Amino acid dipepetide frequency for Erysipelatoclostridium ramosum DSM 1402

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.046AlaAla: 4.046 ± 0.085	0.83AlaCys: 0.83 ± 0.031	2.865AlaAsp: 2.865 ± 0.066	2.616AlaGlu: 2.616 ± 0.064	2.705AlaPhe: 2.705 ± 0.06	4.323AlaGly: 4.323 ± 0.076	1.051AlaHis: 1.051 ± 0.036	5.992AlaIle: 5.992 ± 0.08	5.191AlaLys: 5.191 ± 0.073	6.503AlaLeu: 6.503 ± 0.099	1.998AlaMet: 1.998 ± 0.05	3.329AlaAsn: 3.329 ± 0.059	1.644AlaPro: 1.644 ± 0.045	1.749AlaGln: 1.749 ± 0.044	2.086AlaArg: 2.086 ± 0.048	3.629AlaSer: 3.629 ± 0.071	3.463AlaThr: 3.463 ± 0.081	4.291AlaVal: 4.291 ± 0.075	0.458AlaTrp: 0.458 ± 0.026	2.563AlaTyr: 2.563 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.711CysAla: 0.711 ± 0.028	0.225CysCys: 0.225 ± 0.019	0.753CysAsp: 0.753 ± 0.03	0.61CysGlu: 0.61 ± 0.026	0.669CysPhe: 0.669 ± 0.028	1.134CysGly: 1.134 ± 0.04	0.315CysHis: 0.315 ± 0.018	1.18CysIle: 1.18 ± 0.038	0.888CysLys: 0.888 ± 0.034	1.361CysLeu: 1.361 ± 0.042	0.344CysMet: 0.344 ± 0.02	0.699CysAsn: 0.699 ± 0.03	0.562CysPro: 0.562 ± 0.031	0.506CysGln: 0.506 ± 0.023	0.42CysArg: 0.42 ± 0.02	0.819CysSer: 0.819 ± 0.032	0.602CysThr: 0.602 ± 0.03	0.786CysVal: 0.786 ± 0.032	0.102CysTrp: 0.102 ± 0.01	0.599CysTyr: 0.599 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	3.077AspAla: 3.077 ± 0.062	0.734AspCys: 0.734 ± 0.027	3.67AspAsp: 3.67 ± 0.078	4.884AspGlu: 4.884 ± 0.072	3.025AspPhe: 3.025 ± 0.061	3.78AspGly: 3.78 ± 0.089	1.138AspHis: 1.138 ± 0.039	5.256AspIle: 5.256 ± 0.077	4.231AspLys: 4.231 ± 0.073	5.552AspLeu: 5.552 ± 0.076	1.547AspMet: 1.547 ± 0.042	3.425AspAsn: 3.425 ± 0.069	1.571AspPro: 1.571 ± 0.04	2.002AspGln: 2.002 ± 0.046	1.756AspArg: 1.756 ± 0.042	3.137AspSer: 3.137 ± 0.068	2.669AspThr: 2.669 ± 0.053	3.799AspVal: 3.799 ± 0.07	0.427AspTrp: 0.427 ± 0.023	3.584AspTyr: 3.584 ± 0.072	0.0AspXaa: 0.0 ± 0.0
Glu	4.324GluAla: 4.324 ± 0.079	0.751GluCys: 0.751 ± 0.031	3.429GluAsp: 3.429 ± 0.065	4.873GluGlu: 4.873 ± 0.097	2.665GluPhe: 2.665 ± 0.06	3.306GluGly: 3.306 ± 0.06	1.235GluHis: 1.235 ± 0.033	6.386GluIle: 6.386 ± 0.081	5.352GluLys: 5.352 ± 0.072	6.693GluLeu: 6.693 ± 0.083	2.184GluMet: 2.184 ± 0.048	4.188GluAsn: 4.188 ± 0.075	1.495GluPro: 1.495 ± 0.04	2.47GluGln: 2.47 ± 0.05	2.385GluArg: 2.385 ± 0.055	2.757GluSer: 2.757 ± 0.053	3.32GluThr: 3.32 ± 0.064	4.545GluVal: 4.545 ± 0.078	0.415GluTrp: 0.415 ± 0.022	3.105GluTyr: 3.105 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	2.615PheAla: 2.615 ± 0.053	0.574PheCys: 0.574 ± 0.028	3.051PheAsp: 3.051 ± 0.056	2.835PheGlu: 2.835 ± 0.062	1.883PhePhe: 1.883 ± 0.05	2.932PheGly: 2.932 ± 0.065	0.642PheHis: 0.642 ± 0.028	4.265PheIle: 4.265 ± 0.079	3.537PheLys: 3.537 ± 0.061	3.559PheLeu: 3.559 ± 0.077	1.185PheMet: 1.185 ± 0.034	2.928PheAsn: 2.928 ± 0.062	1.139PhePro: 1.139 ± 0.035	1.114PheGln: 1.114 ± 0.035	1.084PheArg: 1.084 ± 0.033	2.959PheSer: 2.959 ± 0.058	2.409PheThr: 2.409 ± 0.052	3.0PheVal: 3.0 ± 0.068	0.293PheTrp: 0.293 ± 0.016	1.993PheTyr: 1.993 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.117GlyAla: 4.117 ± 0.101	1.067GlyCys: 1.067 ± 0.038	3.367GlyAsp: 3.367 ± 0.07	3.338GlyGlu: 3.338 ± 0.078	3.023GlyPhe: 3.023 ± 0.056	4.032GlyGly: 4.032 ± 0.077	1.181GlyHis: 1.181 ± 0.035	6.142GlyIle: 6.142 ± 0.078	4.771GlyLys: 4.771 ± 0.085	5.695GlyLeu: 5.695 ± 0.086	1.856GlyMet: 1.856 ± 0.046	3.196GlyAsn: 3.196 ± 0.075	1.217GlyPro: 1.217 ± 0.061	1.815GlyGln: 1.815 ± 0.049	1.926GlyArg: 1.926 ± 0.053	3.435GlySer: 3.435 ± 0.062	3.549GlyThr: 3.549 ± 0.068	4.228GlyVal: 4.228 ± 0.067	0.59GlyTrp: 0.59 ± 0.028	3.46GlyTyr: 3.46 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	0.876HisAla: 0.876 ± 0.032	0.33HisCys: 0.33 ± 0.018	1.263HisAsp: 1.263 ± 0.042	1.113HisGlu: 1.113 ± 0.039	0.866HisPhe: 0.866 ± 0.034	1.285HisGly: 1.285 ± 0.043	0.59HisHis: 0.59 ± 0.03	1.393HisIle: 1.393 ± 0.034	1.017HisLys: 1.017 ± 0.033	1.76HisLeu: 1.76 ± 0.045	0.426HisMet: 0.426 ± 0.021	0.98HisAsn: 0.98 ± 0.031	0.809HisPro: 0.809 ± 0.032	0.896HisGln: 0.896 ± 0.03	0.687HisArg: 0.687 ± 0.026	0.952HisSer: 0.952 ± 0.031	0.813HisThr: 0.813 ± 0.027	1.008HisVal: 1.008 ± 0.037	0.147HisTrp: 0.147 ± 0.014	0.916HisTyr: 0.916 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.037IleAla: 6.037 ± 0.087	1.358IleCys: 1.358 ± 0.041	6.146IleAsp: 6.146 ± 0.084	6.355IleGlu: 6.355 ± 0.096	3.945IlePhe: 3.945 ± 0.09	5.528IleGly: 5.528 ± 0.097	1.42IleHis: 1.42 ± 0.038	8.94IleIle: 8.94 ± 0.151	7.461IleLys: 7.461 ± 0.089	7.855IleLeu: 7.855 ± 0.108	2.338IleMet: 2.338 ± 0.056	5.757IleAsn: 5.757 ± 0.087	2.99IlePro: 2.99 ± 0.058	2.264IleGln: 2.264 ± 0.049	2.724IleArg: 2.724 ± 0.055	5.848IleSer: 5.848 ± 0.086	4.998IleThr: 4.998 ± 0.069	6.126IleVal: 6.126 ± 0.099	0.535IleTrp: 0.535 ± 0.024	3.795IleTyr: 3.795 ± 0.07	0.0IleXaa: 0.0 ± 0.0
Lys	4.663LysAla: 4.663 ± 0.079	0.718LysCys: 0.718 ± 0.027	4.938LysAsp: 4.938 ± 0.087	7.093LysGlu: 7.093 ± 0.097	2.336LysPhe: 2.336 ± 0.054	3.79LysGly: 3.79 ± 0.071	1.346LysHis: 1.346 ± 0.04	6.952LysIle: 6.952 ± 0.082	6.664LysLys: 6.664 ± 0.094	6.648LysLeu: 6.648 ± 0.085	2.578LysMet: 2.578 ± 0.055	4.814LysAsn: 4.814 ± 0.076	1.854LysPro: 1.854 ± 0.053	3.03LysGln: 3.03 ± 0.061	2.972LysArg: 2.972 ± 0.063	3.539LysSer: 3.539 ± 0.055	4.107LysThr: 4.107 ± 0.068	5.035LysVal: 5.035 ± 0.089	0.548LysTrp: 0.548 ± 0.024	3.908LysTyr: 3.908 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	6.423LeuAla: 6.423 ± 0.088	1.28LeuCys: 1.28 ± 0.035	5.773LeuAsp: 5.773 ± 0.082	6.467LeuGlu: 6.467 ± 0.095	4.149LeuPhe: 4.149 ± 0.081	5.851LeuGly: 5.851 ± 0.092	1.404LeuHis: 1.404 ± 0.042	8.308LeuIle: 8.308 ± 0.131	8.047LeuLys: 8.047 ± 0.112	8.766LeuLeu: 8.766 ± 0.128	2.576LeuMet: 2.576 ± 0.057	5.597LeuAsn: 5.597 ± 0.086	3.035LeuPro: 3.035 ± 0.059	2.673LeuGln: 2.673 ± 0.058	2.719LeuArg: 2.719 ± 0.055	6.229LeuSer: 6.229 ± 0.092	5.028LeuThr: 5.028 ± 0.071	6.144LeuVal: 6.144 ± 0.087	0.599LeuTrp: 0.599 ± 0.026	3.526LeuTyr: 3.526 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	1.933MetAla: 1.933 ± 0.053	0.292MetCys: 0.292 ± 0.019	1.471MetAsp: 1.471 ± 0.039	1.733MetGlu: 1.733 ± 0.045	1.213MetPhe: 1.213 ± 0.04	1.619MetGly: 1.619 ± 0.044	0.444MetHis: 0.444 ± 0.024	3.001MetIle: 3.001 ± 0.066	2.556MetLys: 2.556 ± 0.053	2.597MetLeu: 2.597 ± 0.053	1.043MetMet: 1.043 ± 0.032	1.661MetAsn: 1.661 ± 0.047	0.909MetPro: 0.909 ± 0.037	0.901MetGln: 0.901 ± 0.032	0.87MetArg: 0.87 ± 0.032	1.654MetSer: 1.654 ± 0.039	1.414MetThr: 1.414 ± 0.039	1.782MetVal: 1.782 ± 0.043	0.165MetTrp: 0.165 ± 0.013	0.974MetTyr: 0.974 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	2.983AsnAla: 2.983 ± 0.059	0.768AsnCys: 0.768 ± 0.026	3.886AsnAsp: 3.886 ± 0.072	4.181AsnGlu: 4.181 ± 0.069	2.338AsnPhe: 2.338 ± 0.051	3.691AsnGly: 3.691 ± 0.077	1.324AsnHis: 1.324 ± 0.045	5.268AsnIle: 5.268 ± 0.078	4.628AsnLys: 4.628 ± 0.081	5.058AsnLeu: 5.058 ± 0.071	1.373AsnMet: 1.373 ± 0.032	4.011AsnAsn: 4.011 ± 0.073	1.954AsnPro: 1.954 ± 0.045	2.548AsnGln: 2.548 ± 0.053	1.97AsnArg: 1.97 ± 0.05	3.147AsnSer: 3.147 ± 0.056	2.868AsnThr: 2.868 ± 0.071	3.351AsnVal: 3.351 ± 0.054	0.426AsnTrp: 0.426 ± 0.021	3.099AsnTyr: 3.099 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	1.717ProAla: 1.717 ± 0.047	0.351ProCys: 0.351 ± 0.02	1.656ProAsp: 1.656 ± 0.041	2.092ProGlu: 2.092 ± 0.05	1.449ProPhe: 1.449 ± 0.042	1.714ProGly: 1.714 ± 0.047	0.532ProHis: 0.532 ± 0.024	2.494ProIle: 2.494 ± 0.053	1.801ProLys: 1.801 ± 0.042	2.746ProLeu: 2.746 ± 0.061	0.739ProMet: 0.739 ± 0.028	1.548ProAsn: 1.548 ± 0.037	0.524ProPro: 0.524 ± 0.026	0.994ProGln: 0.994 ± 0.035	0.909ProArg: 0.909 ± 0.028	1.571ProSer: 1.571 ± 0.036	1.747ProThr: 1.747 ± 0.07	2.148ProVal: 2.148 ± 0.047	0.231ProTrp: 0.231 ± 0.018	1.415ProTyr: 1.415 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.277GlnAla: 2.277 ± 0.055	0.358GlnCys: 0.358 ± 0.021	1.786GlnAsp: 1.786 ± 0.051	2.54GlnGlu: 2.54 ± 0.051	1.331GlnPhe: 1.331 ± 0.035	1.982GlnGly: 1.982 ± 0.044	0.566GlnHis: 0.566 ± 0.024	3.047GlnIle: 3.047 ± 0.06	2.605GlnLys: 2.605 ± 0.057	3.398GlnLeu: 3.398 ± 0.066	0.962GlnMet: 0.962 ± 0.031	1.825GlnAsn: 1.825 ± 0.045	0.794GlnPro: 0.794 ± 0.028	1.244GlnGln: 1.244 ± 0.04	1.279GlnArg: 1.279 ± 0.038	1.668GlnSer: 1.668 ± 0.045	1.686GlnThr: 1.686 ± 0.048	2.134GlnVal: 2.134 ± 0.053	0.294GlnTrp: 0.294 ± 0.02	1.56GlnTyr: 1.56 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	1.801ArgAla: 1.801 ± 0.041	0.462ArgCys: 0.462 ± 0.024	1.822ArgAsp: 1.822 ± 0.046	2.154ArgGlu: 2.154 ± 0.056	1.525ArgPhe: 1.525 ± 0.035	1.823ArgGly: 1.823 ± 0.047	0.631ArgHis: 0.631 ± 0.029	3.027ArgIle: 3.027 ± 0.06	2.588ArgLys: 2.588 ± 0.054	3.272ArgLeu: 3.272 ± 0.064	0.989ArgMet: 0.989 ± 0.035	1.768ArgAsn: 1.768 ± 0.045	0.887ArgPro: 0.887 ± 0.031	1.184ArgGln: 1.184 ± 0.038	1.317ArgArg: 1.317 ± 0.04	1.659ArgSer: 1.659 ± 0.043	1.496ArgThr: 1.496 ± 0.034	2.134ArgVal: 2.134 ± 0.047	0.277ArgTrp: 0.277 ± 0.019	1.914ArgTyr: 1.914 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	3.184SerAla: 3.184 ± 0.06	0.732SerCys: 0.732 ± 0.03	3.148SerAsp: 3.148 ± 0.057	3.128SerGlu: 3.128 ± 0.051	2.992SerPhe: 2.992 ± 0.048	3.957SerGly: 3.957 ± 0.071	1.091SerHis: 1.091 ± 0.029	5.171SerIle: 5.171 ± 0.084	4.464SerLys: 4.464 ± 0.069	6.026SerLeu: 6.026 ± 0.092	1.6SerMet: 1.6 ± 0.042	3.366SerAsn: 3.366 ± 0.067	1.363SerPro: 1.363 ± 0.035	1.919SerGln: 1.919 ± 0.046	2.055SerArg: 2.055 ± 0.047	3.921SerSer: 3.921 ± 0.073	2.897SerThr: 2.897 ± 0.069	3.4SerVal: 3.4 ± 0.062	0.464SerTrp: 0.464 ± 0.022	2.648SerTyr: 2.648 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	3.242ThrAla: 3.242 ± 0.068	0.601ThrCys: 0.601 ± 0.026	2.652ThrAsp: 2.652 ± 0.067	2.343ThrGlu: 2.343 ± 0.055	2.414ThrPhe: 2.414 ± 0.049	3.79ThrGly: 3.79 ± 0.14	0.883ThrHis: 0.883 ± 0.035	5.178ThrIle: 5.178 ± 0.081	3.925ThrLys: 3.925 ± 0.061	5.122ThrLeu: 5.122 ± 0.09	1.445ThrMet: 1.445 ± 0.04	3.109ThrAsn: 3.109 ± 0.068	1.913ThrPro: 1.913 ± 0.045	1.305ThrGln: 1.305 ± 0.036	1.613ThrArg: 1.613 ± 0.04	3.291ThrSer: 3.291 ± 0.072	3.17ThrThr: 3.17 ± 0.077	3.815ThrVal: 3.815 ± 0.08	0.4ThrTrp: 0.4 ± 0.024	2.409ThrTyr: 2.409 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	4.478ValAla: 4.478 ± 0.087	1.021ValCys: 1.021 ± 0.036	4.111ValAsp: 4.111 ± 0.072	4.373ValGlu: 4.373 ± 0.068	2.874ValPhe: 2.874 ± 0.063	4.025ValGly: 4.025 ± 0.07	0.946ValHis: 0.946 ± 0.028	6.312ValIle: 6.312 ± 0.1	4.661ValLys: 4.661 ± 0.079	6.059ValLeu: 6.059 ± 0.098	1.781ValMet: 1.781 ± 0.042	3.599ValAsn: 3.599 ± 0.073	1.907ValPro: 1.907 ± 0.047	1.564ValGln: 1.564 ± 0.044	1.877ValArg: 1.877 ± 0.043	4.252ValSer: 4.252 ± 0.073	3.749ValThr: 3.749 ± 0.078	4.775ValVal: 4.775 ± 0.081	0.402ValTrp: 0.402 ± 0.018	2.751ValTyr: 2.751 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.408TrpAla: 0.408 ± 0.024	0.109TrpCys: 0.109 ± 0.01	0.344TrpAsp: 0.344 ± 0.018	0.354TrpGlu: 0.354 ± 0.023	0.351TrpPhe: 0.351 ± 0.018	0.588TrpGly: 0.588 ± 0.028	0.164TrpHis: 0.164 ± 0.014	0.612TrpIle: 0.612 ± 0.03	0.448TrpLys: 0.448 ± 0.022	0.798TrpLeu: 0.798 ± 0.03	0.232TrpMet: 0.232 ± 0.014	0.373TrpAsn: 0.373 ± 0.022	0.175TrpPro: 0.175 ± 0.014	0.394TrpGln: 0.394 ± 0.022	0.229TrpArg: 0.229 ± 0.018	0.413TrpSer: 0.413 ± 0.024	0.33TrpThr: 0.33 ± 0.021	0.41TrpVal: 0.41 ± 0.022	0.089TrpTrp: 0.089 ± 0.011	0.406TrpTyr: 0.406 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.419TyrAla: 2.419 ± 0.055	0.722TyrCys: 0.722 ± 0.027	3.135TyrAsp: 3.135 ± 0.059	2.794TyrGlu: 2.794 ± 0.056	2.244TyrPhe: 2.244 ± 0.047	2.855TyrGly: 2.855 ± 0.06	1.227TyrHis: 1.227 ± 0.039	3.495TyrIle: 3.495 ± 0.07	2.698TyrLys: 2.698 ± 0.056	5.127TyrLeu: 5.127 ± 0.081	1.036TyrMet: 1.036 ± 0.036	2.698TyrAsn: 2.698 ± 0.047	1.635TyrPro: 1.635 ± 0.043	2.763TyrGln: 2.763 ± 0.07	1.85TyrArg: 1.85 ± 0.049	2.646TyrSer: 2.646 ± 0.051	2.305TyrThr: 2.305 ± 0.06	2.609TyrVal: 2.609 ± 0.055	0.366TyrTrp: 0.366 ± 0.021	2.5TyrTyr: 2.5 ± 0.063	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3166 proteins (959423 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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