Amino acid dipepetide frequency for Hypericibacter adhaerens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.71AlaAla: 18.71 ± 0.196	1.127AlaCys: 1.127 ± 0.029	6.713AlaAsp: 6.713 ± 0.072	7.78AlaGlu: 7.78 ± 0.083	4.103AlaPhe: 4.103 ± 0.049	11.451AlaGly: 11.451 ± 0.092	2.25AlaHis: 2.25 ± 0.036	6.479AlaIle: 6.479 ± 0.063	4.225AlaLys: 4.225 ± 0.062	14.126AlaLeu: 14.126 ± 0.151	3.438AlaMet: 3.438 ± 0.046	2.661AlaAsn: 2.661 ± 0.04	6.022AlaPro: 6.022 ± 0.071	3.99AlaGln: 3.99 ± 0.048	9.167AlaArg: 9.167 ± 0.104	6.138AlaSer: 6.138 ± 0.064	5.915AlaThr: 5.915 ± 0.088	8.827AlaVal: 8.827 ± 0.08	1.662AlaTrp: 1.662 ± 0.036	2.671AlaTyr: 2.671 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.926CysAla: 0.926 ± 0.027	0.127CysCys: 0.127 ± 0.011	0.518CysAsp: 0.518 ± 0.017	0.44CysGlu: 0.44 ± 0.015	0.366CysPhe: 0.366 ± 0.016	0.961CysGly: 0.961 ± 0.029	0.261CysHis: 0.261 ± 0.013	0.396CysIle: 0.396 ± 0.015	0.227CysLys: 0.227 ± 0.011	0.868CysLeu: 0.868 ± 0.021	0.15CysMet: 0.15 ± 0.008	0.224CysAsn: 0.224 ± 0.013	0.458CysPro: 0.458 ± 0.019	0.243CysGln: 0.243 ± 0.012	0.717CysArg: 0.717 ± 0.021	0.458CysSer: 0.458 ± 0.015	0.363CysThr: 0.363 ± 0.016	0.57CysVal: 0.57 ± 0.018	0.159CysTrp: 0.159 ± 0.01	0.258CysTyr: 0.258 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.135AspAla: 6.135 ± 0.065	0.485AspCys: 0.485 ± 0.021	2.754AspAsp: 2.754 ± 0.141	3.155AspGlu: 3.155 ± 0.044	2.066AspPhe: 2.066 ± 0.037	5.06AspGly: 5.06 ± 0.11	1.22AspHis: 1.22 ± 0.029	2.804AspIle: 2.804 ± 0.048	1.742AspLys: 1.742 ± 0.041	6.144AspLeu: 6.144 ± 0.068	1.114AspMet: 1.114 ± 0.024	1.282AspAsn: 1.282 ± 0.051	3.825AspPro: 3.825 ± 0.047	1.741AspGln: 1.741 ± 0.04	4.669AspArg: 4.669 ± 0.07	2.51AspSer: 2.51 ± 0.1	2.394AspThr: 2.394 ± 0.141	3.334AspVal: 3.334 ± 0.05	1.028AspTrp: 1.028 ± 0.024	1.619AspTyr: 1.619 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.897GluAla: 7.897 ± 0.091	0.368GluCys: 0.368 ± 0.014	2.472GluAsp: 2.472 ± 0.041	3.097GluGlu: 3.097 ± 0.049	1.744GluPhe: 1.744 ± 0.035	4.649GluGly: 4.649 ± 0.078	1.113GluHis: 1.113 ± 0.029	3.611GluIle: 3.611 ± 0.051	1.959GluLys: 1.959 ± 0.037	5.597GluLeu: 5.597 ± 0.071	1.414GluMet: 1.414 ± 0.028	1.444GluAsn: 1.444 ± 0.031	3.079GluPro: 3.079 ± 0.047	2.027GluGln: 2.027 ± 0.041	5.131GluArg: 5.131 ± 0.065	2.35GluSer: 2.35 ± 0.034	3.326GluThr: 3.326 ± 0.049	3.468GluVal: 3.468 ± 0.046	0.694GluTrp: 0.694 ± 0.021	0.938GluTyr: 0.938 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.359PheAla: 4.359 ± 0.061	0.405PheCys: 0.405 ± 0.015	2.559PheAsp: 2.559 ± 0.041	2.023PheGlu: 2.023 ± 0.036	1.378PhePhe: 1.378 ± 0.03	3.536PheGly: 3.536 ± 0.066	0.777PheHis: 0.777 ± 0.02	1.57PheIle: 1.57 ± 0.031	1.021PheLys: 1.021 ± 0.026	3.489PheLeu: 3.489 ± 0.055	0.717PheMet: 0.717 ± 0.023	0.97PheAsn: 0.97 ± 0.023	1.639PhePro: 1.639 ± 0.033	1.032PheGln: 1.032 ± 0.023	2.197PheArg: 2.197 ± 0.039	1.918PheSer: 1.918 ± 0.037	1.891PheThr: 1.891 ± 0.041	2.577PheVal: 2.577 ± 0.041	0.567PheTrp: 0.567 ± 0.019	0.935PheTyr: 0.935 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.494GlyAla: 9.494 ± 0.087	0.896GlyCys: 0.896 ± 0.024	4.748GlyAsp: 4.748 ± 0.225	4.852GlyGlu: 4.852 ± 0.066	3.674GlyPhe: 3.674 ± 0.047	8.218GlyGly: 8.218 ± 0.211	2.069GlyHis: 2.069 ± 0.04	4.666GlyIle: 4.666 ± 0.053	3.342GlyLys: 3.342 ± 0.047	9.574GlyLeu: 9.574 ± 0.104	2.275GlyMet: 2.275 ± 0.039	2.495GlyAsn: 2.495 ± 0.194	3.995GlyPro: 3.995 ± 0.05	3.131GlyGln: 3.131 ± 0.067	6.838GlyArg: 6.838 ± 0.071	4.808GlySer: 4.808 ± 0.068	4.743GlyThr: 4.743 ± 0.097	5.787GlyVal: 5.787 ± 0.063	1.526GlyTrp: 1.526 ± 0.036	2.436GlyTyr: 2.436 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.196HisAla: 2.196 ± 0.035	0.249HisCys: 0.249 ± 0.012	1.162HisAsp: 1.162 ± 0.025	1.082HisGlu: 1.082 ± 0.023	0.871HisPhe: 0.871 ± 0.023	2.025HisGly: 2.025 ± 0.037	0.604HisHis: 0.604 ± 0.019	0.936HisIle: 0.936 ± 0.023	0.531HisLys: 0.531 ± 0.016	2.26HisLeu: 2.26 ± 0.037	0.444HisMet: 0.444 ± 0.016	0.479HisAsn: 0.479 ± 0.017	1.483HisPro: 1.483 ± 0.029	0.604HisGln: 0.604 ± 0.018	1.685HisArg: 1.685 ± 0.035	0.892HisSer: 0.892 ± 0.025	0.764HisThr: 0.764 ± 0.031	1.468HisVal: 1.468 ± 0.027	0.403HisTrp: 0.403 ± 0.021	0.588HisTyr: 0.588 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.347IleAla: 7.347 ± 0.08	0.507IleCys: 0.507 ± 0.019	3.616IleAsp: 3.616 ± 0.055	3.841IleGlu: 3.841 ± 0.051	1.623IlePhe: 1.623 ± 0.042	5.084IleGly: 5.084 ± 0.061	0.99IleHis: 0.99 ± 0.021	1.845IleIle: 1.845 ± 0.041	1.46IleLys: 1.46 ± 0.034	4.809IleLeu: 4.809 ± 0.07	0.924IleMet: 0.924 ± 0.027	1.303IleAsn: 1.303 ± 0.029	2.236IlePro: 2.236 ± 0.039	1.343IleGln: 1.343 ± 0.028	3.181IleArg: 3.181 ± 0.048	2.329IleSer: 2.329 ± 0.045	2.408IleThr: 2.408 ± 0.056	4.049IleVal: 4.049 ± 0.053	0.631IleTrp: 0.631 ± 0.02	1.241IleTyr: 1.241 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.322LysAla: 4.322 ± 0.064	0.149LysCys: 0.149 ± 0.008	1.612LysAsp: 1.612 ± 0.034	1.561LysGlu: 1.561 ± 0.037	0.832LysPhe: 0.832 ± 0.024	2.735LysGly: 2.735 ± 0.05	0.583LysHis: 0.583 ± 0.018	1.732LysIle: 1.732 ± 0.037	1.236LysLys: 1.236 ± 0.035	3.591LysLeu: 3.591 ± 0.053	0.638LysMet: 0.638 ± 0.021	0.732LysAsn: 0.732 ± 0.021	2.326LysPro: 2.326 ± 0.039	0.996LysGln: 0.996 ± 0.027	2.46LysArg: 2.46 ± 0.046	1.701LysSer: 1.701 ± 0.036	1.801LysThr: 1.801 ± 0.032	2.301LysVal: 2.301 ± 0.04	0.306LysTrp: 0.306 ± 0.014	0.559LysTyr: 0.559 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.107LeuAla: 15.107 ± 0.158	0.933LeuCys: 0.933 ± 0.026	6.122LeuAsp: 6.122 ± 0.077	5.657LeuGlu: 5.657 ± 0.074	3.711LeuPhe: 3.711 ± 0.057	9.24LeuGly: 9.24 ± 0.098	2.011LeuHis: 2.011 ± 0.035	4.942LeuIle: 4.942 ± 0.065	3.773LeuLys: 3.773 ± 0.053	11.202LeuLeu: 11.202 ± 0.143	2.331LeuMet: 2.331 ± 0.04	2.305LeuAsn: 2.305 ± 0.038	6.227LeuPro: 6.227 ± 0.078	3.076LeuGln: 3.076 ± 0.044	7.244LeuArg: 7.244 ± 0.082	5.802LeuSer: 5.802 ± 0.069	5.501LeuThr: 5.501 ± 0.064	7.815LeuVal: 7.815 ± 0.086	1.364LeuTrp: 1.364 ± 0.033	2.2LeuTyr: 2.2 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.291MetAla: 3.291 ± 0.043	0.121MetCys: 0.121 ± 0.008	0.946MetAsp: 0.946 ± 0.024	1.017MetGlu: 1.017 ± 0.026	0.641MetPhe: 0.641 ± 0.02	1.831MetGly: 1.831 ± 0.04	0.364MetHis: 0.364 ± 0.014	1.224MetIle: 1.224 ± 0.03	0.903MetLys: 0.903 ± 0.023	2.318MetLeu: 2.318 ± 0.046	0.601MetMet: 0.601 ± 0.019	0.651MetAsn: 0.651 ± 0.021	1.41MetPro: 1.41 ± 0.034	0.725MetGln: 0.725 ± 0.023	1.688MetArg: 1.688 ± 0.031	1.5MetSer: 1.5 ± 0.03	1.834MetThr: 1.834 ± 0.031	1.636MetVal: 1.636 ± 0.029	0.195MetTrp: 0.195 ± 0.012	0.297MetTyr: 0.297 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.75AsnAla: 2.75 ± 0.039	0.248AsnCys: 0.248 ± 0.012	1.571AsnAsp: 1.571 ± 0.147	1.158AsnGlu: 1.158 ± 0.026	0.87AsnPhe: 0.87 ± 0.025	2.495AsnGly: 2.495 ± 0.103	0.468AsnHis: 0.468 ± 0.015	1.183AsnIle: 1.183 ± 0.03	0.649AsnLys: 0.649 ± 0.021	2.679AsnLeu: 2.679 ± 0.044	0.543AsnMet: 0.543 ± 0.019	0.635AsnAsn: 0.635 ± 0.021	1.779AsnPro: 1.779 ± 0.033	0.751AsnGln: 0.751 ± 0.022	1.769AsnArg: 1.769 ± 0.037	1.095AsnSer: 1.095 ± 0.026	1.036AsnThr: 1.036 ± 0.036	1.551AsnVal: 1.551 ± 0.034	0.44AsnTrp: 0.44 ± 0.016	0.677AsnTyr: 0.677 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.472ProAla: 7.472 ± 0.079	0.348ProCys: 0.348 ± 0.015	3.601ProAsp: 3.601 ± 0.043	3.82ProGlu: 3.82 ± 0.055	1.967ProPhe: 1.967 ± 0.039	5.098ProGly: 5.098 ± 0.065	1.115ProHis: 1.115 ± 0.03	2.399ProIle: 2.399 ± 0.037	1.712ProLys: 1.712 ± 0.038	5.261ProLeu: 5.261 ± 0.063	1.22ProMet: 1.22 ± 0.029	1.267ProAsn: 1.267 ± 0.025	3.07ProPro: 3.07 ± 0.057	1.694ProGln: 1.694 ± 0.036	3.249ProArg: 3.249 ± 0.054	2.856ProSer: 2.856 ± 0.045	2.625ProThr: 2.625 ± 0.047	4.299ProVal: 4.299 ± 0.057	0.822ProTrp: 0.822 ± 0.026	1.249ProTyr: 1.249 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.351GlnAla: 4.351 ± 0.057	0.203GlnCys: 0.203 ± 0.011	1.397GlnAsp: 1.397 ± 0.028	1.481GlnGlu: 1.481 ± 0.032	0.984GlnPhe: 0.984 ± 0.026	2.803GlnGly: 2.803 ± 0.041	0.64GlnHis: 0.64 ± 0.018	1.92GlnIle: 1.92 ± 0.034	1.033GlnLys: 1.033 ± 0.025	2.978GlnLeu: 2.978 ± 0.044	0.807GlnMet: 0.807 ± 0.024	0.809GlnAsn: 0.809 ± 0.025	1.855GlnPro: 1.855 ± 0.039	1.312GlnGln: 1.312 ± 0.034	2.639GlnArg: 2.639 ± 0.043	1.67GlnSer: 1.67 ± 0.033	1.684GlnThr: 1.684 ± 0.094	2.215GlnVal: 2.215 ± 0.042	0.429GlnTrp: 0.429 ± 0.018	0.564GlnTyr: 0.564 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.127ArgAla: 8.127 ± 0.099	0.625ArgCys: 0.625 ± 0.02	3.93ArgAsp: 3.93 ± 0.05	4.209ArgGlu: 4.209 ± 0.062	3.016ArgPhe: 3.016 ± 0.05	4.98ArgGly: 4.98 ± 0.061	1.945ArgHis: 1.945 ± 0.037	4.104ArgIle: 4.104 ± 0.054	2.339ArgLys: 2.339 ± 0.042	8.937ArgLeu: 8.937 ± 0.099	1.771ArgMet: 1.771 ± 0.032	1.746ArgAsn: 1.746 ± 0.031	4.057ArgPro: 4.057 ± 0.066	2.92ArgGln: 2.92 ± 0.043	6.783ArgArg: 6.783 ± 0.091	3.703ArgSer: 3.703 ± 0.06	2.967ArgThr: 2.967 ± 0.044	4.649ArgVal: 4.649 ± 0.061	1.147ArgTrp: 1.147 ± 0.029	1.894ArgTyr: 1.894 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.656SerAla: 5.656 ± 0.064	0.436SerCys: 0.436 ± 0.016	2.769SerAsp: 2.769 ± 0.046	2.419SerGlu: 2.419 ± 0.04	2.234SerPhe: 2.234 ± 0.034	5.28SerGly: 5.28 ± 0.086	1.114SerHis: 1.114 ± 0.021	2.616SerIle: 2.616 ± 0.058	1.345SerLys: 1.345 ± 0.026	5.634SerLeu: 5.634 ± 0.065	1.231SerMet: 1.231 ± 0.027	1.251SerAsn: 1.251 ± 0.033	2.892SerPro: 2.892 ± 0.041	1.502SerGln: 1.502 ± 0.034	3.435SerArg: 3.435 ± 0.043	2.685SerSer: 2.685 ± 0.047	2.411SerThr: 2.411 ± 0.046	3.568SerVal: 3.568 ± 0.046	0.78SerTrp: 0.78 ± 0.023	1.334SerTyr: 1.334 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.27ThrAla: 6.27 ± 0.103	0.378ThrCys: 0.378 ± 0.016	2.638ThrAsp: 2.638 ± 0.062	2.634ThrGlu: 2.634 ± 0.054	1.619ThrPhe: 1.619 ± 0.042	5.098ThrGly: 5.098 ± 0.082	0.967ThrHis: 0.967 ± 0.026	2.855ThrIle: 2.855 ± 0.096	1.307ThrLys: 1.307 ± 0.034	5.652ThrLeu: 5.652 ± 0.066	1.087ThrMet: 1.087 ± 0.026	1.174ThrAsn: 1.174 ± 0.04	3.186ThrPro: 3.186 ± 0.045	1.43ThrGln: 1.43 ± 0.035	3.135ThrArg: 3.135 ± 0.047	2.372ThrSer: 2.372 ± 0.039	2.525ThrThr: 2.525 ± 0.047	4.35ThrVal: 4.35 ± 0.105	0.606ThrTrp: 0.606 ± 0.021	1.141ThrTyr: 1.141 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	9.228ValAla: 9.228 ± 0.085	0.64ValCys: 0.64 ± 0.021	3.757ValAsp: 3.757 ± 0.05	4.323ValGlu: 4.323 ± 0.049	2.41ValPhe: 2.41 ± 0.041	5.761ValGly: 5.761 ± 0.062	1.344ValHis: 1.344 ± 0.034	3.779ValIle: 3.779 ± 0.052	2.29ValLys: 2.29 ± 0.047	7.166ValLeu: 7.166 ± 0.071	1.726ValMet: 1.726 ± 0.034	1.817ValAsn: 1.817 ± 0.037	3.671ValPro: 3.671 ± 0.053	1.898ValGln: 1.898 ± 0.041	4.503ValArg: 4.503 ± 0.051	3.841ValSer: 3.841 ± 0.052	4.498ValThr: 4.498 ± 0.058	5.389ValVal: 5.389 ± 0.067	0.899ValTrp: 0.899 ± 0.025	1.439ValTyr: 1.439 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.324TrpAla: 1.324 ± 0.03	0.153TrpCys: 0.153 ± 0.01	0.728TrpAsp: 0.728 ± 0.023	0.578TrpGlu: 0.578 ± 0.02	0.525TrpPhe: 0.525 ± 0.018	1.014TrpGly: 1.014 ± 0.026	0.362TrpHis: 0.362 ± 0.015	0.784TrpIle: 0.784 ± 0.023	0.459TrpLys: 0.459 ± 0.019	1.84TrpLeu: 1.84 ± 0.04	0.318TrpMet: 0.318 ± 0.012	0.491TrpAsn: 0.491 ± 0.019	0.809TrpPro: 0.809 ± 0.023	0.623TrpGln: 0.623 ± 0.019	1.329TrpArg: 1.329 ± 0.036	0.85TrpSer: 0.85 ± 0.024	0.707TrpThr: 0.707 ± 0.022	0.894TrpVal: 0.894 ± 0.027	0.25TrpTrp: 0.25 ± 0.015	0.318TrpTyr: 0.318 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.494TyrAla: 2.494 ± 0.038	0.292TyrCys: 0.292 ± 0.016	1.472TyrAsp: 1.472 ± 0.034	1.252TyrGlu: 1.252 ± 0.026	0.928TyrPhe: 0.928 ± 0.024	2.247TyrGly: 2.247 ± 0.062	0.529TyrHis: 0.529 ± 0.02	0.921TyrIle: 0.921 ± 0.028	0.62TyrLys: 0.62 ± 0.019	2.439TyrLeu: 2.439 ± 0.039	0.441TyrMet: 0.441 ± 0.017	0.611TyrAsn: 0.611 ± 0.026	1.127TyrPro: 1.127 ± 0.029	0.737TyrGln: 0.737 ± 0.02	2.028TyrArg: 2.028 ± 0.036	1.115TyrSer: 1.115 ± 0.035	1.03TyrThr: 1.03 ± 0.047	1.631TyrVal: 1.631 ± 0.032	0.446TyrTrp: 0.446 ± 0.019	0.633TyrTyr: 0.633 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5227 proteins (1721620 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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