Amino acid dipepetide frequency for Desulfitobacterium dichloroeliminans (strain LMG P-21439 / DCA1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.41AlaAla: 6.41 ± 0.109	0.84AlaCys: 0.84 ± 0.032	3.751AlaAsp: 3.751 ± 0.063	5.418AlaGlu: 5.418 ± 0.085	3.041AlaPhe: 3.041 ± 0.06	6.04AlaGly: 6.04 ± 0.098	1.414AlaHis: 1.414 ± 0.036	5.764AlaIle: 5.764 ± 0.091	4.943AlaLys: 4.943 ± 0.071	8.883AlaLeu: 8.883 ± 0.11	2.236AlaMet: 2.236 ± 0.042	2.734AlaAsn: 2.734 ± 0.043	2.44AlaPro: 2.44 ± 0.051	3.456AlaGln: 3.456 ± 0.056	3.338AlaArg: 3.338 ± 0.068	4.073AlaSer: 4.073 ± 0.058	3.808AlaThr: 3.808 ± 0.064	5.626AlaVal: 5.626 ± 0.091	0.828AlaTrp: 0.828 ± 0.03	2.411AlaTyr: 2.411 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.769CysAla: 0.769 ± 0.03	0.174CysCys: 0.174 ± 0.016	0.508CysAsp: 0.508 ± 0.025	0.65CysGlu: 0.65 ± 0.027	0.42CysPhe: 0.42 ± 0.024	1.072CysGly: 1.072 ± 0.04	0.297CysHis: 0.297 ± 0.022	0.701CysIle: 0.701 ± 0.026	0.507CysLys: 0.507 ± 0.023	1.015CysLeu: 1.015 ± 0.032	0.236CysMet: 0.236 ± 0.018	0.399CysAsn: 0.399 ± 0.019	0.652CysPro: 0.652 ± 0.032	0.443CysGln: 0.443 ± 0.021	0.487CysArg: 0.487 ± 0.021	0.692CysSer: 0.692 ± 0.029	0.57CysThr: 0.57 ± 0.024	0.721CysVal: 0.721 ± 0.03	0.136CysTrp: 0.136 ± 0.013	0.339CysTyr: 0.339 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.434AspAla: 3.434 ± 0.061	0.57AspCys: 0.57 ± 0.027	2.147AspAsp: 2.147 ± 0.047	3.671AspGlu: 3.671 ± 0.062	2.356AspPhe: 2.356 ± 0.047	3.296AspGly: 3.296 ± 0.068	0.977AspHis: 0.977 ± 0.034	3.835AspIle: 3.835 ± 0.071	2.895AspLys: 2.895 ± 0.062	5.321AspLeu: 5.321 ± 0.077	1.402AspMet: 1.402 ± 0.036	1.754AspAsn: 1.754 ± 0.04	2.253AspPro: 2.253 ± 0.058	1.96AspGln: 1.96 ± 0.047	2.443AspArg: 2.443 ± 0.051	2.839AspSer: 2.839 ± 0.056	2.446AspThr: 2.446 ± 0.047	3.291AspVal: 3.291 ± 0.057	0.639AspTrp: 0.639 ± 0.024	2.177AspTyr: 2.177 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.609GluAla: 5.609 ± 0.077	0.648GluCys: 0.648 ± 0.026	3.603GluAsp: 3.603 ± 0.062	6.349GluGlu: 6.349 ± 0.101	2.69GluPhe: 2.69 ± 0.054	4.955GluGly: 4.955 ± 0.069	1.366GluHis: 1.366 ± 0.038	5.549GluIle: 5.549 ± 0.076	5.301GluLys: 5.301 ± 0.077	7.189GluLeu: 7.189 ± 0.095	2.083GluMet: 2.083 ± 0.045	3.156GluAsn: 3.156 ± 0.057	2.052GluPro: 2.052 ± 0.049	3.157GluGln: 3.157 ± 0.056	3.687GluArg: 3.687 ± 0.065	3.529GluSer: 3.529 ± 0.062	3.206GluThr: 3.206 ± 0.057	5.187GluVal: 5.187 ± 0.072	0.753GluTrp: 0.753 ± 0.03	2.273GluTyr: 2.273 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.074PheAla: 3.074 ± 0.059	0.527PheCys: 0.527 ± 0.026	2.053PheAsp: 2.053 ± 0.045	2.401PheGlu: 2.401 ± 0.052	1.891PhePhe: 1.891 ± 0.055	3.104PheGly: 3.104 ± 0.058	0.744PheHis: 0.744 ± 0.027	2.997PheIle: 2.997 ± 0.061	2.042PheLys: 2.042 ± 0.049	4.365PheLeu: 4.365 ± 0.074	1.044PheMet: 1.044 ± 0.033	1.558PheAsn: 1.558 ± 0.04	1.631PhePro: 1.631 ± 0.043	1.458PheGln: 1.458 ± 0.043	1.678PheArg: 1.678 ± 0.043	2.778PheSer: 2.778 ± 0.057	2.291PheThr: 2.291 ± 0.049	2.702PheVal: 2.702 ± 0.053	0.508PheTrp: 0.508 ± 0.026	1.401PheTyr: 1.401 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	5.456GlyAla: 5.456 ± 0.087	1.047GlyCys: 1.047 ± 0.038	3.463GlyAsp: 3.463 ± 0.067	4.931GlyGlu: 4.931 ± 0.069	3.182GlyPhe: 3.182 ± 0.052	5.319GlyGly: 5.319 ± 0.091	1.393GlyHis: 1.393 ± 0.041	6.319GlyIle: 6.319 ± 0.087	5.135GlyLys: 5.135 ± 0.078	7.383GlyLeu: 7.383 ± 0.09	2.412GlyMet: 2.412 ± 0.049	2.859GlyAsn: 2.859 ± 0.052	1.879GlyPro: 1.879 ± 0.047	2.708GlyGln: 2.708 ± 0.058	3.315GlyArg: 3.315 ± 0.067	4.26GlySer: 4.26 ± 0.074	4.126GlyThr: 4.126 ± 0.077	5.756GlyVal: 5.756 ± 0.079	0.868GlyTrp: 0.868 ± 0.033	2.874GlyTyr: 2.874 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.207HisAla: 1.207 ± 0.033	0.305HisCys: 0.305 ± 0.018	0.916HisAsp: 0.916 ± 0.031	1.176HisGlu: 1.176 ± 0.037	0.875HisPhe: 0.875 ± 0.03	1.435HisGly: 1.435 ± 0.037	0.536HisHis: 0.536 ± 0.026	1.25HisIle: 1.25 ± 0.036	0.939HisLys: 0.939 ± 0.033	1.998HisLeu: 1.998 ± 0.042	0.448HisMet: 0.448 ± 0.022	0.697HisAsn: 0.697 ± 0.028	1.161HisPro: 1.161 ± 0.032	0.768HisGln: 0.768 ± 0.029	0.918HisArg: 0.918 ± 0.031	1.205HisSer: 1.205 ± 0.038	0.97HisThr: 0.97 ± 0.032	1.14HisVal: 1.14 ± 0.034	0.243HisTrp: 0.243 ± 0.016	0.746HisTyr: 0.746 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.147IleAla: 6.147 ± 0.076	0.799IleCys: 0.799 ± 0.03	3.757IleAsp: 3.757 ± 0.064	4.958IleGlu: 4.958 ± 0.079	2.912IlePhe: 2.912 ± 0.064	5.264IleGly: 5.264 ± 0.077	1.395IleHis: 1.395 ± 0.034	5.303IleIle: 5.303 ± 0.079	3.951IleLys: 3.951 ± 0.06	7.698IleLeu: 7.698 ± 0.089	1.732IleMet: 1.732 ± 0.046	2.875IleAsn: 2.875 ± 0.06	3.51IlePro: 3.51 ± 0.062	2.651IleGln: 2.651 ± 0.054	3.448IleArg: 3.448 ± 0.065	4.677IleSer: 4.677 ± 0.072	4.048IleThr: 4.048 ± 0.07	4.976IleVal: 4.976 ± 0.073	0.651IleTrp: 0.651 ± 0.024	2.208IleTyr: 2.208 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.867LysAla: 4.867 ± 0.079	0.5LysCys: 0.5 ± 0.021	3.483LysAsp: 3.483 ± 0.069	5.357LysGlu: 5.357 ± 0.082	1.75LysPhe: 1.75 ± 0.048	4.324LysGly: 4.324 ± 0.076	0.986LysHis: 0.986 ± 0.033	4.338LysIle: 4.338 ± 0.074	4.177LysLys: 4.177 ± 0.078	5.226LysLeu: 5.226 ± 0.072	1.706LysMet: 1.706 ± 0.044	2.623LysAsn: 2.623 ± 0.055	2.224LysPro: 2.224 ± 0.048	2.119LysGln: 2.119 ± 0.048	2.946LysArg: 2.946 ± 0.055	3.352LysSer: 3.352 ± 0.055	3.234LysThr: 3.234 ± 0.059	4.568LysVal: 4.568 ± 0.064	0.485LysTrp: 0.485 ± 0.025	2.043LysTyr: 2.043 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	9.049LeuAla: 9.049 ± 0.11	1.001LeuCys: 1.001 ± 0.037	5.179LeuAsp: 5.179 ± 0.067	7.138LeuGlu: 7.138 ± 0.084	4.026LeuPhe: 4.026 ± 0.073	7.969LeuGly: 7.969 ± 0.104	1.816LeuHis: 1.816 ± 0.045	6.93LeuIle: 6.93 ± 0.1	6.422LeuLys: 6.422 ± 0.084	10.559LeuLeu: 10.559 ± 0.14	2.593LeuMet: 2.593 ± 0.052	4.172LeuAsn: 4.172 ± 0.063	4.558LeuPro: 4.558 ± 0.078	3.84LeuGln: 3.84 ± 0.068	4.837LeuArg: 4.837 ± 0.086	6.662LeuSer: 6.662 ± 0.08	5.849LeuThr: 5.849 ± 0.083	6.911LeuVal: 6.911 ± 0.083	1.066LeuTrp: 1.066 ± 0.036	2.918LeuTyr: 2.918 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.409MetAla: 2.409 ± 0.049	0.219MetCys: 0.219 ± 0.018	1.581MetAsp: 1.581 ± 0.041	1.95MetGlu: 1.95 ± 0.052	0.915MetPhe: 0.915 ± 0.032	2.258MetGly: 2.258 ± 0.046	0.461MetHis: 0.461 ± 0.021	1.809MetIle: 1.809 ± 0.042	1.863MetLys: 1.863 ± 0.04	2.44MetLeu: 2.44 ± 0.059	0.806MetMet: 0.806 ± 0.028	1.335MetAsn: 1.335 ± 0.038	1.009MetPro: 1.009 ± 0.031	0.884MetGln: 0.884 ± 0.029	1.217MetArg: 1.217 ± 0.032	1.757MetSer: 1.757 ± 0.042	1.508MetThr: 1.508 ± 0.036	1.938MetVal: 1.938 ± 0.043	0.179MetTrp: 0.179 ± 0.011	0.597MetTyr: 0.597 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.724AsnAla: 2.724 ± 0.055	0.44AsnCys: 0.44 ± 0.021	1.69AsnAsp: 1.69 ± 0.048	2.409AsnGlu: 2.409 ± 0.051	1.511AsnPhe: 1.511 ± 0.046	2.593AsnGly: 2.593 ± 0.058	0.82AsnHis: 0.82 ± 0.03	2.847AsnIle: 2.847 ± 0.052	2.296AsnLys: 2.296 ± 0.045	4.314AsnLeu: 4.314 ± 0.067	1.034AsnMet: 1.034 ± 0.034	1.61AsnAsn: 1.61 ± 0.046	2.469AsnPro: 2.469 ± 0.057	1.69AsnGln: 1.69 ± 0.039	1.959AsnArg: 1.959 ± 0.045	2.425AsnSer: 2.425 ± 0.057	2.094AsnThr: 2.094 ± 0.052	2.514AsnVal: 2.514 ± 0.062	0.456AsnTrp: 0.456 ± 0.021	1.54AsnTyr: 1.54 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	2.843ProAla: 2.843 ± 0.061	0.37ProCys: 0.37 ± 0.023	2.283ProAsp: 2.283 ± 0.045	3.624ProGlu: 3.624 ± 0.053	1.642ProPhe: 1.642 ± 0.045	2.88ProGly: 2.88 ± 0.065	0.858ProHis: 0.858 ± 0.031	2.741ProIle: 2.741 ± 0.05	2.084ProLys: 2.084 ± 0.046	4.004ProLeu: 4.004 ± 0.062	0.977ProMet: 0.977 ± 0.029	1.607ProAsn: 1.607 ± 0.043	1.344ProPro: 1.344 ± 0.039	1.718ProGln: 1.718 ± 0.045	1.587ProArg: 1.587 ± 0.042	2.392ProSer: 2.392 ± 0.052	2.083ProThr: 2.083 ± 0.048	3.162ProVal: 3.162 ± 0.064	0.477ProTrp: 0.477 ± 0.024	1.459ProTyr: 1.459 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.437GlnAla: 3.437 ± 0.059	0.318GlnCys: 0.318 ± 0.017	1.851GlnAsp: 1.851 ± 0.041	3.553GlnGlu: 3.553 ± 0.059	1.248GlnPhe: 1.248 ± 0.037	3.243GlnGly: 3.243 ± 0.081	0.646GlnHis: 0.646 ± 0.023	2.666GlnIle: 2.666 ± 0.063	2.49GlnLys: 2.49 ± 0.05	3.66GlnLeu: 3.66 ± 0.067	1.125GlnMet: 1.125 ± 0.037	1.551GlnAsn: 1.551 ± 0.04	1.33GlnPro: 1.33 ± 0.039	1.473GlnGln: 1.473 ± 0.039	2.026GlnArg: 2.026 ± 0.055	2.087GlnSer: 2.087 ± 0.051	1.874GlnThr: 1.874 ± 0.04	2.929GlnVal: 2.929 ± 0.056	0.464GlnTrp: 0.464 ± 0.02	1.18GlnTyr: 1.18 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.938ArgAla: 2.938 ± 0.054	0.489ArgCys: 0.489 ± 0.024	2.188ArgAsp: 2.188 ± 0.05	3.857ArgGlu: 3.857 ± 0.073	2.007ArgPhe: 2.007 ± 0.044	3.052ArgGly: 3.052 ± 0.064	0.845ArgHis: 0.845 ± 0.036	3.659ArgIle: 3.659 ± 0.066	3.03ArgLys: 3.03 ± 0.06	4.896ArgLeu: 4.896 ± 0.087	1.417ArgMet: 1.417 ± 0.035	1.897ArgAsn: 1.897 ± 0.047	1.688ArgPro: 1.688 ± 0.055	1.983ArgGln: 1.983 ± 0.053	2.48ArgArg: 2.48 ± 0.057	2.5ArgSer: 2.5 ± 0.05	2.236ArgThr: 2.236 ± 0.05	3.463ArgVal: 3.463 ± 0.057	0.558ArgTrp: 0.558 ± 0.028	1.713ArgTyr: 1.713 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.22SerAla: 4.22 ± 0.065	0.684SerCys: 0.684 ± 0.029	2.63SerAsp: 2.63 ± 0.046	3.804SerGlu: 3.804 ± 0.069	2.691SerPhe: 2.691 ± 0.063	4.818SerGly: 4.818 ± 0.082	1.167SerHis: 1.167 ± 0.033	4.272SerIle: 4.272 ± 0.07	3.172SerLys: 3.172 ± 0.055	6.424SerLeu: 6.424 ± 0.09	1.611SerMet: 1.611 ± 0.039	2.172SerAsn: 2.172 ± 0.051	2.51SerPro: 2.51 ± 0.051	2.422SerGln: 2.422 ± 0.054	2.788SerArg: 2.788 ± 0.053	3.921SerSer: 3.921 ± 0.079	3.025SerThr: 3.025 ± 0.066	3.926SerVal: 3.926 ± 0.066	0.67SerTrp: 0.67 ± 0.027	2.033SerTyr: 2.033 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.029ThrAla: 4.029 ± 0.067	0.498ThrCys: 0.498 ± 0.027	2.488ThrAsp: 2.488 ± 0.06	3.342ThrGlu: 3.342 ± 0.061	2.081ThrPhe: 2.081 ± 0.052	4.508ThrGly: 4.508 ± 0.074	1.105ThrHis: 1.105 ± 0.033	3.846ThrIle: 3.846 ± 0.078	2.716ThrLys: 2.716 ± 0.055	5.761ThrLeu: 5.761 ± 0.086	1.343ThrMet: 1.343 ± 0.036	1.882ThrAsn: 1.882 ± 0.05	2.681ThrPro: 2.681 ± 0.063	1.964ThrGln: 1.964 ± 0.05	2.211ThrArg: 2.211 ± 0.044	2.948ThrSer: 2.948 ± 0.054	2.975ThrThr: 2.975 ± 0.073	3.832ThrVal: 3.832 ± 0.062	0.586ThrTrp: 0.586 ± 0.025	1.731ThrTyr: 1.731 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	5.622ValAla: 5.622 ± 0.08	0.818ValCys: 0.818 ± 0.024	3.743ValAsp: 3.743 ± 0.069	4.804ValGlu: 4.804 ± 0.078	3.102ValPhe: 3.102 ± 0.06	5.137ValGly: 5.137 ± 0.086	1.189ValHis: 1.189 ± 0.035	5.349ValIle: 5.349 ± 0.082	4.066ValLys: 4.066 ± 0.068	7.58ValLeu: 7.58 ± 0.09	1.929ValMet: 1.929 ± 0.045	2.766ValAsn: 2.766 ± 0.056	2.761ValPro: 2.761 ± 0.064	2.471ValGln: 2.471 ± 0.046	3.159ValArg: 3.159 ± 0.057	4.22ValSer: 4.22 ± 0.057	3.8ValThr: 3.8 ± 0.068	5.341ValVal: 5.341 ± 0.083	0.702ValTrp: 0.702 ± 0.025	2.129ValTyr: 2.129 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.775TrpAla: 0.775 ± 0.032	0.095TrpCys: 0.095 ± 0.011	0.616TrpAsp: 0.616 ± 0.025	0.786TrpGlu: 0.786 ± 0.032	0.398TrpPhe: 0.398 ± 0.021	0.848TrpGly: 0.848 ± 0.031	0.21TrpHis: 0.21 ± 0.013	0.698TrpIle: 0.698 ± 0.029	0.579TrpLys: 0.579 ± 0.026	1.195TrpLeu: 1.195 ± 0.038	0.309TrpMet: 0.309 ± 0.017	0.484TrpAsn: 0.484 ± 0.023	0.372TrpPro: 0.372 ± 0.019	0.551TrpGln: 0.551 ± 0.022	0.567TrpArg: 0.567 ± 0.022	0.598TrpSer: 0.598 ± 0.022	0.501TrpThr: 0.501 ± 0.023	0.727TrpVal: 0.727 ± 0.031	0.144TrpTrp: 0.144 ± 0.013	0.334TrpTyr: 0.334 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.436TyrAla: 2.436 ± 0.054	0.444TyrCys: 0.444 ± 0.021	1.778TyrAsp: 1.778 ± 0.043	2.163TyrGlu: 2.163 ± 0.039	1.511TyrPhe: 1.511 ± 0.037	2.568TyrGly: 2.568 ± 0.046	0.707TyrHis: 0.707 ± 0.026	2.088TyrIle: 2.088 ± 0.048	1.699TyrLys: 1.699 ± 0.049	3.583TyrLeu: 3.583 ± 0.065	0.693TyrMet: 0.693 ± 0.03	1.304TyrAsn: 1.304 ± 0.038	1.609TyrPro: 1.609 ± 0.036	1.438TyrGln: 1.438 ± 0.042	1.804TyrArg: 1.804 ± 0.049	2.046TyrSer: 2.046 ± 0.054	1.884TyrThr: 1.884 ± 0.05	1.976TyrVal: 1.976 ± 0.046	0.374TyrTrp: 0.374 ± 0.019	1.258TyrTyr: 1.258 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3294 proteins (1018540 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---