Amino acid dipepetide frequency for Eptesicus fuscus gammaherpesvirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.896AlaAla: 13.896 ± 1.03
1.808AlaCys: 1.808 ± 0.21
4.164AlaAsp: 4.164 ± 0.291
5.758AlaGlu: 5.758 ± 0.345
3.331AlaPhe: 3.331 ± 0.335
7.638AlaGly: 7.638 ± 0.389
2.736AlaHis: 2.736 ± 0.232
3.022AlaIle: 3.022 ± 0.269
2.689AlaLys: 2.689 ± 0.294
11.231AlaLeu: 11.231 ± 0.67
2.284AlaMet: 2.284 ± 0.261
2.308AlaAsn: 2.308 ± 0.253
8.209AlaPro: 8.209 ± 0.52
3.902AlaGln: 3.902 ± 0.466
8.614AlaArg: 8.614 ± 0.603
7.947AlaSer: 7.947 ± 0.469
7.59AlaThr: 7.59 ± 0.787
5.996AlaVal: 5.996 ± 0.396
1.118AlaTrp: 1.118 ± 0.151
2.879AlaTyr: 2.879 ± 0.327
0.0AlaXaa: 0.0 ± 0.0
Cys
2.546CysAla: 2.546 ± 0.351
0.452CysCys: 0.452 ± 0.119
1.142CysAsp: 1.142 ± 0.169
0.976CysGlu: 0.976 ± 0.191
0.976CysPhe: 0.976 ± 0.17
1.856CysGly: 1.856 ± 0.249
0.547CysHis: 0.547 ± 0.127
0.547CysIle: 0.547 ± 0.115
0.381CysLys: 0.381 ± 0.092
2.903CysLeu: 2.903 ± 0.353
0.428CysMet: 0.428 ± 0.088
0.642CysAsn: 0.642 ± 0.146
1.214CysPro: 1.214 ± 0.196
0.928CysGln: 0.928 ± 0.209
1.499CysArg: 1.499 ± 0.227
1.404CysSer: 1.404 ± 0.224
1.047CysThr: 1.047 ± 0.153
1.547CysVal: 1.547 ± 0.197
0.309CysTrp: 0.309 ± 0.089
0.5CysTyr: 0.5 ± 0.121
0.0CysXaa: 0.0 ± 0.0
Asp
5.568AspAla: 5.568 ± 0.358
1.095AspCys: 1.095 ± 0.162
3.474AspAsp: 3.474 ± 0.66
3.759AspGlu: 3.759 ± 0.442
1.57AspPhe: 1.57 ± 0.219
4.188AspGly: 4.188 ± 0.377
0.976AspHis: 0.976 ± 0.126
1.975AspIle: 1.975 ± 0.163
1.19AspLys: 1.19 ± 0.232
4.331AspLeu: 4.331 ± 0.346
1.499AspMet: 1.499 ± 0.208
1.309AspAsn: 1.309 ± 0.185
3.498AspPro: 3.498 ± 0.294
1.214AspGln: 1.214 ± 0.191
3.117AspArg: 3.117 ± 0.242
3.617AspSer: 3.617 ± 0.364
2.641AspThr: 2.641 ± 0.264
3.736AspVal: 3.736 ± 0.314
0.666AspTrp: 0.666 ± 0.111
1.499AspTyr: 1.499 ± 0.139
0.0AspXaa: 0.0 ± 0.0
Glu
6.353GluAla: 6.353 ± 0.479
0.999GluCys: 0.999 ± 0.199
4.354GluAsp: 4.354 ± 0.537
3.783GluGlu: 3.783 ± 0.518
1.737GluPhe: 1.737 ± 0.192
3.974GluGly: 3.974 ± 0.463
1.475GluHis: 1.475 ± 0.165
1.737GluIle: 1.737 ± 0.166
1.737GluLys: 1.737 ± 0.231
5.52GluLeu: 5.52 ± 0.397
1.261GluMet: 1.261 ± 0.17
1.999GluAsn: 1.999 ± 0.226
3.046GluPro: 3.046 ± 0.237
1.618GluGln: 1.618 ± 0.242
4.592GluArg: 4.592 ± 0.49
3.641GluSer: 3.641 ± 0.301
4.14GluThr: 4.14 ± 0.287
3.545GluVal: 3.545 ± 0.323
0.547GluTrp: 0.547 ± 0.104
0.976GluTyr: 0.976 ± 0.173
0.0GluXaa: 0.0 ± 0.0
Phe
2.403PheAla: 2.403 ± 0.321
0.857PheCys: 0.857 ± 0.137
1.856PheAsp: 1.856 ± 0.196
1.737PheGlu: 1.737 ± 0.211
2.118PhePhe: 2.118 ± 0.267
2.189PheGly: 2.189 ± 0.266
0.809PheHis: 0.809 ± 0.138
1.451PheIle: 1.451 ± 0.176
1.666PheLys: 1.666 ± 0.212
4.331PheLeu: 4.331 ± 0.45
0.976PheMet: 0.976 ± 0.207
1.309PheAsn: 1.309 ± 0.154
1.927PhePro: 1.927 ± 0.281
1.261PheGln: 1.261 ± 0.225
2.284PheArg: 2.284 ± 0.33
2.903PheSer: 2.903 ± 0.251
1.785PheThr: 1.785 ± 0.186
2.308PheVal: 2.308 ± 0.316
0.333PheTrp: 0.333 ± 0.086
1.594PheTyr: 1.594 ± 0.199
0.0PheXaa: 0.0 ± 0.0
Gly
9.351GlyAla: 9.351 ± 0.603
1.832GlyCys: 1.832 ± 0.272
4.854GlyAsp: 4.854 ± 0.564
4.902GlyGlu: 4.902 ± 0.441
1.904GlyPhe: 1.904 ± 0.242
8.304GlyGly: 8.304 ± 0.627
1.499GlyHis: 1.499 ± 0.144
1.808GlyIle: 1.808 ± 0.199
1.761GlyLys: 1.761 ± 0.223
5.377GlyLeu: 5.377 ± 0.524
1.071GlyMet: 1.071 ± 0.164
1.927GlyAsn: 1.927 ± 0.213
4.735GlyPro: 4.735 ± 0.369
2.403GlyGln: 2.403 ± 0.363
5.425GlyArg: 5.425 ± 0.454
5.401GlySer: 5.401 ± 0.431
3.664GlyThr: 3.664 ± 0.319
4.545GlyVal: 4.545 ± 0.409
0.904GlyTrp: 0.904 ± 0.162
1.547GlyTyr: 1.547 ± 0.21
0.0GlyXaa: 0.0 ± 0.0
His
3.046HisAla: 3.046 ± 0.225
0.286HisCys: 0.286 ± 0.083
1.095HisAsp: 1.095 ± 0.136
0.976HisGlu: 0.976 ± 0.155
0.595HisPhe: 0.595 ± 0.134
1.88HisGly: 1.88 ± 0.186
0.69HisHis: 0.69 ± 0.114
0.833HisIle: 0.833 ± 0.184
0.619HisLys: 0.619 ± 0.146
2.546HisLeu: 2.546 ± 0.239
0.809HisMet: 0.809 ± 0.135
0.619HisAsn: 0.619 ± 0.127
2.023HisPro: 2.023 ± 0.311
0.999HisGln: 0.999 ± 0.126
1.666HisArg: 1.666 ± 0.219
1.332HisSer: 1.332 ± 0.194
1.332HisThr: 1.332 ± 0.213
2.237HisVal: 2.237 ± 0.198
0.214HisTrp: 0.214 ± 0.093
0.619HisTyr: 0.619 ± 0.11
0.0HisXaa: 0.0 ± 0.0
Ile
2.998IleAla: 2.998 ± 0.292
0.714IleCys: 0.714 ± 0.146
1.761IleAsp: 1.761 ± 0.191
1.88IleGlu: 1.88 ± 0.211
1.499IlePhe: 1.499 ± 0.228
1.689IleGly: 1.689 ± 0.186
0.761IleHis: 0.761 ± 0.155
1.214IleIle: 1.214 ± 0.245
1.095IleLys: 1.095 ± 0.174
2.403IleLeu: 2.403 ± 0.27
0.642IleMet: 0.642 ± 0.131
1.332IleAsn: 1.332 ± 0.215
1.618IlePro: 1.618 ± 0.174
1.309IleGln: 1.309 ± 0.248
1.785IleArg: 1.785 ± 0.179
2.879IleSer: 2.879 ± 0.263
2.094IleThr: 2.094 ± 0.279
1.666IleVal: 1.666 ± 0.215
0.405IleTrp: 0.405 ± 0.104
1.118IleTyr: 1.118 ± 0.154
0.0IleXaa: 0.0 ± 0.0
Lys
2.165LysAla: 2.165 ± 0.215
0.476LysCys: 0.476 ± 0.124
1.713LysAsp: 1.713 ± 0.235
1.428LysGlu: 1.428 ± 0.189
0.928LysPhe: 0.928 ± 0.146
1.713LysGly: 1.713 ± 0.205
0.619LysHis: 0.619 ± 0.117
1.332LysIle: 1.332 ± 0.189
1.166LysLys: 1.166 ± 0.201
2.546LysLeu: 2.546 ± 0.218
0.809LysMet: 0.809 ± 0.172
1.214LysAsn: 1.214 ± 0.18
1.475LysPro: 1.475 ± 0.225
1.428LysGln: 1.428 ± 0.208
2.356LysArg: 2.356 ± 0.268
1.975LysSer: 1.975 ± 0.286
1.856LysThr: 1.856 ± 0.252
1.547LysVal: 1.547 ± 0.191
0.214LysTrp: 0.214 ± 0.064
0.738LysTyr: 0.738 ± 0.135
0.0LysXaa: 0.0 ± 0.0
Leu
9.732LeuAla: 9.732 ± 0.442
2.308LeuCys: 2.308 ± 0.266
4.664LeuAsp: 4.664 ± 0.344
5.592LeuGlu: 5.592 ± 0.466
4.188LeuPhe: 4.188 ± 0.517
6.068LeuGly: 6.068 ± 0.402
2.403LeuHis: 2.403 ± 0.265
2.95LeuIle: 2.95 ± 0.359
2.332LeuLys: 2.332 ± 0.221
9.732LeuLeu: 9.732 ± 0.719
2.023LeuMet: 2.023 ± 0.226
2.998LeuAsn: 2.998 ± 0.277
6.329LeuPro: 6.329 ± 0.469
3.569LeuGln: 3.569 ± 0.435
8.28LeuArg: 8.28 ± 0.533
8.328LeuSer: 8.328 ± 0.494
5.496LeuThr: 5.496 ± 0.412
5.83LeuVal: 5.83 ± 0.35
1.095LeuTrp: 1.095 ± 0.194
2.546LeuTyr: 2.546 ± 0.299
0.0LeuXaa: 0.0 ± 0.0
Met
2.546MetAla: 2.546 ± 0.305
0.642MetCys: 0.642 ± 0.126
0.809MetAsp: 0.809 ± 0.116
1.118MetGlu: 1.118 ± 0.186
1.214MetPhe: 1.214 ± 0.163
1.523MetGly: 1.523 ± 0.223
0.476MetHis: 0.476 ± 0.111
0.571MetIle: 0.571 ± 0.107
0.381MetLys: 0.381 ± 0.081
2.451MetLeu: 2.451 ± 0.269
0.428MetMet: 0.428 ± 0.083
0.69MetAsn: 0.69 ± 0.169
0.928MetPro: 0.928 ± 0.141
0.714MetGln: 0.714 ± 0.148
1.451MetArg: 1.451 ± 0.193
1.785MetSer: 1.785 ± 0.227
0.928MetThr: 0.928 ± 0.13
1.309MetVal: 1.309 ± 0.16
0.286MetTrp: 0.286 ± 0.07
0.857MetTyr: 0.857 ± 0.134
0.0MetXaa: 0.0 ± 0.0
Asn
3.046AsnAla: 3.046 ± 0.29
0.547AsnCys: 0.547 ± 0.102
1.142AsnAsp: 1.142 ± 0.212
1.713AsnGlu: 1.713 ± 0.174
1.071AsnPhe: 1.071 ± 0.188
1.737AsnGly: 1.737 ± 0.229
0.571AsnHis: 0.571 ± 0.117
1.57AsnIle: 1.57 ± 0.177
1.047AsnLys: 1.047 ± 0.196
2.689AsnLeu: 2.689 ± 0.25
0.761AsnMet: 0.761 ± 0.146
1.237AsnAsn: 1.237 ± 0.215
1.999AsnPro: 1.999 ± 0.207
1.023AsnGln: 1.023 ± 0.206
2.023AsnArg: 2.023 ± 0.186
2.308AsnSer: 2.308 ± 0.259
1.523AsnThr: 1.523 ± 0.196
1.904AsnVal: 1.904 ± 0.249
0.476AsnTrp: 0.476 ± 0.09
0.976AsnTyr: 0.976 ± 0.124
0.0AsnXaa: 0.0 ± 0.0
Pro
6.781ProAla: 6.781 ± 0.512
1.261ProCys: 1.261 ± 0.181
2.974ProAsp: 2.974 ± 0.281
4.116ProGlu: 4.116 ± 0.43
2.141ProPhe: 2.141 ± 0.24
6.258ProGly: 6.258 ± 0.482
1.594ProHis: 1.594 ± 0.168
1.785ProIle: 1.785 ± 0.19
1.666ProLys: 1.666 ± 0.23
6.186ProLeu: 6.186 ± 0.41
1.142ProMet: 1.142 ± 0.161
1.618ProAsn: 1.618 ± 0.338
7.781ProPro: 7.781 ± 0.733
3.046ProGln: 3.046 ± 0.592
5.592ProArg: 5.592 ± 0.418
5.568ProSer: 5.568 ± 0.578
4.973ProThr: 4.973 ± 0.782
4.759ProVal: 4.759 ± 0.296
0.714ProTrp: 0.714 ± 0.126
1.095ProTyr: 1.095 ± 0.153
0.0ProXaa: 0.0 ± 0.0
Gln
3.45GlnAla: 3.45 ± 0.507
0.738GlnCys: 0.738 ± 0.11
1.642GlnAsp: 1.642 ± 0.187
1.642GlnGlu: 1.642 ± 0.231
1.547GlnPhe: 1.547 ± 0.279
2.237GlnGly: 2.237 ± 0.304
1.261GlnHis: 1.261 ± 0.187
0.976GlnIle: 0.976 ± 0.144
1.261GlnLys: 1.261 ± 0.206
4.069GlnLeu: 4.069 ± 0.424
0.809GlnMet: 0.809 ± 0.127
1.166GlnAsn: 1.166 ± 0.16
3.522GlnPro: 3.522 ± 0.697
3.188GlnGln: 3.188 ± 0.79
2.998GlnArg: 2.998 ± 0.246
2.26GlnSer: 2.26 ± 0.272
2.475GlnThr: 2.475 ± 0.329
1.975GlnVal: 1.975 ± 0.195
0.547GlnTrp: 0.547 ± 0.112
1.142GlnTyr: 1.142 ± 0.179
0.0GlnXaa: 0.0 ± 0.0
Arg
9.47ArgAla: 9.47 ± 0.558
1.642ArgCys: 1.642 ± 0.289
4.378ArgAsp: 4.378 ± 0.272
5.473ArgGlu: 5.473 ± 0.391
2.189ArgPhe: 2.189 ± 0.261
5.401ArgGly: 5.401 ± 0.421
2.689ArgHis: 2.689 ± 0.3
1.904ArgIle: 1.904 ± 0.193
2.165ArgLys: 2.165 ± 0.263
6.924ArgLeu: 6.924 ± 0.47
1.142ArgMet: 1.142 ± 0.184
2.356ArgAsn: 2.356 ± 0.232
5.282ArgPro: 5.282 ± 0.375
3.141ArgGln: 3.141 ± 0.349
6.853ArgArg: 6.853 ± 0.607
4.426ArgSer: 4.426 ± 0.361
2.903ArgThr: 2.903 ± 0.314
5.377ArgVal: 5.377 ± 0.453
0.952ArgTrp: 0.952 ± 0.152
1.88ArgTyr: 1.88 ± 0.192
0.0ArgXaa: 0.0 ± 0.0
Ser
7.995SerAla: 7.995 ± 0.532
1.642SerCys: 1.642 ± 0.231
3.26SerAsp: 3.26 ± 0.296
3.641SerGlu: 3.641 ± 0.365
2.76SerPhe: 2.76 ± 0.259
6.234SerGly: 6.234 ± 0.416
1.451SerHis: 1.451 ± 0.157
1.689SerIle: 1.689 ± 0.194
2.213SerLys: 2.213 ± 0.213
6.948SerLeu: 6.948 ± 0.414
1.428SerMet: 1.428 ± 0.192
2.07SerAsn: 2.07 ± 0.265
5.83SerPro: 5.83 ± 0.558
2.879SerGln: 2.879 ± 0.286
5.877SerArg: 5.877 ± 0.393
6.091SerSer: 6.091 ± 0.427
4.164SerThr: 4.164 ± 0.368
5.401SerVal: 5.401 ± 0.425
0.666SerTrp: 0.666 ± 0.133
1.475SerTyr: 1.475 ± 0.204
0.0SerXaa: 0.0 ± 0.0
Thr
5.925ThrAla: 5.925 ± 0.516
1.475ThrCys: 1.475 ± 0.181
2.808ThrAsp: 2.808 ± 0.238
2.927ThrGlu: 2.927 ± 0.346
1.951ThrPhe: 1.951 ± 0.199
4.116ThrGly: 4.116 ± 0.417
1.713ThrHis: 1.713 ± 0.221
2.07ThrIle: 2.07 ± 0.236
1.523ThrLys: 1.523 ± 0.227
5.806ThrLeu: 5.806 ± 0.384
1.38ThrMet: 1.38 ± 0.204
1.499ThrAsn: 1.499 ± 0.16
5.14ThrPro: 5.14 ± 0.716
2.356ThrGln: 2.356 ± 0.305
4.093ThrArg: 4.093 ± 0.349
4.14ThrSer: 4.14 ± 0.36
5.14ThrThr: 5.14 ± 1.6
4.616ThrVal: 4.616 ± 0.322
0.69ThrTrp: 0.69 ± 0.118
1.666ThrTyr: 1.666 ± 0.182
0.0ThrXaa: 0.0 ± 0.0
Val
6.543ValAla: 6.543 ± 0.443
1.927ValCys: 1.927 ± 0.264
3.236ValAsp: 3.236 ± 0.326
3.45ValGlu: 3.45 ± 0.293
3.069ValPhe: 3.069 ± 0.312
3.331ValGly: 3.331 ± 0.385
1.404ValHis: 1.404 ± 0.216
1.975ValIle: 1.975 ± 0.179
1.642ValLys: 1.642 ± 0.203
6.21ValLeu: 6.21 ± 0.482
1.118ValMet: 1.118 ± 0.16
1.689ValAsn: 1.689 ± 0.265
4.331ValPro: 4.331 ± 0.312
2.498ValGln: 2.498 ± 0.242
5.235ValArg: 5.235 ± 0.49
5.354ValSer: 5.354 ± 0.376
4.973ValThr: 4.973 ± 0.326
3.831ValVal: 3.831 ± 0.418
0.595ValTrp: 0.595 ± 0.116
2.475ValTyr: 2.475 ± 0.209
0.0ValXaa: 0.0 ± 0.0
Trp
1.047TrpAla: 1.047 ± 0.138
0.214TrpCys: 0.214 ± 0.081
0.5TrpAsp: 0.5 ± 0.165
0.642TrpGlu: 0.642 ± 0.127
0.286TrpPhe: 0.286 ± 0.075
0.976TrpGly: 0.976 ± 0.145
0.167TrpHis: 0.167 ± 0.072
0.357TrpIle: 0.357 ± 0.083
0.381TrpLys: 0.381 ± 0.113
1.428TrpLeu: 1.428 ± 0.169
0.238TrpMet: 0.238 ± 0.073
0.381TrpAsn: 0.381 ± 0.1
0.809TrpPro: 0.809 ± 0.131
0.452TrpGln: 0.452 ± 0.111
0.928TrpArg: 0.928 ± 0.179
0.5TrpSer: 0.5 ± 0.126
0.761TrpThr: 0.761 ± 0.125
0.761TrpVal: 0.761 ± 0.137
0.143TrpTrp: 0.143 ± 0.053
0.309TrpTyr: 0.309 ± 0.094
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.26TyrAla: 2.26 ± 0.199
0.928TyrCys: 0.928 ± 0.176
1.095TyrAsp: 1.095 ± 0.187
1.523TyrGlu: 1.523 ± 0.239
1.023TyrPhe: 1.023 ± 0.152
1.904TyrGly: 1.904 ± 0.249
0.571TyrHis: 0.571 ± 0.121
1.095TyrIle: 1.095 ± 0.189
0.785TyrLys: 0.785 ± 0.138
2.855TyrLeu: 2.855 ± 0.252
0.833TyrMet: 0.833 ± 0.144
0.999TyrAsn: 0.999 ± 0.152
1.356TyrPro: 1.356 ± 0.157
0.976TyrGln: 0.976 ± 0.119
1.88TyrArg: 1.88 ± 0.292
1.856TyrSer: 1.856 ± 0.27
1.547TyrThr: 1.547 ± 0.209
1.999TyrVal: 1.999 ± 0.276
0.405TyrTrp: 0.405 ± 0.098
0.571TyrTyr: 0.571 ± 0.12
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 75 proteins (42028 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski