Amino acid dipepetide frequency for Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.87AlaAla: 9.87 ± 1.678
1.116AlaCys: 1.116 ± 0.323
3.175AlaAsp: 3.175 ± 0.503
3.776AlaGlu: 3.776 ± 0.793
2.403AlaPhe: 2.403 ± 0.499
4.377AlaGly: 4.377 ± 0.679
1.974AlaHis: 1.974 ± 0.432
3.69AlaIle: 3.69 ± 0.653
2.403AlaLys: 2.403 ± 0.508
8.496AlaLeu: 8.496 ± 1.007
1.631AlaMet: 1.631 ± 0.398
3.433AlaAsn: 3.433 ± 0.673
5.235AlaPro: 5.235 ± 0.804
2.489AlaGln: 2.489 ± 0.507
5.75AlaArg: 5.75 ± 1.051
5.578AlaSer: 5.578 ± 0.634
4.549AlaThr: 4.549 ± 0.561
5.836AlaVal: 5.836 ± 0.579
0.601AlaTrp: 0.601 ± 0.175
3.09AlaTyr: 3.09 ± 0.492
0.0AlaXaa: 0.0 ± 0.0
Cys
1.373CysAla: 1.373 ± 0.38
1.116CysCys: 1.116 ± 0.408
0.858CysAsp: 0.858 ± 0.26
0.858CysGlu: 0.858 ± 0.29
0.515CysPhe: 0.515 ± 0.188
1.459CysGly: 1.459 ± 0.41
0.601CysHis: 0.601 ± 0.223
0.687CysIle: 0.687 ± 0.278
0.772CysLys: 0.772 ± 0.249
1.974CysLeu: 1.974 ± 0.491
0.687CysMet: 0.687 ± 0.274
1.373CysAsn: 1.373 ± 0.371
0.601CysPro: 0.601 ± 0.199
0.601CysGln: 0.601 ± 0.248
0.601CysArg: 0.601 ± 0.239
0.944CysSer: 0.944 ± 0.296
0.944CysThr: 0.944 ± 0.277
1.287CysVal: 1.287 ± 0.392
0.343CysTrp: 0.343 ± 0.18
1.116CysTyr: 1.116 ± 0.279
0.0CysXaa: 0.0 ± 0.0
Asp
3.347AspAla: 3.347 ± 0.568
0.858AspCys: 0.858 ± 0.302
2.575AspAsp: 2.575 ± 0.721
4.463AspGlu: 4.463 ± 0.722
1.631AspPhe: 1.631 ± 0.409
3.09AspGly: 3.09 ± 0.638
1.373AspHis: 1.373 ± 0.359
1.888AspIle: 1.888 ± 0.477
1.888AspLys: 1.888 ± 0.451
5.664AspLeu: 5.664 ± 0.842
1.716AspMet: 1.716 ± 0.356
1.202AspAsn: 1.202 ± 0.342
4.119AspPro: 4.119 ± 0.466
1.202AspGln: 1.202 ± 0.277
3.519AspArg: 3.519 ± 0.735
3.519AspSer: 3.519 ± 0.679
2.231AspThr: 2.231 ± 0.638
3.09AspVal: 3.09 ± 0.475
0.944AspTrp: 0.944 ± 0.281
1.716AspTyr: 1.716 ± 0.365
0.0AspXaa: 0.0 ± 0.0
Glu
4.549GluAla: 4.549 ± 0.608
1.287GluCys: 1.287 ± 0.38
4.806GluAsp: 4.806 ± 0.86
7.552GluGlu: 7.552 ± 1.671
1.716GluPhe: 1.716 ± 0.383
4.205GluGly: 4.205 ± 0.659
1.373GluHis: 1.373 ± 0.326
2.575GluIle: 2.575 ± 0.469
2.575GluLys: 2.575 ± 0.551
6.008GluLeu: 6.008 ± 1.009
1.459GluMet: 1.459 ± 0.371
2.231GluAsn: 2.231 ± 0.487
1.974GluPro: 1.974 ± 0.346
2.403GluGln: 2.403 ± 0.438
3.948GluArg: 3.948 ± 0.818
3.519GluSer: 3.519 ± 0.655
3.433GluThr: 3.433 ± 0.496
4.291GluVal: 4.291 ± 0.661
0.601GluTrp: 0.601 ± 0.243
1.03GluTyr: 1.03 ± 0.296
0.0GluXaa: 0.0 ± 0.0
Phe
2.403PheAla: 2.403 ± 0.434
0.601PheCys: 0.601 ± 0.228
2.746PheAsp: 2.746 ± 0.571
1.888PheGlu: 1.888 ± 0.293
1.716PhePhe: 1.716 ± 0.346
1.459PheGly: 1.459 ± 0.352
0.944PheHis: 0.944 ± 0.239
2.231PheIle: 2.231 ± 0.494
1.116PheLys: 1.116 ± 0.293
3.261PheLeu: 3.261 ± 0.632
1.545PheMet: 1.545 ± 0.352
1.888PheAsn: 1.888 ± 0.342
1.974PhePro: 1.974 ± 0.369
1.888PheGln: 1.888 ± 0.321
2.317PheArg: 2.317 ± 0.391
3.175PheSer: 3.175 ± 0.425
1.888PheThr: 1.888 ± 0.361
2.746PheVal: 2.746 ± 0.422
0.086PheTrp: 0.086 ± 0.077
1.287PheTyr: 1.287 ± 0.33
0.0PheXaa: 0.0 ± 0.0
Gly
5.149GlyAla: 5.149 ± 0.622
1.287GlyCys: 1.287 ± 0.397
2.918GlyAsp: 2.918 ± 0.443
2.918GlyGlu: 2.918 ± 0.545
2.66GlyPhe: 2.66 ± 0.414
5.149GlyGly: 5.149 ± 0.948
1.545GlyHis: 1.545 ± 0.396
2.403GlyIle: 2.403 ± 0.387
1.716GlyLys: 1.716 ± 0.393
6.522GlyLeu: 6.522 ± 0.741
1.202GlyMet: 1.202 ± 0.344
2.66GlyAsn: 2.66 ± 0.676
2.489GlyPro: 2.489 ± 0.627
2.403GlyGln: 2.403 ± 0.47
5.493GlyArg: 5.493 ± 0.697
4.806GlySer: 4.806 ± 0.573
3.433GlyThr: 3.433 ± 0.57
4.978GlyVal: 4.978 ± 0.914
0.772GlyTrp: 0.772 ± 0.236
1.888GlyTyr: 1.888 ± 0.395
0.0GlyXaa: 0.0 ± 0.0
His
1.459HisAla: 1.459 ± 0.283
1.03HisCys: 1.03 ± 0.328
0.858HisAsp: 0.858 ± 0.236
1.202HisGlu: 1.202 ± 0.316
0.858HisPhe: 0.858 ± 0.329
1.974HisGly: 1.974 ± 0.4
1.03HisHis: 1.03 ± 0.285
0.601HisIle: 0.601 ± 0.23
0.858HisLys: 0.858 ± 0.267
2.403HisLeu: 2.403 ± 0.532
0.687HisMet: 0.687 ± 0.366
1.03HisAsn: 1.03 ± 0.314
2.66HisPro: 2.66 ± 0.604
1.03HisGln: 1.03 ± 0.286
2.06HisArg: 2.06 ± 0.316
1.459HisSer: 1.459 ± 0.362
1.459HisThr: 1.459 ± 0.315
1.545HisVal: 1.545 ± 0.294
0.429HisTrp: 0.429 ± 0.228
0.343HisTyr: 0.343 ± 0.16
0.0HisXaa: 0.0 ± 0.0
Ile
2.746IleAla: 2.746 ± 0.623
0.858IleCys: 0.858 ± 0.234
1.459IleAsp: 1.459 ± 0.332
1.631IleGlu: 1.631 ± 0.311
1.545IlePhe: 1.545 ± 0.476
2.231IleGly: 2.231 ± 0.458
0.772IleHis: 0.772 ± 0.319
1.974IleIle: 1.974 ± 0.458
2.06IleLys: 2.06 ± 0.409
2.918IleLeu: 2.918 ± 0.475
1.373IleMet: 1.373 ± 0.36
1.888IleAsn: 1.888 ± 0.404
2.575IlePro: 2.575 ± 0.539
1.974IleGln: 1.974 ± 0.316
2.403IleArg: 2.403 ± 0.535
2.746IleSer: 2.746 ± 0.462
3.261IleThr: 3.261 ± 0.571
3.261IleVal: 3.261 ± 0.52
0.429IleTrp: 0.429 ± 0.207
1.202IleTyr: 1.202 ± 0.333
0.0IleXaa: 0.0 ± 0.0
Lys
1.974LysAla: 1.974 ± 0.416
0.687LysCys: 0.687 ± 0.279
2.06LysAsp: 2.06 ± 0.586
2.146LysGlu: 2.146 ± 0.426
1.459LysPhe: 1.459 ± 0.4
2.146LysGly: 2.146 ± 0.572
0.858LysHis: 0.858 ± 0.308
2.06LysIle: 2.06 ± 0.393
2.575LysLys: 2.575 ± 0.578
3.175LysLeu: 3.175 ± 0.708
1.116LysMet: 1.116 ± 0.404
1.888LysAsn: 1.888 ± 0.427
2.317LysPro: 2.317 ± 0.47
1.459LysGln: 1.459 ± 0.345
2.918LysArg: 2.918 ± 0.57
2.146LysSer: 2.146 ± 0.352
1.974LysThr: 1.974 ± 0.414
1.802LysVal: 1.802 ± 0.444
0.515LysTrp: 0.515 ± 0.185
1.373LysTyr: 1.373 ± 0.275
0.0LysXaa: 0.0 ± 0.0
Leu
8.067LeuAla: 8.067 ± 0.806
1.974LeuCys: 1.974 ± 0.54
4.634LeuAsp: 4.634 ± 0.835
5.493LeuGlu: 5.493 ± 0.751
2.146LeuPhe: 2.146 ± 0.386
5.235LeuGly: 5.235 ± 0.772
3.004LeuHis: 3.004 ± 0.622
2.832LeuIle: 2.832 ± 0.599
4.377LeuLys: 4.377 ± 0.665
9.87LeuLeu: 9.87 ± 1.255
2.489LeuMet: 2.489 ± 0.515
4.119LeuAsn: 4.119 ± 0.634
6.78LeuPro: 6.78 ± 0.722
4.291LeuGln: 4.291 ± 0.569
7.724LeuArg: 7.724 ± 0.764
5.836LeuSer: 5.836 ± 0.784
6.866LeuThr: 6.866 ± 0.682
5.578LeuVal: 5.578 ± 0.648
1.631LeuTrp: 1.631 ± 0.375
2.918LeuTyr: 2.918 ± 0.493
0.0LeuXaa: 0.0 ± 0.0
Met
2.403MetAla: 2.403 ± 0.328
0.172MetCys: 0.172 ± 0.119
1.202MetAsp: 1.202 ± 0.23
1.716MetGlu: 1.716 ± 0.336
0.429MetPhe: 0.429 ± 0.197
1.545MetGly: 1.545 ± 0.285
1.459MetHis: 1.459 ± 0.472
0.772MetIle: 0.772 ± 0.224
0.687MetLys: 0.687 ± 0.194
2.489MetLeu: 2.489 ± 0.499
0.944MetMet: 0.944 ± 0.263
1.631MetAsn: 1.631 ± 0.38
2.146MetPro: 2.146 ± 0.312
1.116MetGln: 1.116 ± 0.324
1.802MetArg: 1.802 ± 0.458
2.06MetSer: 2.06 ± 0.453
0.944MetThr: 0.944 ± 0.199
1.202MetVal: 1.202 ± 0.327
0.515MetTrp: 0.515 ± 0.205
1.202MetTyr: 1.202 ± 0.252
0.0MetXaa: 0.0 ± 0.0
Asn
2.832AsnAla: 2.832 ± 0.543
0.772AsnCys: 0.772 ± 0.228
2.146AsnAsp: 2.146 ± 0.464
1.802AsnGlu: 1.802 ± 0.292
2.832AsnPhe: 2.832 ± 0.658
2.746AsnGly: 2.746 ± 0.526
1.03AsnHis: 1.03 ± 0.314
2.403AsnIle: 2.403 ± 0.468
1.287AsnLys: 1.287 ± 0.314
3.605AsnLeu: 3.605 ± 0.786
1.716AsnMet: 1.716 ± 0.534
2.06AsnAsn: 2.06 ± 0.576
3.09AsnPro: 3.09 ± 0.526
1.545AsnGln: 1.545 ± 0.326
2.146AsnArg: 2.146 ± 0.371
2.832AsnSer: 2.832 ± 0.667
2.575AsnThr: 2.575 ± 0.64
2.403AsnVal: 2.403 ± 0.51
0.858AsnTrp: 0.858 ± 0.287
2.231AsnTyr: 2.231 ± 0.55
0.0AsnXaa: 0.0 ± 0.0
Pro
5.493ProAla: 5.493 ± 0.482
0.687ProCys: 0.687 ± 0.277
3.69ProAsp: 3.69 ± 0.481
4.377ProGlu: 4.377 ± 0.595
2.575ProPhe: 2.575 ± 0.466
4.634ProGly: 4.634 ± 0.525
1.202ProHis: 1.202 ± 0.276
2.146ProIle: 2.146 ± 0.376
1.373ProLys: 1.373 ± 0.363
5.235ProLeu: 5.235 ± 0.785
1.287ProMet: 1.287 ± 0.391
2.489ProAsn: 2.489 ± 0.491
7.123ProPro: 7.123 ± 1.621
3.519ProGln: 3.519 ± 0.629
5.493ProArg: 5.493 ± 0.787
4.463ProSer: 4.463 ± 0.672
4.119ProThr: 4.119 ± 0.664
4.291ProVal: 4.291 ± 0.618
0.687ProTrp: 0.687 ± 0.236
1.888ProTyr: 1.888 ± 0.452
0.0ProXaa: 0.0 ± 0.0
Gln
4.205GlnAla: 4.205 ± 0.549
0.601GlnCys: 0.601 ± 0.243
2.06GlnAsp: 2.06 ± 0.337
3.433GlnGlu: 3.433 ± 0.637
1.202GlnPhe: 1.202 ± 0.34
2.489GlnGly: 2.489 ± 0.43
1.03GlnHis: 1.03 ± 0.269
1.373GlnIle: 1.373 ± 0.32
1.116GlnLys: 1.116 ± 0.245
3.948GlnLeu: 3.948 ± 0.567
1.202GlnMet: 1.202 ± 0.238
2.06GlnAsn: 2.06 ± 0.5
3.948GlnPro: 3.948 ± 0.468
3.519GlnGln: 3.519 ± 0.657
3.175GlnArg: 3.175 ± 0.48
2.918GlnSer: 2.918 ± 0.59
2.66GlnThr: 2.66 ± 0.483
2.575GlnVal: 2.575 ± 0.482
0.515GlnTrp: 0.515 ± 0.215
0.944GlnTyr: 0.944 ± 0.321
0.0GlnXaa: 0.0 ± 0.0
Arg
7.896ArgAla: 7.896 ± 1.215
1.802ArgCys: 1.802 ± 0.48
2.66ArgAsp: 2.66 ± 0.591
3.69ArgGlu: 3.69 ± 0.639
2.66ArgPhe: 2.66 ± 0.455
6.265ArgGly: 6.265 ± 0.736
1.974ArgHis: 1.974 ± 0.521
3.175ArgIle: 3.175 ± 0.549
2.746ArgLys: 2.746 ± 0.588
5.578ArgLeu: 5.578 ± 0.831
0.944ArgMet: 0.944 ± 0.257
3.261ArgAsn: 3.261 ± 0.575
4.806ArgPro: 4.806 ± 0.921
3.433ArgGln: 3.433 ± 0.496
8.411ArgArg: 8.411 ± 1.891
4.549ArgSer: 4.549 ± 0.762
3.605ArgThr: 3.605 ± 0.582
3.69ArgVal: 3.69 ± 0.627
1.287ArgTrp: 1.287 ± 0.256
1.373ArgTyr: 1.373 ± 0.361
0.0ArgXaa: 0.0 ± 0.0
Ser
4.549SerAla: 4.549 ± 0.706
0.772SerCys: 0.772 ± 0.236
3.347SerAsp: 3.347 ± 0.626
3.09SerGlu: 3.09 ± 0.432
3.09SerPhe: 3.09 ± 0.484
5.064SerGly: 5.064 ± 0.699
1.631SerHis: 1.631 ± 0.405
2.832SerIle: 2.832 ± 0.601
2.489SerLys: 2.489 ± 0.509
6.351SerLeu: 6.351 ± 0.518
1.545SerMet: 1.545 ± 0.385
2.317SerAsn: 2.317 ± 0.421
3.948SerPro: 3.948 ± 0.739
2.575SerGln: 2.575 ± 0.441
5.493SerArg: 5.493 ± 0.76
7.123SerSer: 7.123 ± 0.998
4.978SerThr: 4.978 ± 0.95
3.605SerVal: 3.605 ± 0.569
0.858SerTrp: 0.858 ± 0.312
2.489SerTyr: 2.489 ± 0.455
0.0SerXaa: 0.0 ± 0.0
Thr
3.862ThrAla: 3.862 ± 0.655
1.545ThrCys: 1.545 ± 0.324
2.317ThrAsp: 2.317 ± 0.543
3.948ThrGlu: 3.948 ± 0.64
3.004ThrPhe: 3.004 ± 0.588
3.605ThrGly: 3.605 ± 0.581
1.03ThrHis: 1.03 ± 0.241
1.888ThrIle: 1.888 ± 0.523
1.802ThrLys: 1.802 ± 0.49
7.123ThrLeu: 7.123 ± 0.839
1.545ThrMet: 1.545 ± 0.46
2.575ThrAsn: 2.575 ± 0.568
4.377ThrPro: 4.377 ± 0.694
3.004ThrGln: 3.004 ± 0.538
3.519ThrArg: 3.519 ± 0.448
3.09ThrSer: 3.09 ± 0.474
5.493ThrThr: 5.493 ± 1.192
4.892ThrVal: 4.892 ± 0.592
0.858ThrTrp: 0.858 ± 0.225
1.974ThrTyr: 1.974 ± 0.52
0.0ThrXaa: 0.0 ± 0.0
Val
4.892ValAla: 4.892 ± 0.535
1.03ValCys: 1.03 ± 0.371
3.605ValAsp: 3.605 ± 0.609
4.634ValGlu: 4.634 ± 0.68
2.575ValPhe: 2.575 ± 0.315
2.317ValGly: 2.317 ± 0.456
0.772ValHis: 0.772 ± 0.248
2.231ValIle: 2.231 ± 0.512
2.231ValLys: 2.231 ± 0.501
6.437ValLeu: 6.437 ± 0.96
1.802ValMet: 1.802 ± 0.443
2.918ValAsn: 2.918 ± 0.491
4.377ValPro: 4.377 ± 0.463
3.605ValGln: 3.605 ± 0.621
4.034ValArg: 4.034 ± 0.624
4.205ValSer: 4.205 ± 0.522
3.862ValThr: 3.862 ± 0.727
4.549ValVal: 4.549 ± 0.605
0.687ValTrp: 0.687 ± 0.245
2.832ValTyr: 2.832 ± 0.505
0.0ValXaa: 0.0 ± 0.0
Trp
0.429TrpAla: 0.429 ± 0.18
0.0TrpCys: 0.0 ± 0.0
1.03TrpAsp: 1.03 ± 0.283
1.116TrpGlu: 1.116 ± 0.311
0.343TrpPhe: 0.343 ± 0.142
0.944TrpGly: 0.944 ± 0.24
0.172TrpHis: 0.172 ± 0.097
0.257TrpIle: 0.257 ± 0.137
1.03TrpLys: 1.03 ± 0.354
1.202TrpLeu: 1.202 ± 0.29
0.429TrpMet: 0.429 ± 0.174
0.687TrpAsn: 0.687 ± 0.279
0.515TrpPro: 0.515 ± 0.209
0.772TrpGln: 0.772 ± 0.266
0.772TrpArg: 0.772 ± 0.309
1.287TrpSer: 1.287 ± 0.347
1.116TrpThr: 1.116 ± 0.331
0.429TrpVal: 0.429 ± 0.176
0.172TrpTrp: 0.172 ± 0.105
0.515TrpTyr: 0.515 ± 0.234
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.974TyrAla: 1.974 ± 0.456
0.515TyrCys: 0.515 ± 0.189
1.974TyrAsp: 1.974 ± 0.377
1.802TyrGlu: 1.802 ± 0.362
1.802TyrPhe: 1.802 ± 0.426
1.459TyrGly: 1.459 ± 0.432
1.202TyrHis: 1.202 ± 0.422
1.287TyrIle: 1.287 ± 0.27
1.545TyrLys: 1.545 ± 0.425
3.605TyrLeu: 3.605 ± 0.755
1.03TyrMet: 1.03 ± 0.241
1.202TyrAsn: 1.202 ± 0.343
1.716TyrPro: 1.716 ± 0.387
2.146TyrGln: 2.146 ± 0.525
2.231TyrArg: 2.231 ± 0.442
1.888TyrSer: 1.888 ± 0.521
2.06TyrThr: 2.06 ± 0.502
1.545TyrVal: 1.545 ± 0.353
0.429TyrTrp: 0.429 ± 0.182
1.202TyrTyr: 1.202 ± 0.481
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 38 proteins (11653 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski