Amino acid dipepetide frequency for Gordonia phage Suerte

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.533AlaAla: 19.533 ± 1.736
0.669AlaCys: 0.669 ± 0.261
8.228AlaAsp: 8.228 ± 0.747
8.562AlaGlu: 8.562 ± 0.866
2.408AlaPhe: 2.408 ± 0.422
8.964AlaGly: 8.964 ± 0.941
2.074AlaHis: 2.074 ± 0.511
5.619AlaIle: 5.619 ± 0.646
3.947AlaLys: 3.947 ± 0.615
9.031AlaLeu: 9.031 ± 0.808
3.345AlaMet: 3.345 ± 0.573
4.147AlaAsn: 4.147 ± 0.652
6.422AlaPro: 6.422 ± 0.838
5.686AlaGln: 5.686 ± 0.953
8.094AlaArg: 8.094 ± 0.777
6.756AlaSer: 6.756 ± 0.938
9.499AlaThr: 9.499 ± 1.205
8.696AlaVal: 8.696 ± 1.254
1.739AlaTrp: 1.739 ± 0.313
2.341AlaTyr: 2.341 ± 0.451
0.0AlaXaa: 0.0 ± 0.0
Cys
0.87CysAla: 0.87 ± 0.237
0.401CysCys: 0.401 ± 0.208
0.334CysAsp: 0.334 ± 0.165
0.401CysGlu: 0.401 ± 0.195
0.134CysPhe: 0.134 ± 0.09
0.937CysGly: 0.937 ± 0.319
0.067CysHis: 0.067 ± 0.073
0.134CysIle: 0.134 ± 0.106
0.268CysLys: 0.268 ± 0.154
0.468CysLeu: 0.468 ± 0.185
0.0CysMet: 0.0 ± 0.0
0.268CysAsn: 0.268 ± 0.155
0.268CysPro: 0.268 ± 0.136
0.201CysGln: 0.201 ± 0.127
0.803CysArg: 0.803 ± 0.228
0.201CysSer: 0.201 ± 0.112
0.535CysThr: 0.535 ± 0.275
0.268CysVal: 0.268 ± 0.143
0.067CysTrp: 0.067 ± 0.067
0.334CysTyr: 0.334 ± 0.142
0.0CysXaa: 0.0 ± 0.0
Asp
6.756AspAla: 6.756 ± 0.763
0.401AspCys: 0.401 ± 0.153
6.02AspAsp: 6.02 ± 0.835
4.482AspGlu: 4.482 ± 0.565
1.806AspPhe: 1.806 ± 0.388
5.887AspGly: 5.887 ± 0.912
1.605AspHis: 1.605 ± 0.458
2.609AspIle: 2.609 ± 0.454
2.141AspLys: 2.141 ± 0.349
7.225AspLeu: 7.225 ± 0.77
1.137AspMet: 1.137 ± 0.316
1.739AspAsn: 1.739 ± 0.46
5.151AspPro: 5.151 ± 0.646
2.007AspGln: 2.007 ± 0.439
4.014AspArg: 4.014 ± 0.614
2.274AspSer: 2.274 ± 0.401
4.281AspThr: 4.281 ± 0.677
4.95AspVal: 4.95 ± 0.483
1.605AspTrp: 1.605 ± 0.305
1.405AspTyr: 1.405 ± 0.213
0.0AspXaa: 0.0 ± 0.0
Glu
7.225GluAla: 7.225 ± 0.609
0.602GluCys: 0.602 ± 0.244
2.943GluAsp: 2.943 ± 0.417
2.542GluGlu: 2.542 ± 0.54
1.739GluPhe: 1.739 ± 0.358
3.813GluGly: 3.813 ± 0.642
1.137GluHis: 1.137 ± 0.3
2.676GluIle: 2.676 ± 0.447
1.405GluLys: 1.405 ± 0.339
5.084GluLeu: 5.084 ± 0.627
1.472GluMet: 1.472 ± 0.465
1.605GluAsn: 1.605 ± 0.337
2.208GluPro: 2.208 ± 0.468
3.478GluGln: 3.478 ± 0.488
4.95GluArg: 4.95 ± 0.66
2.676GluSer: 2.676 ± 0.391
3.612GluThr: 3.612 ± 0.405
3.947GluVal: 3.947 ± 0.476
1.137GluTrp: 1.137 ± 0.277
1.539GluTyr: 1.539 ± 0.259
0.0GluXaa: 0.0 ± 0.0
Phe
2.943PheAla: 2.943 ± 0.422
0.067PheCys: 0.067 ± 0.066
2.475PheAsp: 2.475 ± 0.308
1.204PheGlu: 1.204 ± 0.304
0.803PhePhe: 0.803 ± 0.226
2.274PheGly: 2.274 ± 0.412
0.602PheHis: 0.602 ± 0.23
0.87PheIle: 0.87 ± 0.242
0.736PheLys: 0.736 ± 0.231
0.937PheLeu: 0.937 ± 0.247
0.401PheMet: 0.401 ± 0.129
0.87PheAsn: 0.87 ± 0.244
1.405PhePro: 1.405 ± 0.297
0.736PheGln: 0.736 ± 0.284
1.873PheArg: 1.873 ± 0.526
1.405PheSer: 1.405 ± 0.29
1.806PheThr: 1.806 ± 0.359
1.672PheVal: 1.672 ± 0.432
0.602PheTrp: 0.602 ± 0.236
0.401PheTyr: 0.401 ± 0.176
0.0PheXaa: 0.0 ± 0.0
Gly
8.763GlyAla: 8.763 ± 0.846
0.268GlyCys: 0.268 ± 0.144
5.753GlyAsp: 5.753 ± 0.584
3.746GlyGlu: 3.746 ± 0.437
1.873GlyPhe: 1.873 ± 0.31
7.894GlyGly: 7.894 ± 0.997
1.539GlyHis: 1.539 ± 0.341
4.214GlyIle: 4.214 ± 0.494
3.01GlyLys: 3.01 ± 0.455
6.89GlyLeu: 6.89 ± 0.724
1.806GlyMet: 1.806 ± 0.412
3.412GlyAsn: 3.412 ± 0.461
4.415GlyPro: 4.415 ± 0.649
2.743GlyGln: 2.743 ± 0.599
6.489GlyArg: 6.489 ± 0.602
5.084GlySer: 5.084 ± 0.754
6.154GlyThr: 6.154 ± 0.91
6.556GlyVal: 6.556 ± 0.77
1.539GlyTrp: 1.539 ± 0.379
2.007GlyTyr: 2.007 ± 0.392
0.0GlyXaa: 0.0 ± 0.0
His
1.672HisAla: 1.672 ± 0.324
0.134HisCys: 0.134 ± 0.098
1.07HisAsp: 1.07 ± 0.334
1.271HisGlu: 1.271 ± 0.35
0.334HisPhe: 0.334 ± 0.146
1.806HisGly: 1.806 ± 0.397
0.535HisHis: 0.535 ± 0.262
1.003HisIle: 1.003 ± 0.395
0.468HisLys: 0.468 ± 0.196
1.405HisLeu: 1.405 ± 0.317
0.201HisMet: 0.201 ± 0.098
0.535HisAsn: 0.535 ± 0.202
1.605HisPro: 1.605 ± 0.403
1.271HisGln: 1.271 ± 0.28
1.338HisArg: 1.338 ± 0.291
0.669HisSer: 0.669 ± 0.25
1.539HisThr: 1.539 ± 0.314
1.271HisVal: 1.271 ± 0.291
0.736HisTrp: 0.736 ± 0.204
0.736HisTyr: 0.736 ± 0.234
0.0HisXaa: 0.0 ± 0.0
Ile
6.623IleAla: 6.623 ± 0.792
0.268IleCys: 0.268 ± 0.129
5.084IleAsp: 5.084 ± 0.551
2.274IleGlu: 2.274 ± 0.363
1.137IlePhe: 1.137 ± 0.263
4.415IleGly: 4.415 ± 0.586
0.602IleHis: 0.602 ± 0.194
1.405IleIle: 1.405 ± 0.297
0.937IleLys: 0.937 ± 0.222
2.274IleLeu: 2.274 ± 0.423
0.602IleMet: 0.602 ± 0.247
1.338IleAsn: 1.338 ± 0.266
2.743IlePro: 2.743 ± 0.466
1.605IleGln: 1.605 ± 0.319
3.746IleArg: 3.746 ± 0.514
2.274IleSer: 2.274 ± 0.482
3.01IleThr: 3.01 ± 0.514
3.612IleVal: 3.612 ± 0.524
0.535IleTrp: 0.535 ± 0.22
1.405IleTyr: 1.405 ± 0.372
0.0IleXaa: 0.0 ± 0.0
Lys
4.014LysAla: 4.014 ± 0.669
0.067LysCys: 0.067 ± 0.07
1.338LysAsp: 1.338 ± 0.324
1.672LysGlu: 1.672 ± 0.384
0.602LysPhe: 0.602 ± 0.216
2.341LysGly: 2.341 ± 0.428
0.736LysHis: 0.736 ± 0.186
1.605LysIle: 1.605 ± 0.264
1.405LysLys: 1.405 ± 0.364
3.545LysLeu: 3.545 ± 0.539
0.468LysMet: 0.468 ± 0.152
1.07LysAsn: 1.07 ± 0.248
2.208LysPro: 2.208 ± 0.459
1.405LysGln: 1.405 ± 0.409
1.806LysArg: 1.806 ± 0.349
1.94LysSer: 1.94 ± 0.488
2.141LysThr: 2.141 ± 0.388
2.074LysVal: 2.074 ± 0.425
0.669LysTrp: 0.669 ± 0.294
0.468LysTyr: 0.468 ± 0.16
0.0LysXaa: 0.0 ± 0.0
Leu
10.703LeuAla: 10.703 ± 0.99
0.468LeuCys: 0.468 ± 0.223
5.887LeuAsp: 5.887 ± 0.753
4.482LeuGlu: 4.482 ± 0.534
2.007LeuPhe: 2.007 ± 0.55
6.489LeuGly: 6.489 ± 0.64
1.472LeuHis: 1.472 ± 0.32
3.345LeuIle: 3.345 ± 0.532
2.208LeuLys: 2.208 ± 0.427
6.02LeuLeu: 6.02 ± 0.609
1.539LeuMet: 1.539 ± 0.32
2.341LeuAsn: 2.341 ± 0.343
4.482LeuPro: 4.482 ± 0.598
2.609LeuGln: 2.609 ± 0.431
5.82LeuArg: 5.82 ± 0.588
4.281LeuSer: 4.281 ± 0.637
6.087LeuThr: 6.087 ± 0.766
5.552LeuVal: 5.552 ± 0.697
1.137LeuTrp: 1.137 ± 0.238
1.204LeuTyr: 1.204 ± 0.331
0.0LeuXaa: 0.0 ± 0.0
Met
2.876MetAla: 2.876 ± 0.519
0.134MetCys: 0.134 ± 0.1
0.736MetAsp: 0.736 ± 0.207
0.334MetGlu: 0.334 ± 0.171
0.401MetPhe: 0.401 ± 0.151
1.338MetGly: 1.338 ± 0.355
0.669MetHis: 0.669 ± 0.192
0.468MetIle: 0.468 ± 0.182
0.736MetLys: 0.736 ± 0.2
1.806MetLeu: 1.806 ± 0.33
0.401MetMet: 0.401 ± 0.18
0.535MetAsn: 0.535 ± 0.191
1.204MetPro: 1.204 ± 0.219
0.669MetGln: 0.669 ± 0.198
1.739MetArg: 1.739 ± 0.39
1.405MetSer: 1.405 ± 0.274
3.01MetThr: 3.01 ± 0.371
1.07MetVal: 1.07 ± 0.251
0.468MetTrp: 0.468 ± 0.195
0.468MetTyr: 0.468 ± 0.27
0.0MetXaa: 0.0 ± 0.0
Asn
3.88AsnAla: 3.88 ± 0.666
0.0AsnCys: 0.0 ± 0.0
1.405AsnAsp: 1.405 ± 0.362
1.806AsnGlu: 1.806 ± 0.311
0.602AsnPhe: 0.602 ± 0.195
2.943AsnGly: 2.943 ± 0.495
1.338AsnHis: 1.338 ± 0.391
1.405AsnIle: 1.405 ± 0.254
0.937AsnLys: 0.937 ± 0.295
2.007AsnLeu: 2.007 ± 0.361
0.468AsnMet: 0.468 ± 0.181
0.803AsnAsn: 0.803 ± 0.22
2.475AsnPro: 2.475 ± 0.383
1.003AsnGln: 1.003 ± 0.267
2.676AsnArg: 2.676 ± 0.453
1.672AsnSer: 1.672 ± 0.331
2.074AsnThr: 2.074 ± 0.437
1.873AsnVal: 1.873 ± 0.352
0.535AsnTrp: 0.535 ± 0.151
0.535AsnTyr: 0.535 ± 0.216
0.0AsnXaa: 0.0 ± 0.0
Pro
7.492ProAla: 7.492 ± 0.785
0.468ProCys: 0.468 ± 0.226
4.214ProAsp: 4.214 ± 0.795
3.612ProGlu: 3.612 ± 0.583
1.539ProPhe: 1.539 ± 0.303
5.552ProGly: 5.552 ± 0.737
0.602ProHis: 0.602 ± 0.227
1.94ProIle: 1.94 ± 0.361
1.873ProLys: 1.873 ± 0.385
3.345ProLeu: 3.345 ± 0.376
1.204ProMet: 1.204 ± 0.23
1.94ProAsn: 1.94 ± 0.335
2.274ProPro: 2.274 ± 0.403
1.405ProGln: 1.405 ± 0.34
3.746ProArg: 3.746 ± 0.645
3.947ProSer: 3.947 ± 0.622
4.415ProThr: 4.415 ± 0.622
4.816ProVal: 4.816 ± 0.67
1.338ProTrp: 1.338 ± 0.313
1.07ProTyr: 1.07 ± 0.274
0.0ProXaa: 0.0 ± 0.0
Gln
4.482GlnAla: 4.482 ± 0.65
0.268GlnCys: 0.268 ± 0.151
1.739GlnAsp: 1.739 ± 0.34
1.539GlnGlu: 1.539 ± 0.541
1.204GlnPhe: 1.204 ± 0.269
2.141GlnGly: 2.141 ± 0.664
0.803GlnHis: 0.803 ± 0.272
2.274GlnIle: 2.274 ± 0.474
1.539GlnLys: 1.539 ± 0.352
3.612GlnLeu: 3.612 ± 0.589
0.87GlnMet: 0.87 ± 0.262
0.602GlnAsn: 0.602 ± 0.267
1.405GlnPro: 1.405 ± 0.26
1.07GlnGln: 1.07 ± 0.349
3.947GlnArg: 3.947 ± 0.69
2.141GlnSer: 2.141 ± 0.342
2.943GlnThr: 2.943 ± 0.446
3.077GlnVal: 3.077 ± 0.428
0.803GlnTrp: 0.803 ± 0.18
0.803GlnTyr: 0.803 ± 0.257
0.0GlnXaa: 0.0 ± 0.0
Arg
8.562ArgAla: 8.562 ± 0.896
0.602ArgCys: 0.602 ± 0.235
4.281ArgAsp: 4.281 ± 0.551
4.281ArgGlu: 4.281 ± 0.63
1.806ArgPhe: 1.806 ± 0.326
4.883ArgGly: 4.883 ± 0.454
1.405ArgHis: 1.405 ± 0.412
4.081ArgIle: 4.081 ± 0.654
2.475ArgLys: 2.475 ± 0.416
7.225ArgLeu: 7.225 ± 0.63
2.074ArgMet: 2.074 ± 0.331
2.341ArgAsn: 2.341 ± 0.372
4.816ArgPro: 4.816 ± 0.697
2.876ArgGln: 2.876 ± 0.431
6.355ArgArg: 6.355 ± 0.876
3.545ArgSer: 3.545 ± 0.545
4.147ArgThr: 4.147 ± 0.598
5.418ArgVal: 5.418 ± 0.765
1.672ArgTrp: 1.672 ± 0.351
2.208ArgTyr: 2.208 ± 0.352
0.0ArgXaa: 0.0 ± 0.0
Ser
6.689SerAla: 6.689 ± 0.74
0.268SerCys: 0.268 ± 0.12
3.478SerAsp: 3.478 ± 0.418
3.01SerGlu: 3.01 ± 0.421
1.539SerPhe: 1.539 ± 0.316
5.218SerGly: 5.218 ± 0.883
0.803SerHis: 0.803 ± 0.252
2.743SerIle: 2.743 ± 0.433
1.405SerLys: 1.405 ± 0.283
3.679SerLeu: 3.679 ± 0.486
1.539SerMet: 1.539 ± 0.38
1.204SerAsn: 1.204 ± 0.253
2.141SerPro: 2.141 ± 0.374
2.676SerGln: 2.676 ± 0.592
3.478SerArg: 3.478 ± 0.59
2.943SerSer: 2.943 ± 0.457
4.281SerThr: 4.281 ± 0.544
3.947SerVal: 3.947 ± 0.621
0.87SerTrp: 0.87 ± 0.283
1.539SerTyr: 1.539 ± 0.366
0.0SerXaa: 0.0 ± 0.0
Thr
9.633ThrAla: 9.633 ± 0.964
0.736ThrCys: 0.736 ± 0.225
4.147ThrAsp: 4.147 ± 0.567
3.144ThrGlu: 3.144 ± 0.467
1.472ThrPhe: 1.472 ± 0.26
7.492ThrGly: 7.492 ± 0.726
1.271ThrHis: 1.271 ± 0.272
4.549ThrIle: 4.549 ± 0.52
2.007ThrLys: 2.007 ± 0.379
5.753ThrLeu: 5.753 ± 0.626
1.137ThrMet: 1.137 ± 0.26
1.873ThrAsn: 1.873 ± 0.337
5.017ThrPro: 5.017 ± 0.665
2.475ThrGln: 2.475 ± 0.463
4.883ThrArg: 4.883 ± 0.59
2.876ThrSer: 2.876 ± 0.53
5.552ThrThr: 5.552 ± 0.823
6.689ThrVal: 6.689 ± 0.918
1.405ThrTrp: 1.405 ± 0.429
1.338ThrTyr: 1.338 ± 0.295
0.0ThrXaa: 0.0 ± 0.0
Val
8.964ValAla: 8.964 ± 1.248
0.736ValCys: 0.736 ± 0.222
6.02ValAsp: 6.02 ± 0.675
4.883ValGlu: 4.883 ± 0.538
1.672ValPhe: 1.672 ± 0.327
5.887ValGly: 5.887 ± 0.619
1.07ValHis: 1.07 ± 0.227
3.679ValIle: 3.679 ± 0.579
2.609ValLys: 2.609 ± 0.572
4.749ValLeu: 4.749 ± 0.733
1.271ValMet: 1.271 ± 0.253
2.876ValAsn: 2.876 ± 0.537
4.281ValPro: 4.281 ± 0.549
2.074ValGln: 2.074 ± 0.625
5.619ValArg: 5.619 ± 0.61
4.616ValSer: 4.616 ± 0.705
5.285ValThr: 5.285 ± 0.597
5.017ValVal: 5.017 ± 0.685
0.803ValTrp: 0.803 ± 0.271
1.137ValTyr: 1.137 ± 0.302
0.0ValXaa: 0.0 ± 0.0
Trp
1.806TrpAla: 1.806 ± 0.281
0.268TrpCys: 0.268 ± 0.138
1.07TrpAsp: 1.07 ± 0.314
0.937TrpGlu: 0.937 ± 0.281
0.401TrpPhe: 0.401 ± 0.167
1.539TrpGly: 1.539 ± 0.276
0.669TrpHis: 0.669 ± 0.261
1.003TrpIle: 1.003 ± 0.223
0.535TrpLys: 0.535 ± 0.223
1.672TrpLeu: 1.672 ± 0.453
0.268TrpMet: 0.268 ± 0.125
0.334TrpAsn: 0.334 ± 0.139
1.137TrpPro: 1.137 ± 0.246
0.401TrpGln: 0.401 ± 0.141
1.94TrpArg: 1.94 ± 0.352
1.003TrpSer: 1.003 ± 0.35
1.672TrpThr: 1.672 ± 0.304
1.07TrpVal: 1.07 ± 0.257
0.468TrpTrp: 0.468 ± 0.212
0.334TrpTyr: 0.334 ± 0.161
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.274TyrAla: 2.274 ± 0.42
0.134TyrCys: 0.134 ± 0.09
1.271TyrAsp: 1.271 ± 0.258
1.605TyrGlu: 1.605 ± 0.372
0.602TyrPhe: 0.602 ± 0.175
2.341TyrGly: 2.341 ± 0.457
0.602TyrHis: 0.602 ± 0.263
0.268TyrIle: 0.268 ± 0.149
0.937TyrLys: 0.937 ± 0.276
1.472TyrLeu: 1.472 ± 0.367
0.201TyrMet: 0.201 ± 0.136
0.602TyrAsn: 0.602 ± 0.286
1.137TyrPro: 1.137 ± 0.304
0.87TyrGln: 0.87 ± 0.227
1.739TyrArg: 1.739 ± 0.467
1.739TyrSer: 1.739 ± 0.251
1.405TyrThr: 1.405 ± 0.263
1.672TyrVal: 1.672 ± 0.296
0.401TyrTrp: 0.401 ± 0.16
0.602TyrTyr: 0.602 ± 0.188
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 74 proteins (14950 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski