Amino acid dipepetide frequency for Clostridium luticellarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.354AlaAla: 5.354 ± 0.082	0.777AlaCys: 0.777 ± 0.03	3.189AlaAsp: 3.189 ± 0.058	3.832AlaGlu: 3.832 ± 0.063	2.648AlaPhe: 2.648 ± 0.055	4.579AlaGly: 4.579 ± 0.082	0.843AlaHis: 0.843 ± 0.031	4.843AlaIle: 4.843 ± 0.083	4.148AlaLys: 4.148 ± 0.072	5.984AlaLeu: 5.984 ± 0.098	1.622AlaMet: 1.622 ± 0.044	2.35AlaAsn: 2.35 ± 0.05	1.523AlaPro: 1.523 ± 0.038	1.731AlaGln: 1.731 ± 0.038	2.356AlaArg: 2.356 ± 0.046	3.723AlaSer: 3.723 ± 0.06	2.285AlaThr: 2.285 ± 0.058	5.594AlaVal: 5.594 ± 0.092	0.395AlaTrp: 0.395 ± 0.021	2.105AlaTyr: 2.105 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.766CysAla: 0.766 ± 0.029	0.276CysCys: 0.276 ± 0.016	0.706CysAsp: 0.706 ± 0.027	0.775CysGlu: 0.775 ± 0.03	0.558CysPhe: 0.558 ± 0.023	1.307CysGly: 1.307 ± 0.037	0.254CysHis: 0.254 ± 0.015	1.359CysIle: 1.359 ± 0.038	0.979CysLys: 0.979 ± 0.034	0.956CysLeu: 0.956 ± 0.032	0.354CysMet: 0.354 ± 0.017	0.677CysAsn: 0.677 ± 0.03	0.616CysPro: 0.616 ± 0.028	0.297CysGln: 0.297 ± 0.016	0.676CysArg: 0.676 ± 0.025	1.028CysSer: 1.028 ± 0.038	0.654CysThr: 0.654 ± 0.023	0.722CysVal: 0.722 ± 0.025	0.086CysTrp: 0.086 ± 0.01	0.488CysTyr: 0.488 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	2.923AspAla: 2.923 ± 0.065	0.667AspCys: 0.667 ± 0.025	2.7AspAsp: 2.7 ± 0.063	4.305AspGlu: 4.305 ± 0.077	2.699AspPhe: 2.699 ± 0.061	3.353AspGly: 3.353 ± 0.057	0.634AspHis: 0.634 ± 0.027	6.224AspIle: 6.224 ± 0.076	5.347AspLys: 5.347 ± 0.075	4.644AspLeu: 4.644 ± 0.067	1.781AspMet: 1.781 ± 0.043	3.056AspAsn: 3.056 ± 0.055	1.544AspPro: 1.544 ± 0.045	0.893AspGln: 0.893 ± 0.031	2.352AspArg: 2.352 ± 0.053	3.528AspSer: 3.528 ± 0.053	2.617AspThr: 2.617 ± 0.05	3.776AspVal: 3.776 ± 0.064	0.401AspTrp: 0.401 ± 0.021	2.449AspTyr: 2.449 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	3.784GluAla: 3.784 ± 0.066	0.672GluCys: 0.672 ± 0.029	4.161GluAsp: 4.161 ± 0.07	5.218GluGlu: 5.218 ± 0.081	2.699GluPhe: 2.699 ± 0.053	3.781GluGly: 3.781 ± 0.06	0.91GluHis: 0.91 ± 0.029	6.149GluIle: 6.149 ± 0.078	7.446GluLys: 7.446 ± 0.107	5.93GluLeu: 5.93 ± 0.069	1.74GluMet: 1.74 ± 0.04	5.143GluAsn: 5.143 ± 0.073	1.387GluPro: 1.387 ± 0.039	1.797GluGln: 1.797 ± 0.047	2.48GluArg: 2.48 ± 0.055	3.43GluSer: 3.43 ± 0.06	2.632GluThr: 2.632 ± 0.047	3.997GluVal: 3.997 ± 0.064	0.397GluTrp: 0.397 ± 0.019	2.651GluTyr: 2.651 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.337PheAla: 2.337 ± 0.05	0.588PheCys: 0.588 ± 0.02	2.397PheAsp: 2.397 ± 0.047	2.48PheGlu: 2.48 ± 0.051	1.869PhePhe: 1.869 ± 0.045	2.938PheGly: 2.938 ± 0.057	0.615PheHis: 0.615 ± 0.027	4.27PheIle: 4.27 ± 0.074	3.73PheLys: 3.73 ± 0.064	3.934PheLeu: 3.934 ± 0.068	1.277PheMet: 1.277 ± 0.037	2.577PheAsn: 2.577 ± 0.05	1.341PhePro: 1.341 ± 0.038	1.159PheGln: 1.159 ± 0.037	1.443PheArg: 1.443 ± 0.035	3.329PheSer: 3.329 ± 0.055	2.33PheThr: 2.33 ± 0.05	2.715PheVal: 2.715 ± 0.055	0.339PheTrp: 0.339 ± 0.02	1.774PheTyr: 1.774 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.284GlyAla: 4.284 ± 0.083	1.169GlyCys: 1.169 ± 0.04	3.376GlyAsp: 3.376 ± 0.073	4.154GlyGlu: 4.154 ± 0.064	3.123GlyPhe: 3.123 ± 0.059	4.646GlyGly: 4.646 ± 0.09	1.091GlyHis: 1.091 ± 0.029	7.194GlyIle: 7.194 ± 0.1	6.134GlyLys: 6.134 ± 0.076	5.22GlyLeu: 5.22 ± 0.079	1.911GlyMet: 1.911 ± 0.048	3.42GlyAsn: 3.42 ± 0.062	1.434GlyPro: 1.434 ± 0.065	1.615GlyGln: 1.615 ± 0.038	2.747GlyArg: 2.747 ± 0.052	4.159GlySer: 4.159 ± 0.075	3.615GlyThr: 3.615 ± 0.063	4.531GlyVal: 4.531 ± 0.069	0.596GlyTrp: 0.596 ± 0.023	3.016GlyTyr: 3.016 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	0.67HisAla: 0.67 ± 0.023	0.265HisCys: 0.265 ± 0.017	0.71HisAsp: 0.71 ± 0.025	0.839HisGlu: 0.839 ± 0.027	0.645HisPhe: 0.645 ± 0.025	1.046HisGly: 1.046 ± 0.035	0.318HisHis: 0.318 ± 0.02	1.432HisIle: 1.432 ± 0.034	1.054HisLys: 1.054 ± 0.035	1.194HisLeu: 1.194 ± 0.036	0.443HisMet: 0.443 ± 0.02	0.735HisAsn: 0.735 ± 0.025	0.684HisPro: 0.684 ± 0.027	0.354HisGln: 0.354 ± 0.019	0.64HisArg: 0.64 ± 0.024	0.969HisSer: 0.969 ± 0.033	0.665HisThr: 0.665 ± 0.022	0.856HisVal: 0.856 ± 0.03	0.106HisTrp: 0.106 ± 0.01	0.559HisTyr: 0.559 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.765IleAla: 5.765 ± 0.089	1.435IleCys: 1.435 ± 0.039	5.373IleAsp: 5.373 ± 0.085	6.039IleGlu: 6.039 ± 0.093	4.267IlePhe: 4.267 ± 0.073	6.223IleGly: 6.223 ± 0.091	1.257IleHis: 1.257 ± 0.037	8.624IleIle: 8.624 ± 0.121	8.097IleLys: 8.097 ± 0.093	8.811IleLeu: 8.811 ± 0.112	2.426IleMet: 2.426 ± 0.059	5.136IleAsn: 5.136 ± 0.08	3.581IlePro: 3.581 ± 0.061	2.326IleGln: 2.326 ± 0.049	3.224IleArg: 3.224 ± 0.054	6.956IleSer: 6.956 ± 0.087	4.544IleThr: 4.544 ± 0.074	6.143IleVal: 6.143 ± 0.091	0.619IleTrp: 0.619 ± 0.025	3.571IleTyr: 3.571 ± 0.066	0.0IleXaa: 0.0 ± 0.0
Lys	4.72LysAla: 4.72 ± 0.07	0.96LysCys: 0.96 ± 0.037	5.502LysAsp: 5.502 ± 0.077	6.319LysGlu: 6.319 ± 0.099	3.474LysPhe: 3.474 ± 0.053	4.9LysGly: 4.9 ± 0.073	1.051LysHis: 1.051 ± 0.034	8.569LysIle: 8.569 ± 0.1	8.585LysLys: 8.585 ± 0.099	7.751LysLeu: 7.751 ± 0.092	2.567LysMet: 2.567 ± 0.044	6.878LysAsn: 6.878 ± 0.098	2.154LysPro: 2.154 ± 0.042	2.233LysGln: 2.233 ± 0.042	3.257LysArg: 3.257 ± 0.062	5.558LysSer: 5.558 ± 0.081	3.726LysThr: 3.726 ± 0.056	5.607LysVal: 5.607 ± 0.074	0.671LysTrp: 0.671 ± 0.026	4.217LysTyr: 4.217 ± 0.074	0.0LysXaa: 0.0 ± 0.0
Leu	5.17LeuAla: 5.17 ± 0.079	1.221LeuCys: 1.221 ± 0.035	4.833LeuAsp: 4.833 ± 0.066	5.485LeuGlu: 5.485 ± 0.08	3.702LeuPhe: 3.702 ± 0.073	6.012LeuGly: 6.012 ± 0.079	1.18LeuHis: 1.18 ± 0.032	7.419LeuIle: 7.419 ± 0.096	9.123LeuLys: 9.123 ± 0.101	7.451LeuLeu: 7.451 ± 0.108	2.355LeuMet: 2.355 ± 0.045	5.624LeuAsn: 5.624 ± 0.072	3.038LeuPro: 3.038 ± 0.059	2.384LeuGln: 2.384 ± 0.044	3.115LeuArg: 3.115 ± 0.063	6.522LeuSer: 6.522 ± 0.09	4.121LeuThr: 4.121 ± 0.062	5.257LeuVal: 5.257 ± 0.075	0.643LeuTrp: 0.643 ± 0.026	3.204LeuTyr: 3.204 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.96MetAla: 1.96 ± 0.041	0.311MetCys: 0.311 ± 0.017	1.914MetAsp: 1.914 ± 0.049	2.047MetGlu: 2.047 ± 0.044	0.99MetPhe: 0.99 ± 0.032	1.976MetGly: 1.976 ± 0.057	0.338MetHis: 0.338 ± 0.019	2.113MetIle: 2.113 ± 0.043	2.643MetLys: 2.643 ± 0.053	2.463MetLeu: 2.463 ± 0.049	0.724MetMet: 0.724 ± 0.027	1.734MetAsn: 1.734 ± 0.04	0.896MetPro: 0.896 ± 0.03	0.701MetGln: 0.701 ± 0.026	1.013MetArg: 1.013 ± 0.031	1.818MetSer: 1.818 ± 0.041	1.325MetThr: 1.325 ± 0.033	1.717MetVal: 1.717 ± 0.042	0.185MetTrp: 0.185 ± 0.014	0.922MetTyr: 0.922 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	2.956AsnAla: 2.956 ± 0.058	0.869AsnCys: 0.869 ± 0.03	2.459AsnAsp: 2.459 ± 0.047	3.362AsnGlu: 3.362 ± 0.062	2.682AsnPhe: 2.682 ± 0.057	3.564AsnGly: 3.564 ± 0.056	0.814AsnHis: 0.814 ± 0.026	6.517AsnIle: 6.517 ± 0.092	4.996AsnLys: 4.996 ± 0.072	5.245AsnLeu: 5.245 ± 0.081	1.859AsnMet: 1.859 ± 0.045	3.214AsnAsn: 3.214 ± 0.064	2.097AsnPro: 2.097 ± 0.048	1.372AsnGln: 1.372 ± 0.04	2.362AsnArg: 2.362 ± 0.049	4.215AsnSer: 4.215 ± 0.069	2.938AsnThr: 2.938 ± 0.058	3.702AsnVal: 3.702 ± 0.068	0.476AsnTrp: 0.476 ± 0.023	2.545AsnTyr: 2.545 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	1.758ProAla: 1.758 ± 0.043	0.423ProCys: 0.423 ± 0.021	1.912ProAsp: 1.912 ± 0.05	2.493ProGlu: 2.493 ± 0.063	1.421ProPhe: 1.421 ± 0.039	2.19ProGly: 2.19 ± 0.067	0.513ProHis: 0.513 ± 0.026	2.58ProIle: 2.58 ± 0.051	2.157ProLys: 2.157 ± 0.057	2.522ProLeu: 2.522 ± 0.052	0.746ProMet: 0.746 ± 0.025	1.347ProAsn: 1.347 ± 0.038	0.753ProPro: 0.753 ± 0.03	0.945ProGln: 0.945 ± 0.043	1.061ProArg: 1.061 ± 0.031	1.812ProSer: 1.812 ± 0.043	1.375ProThr: 1.375 ± 0.042	2.531ProVal: 2.531 ± 0.049	0.291ProTrp: 0.291 ± 0.019	1.408ProTyr: 1.408 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.466GlnAla: 1.466 ± 0.039	0.326GlnCys: 0.326 ± 0.02	1.395GlnAsp: 1.395 ± 0.035	1.573GlnGlu: 1.573 ± 0.041	1.034GlnPhe: 1.034 ± 0.033	1.676GlnGly: 1.676 ± 0.056	0.416GlnHis: 0.416 ± 0.02	2.295GlnIle: 2.295 ± 0.047	2.296GlnLys: 2.296 ± 0.048	2.411GlnLeu: 2.411 ± 0.048	0.762GlnMet: 0.762 ± 0.025	1.735GlnAsn: 1.735 ± 0.039	0.65GlnPro: 0.65 ± 0.025	0.865GlnGln: 0.865 ± 0.034	0.979GlnArg: 0.979 ± 0.03	1.536GlnSer: 1.536 ± 0.041	1.095GlnThr: 1.095 ± 0.036	1.729GlnVal: 1.729 ± 0.042	0.221GlnTrp: 0.221 ± 0.014	1.133GlnTyr: 1.133 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.232ArgAla: 2.232 ± 0.049	0.495ArgCys: 0.495 ± 0.021	2.153ArgAsp: 2.153 ± 0.039	3.437ArgGlu: 3.437 ± 0.063	1.503ArgPhe: 1.503 ± 0.039	2.525ArgGly: 2.525 ± 0.046	0.588ArgHis: 0.588 ± 0.027	3.505ArgIle: 3.505 ± 0.059	3.619ArgLys: 3.619 ± 0.067	3.03ArgLeu: 3.03 ± 0.057	1.068ArgMet: 1.068 ± 0.032	2.304ArgAsn: 2.304 ± 0.043	0.982ArgPro: 0.982 ± 0.037	1.109ArgGln: 1.109 ± 0.035	1.729ArgArg: 1.729 ± 0.047	1.937ArgSer: 1.937 ± 0.033	1.771ArgThr: 1.771 ± 0.038	2.371ArgVal: 2.371 ± 0.051	0.307ArgTrp: 0.307 ± 0.018	1.603ArgTyr: 1.603 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.861SerAla: 3.861 ± 0.069	0.811SerCys: 0.811 ± 0.029	3.455SerAsp: 3.455 ± 0.06	4.019SerGlu: 4.019 ± 0.068	2.866SerPhe: 2.866 ± 0.055	5.14SerGly: 5.14 ± 0.078	1.012SerHis: 1.012 ± 0.029	6.499SerIle: 6.499 ± 0.075	5.414SerLys: 5.414 ± 0.073	5.764SerLeu: 5.764 ± 0.074	1.885SerMet: 1.885 ± 0.046	3.438SerAsn: 3.438 ± 0.058	1.944SerPro: 1.944 ± 0.047	1.985SerGln: 1.985 ± 0.047	2.753SerArg: 2.753 ± 0.057	4.983SerSer: 4.983 ± 0.096	3.332SerThr: 3.332 ± 0.066	4.236SerVal: 4.236 ± 0.063	0.525SerTrp: 0.525 ± 0.02	2.536SerTyr: 2.536 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.606ThrAla: 3.606 ± 0.072	0.557ThrCys: 0.557 ± 0.022	2.554ThrAsp: 2.554 ± 0.052	2.724ThrGlu: 2.724 ± 0.043	1.918ThrPhe: 1.918 ± 0.044	4.071ThrGly: 4.071 ± 0.073	0.676ThrHis: 0.676 ± 0.027	4.253ThrIle: 4.253 ± 0.067	3.009ThrLys: 3.009 ± 0.06	4.351ThrLeu: 4.351 ± 0.073	1.147ThrMet: 1.147 ± 0.028	2.099ThrAsn: 2.099 ± 0.047	1.796ThrPro: 1.796 ± 0.042	1.13ThrGln: 1.13 ± 0.041	1.698ThrArg: 1.698 ± 0.039	3.176ThrSer: 3.176 ± 0.064	2.359ThrThr: 2.359 ± 0.057	3.729ThrVal: 3.729 ± 0.067	0.34ThrTrp: 0.34 ± 0.019	1.729ThrTyr: 1.729 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	3.74ValAla: 3.74 ± 0.069	0.984ValCys: 0.984 ± 0.03	4.223ValAsp: 4.223 ± 0.073	4.406ValGlu: 4.406 ± 0.068	3.026ValPhe: 3.026 ± 0.057	4.243ValGly: 4.243 ± 0.068	0.925ValHis: 0.925 ± 0.026	6.021ValIle: 6.021 ± 0.079	5.899ValLys: 5.899 ± 0.078	6.159ValLeu: 6.159 ± 0.074	1.777ValMet: 1.777 ± 0.04	3.747ValAsn: 3.747 ± 0.066	2.304ValPro: 2.304 ± 0.047	1.706ValGln: 1.706 ± 0.044	2.229ValArg: 2.229 ± 0.046	4.542ValSer: 4.542 ± 0.071	3.232ValThr: 3.232 ± 0.063	4.749ValVal: 4.749 ± 0.086	0.416ValTrp: 0.416 ± 0.02	2.502ValTyr: 2.502 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.419TrpAla: 0.419 ± 0.023	0.107TrpCys: 0.107 ± 0.009	0.43TrpAsp: 0.43 ± 0.018	0.436TrpGlu: 0.436 ± 0.022	0.338TrpPhe: 0.338 ± 0.018	0.506TrpGly: 0.506 ± 0.02	0.156TrpHis: 0.156 ± 0.012	0.738TrpIle: 0.738 ± 0.028	0.613TrpLys: 0.613 ± 0.027	0.616TrpLeu: 0.616 ± 0.026	0.23TrpMet: 0.23 ± 0.016	0.491TrpAsn: 0.491 ± 0.018	0.185TrpPro: 0.185 ± 0.014	0.256TrpGln: 0.256 ± 0.014	0.289TrpArg: 0.289 ± 0.019	0.483TrpSer: 0.483 ± 0.023	0.301TrpThr: 0.301 ± 0.018	0.439TrpVal: 0.439 ± 0.021	0.075TrpTrp: 0.075 ± 0.009	0.281TrpTyr: 0.281 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.11TyrAla: 2.11 ± 0.041	0.621TyrCys: 0.621 ± 0.024	2.451TyrAsp: 2.451 ± 0.051	2.463TyrGlu: 2.463 ± 0.059	1.981TyrPhe: 1.981 ± 0.045	2.759TyrGly: 2.759 ± 0.052	0.592TyrHis: 0.592 ± 0.021	3.809TyrIle: 3.809 ± 0.058	3.408TyrLys: 3.408 ± 0.064	3.421TyrLeu: 3.421 ± 0.059	1.117TyrMet: 1.117 ± 0.035	2.535TyrAsn: 2.535 ± 0.058	1.328TyrPro: 1.328 ± 0.035	0.736TyrGln: 0.736 ± 0.027	1.865TyrArg: 1.865 ± 0.052	2.754TyrSer: 2.754 ± 0.048	2.005TyrThr: 2.005 ± 0.043	2.433TyrVal: 2.433 ± 0.048	0.302TyrTrp: 0.302 ± 0.02	1.83TyrTyr: 1.83 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3630 proteins (1076556 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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