Amino acid dipepetide frequency for Sphaceloma murrayae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.621AlaAla: 9.621 ± 0.069	1.0AlaCys: 1.0 ± 0.017	4.552AlaAsp: 4.552 ± 0.034	5.233AlaGlu: 5.233 ± 0.045	3.114AlaPhe: 3.114 ± 0.03	6.483AlaGly: 6.483 ± 0.053	1.785AlaHis: 1.785 ± 0.023	4.153AlaIle: 4.153 ± 0.033	4.29AlaLys: 4.29 ± 0.04	7.954AlaLeu: 7.954 ± 0.057	2.014AlaMet: 2.014 ± 0.026	2.993AlaAsn: 2.993 ± 0.028	5.253AlaPro: 5.253 ± 0.047	3.712AlaGln: 3.712 ± 0.033	5.505AlaArg: 5.505 ± 0.042	7.814AlaSer: 7.814 ± 0.054	5.571AlaThr: 5.571 ± 0.04	5.591AlaVal: 5.591 ± 0.043	1.122AlaTrp: 1.122 ± 0.015	2.145AlaTyr: 2.145 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	0.886CysAla: 0.886 ± 0.017	0.182CysCys: 0.182 ± 0.008	0.568CysAsp: 0.568 ± 0.013	0.515CysGlu: 0.515 ± 0.012	0.461CysPhe: 0.461 ± 0.011	0.82CysGly: 0.82 ± 0.017	0.265CysHis: 0.265 ± 0.008	0.585CysIle: 0.585 ± 0.013	0.456CysLys: 0.456 ± 0.012	1.056CysLeu: 1.056 ± 0.019	0.226CysMet: 0.226 ± 0.006	0.386CysAsn: 0.386 ± 0.01	0.582CysPro: 0.582 ± 0.013	0.369CysGln: 0.369 ± 0.009	0.633CysArg: 0.633 ± 0.015	0.73CysSer: 0.73 ± 0.015	0.627CysThr: 0.627 ± 0.012	0.688CysVal: 0.688 ± 0.013	0.162CysTrp: 0.162 ± 0.006	0.3CysTyr: 0.3 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.102AspAla: 5.102 ± 0.04	0.556AspCys: 0.556 ± 0.012	4.471AspAsp: 4.471 ± 0.043	4.677AspGlu: 4.677 ± 0.05	2.228AspPhe: 2.228 ± 0.022	4.356AspGly: 4.356 ± 0.035	1.249AspHis: 1.249 ± 0.018	2.775AspIle: 2.775 ± 0.031	2.489AspLys: 2.489 ± 0.032	5.151AspLeu: 5.151 ± 0.039	1.374AspMet: 1.374 ± 0.019	1.728AspAsn: 1.728 ± 0.018	3.367AspPro: 3.367 ± 0.032	1.981AspGln: 1.981 ± 0.022	3.33AspArg: 3.33 ± 0.031	4.065AspSer: 4.065 ± 0.038	3.076AspThr: 3.076 ± 0.023	3.923AspVal: 3.923 ± 0.034	0.874AspTrp: 0.874 ± 0.014	1.567AspTyr: 1.567 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.486GluAla: 5.486 ± 0.047	0.518GluCys: 0.518 ± 0.011	4.365GluAsp: 4.365 ± 0.043	5.726GluGlu: 5.726 ± 0.06	1.643GluPhe: 1.643 ± 0.021	4.522GluGly: 4.522 ± 0.041	1.322GluHis: 1.322 ± 0.02	2.742GluIle: 2.742 ± 0.026	3.687GluLys: 3.687 ± 0.047	4.856GluLeu: 4.856 ± 0.041	1.495GluMet: 1.495 ± 0.02	1.867GluAsn: 1.867 ± 0.02	2.493GluPro: 2.493 ± 0.029	2.584GluGln: 2.584 ± 0.032	4.391GluArg: 4.391 ± 0.044	4.02GluSer: 4.02 ± 0.034	3.343GluThr: 3.343 ± 0.03	3.839GluVal: 3.839 ± 0.031	0.862GluTrp: 0.862 ± 0.015	1.536GluTyr: 1.536 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.116PheAla: 3.116 ± 0.029	0.465PheCys: 0.465 ± 0.012	2.228PheAsp: 2.228 ± 0.022	2.084PheGlu: 2.084 ± 0.022	1.486PhePhe: 1.486 ± 0.024	2.849PheGly: 2.849 ± 0.034	0.766PheHis: 0.766 ± 0.015	1.543PheIle: 1.543 ± 0.024	1.466PheLys: 1.466 ± 0.019	3.161PheLeu: 3.161 ± 0.036	0.713PheMet: 0.713 ± 0.016	1.324PheAsn: 1.324 ± 0.019	1.768PhePro: 1.768 ± 0.021	1.24PheGln: 1.24 ± 0.019	1.863PheArg: 1.863 ± 0.022	2.794PheSer: 2.794 ± 0.028	2.143PheThr: 2.143 ± 0.023	2.354PheVal: 2.354 ± 0.025	0.577PheTrp: 0.577 ± 0.013	1.003PheTyr: 1.003 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	5.752GlyAla: 5.752 ± 0.055	0.776GlyCys: 0.776 ± 0.013	3.88GlyAsp: 3.88 ± 0.032	4.117GlyGlu: 4.117 ± 0.037	2.755GlyPhe: 2.755 ± 0.032	6.502GlyGly: 6.502 ± 0.082	1.647GlyHis: 1.647 ± 0.023	3.43GlyIle: 3.43 ± 0.031	3.861GlyLys: 3.861 ± 0.036	6.157GlyLeu: 6.157 ± 0.047	1.828GlyMet: 1.828 ± 0.025	2.478GlyAsn: 2.478 ± 0.03	3.538GlyPro: 3.538 ± 0.036	2.883GlyGln: 2.883 ± 0.034	4.746GlyArg: 4.746 ± 0.037	6.006GlySer: 6.006 ± 0.046	4.376GlyThr: 4.376 ± 0.038	4.601GlyVal: 4.601 ± 0.036	1.177GlyTrp: 1.177 ± 0.02	2.166GlyTyr: 2.166 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	1.902HisAla: 1.902 ± 0.021	0.259HisCys: 0.259 ± 0.007	1.339HisAsp: 1.339 ± 0.019	1.277HisGlu: 1.277 ± 0.018	0.867HisPhe: 0.867 ± 0.015	1.64HisGly: 1.64 ± 0.022	0.792HisHis: 0.792 ± 0.016	1.071HisIle: 1.071 ± 0.017	0.897HisLys: 0.897 ± 0.018	2.154HisLeu: 2.154 ± 0.026	0.472HisMet: 0.472 ± 0.011	0.755HisAsn: 0.755 ± 0.013	1.538HisPro: 1.538 ± 0.019	0.908HisGln: 0.908 ± 0.015	1.462HisArg: 1.462 ± 0.019	1.753HisSer: 1.753 ± 0.021	1.24HisThr: 1.24 ± 0.019	1.474HisVal: 1.474 ± 0.018	0.3HisTrp: 0.3 ± 0.008	0.631HisTyr: 0.631 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.163IleAla: 4.163 ± 0.035	0.627IleCys: 0.627 ± 0.012	2.866IleAsp: 2.866 ± 0.026	2.681IleGlu: 2.681 ± 0.027	1.765IlePhe: 1.765 ± 0.022	3.062IleGly: 3.062 ± 0.031	1.046IleHis: 1.046 ± 0.017	2.211IleIle: 2.211 ± 0.029	2.155IleLys: 2.155 ± 0.025	4.03IleLeu: 4.03 ± 0.035	0.941IleMet: 0.941 ± 0.018	1.689IleAsn: 1.689 ± 0.02	2.797IlePro: 2.797 ± 0.027	1.643IleGln: 1.643 ± 0.019	2.78IleArg: 2.78 ± 0.028	3.583IleSer: 3.583 ± 0.037	2.817IleThr: 2.817 ± 0.028	2.984IleVal: 2.984 ± 0.028	0.645IleTrp: 0.645 ± 0.014	1.258IleTyr: 1.258 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.525LysAla: 4.525 ± 0.043	0.423LysCys: 0.423 ± 0.011	2.949LysAsp: 2.949 ± 0.035	3.374LysGlu: 3.374 ± 0.042	1.32LysPhe: 1.32 ± 0.019	3.382LysGly: 3.382 ± 0.038	1.097LysHis: 1.097 ± 0.018	2.152LysIle: 2.152 ± 0.024	3.416LysLys: 3.416 ± 0.052	3.842LysLeu: 3.842 ± 0.032	1.07LysMet: 1.07 ± 0.017	1.509LysAsn: 1.509 ± 0.023	2.684LysPro: 2.684 ± 0.034	1.894LysGln: 1.894 ± 0.023	3.794LysArg: 3.794 ± 0.04	3.583LysSer: 3.583 ± 0.035	2.946LysThr: 2.946 ± 0.034	2.94LysVal: 2.94 ± 0.029	0.648LysTrp: 0.648 ± 0.012	1.276LysTyr: 1.276 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	7.84LeuAla: 7.84 ± 0.046	1.039LeuCys: 1.039 ± 0.018	5.22LeuAsp: 5.22 ± 0.036	5.165LeuGlu: 5.165 ± 0.045	3.073LeuPhe: 3.073 ± 0.034	5.878LeuGly: 5.878 ± 0.044	2.126LeuHis: 2.126 ± 0.026	3.607LeuIle: 3.607 ± 0.038	3.997LeuLys: 3.997 ± 0.037	7.991LeuLeu: 7.991 ± 0.067	1.687LeuMet: 1.687 ± 0.022	2.887LeuAsn: 2.887 ± 0.026	5.47LeuPro: 5.47 ± 0.041	3.641LeuGln: 3.641 ± 0.037	5.703LeuArg: 5.703 ± 0.046	7.173LeuSer: 7.173 ± 0.046	4.899LeuThr: 4.899 ± 0.037	5.314LeuVal: 5.314 ± 0.044	1.06LeuTrp: 1.06 ± 0.02	2.191LeuTyr: 2.191 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.27MetAla: 2.27 ± 0.025	0.215MetCys: 0.215 ± 0.007	1.27MetAsp: 1.27 ± 0.019	1.267MetGlu: 1.267 ± 0.019	0.696MetPhe: 0.696 ± 0.013	1.58MetGly: 1.58 ± 0.021	0.502MetHis: 0.502 ± 0.013	0.93MetIle: 0.93 ± 0.014	0.999MetLys: 0.999 ± 0.016	1.833MetLeu: 1.833 ± 0.024	0.559MetMet: 0.559 ± 0.012	0.764MetAsn: 0.764 ± 0.014	1.286MetPro: 1.286 ± 0.019	0.911MetGln: 0.911 ± 0.017	1.319MetArg: 1.319 ± 0.017	1.95MetSer: 1.95 ± 0.02	1.347MetThr: 1.347 ± 0.019	1.285MetVal: 1.285 ± 0.02	0.255MetTrp: 0.255 ± 0.009	0.544MetTyr: 0.544 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.177AsnAla: 3.177 ± 0.029	0.343AsnCys: 0.343 ± 0.01	1.916AsnAsp: 1.916 ± 0.023	1.862AsnGlu: 1.862 ± 0.022	1.256AsnPhe: 1.256 ± 0.022	3.028AsnGly: 3.028 ± 0.032	0.723AsnHis: 0.723 ± 0.014	1.788AsnIle: 1.788 ± 0.021	1.467AsnLys: 1.467 ± 0.024	2.975AsnLeu: 2.975 ± 0.032	0.758AsnMet: 0.758 ± 0.014	1.276AsnAsn: 1.276 ± 0.023	2.264AsnPro: 2.264 ± 0.025	1.231AsnGln: 1.231 ± 0.019	1.83AsnArg: 1.83 ± 0.022	2.419AsnSer: 2.419 ± 0.027	2.119AsnThr: 2.119 ± 0.027	2.312AsnVal: 2.312 ± 0.027	0.48AsnTrp: 0.48 ± 0.012	0.987AsnTyr: 0.987 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	5.59ProAla: 5.59 ± 0.057	0.432ProCys: 0.432 ± 0.009	3.228ProAsp: 3.228 ± 0.03	3.428ProGlu: 3.428 ± 0.034	2.003ProPhe: 2.003 ± 0.024	4.078ProGly: 4.078 ± 0.039	1.292ProHis: 1.292 ± 0.018	2.41ProIle: 2.41 ± 0.029	2.606ProLys: 2.606 ± 0.03	4.687ProLeu: 4.687 ± 0.037	1.076ProMet: 1.076 ± 0.018	2.069ProAsn: 2.069 ± 0.024	5.32ProPro: 5.32 ± 0.075	2.504ProGln: 2.504 ± 0.042	3.487ProArg: 3.487 ± 0.037	6.568ProSer: 6.568 ± 0.059	4.277ProThr: 4.277 ± 0.044	3.564ProVal: 3.564 ± 0.031	0.653ProTrp: 0.653 ± 0.012	1.468ProTyr: 1.468 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.67GlnAla: 3.67 ± 0.036	0.401GlnCys: 0.401 ± 0.009	2.201GlnAsp: 2.201 ± 0.027	2.352GlnGlu: 2.352 ± 0.028	1.119GlnPhe: 1.119 ± 0.018	2.726GlnGly: 2.726 ± 0.032	1.073GlnHis: 1.073 ± 0.019	1.879GlnIle: 1.879 ± 0.024	1.946GlnLys: 1.946 ± 0.026	3.209GlnLeu: 3.209 ± 0.029	0.933GlnMet: 0.933 ± 0.017	1.457GlnAsn: 1.457 ± 0.022	2.454GlnPro: 2.454 ± 0.032	2.658GlnGln: 2.658 ± 0.067	2.83GlnArg: 2.83 ± 0.028	3.313GlnSer: 3.313 ± 0.033	2.487GlnThr: 2.487 ± 0.025	2.198GlnVal: 2.198 ± 0.023	0.552GlnTrp: 0.552 ± 0.01	1.139GlnTyr: 1.139 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	5.081ArgAla: 5.081 ± 0.04	0.621ArgCys: 0.621 ± 0.012	3.619ArgAsp: 3.619 ± 0.035	4.172ArgGlu: 4.172 ± 0.043	2.115ArgPhe: 2.115 ± 0.021	4.209ArgGly: 4.209 ± 0.047	1.525ArgHis: 1.525 ± 0.019	2.888ArgIle: 2.888 ± 0.028	3.77ArgLys: 3.77 ± 0.041	5.467ArgLeu: 5.467 ± 0.043	1.424ArgMet: 1.424 ± 0.02	2.224ArgAsn: 2.224 ± 0.025	3.811ArgPro: 3.811 ± 0.041	2.801ArgGln: 2.801 ± 0.029	5.456ArgArg: 5.456 ± 0.052	5.108ArgSer: 5.108 ± 0.044	3.691ArgThr: 3.691 ± 0.032	3.459ArgVal: 3.459 ± 0.031	0.903ArgTrp: 0.903 ± 0.016	1.656ArgTyr: 1.656 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	7.341SerAla: 7.341 ± 0.048	0.71SerCys: 0.71 ± 0.012	4.443SerAsp: 4.443 ± 0.037	4.045SerGlu: 4.045 ± 0.038	2.852SerPhe: 2.852 ± 0.027	5.837SerGly: 5.837 ± 0.049	1.896SerHis: 1.896 ± 0.021	3.8SerIle: 3.8 ± 0.034	3.732SerLys: 3.732 ± 0.041	7.012SerLeu: 7.012 ± 0.046	1.731SerMet: 1.731 ± 0.023	2.891SerAsn: 2.891 ± 0.03	5.927SerPro: 5.927 ± 0.06	3.304SerGln: 3.304 ± 0.036	5.171SerArg: 5.171 ± 0.046	9.162SerSer: 9.162 ± 0.091	6.093SerThr: 6.093 ± 0.062	4.688SerVal: 4.688 ± 0.039	0.971SerTrp: 0.971 ± 0.015	1.976SerTyr: 1.976 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.707ThrAla: 5.707 ± 0.042	0.686ThrCys: 0.686 ± 0.014	2.956ThrAsp: 2.956 ± 0.032	3.027ThrGlu: 3.027 ± 0.03	2.283ThrPhe: 2.283 ± 0.025	4.498ThrGly: 4.498 ± 0.04	1.271ThrHis: 1.271 ± 0.018	3.046ThrIle: 3.046 ± 0.03	2.683ThrLys: 2.683 ± 0.025	5.23ThrLeu: 5.23 ± 0.038	1.218ThrMet: 1.218 ± 0.017	2.151ThrAsn: 2.151 ± 0.025	4.584ThrPro: 4.584 ± 0.046	2.202ThrGln: 2.202 ± 0.025	3.362ThrArg: 3.362 ± 0.028	6.085ThrSer: 6.085 ± 0.059	5.089ThrThr: 5.089 ± 0.084	3.799ThrVal: 3.799 ± 0.04	0.823ThrTrp: 0.823 ± 0.014	1.645ThrTyr: 1.645 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	5.405ValAla: 5.405 ± 0.035	0.728ValCys: 0.728 ± 0.014	3.777ValAsp: 3.777 ± 0.033	4.053ValGlu: 4.053 ± 0.032	2.299ValPhe: 2.299 ± 0.026	4.264ValGly: 4.264 ± 0.036	1.332ValHis: 1.332 ± 0.019	2.758ValIle: 2.758 ± 0.032	3.139ValLys: 3.139 ± 0.037	5.467ValLeu: 5.467 ± 0.046	1.344ValMet: 1.344 ± 0.019	2.179ValAsn: 2.179 ± 0.021	3.619ValPro: 3.619 ± 0.035	2.462ValGln: 2.462 ± 0.023	3.773ValArg: 3.773 ± 0.026	4.595ValSer: 4.595 ± 0.034	3.659ValThr: 3.659 ± 0.037	4.513ValVal: 4.513 ± 0.043	0.855ValTrp: 0.855 ± 0.016	1.627ValTyr: 1.627 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.049TrpAla: 1.049 ± 0.016	0.169TrpCys: 0.169 ± 0.006	0.83TrpAsp: 0.83 ± 0.017	0.788TrpGlu: 0.788 ± 0.014	0.487TrpPhe: 0.487 ± 0.011	0.89TrpGly: 0.89 ± 0.015	0.315TrpHis: 0.315 ± 0.009	0.72TrpIle: 0.72 ± 0.013	0.722TrpLys: 0.722 ± 0.013	1.228TrpLeu: 1.228 ± 0.02	0.349TrpMet: 0.349 ± 0.009	0.537TrpAsn: 0.537 ± 0.011	0.551TrpPro: 0.551 ± 0.012	0.563TrpGln: 0.563 ± 0.012	0.982TrpArg: 0.982 ± 0.017	1.026TrpSer: 1.026 ± 0.017	0.932TrpThr: 0.932 ± 0.015	0.774TrpVal: 0.774 ± 0.014	0.252TrpTrp: 0.252 ± 0.01	0.411TrpTyr: 0.411 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.221TyrAla: 2.221 ± 0.026	0.348TyrCys: 0.348 ± 0.009	1.665TyrAsp: 1.665 ± 0.022	1.453TyrGlu: 1.453 ± 0.019	1.121TyrPhe: 1.121 ± 0.017	2.074TyrGly: 2.074 ± 0.03	0.708TyrHis: 0.708 ± 0.013	1.253TyrIle: 1.253 ± 0.02	1.045TyrLys: 1.045 ± 0.018	2.498TyrLeu: 2.498 ± 0.026	0.568TyrMet: 0.568 ± 0.014	1.047TyrAsn: 1.047 ± 0.019	1.432TyrPro: 1.432 ± 0.019	1.107TyrGln: 1.107 ± 0.018	1.583TyrArg: 1.583 ± 0.019	1.836TyrSer: 1.836 ± 0.025	1.614TyrThr: 1.614 ± 0.021	1.549TyrVal: 1.549 ± 0.022	0.402TyrTrp: 0.402 ± 0.01	0.88TyrTyr: 0.88 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8255 proteins (4222183 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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