.983LysGlu: 0.983 ± 0.035	0.695LysPhe: 0.695 ± 0.024	1.74LysGly: 1.74 ± 0.041	0.581LysHis: 0.581 ± 0.021	0.96LysIle: 0.96 ± 0.035	0.873LysLys: 0.873 ± 0.055	2.666LysLeu: 2.666 ± 0.06	0.483LysMet: 0.483 ± 0.023	0.499LysAsn: 0.499 ± 0.022	1.64LysPro: 1.64 ± 0.044	1.007LysGln: 1.007 ± 0.037	2.085LysArg: 2.085 ± 0.049	1.22LysSer: 1.22 ± 0.038	1.35LysThr: 1.35 ± 0.039	1.87LysVal: 1.87 ± 0.046	0.282LysTrp: 0.282 ± 0.017	0.5LysTyr: 0.5 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.903LeuAla: 14.903 ± 0.144	0.885LeuCys: 0.885 ± 0.032	6.848LeuAsp: 6.848 ± 0.094	5.176LeuGlu: 5.176 ± 0.08	3.496LeuPhe: 3.496 ± 0.058	8.264LeuGly: 8.264 ± 0.103	2.513LeuHis: 2.513 ± 0.058	3.08LeuIle: 3.08 ± 0.061	2.616LeuLys: 2.616 ± 0.06	11.999LeuLeu: 11.999 ± 0.154	2.042LeuMet: 2.042 ± 0.038	2.079LeuAsn: 2.079 ± 0.051	6.415LeuPro: 6.415 ± 0.085	4.031LeuGln: 4.031 ± 0.073	9.188LeuArg: 9.188 ± 0.111	5.874LeuSer: 5.874 ± 0.078	4.381LeuThr: 4.381 ± 0.067	8.404LeuVal: 8.404 ± 0.098	1.323LeuTrp: 1.323 ± 0.043	2.07LeuTyr: 2.07 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.95MetAla: 2.95 ± 0.054	0.133MetCys: 0.133 ± 0.011	1.133MetAsp: 1.133 ± 0.037	0.982MetGlu: 0.982 ± 0.031	0.651MetPhe: 0.651 ± 0.027	1.576MetGly: 1.576 ± 0.039	0.533MetHis: 0.533 ± 0.024	0.815MetIle: 0.815 ± 0.025	0.695MetLys: 0.695 ± 0.026	2.452MetLeu: 2.452 ± 0.048	0.47MetMet: 0.47 ± 0.022	0.594MetAsn: 0.594 ± 0.024	1.608MetPro: 1.608 ± 0.041	1.015MetGln: 1.015 ± 0.032	1.977MetArg: 1.977 ± 0.05	1.354MetSer: 1.354 ± 0.038	1.431MetThr: 1.431 ± 0.032	1.536MetVal: 1.536 ± 0.04	0.202MetTrp: 0.202 ± 0.015	0.34MetTyr: 0.34 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.376AsnAla: 3.376 ± 0.059	0.195AsnCys: 0.195 ± 0.014	1.392AsnAsp: 1.392 ± 0.035	1.071AsnGlu: 1.071 ± 0.029	0.764AsnPhe: 0.764 ± 0.031	2.223AsnGly: 2.223 ± 0.056	0.5AsnHis: 0.5 ± 0.022	1.026AsnIle: 1.026 ± 0.031	0.509AsnLys: 0.509 ± 0.025	2.252AsnLeu: 2.252 ± 0.05	0.406AsnMet: 0.406 ± 0.019	0.629AsnAsn: 0.629 ± 0.031	1.718AsnPro: 1.718 ± 0.039	0.656AsnGln: 0.656 ± 0.028	1.717AsnArg: 1.717 ± 0.043	0.966AsnSer: 0.966 ± 0.036	1.281AsnThr: 1.281 ± 0.042	1.854AsnVal: 1.854 ± 0.045	0.356AsnTrp: 0.356 ± 0.021	0.621AsnTyr: 0.621 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	7.282ProAla: 7.282 ± 0.102	0.336ProCys: 0.336 ± 0.019	3.908ProAsp: 3.908 ± 0.061	3.278ProGlu: 3.278 ± 0.061	1.655ProPhe: 1.655 ± 0.036	5.183ProGly: 5.183 ± 0.075	1.126ProHis: 1.126 ± 0.036	1.728ProIle: 1.728 ± 0.037	1.209ProLys: 1.209 ± 0.041	5.278ProLeu: 5.278 ± 0.079	1.394ProMet: 1.394 ± 0.035	1.152ProAsn: 1.152 ± 0.035	3.108ProPro: 3.108 ± 0.079	1.848ProGln: 1.848 ± 0.04	3.815ProArg: 3.815 ± 0.061	2.712ProSer: 2.712 ± 0.053	2.55ProThr: 2.55 ± 0.049	4.404ProVal: 4.404 ± 0.073	0.899ProTrp: 0.899 ± 0.031	1.142ProTyr: 1.142 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.162GlnAla: 5.162 ± 0.08	0.227GlnCys: 0.227 ± 0.014	1.622GlnAsp: 1.622 ± 0.038	1.357GlnGlu: 1.357 ± 0.039	1.068GlnPhe: 1.068 ± 0.032	2.671GlnGly: 2.671 ± 0.058	0.857GlnHis: 0.857 ± 0.027	1.229GlnIle: 1.229 ± 0.036	0.784GlnLys: 0.784 ± 0.032	3.642GlnLeu: 3.642 ± 0.067	0.75GlnMet: 0.75 ± 0.03	0.598GlnAsn: 0.598 ± 0.022	2.232GlnPro: 2.232 ± 0.048	1.662GlnGln: 1.662 ± 0.05	3.605GlnArg: 3.605 ± 0.065	1.738GlnSer: 1.738 ± 0.046	1.388GlnThr: 1.388 ± 0.037	2.921GlnVal: 2.921 ± 0.055	0.596GlnTrp: 0.596 ± 0.027	0.772GlnTyr: 0.772 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.02ArgAla: 9.02 ± 0.111	0.57ArgCys: 0.57 ± 0.026	5.34ArgAsp: 5.34 ± 0.071	4.976ArgGlu: 4.976 ± 0.079	3.053ArgPhe: 3.053 ± 0.06	5.919ArgGly: 5.919 ± 0.087	2.242ArgHis: 2.242 ± 0.055	4.341ArgIle: 4.341 ± 0.066	2.102ArgLys: 2.102 ± 0.047	8.595ArgLeu: 8.595 ± 0.093	2.246ArgMet: 2.246 ± 0.044	2.173ArgAsn: 2.173 ± 0.043	3.76ArgPro: 3.76 ± 0.062	2.983ArgGln: 2.983 ± 0.066	6.641ArgArg: 6.641 ± 0.102	3.737ArgSer: 3.737 ± 0.06	3.767ArgThr: 3.767 ± 0.067	5.875ArgVal: 5.875 ± 0.076	1.471ArgTrp: 1.471 ± 0.037	2.169ArgTyr: 2.169 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.039SerAla: 6.039 ± 0.084	0.381SerCys: 0.381 ± 0.019	2.929SerAsp: 2.929 ± 0.054	2.371SerGlu: 2.371 ± 0.05	1.716SerPhe: 1.716 ± 0.045	5.169SerGly: 5.169 ± 0.083	1.156SerHis: 1.156 ± 0.036	2.134SerIle: 2.134 ± 0.047	1.182SerLys: 1.182 ± 0.032	5.279SerLeu: 5.279 ± 0.076	1.055SerMet: 1.055 ± 0.031	1.265SerAsn: 1.265 ± 0.037	2.925SerPro: 2.925 ± 0.053	1.716SerGln: 1.716 ± 0.045	3.913SerArg: 3.913 ± 0.055	2.699SerSer: 2.699 ± 0.056	2.699SerThr: 2.699 ± 0.049	3.515SerVal: 3.515 ± 0.064	0.692SerTrp: 0.692 ± 0.028	1.109SerTyr: 1.109 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.903ThrAla: 5.903 ± 0.085	0.421ThrCys: 0.421 ± 0.023	2.542ThrAsp: 2.542 ± 0.04	2.149ThrGlu: 2.149 ± 0.05	1.633ThrPhe: 1.633 ± 0.042	4.764ThrGly: 4.764 ± 0.082	1.155ThrHis: 1.155 ± 0.032	2.061ThrIle: 2.061 ± 0.052	0.921ThrLys: 0.921 ± 0.031	6.303ThrLeu: 6.303 ± 0.086	1.014ThrMet: 1.014 ± 0.031	1.02ThrAsn: 1.02 ± 0.034	3.494ThrPro: 3.494 ± 0.061	1.566ThrGln: 1.566 ± 0.039	3.841ThrArg: 3.841 ± 0.063	2.369ThrSer: 2.369 ± 0.045	2.847ThrThr: 2.847 ± 0.064	3.827ThrVal: 3.827 ± 0.059	0.769ThrTrp: 0.769 ± 0.032	1.059ThrTyr: 1.059 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	10.323ValAla: 10.323 ± 0.096	0.631ValCys: 0.631 ± 0.023	5.002ValAsp: 5.002 ± 0.07	4.578ValGlu: 4.578 ± 0.075	2.737ValPhe: 2.737 ± 0.051	5.716ValGly: 5.716 ± 0.082	1.756ValHis: 1.756 ± 0.046	2.92ValIle: 2.92 ± 0.06	1.586ValLys: 1.586 ± 0.044	8.367ValLeu: 8.367 ± 0.104	1.541ValMet: 1.541 ± 0.038	1.785ValAsn: 1.785 ± 0.045	4.164ValPro: 4.164 ± 0.059	2.559ValGln: 2.559 ± 0.05	5.84ValArg: 5.84 ± 0.075	3.969ValSer: 3.969 ± 0.066	3.584ValThr: 3.584 ± 0.067	6.802ValVal: 6.802 ± 0.095	0.898ValTrp: 0.898 ± 0.026	1.484ValTyr: 1.484 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.313TrpAla: 1.313 ± 0.041	0.16TrpCys: 0.16 ± 0.012	0.691TrpAsp: 0.691 ± 0.028	0.57TrpGlu: 0.57 ± 0.023	0.595TrpPhe: 0.595 ± 0.026	0.906TrpGly: 0.906 ± 0.032	0.404TrpHis: 0.404 ± 0.019	0.792TrpIle: 0.792 ± 0.028	0.408TrpLys: 0.408 ± 0.02	2.247TrpLeu: 2.247 ± 0.055	0.492TrpMet: 0.492 ± 0.023	0.483TrpAsn: 0.483 ± 0.022	0.791TrpPro: 0.791 ± 0.028	0.73TrpGln: 0.73 ± 0.026	1.601TrpArg: 1.601 ± 0.04	0.879TrpSer: 0.879 ± 0.026	0.835TrpThr: 0.835 ± 0.034	0.941TrpVal: 0.941 ± 0.034	0.335TrpTrp: 0.335 ± 0.018	0.332TrpTyr: 0.332 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.789TyrAla: 2.789 ± 0.052	0.176TyrCys: 0.176 ± 0.012	1.407TyrAsp: 1.407 ± 0.041	1.107TyrGlu: 1.107 ± 0.034	0.868TyrPhe: 0.868 ± 0.029	2.068TyrGly: 2.068 ± 0.047	0.468TyrHis: 0.468 ± 0.018	0.744TyrIle: 0.744 ± 0.028	0.445TyrLys: 0.445 ± 0.024	2.287TyrLeu: 2.287 ± 0.046	0.361TyrMet: 0.361 ± 0.02	0.604TyrAsn: 0.604 ± 0.027	1.092TyrPro: 1.092 ± 0.037	0.719TyrGln: 0.719 ± 0.024	2.101TyrArg: 2.101 ± 0.047	1.1TyrSer: 1.1 ± 0.037	1.183TyrThr: 1.183 ± 0.039	1.684TyrVal: 1.684 ± 0.039	0.376TyrTrp: 0.376 ± 0.019	0.598TyrTyr: 0.598 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3335 proteins (1091155 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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