Amino acid dipepetide frequency for Liberibacter crescens (strain BT-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.661AlaAla: 5.661 ± 0.167
0.86AlaCys: 0.86 ± 0.044
3.239AlaAsp: 3.239 ± 0.086
3.848AlaGlu: 3.848 ± 0.099
3.294AlaPhe: 3.294 ± 0.096
4.372AlaGly: 4.372 ± 0.127
1.596AlaHis: 1.596 ± 0.065
6.204AlaIle: 6.204 ± 0.118
3.567AlaLys: 3.567 ± 0.105
7.804AlaLeu: 7.804 ± 0.17
1.929AlaMet: 1.929 ± 0.074
2.712AlaAsn: 2.712 ± 0.081
1.953AlaPro: 1.953 ± 0.066
2.289AlaGln: 2.289 ± 0.086
3.698AlaArg: 3.698 ± 0.1
4.651AlaSer: 4.651 ± 0.108
3.065AlaThr: 3.065 ± 0.087
4.66AlaVal: 4.66 ± 0.108
0.624AlaTrp: 0.624 ± 0.038
2.153AlaTyr: 2.153 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.686CysAla: 0.686 ± 0.038
0.176CysCys: 0.176 ± 0.02
0.56CysAsp: 0.56 ± 0.037
0.529CysGlu: 0.529 ± 0.035
0.669CysPhe: 0.669 ± 0.042
0.836CysGly: 0.836 ± 0.048
0.238CysHis: 0.238 ± 0.024
0.976CysIle: 0.976 ± 0.052
0.638CysLys: 0.638 ± 0.043
1.191CysLeu: 1.191 ± 0.053
0.241CysMet: 0.241 ± 0.023
0.526CysAsn: 0.526 ± 0.034
0.429CysPro: 0.429 ± 0.032
0.338CysGln: 0.338 ± 0.028
0.617CysArg: 0.617 ± 0.038
0.943CysSer: 0.943 ± 0.048
0.502CysThr: 0.502 ± 0.044
0.655CysVal: 0.655 ± 0.043
0.133CysTrp: 0.133 ± 0.018
0.338CysTyr: 0.338 ± 0.033
0.0CysXaa: 0.0 ± 0.0
Asp
3.105AspAla: 3.105 ± 0.09
0.66AspCys: 0.66 ± 0.034
2.448AspAsp: 2.448 ± 0.089
2.832AspGlu: 2.832 ± 0.092
2.498AspPhe: 2.498 ± 0.077
2.939AspGly: 2.939 ± 0.104
1.167AspHis: 1.167 ± 0.047
5.244AspIle: 5.244 ± 0.126
3.06AspLys: 3.06 ± 0.089
4.994AspLeu: 4.994 ± 0.122
1.284AspMet: 1.284 ± 0.052
2.405AspAsn: 2.405 ± 0.079
2.246AspPro: 2.246 ± 0.07
1.662AspGln: 1.662 ± 0.063
2.489AspArg: 2.489 ± 0.083
3.498AspSer: 3.498 ± 0.102
2.498AspThr: 2.498 ± 0.069
3.396AspVal: 3.396 ± 0.087
0.626AspTrp: 0.626 ± 0.038
1.85AspTyr: 1.85 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
4.618GluAla: 4.618 ± 0.124
0.55GluCys: 0.55 ± 0.038
2.789GluAsp: 2.789 ± 0.09
4.384GluGlu: 4.384 ± 0.129
2.119GluPhe: 2.119 ± 0.076
3.315GluGly: 3.315 ± 0.094
1.172GluHis: 1.172 ± 0.047
5.744GluIle: 5.744 ± 0.135
5.553GluLys: 5.553 ± 0.138
4.889GluLeu: 4.889 ± 0.128
1.638GluMet: 1.638 ± 0.048
3.374GluAsn: 3.374 ± 0.081
1.698GluPro: 1.698 ± 0.082
2.193GluGln: 2.193 ± 0.08
3.458GluArg: 3.458 ± 0.095
3.303GluSer: 3.303 ± 0.096
3.217GluThr: 3.217 ± 0.096
3.708GluVal: 3.708 ± 0.097
0.536GluTrp: 0.536 ± 0.042
1.686GluTyr: 1.686 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
2.441PheAla: 2.441 ± 0.079
0.712PheCys: 0.712 ± 0.043
2.52PheAsp: 2.52 ± 0.099
2.355PheGlu: 2.355 ± 0.083
2.755PhePhe: 2.755 ± 0.119
3.103PheGly: 3.103 ± 0.091
0.964PheHis: 0.964 ± 0.049
4.401PheIle: 4.401 ± 0.123
2.396PheLys: 2.396 ± 0.092
5.332PheLeu: 5.332 ± 0.152
1.226PheMet: 1.226 ± 0.054
2.181PheAsn: 2.181 ± 0.074
1.917PhePro: 1.917 ± 0.067
1.479PheGln: 1.479 ± 0.065
1.877PheArg: 1.877 ± 0.069
4.882PheSer: 4.882 ± 0.114
2.046PheThr: 2.046 ± 0.068
2.541PheVal: 2.541 ± 0.093
0.562PheTrp: 0.562 ± 0.039
1.548PheTyr: 1.548 ± 0.067
0.0PheXaa: 0.0 ± 0.0
Gly
4.284GlyAla: 4.284 ± 0.115
0.822GlyCys: 0.822 ± 0.046
2.827GlyAsp: 2.827 ± 0.103
3.341GlyGlu: 3.341 ± 0.098
3.348GlyPhe: 3.348 ± 0.105
4.272GlyGly: 4.272 ± 0.131
1.498GlyHis: 1.498 ± 0.065
5.78GlyIle: 5.78 ± 0.122
4.334GlyLys: 4.334 ± 0.111
6.177GlyLeu: 6.177 ± 0.131
1.572GlyMet: 1.572 ± 0.058
2.791GlyAsn: 2.791 ± 0.093
1.888GlyPro: 1.888 ± 0.068
2.124GlyGln: 2.124 ± 0.083
3.174GlyArg: 3.174 ± 0.105
4.282GlySer: 4.282 ± 0.105
2.996GlyThr: 2.996 ± 0.096
4.296GlyVal: 4.296 ± 0.122
0.726GlyTrp: 0.726 ± 0.045
2.374GlyTyr: 2.374 ± 0.08
0.0GlyXaa: 0.0 ± 0.0
His
1.51HisAla: 1.51 ± 0.059
0.269HisCys: 0.269 ± 0.027
1.041HisAsp: 1.041 ± 0.047
1.217HisGlu: 1.217 ± 0.046
1.179HisPhe: 1.179 ± 0.059
1.398HisGly: 1.398 ± 0.062
0.648HisHis: 0.648 ± 0.048
1.696HisIle: 1.696 ± 0.064
1.245HisLys: 1.245 ± 0.055
2.06HisLeu: 2.06 ± 0.076
0.498HisMet: 0.498 ± 0.033
1.012HisAsn: 1.012 ± 0.052
1.093HisPro: 1.093 ± 0.049
0.864HisGln: 0.864 ± 0.05
1.022HisArg: 1.022 ± 0.052
1.503HisSer: 1.503 ± 0.075
0.876HisThr: 0.876 ± 0.043
1.436HisVal: 1.436 ± 0.061
0.243HisTrp: 0.243 ± 0.028
0.748HisTyr: 0.748 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
6.899IleAla: 6.899 ± 0.148
1.115IleCys: 1.115 ± 0.051
5.268IleAsp: 5.268 ± 0.13
5.594IleGlu: 5.594 ± 0.13
3.972IlePhe: 3.972 ± 0.117
5.849IleGly: 5.849 ± 0.126
1.779IleHis: 1.779 ± 0.071
7.783IleIle: 7.783 ± 0.185
5.489IleLys: 5.489 ± 0.13
8.397IleLeu: 8.397 ± 0.17
1.858IleMet: 1.858 ± 0.071
4.608IleAsn: 4.608 ± 0.103
3.808IlePro: 3.808 ± 0.115
2.598IleGln: 2.598 ± 0.077
4.063IleArg: 4.063 ± 0.105
7.542IleSer: 7.542 ± 0.164
4.515IleThr: 4.515 ± 0.102
5.527IleVal: 5.527 ± 0.12
0.769IleTrp: 0.769 ± 0.047
2.393IleTyr: 2.393 ± 0.075
0.0IleXaa: 0.0 ± 0.0
Lys
4.298LysAla: 4.298 ± 0.11
0.441LysCys: 0.441 ± 0.036
3.417LysAsp: 3.417 ± 0.086
4.458LysGlu: 4.458 ± 0.106
2.146LysPhe: 2.146 ± 0.082
3.71LysGly: 3.71 ± 0.103
1.148LysHis: 1.148 ± 0.05
6.246LysIle: 6.246 ± 0.131
5.751LysLys: 5.751 ± 0.146
5.623LysLeu: 5.623 ± 0.135
1.546LysMet: 1.546 ± 0.06
4.379LysAsn: 4.379 ± 0.118
2.272LysPro: 2.272 ± 0.076
1.941LysGln: 1.941 ± 0.072
3.222LysArg: 3.222 ± 0.093
4.232LysSer: 4.232 ± 0.089
3.386LysThr: 3.386 ± 0.096
3.896LysVal: 3.896 ± 0.097
0.533LysTrp: 0.533 ± 0.036
1.596LysTyr: 1.596 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
7.009LeuAla: 7.009 ± 0.149
1.143LeuCys: 1.143 ± 0.057
5.032LeuAsp: 5.032 ± 0.126
6.497LeuGlu: 6.497 ± 0.125
4.513LeuPhe: 4.513 ± 0.129
6.004LeuGly: 6.004 ± 0.13
1.998LeuHis: 1.998 ± 0.07
7.916LeuIle: 7.916 ± 0.16
6.625LeuLys: 6.625 ± 0.124
9.59LeuLeu: 9.59 ± 0.164
2.515LeuMet: 2.515 ± 0.084
4.482LeuAsn: 4.482 ± 0.109
4.191LeuPro: 4.191 ± 0.1
3.517LeuGln: 3.517 ± 0.09
4.937LeuArg: 4.937 ± 0.121
9.102LeuSer: 9.102 ± 0.143
4.541LeuThr: 4.541 ± 0.106
5.863LeuVal: 5.863 ± 0.144
0.848LeuTrp: 0.848 ± 0.054
2.962LeuTyr: 2.962 ± 0.094
0.0LeuXaa: 0.0 ± 0.0
Met
1.874MetAla: 1.874 ± 0.072
0.257MetCys: 0.257 ± 0.024
1.081MetAsp: 1.081 ± 0.047
1.172MetGlu: 1.172 ± 0.048
0.964MetPhe: 0.964 ± 0.046
1.326MetGly: 1.326 ± 0.061
0.543MetHis: 0.543 ± 0.035
2.289MetIle: 2.289 ± 0.077
1.667MetLys: 1.667 ± 0.059
2.551MetLeu: 2.551 ± 0.075
0.776MetMet: 0.776 ± 0.046
1.398MetAsn: 1.398 ± 0.056
1.176MetPro: 1.176 ± 0.05
0.943MetGln: 0.943 ± 0.046
1.376MetArg: 1.376 ± 0.064
1.953MetSer: 1.953 ± 0.071
1.426MetThr: 1.426 ± 0.054
1.388MetVal: 1.388 ± 0.063
0.15MetTrp: 0.15 ± 0.02
0.474MetTyr: 0.474 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.141AsnAla: 3.141 ± 0.085
0.438AsnCys: 0.438 ± 0.031
2.391AsnAsp: 2.391 ± 0.085
2.417AsnGlu: 2.417 ± 0.072
2.47AsnPhe: 2.47 ± 0.095
2.712AsnGly: 2.712 ± 0.078
1.179AsnHis: 1.179 ± 0.052
4.958AsnIle: 4.958 ± 0.114
3.01AsnLys: 3.01 ± 0.091
4.76AsnLeu: 4.76 ± 0.12
1.15AsnMet: 1.15 ± 0.053
2.901AsnAsn: 2.901 ± 0.093
2.327AsnPro: 2.327 ± 0.08
1.724AsnGln: 1.724 ± 0.075
2.26AsnArg: 2.26 ± 0.07
3.551AsnSer: 3.551 ± 0.107
2.362AsnThr: 2.362 ± 0.085
2.932AsnVal: 2.932 ± 0.082
0.526AsnTrp: 0.526 ± 0.036
1.529AsnTyr: 1.529 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
2.174ProAla: 2.174 ± 0.068
0.341ProCys: 0.341 ± 0.027
2.327ProAsp: 2.327 ± 0.082
2.982ProGlu: 2.982 ± 0.091
1.934ProPhe: 1.934 ± 0.078
2.489ProGly: 2.489 ± 0.077
0.838ProHis: 0.838 ± 0.041
3.234ProIle: 3.234 ± 0.079
2.003ProLys: 2.003 ± 0.068
3.944ProLeu: 3.944 ± 0.088
0.814ProMet: 0.814 ± 0.045
1.596ProAsn: 1.596 ± 0.064
1.334ProPro: 1.334 ± 0.073
1.367ProGln: 1.367 ± 0.061
1.467ProArg: 1.467 ± 0.068
3.122ProSer: 3.122 ± 0.119
1.736ProThr: 1.736 ± 0.07
2.955ProVal: 2.955 ± 0.091
0.429ProTrp: 0.429 ± 0.032
1.281ProTyr: 1.281 ± 0.066
0.0ProXaa: 0.0 ± 0.0
Gln
2.52GlnAla: 2.52 ± 0.097
0.257GlnCys: 0.257 ± 0.024
1.665GlnAsp: 1.665 ± 0.058
2.439GlnGlu: 2.439 ± 0.077
1.255GlnPhe: 1.255 ± 0.054
2.16GlnGly: 2.16 ± 0.07
0.669GlnHis: 0.669 ± 0.049
2.67GlnIle: 2.67 ± 0.09
2.812GlnLys: 2.812 ± 0.086
3.229GlnLeu: 3.229 ± 0.087
0.75GlnMet: 0.75 ± 0.04
1.715GlnAsn: 1.715 ± 0.072
1.26GlnPro: 1.26 ± 0.064
1.381GlnGln: 1.381 ± 0.066
1.86GlnArg: 1.86 ± 0.071
2.312GlnSer: 2.312 ± 0.069
1.481GlnThr: 1.481 ± 0.07
2.103GlnVal: 2.103 ± 0.072
0.388GlnTrp: 0.388 ± 0.034
1.003GlnTyr: 1.003 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
3.093ArgAla: 3.093 ± 0.102
0.5ArgCys: 0.5 ± 0.033
2.496ArgAsp: 2.496 ± 0.072
2.853ArgGlu: 2.853 ± 0.087
2.57ArgPhe: 2.57 ± 0.085
2.636ArgGly: 2.636 ± 0.091
1.105ArgHis: 1.105 ± 0.045
4.83ArgIle: 4.83 ± 0.123
3.239ArgLys: 3.239 ± 0.098
5.213ArgLeu: 5.213 ± 0.109
1.341ArgMet: 1.341 ± 0.063
2.481ArgAsn: 2.481 ± 0.073
1.648ArgPro: 1.648 ± 0.063
1.829ArgGln: 1.829 ± 0.061
2.743ArgArg: 2.743 ± 0.097
3.608ArgSer: 3.608 ± 0.109
2.019ArgThr: 2.019 ± 0.065
3.22ArgVal: 3.22 ± 0.094
0.541ArgTrp: 0.541 ± 0.036
1.712ArgTyr: 1.712 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
4.491SerAla: 4.491 ± 0.116
0.905SerCys: 0.905 ± 0.047
3.775SerAsp: 3.775 ± 0.106
4.446SerGlu: 4.446 ± 0.141
4.225SerPhe: 4.225 ± 0.12
5.765SerGly: 5.765 ± 0.127
1.648SerHis: 1.648 ± 0.06
6.578SerIle: 6.578 ± 0.132
4.31SerLys: 4.31 ± 0.113
8.018SerLeu: 8.018 ± 0.154
1.884SerMet: 1.884 ± 0.072
3.413SerAsn: 3.413 ± 0.114
2.836SerPro: 2.836 ± 0.064
2.705SerGln: 2.705 ± 0.093
3.767SerArg: 3.767 ± 0.094
6.911SerSer: 6.911 ± 0.166
3.239SerThr: 3.239 ± 0.1
5.063SerVal: 5.063 ± 0.159
0.888SerTrp: 0.888 ± 0.047
2.508SerTyr: 2.508 ± 0.081
0.0SerXaa: 0.0 ± 0.0
Thr
3.551ThrAla: 3.551 ± 0.092
0.5ThrCys: 0.5 ± 0.037
2.291ThrAsp: 2.291 ± 0.072
2.636ThrGlu: 2.636 ± 0.083
2.112ThrPhe: 2.112 ± 0.07
3.51ThrGly: 3.51 ± 0.107
1.11ThrHis: 1.11 ± 0.055
4.272ThrIle: 4.272 ± 0.127
2.486ThrLys: 2.486 ± 0.08
5.13ThrLeu: 5.13 ± 0.134
1.184ThrMet: 1.184 ± 0.044
1.915ThrAsn: 1.915 ± 0.073
2.124ThrPro: 2.124 ± 0.085
1.453ThrGln: 1.453 ± 0.054
2.193ThrArg: 2.193 ± 0.071
3.532ThrSer: 3.532 ± 0.097
2.489ThrThr: 2.489 ± 0.082
3.272ThrVal: 3.272 ± 0.088
0.45ThrTrp: 0.45 ± 0.035
1.253ThrTyr: 1.253 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
4.391ValAla: 4.391 ± 0.103
0.743ValCys: 0.743 ± 0.044
3.484ValAsp: 3.484 ± 0.117
3.798ValGlu: 3.798 ± 0.103
3.179ValPhe: 3.179 ± 0.088
3.734ValGly: 3.734 ± 0.109
1.238ValHis: 1.238 ± 0.057
5.77ValIle: 5.77 ± 0.123
3.434ValLys: 3.434 ± 0.095
6.301ValLeu: 6.301 ± 0.114
1.679ValMet: 1.679 ± 0.066
2.798ValAsn: 2.798 ± 0.092
2.403ValPro: 2.403 ± 0.073
1.927ValGln: 1.927 ± 0.073
3.177ValArg: 3.177 ± 0.094
5.53ValSer: 5.53 ± 0.163
3.103ValThr: 3.103 ± 0.092
4.36ValVal: 4.36 ± 0.129
0.574ValTrp: 0.574 ± 0.035
1.955ValTyr: 1.955 ± 0.072
0.0ValXaa: 0.0 ± 0.0
Trp
0.512TrpAla: 0.512 ± 0.04
0.148TrpCys: 0.148 ± 0.019
0.457TrpAsp: 0.457 ± 0.035
0.495TrpGlu: 0.495 ± 0.036
0.512TrpPhe: 0.512 ± 0.039
0.543TrpGly: 0.543 ± 0.037
0.226TrpHis: 0.226 ± 0.023
0.81TrpIle: 0.81 ± 0.045
0.736TrpLys: 0.736 ± 0.044
1.195TrpLeu: 1.195 ± 0.06
0.274TrpMet: 0.274 ± 0.023
0.448TrpAsn: 0.448 ± 0.032
0.412TrpPro: 0.412 ± 0.033
0.405TrpGln: 0.405 ± 0.031
0.626TrpArg: 0.626 ± 0.034
0.695TrpSer: 0.695 ± 0.048
0.472TrpThr: 0.472 ± 0.03
0.581TrpVal: 0.581 ± 0.04
0.138TrpTrp: 0.138 ± 0.021
0.307TrpTyr: 0.307 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.919TyrAla: 1.919 ± 0.071
0.386TyrCys: 0.386 ± 0.024
1.796TyrAsp: 1.796 ± 0.072
1.653TyrGlu: 1.653 ± 0.068
1.524TyrPhe: 1.524 ± 0.065
2.234TyrGly: 2.234 ± 0.088
0.793TyrHis: 0.793 ± 0.046
2.427TyrIle: 2.427 ± 0.072
1.884TyrLys: 1.884 ± 0.073
2.889TyrLeu: 2.889 ± 0.081
0.626TyrMet: 0.626 ± 0.036
1.603TyrAsn: 1.603 ± 0.071
1.35TyrPro: 1.35 ± 0.057
1.188TyrGln: 1.188 ± 0.055
1.65TyrArg: 1.65 ± 0.058
2.224TyrSer: 2.224 ± 0.066
1.491TyrThr: 1.491 ± 0.064
1.727TyrVal: 1.727 ± 0.069
0.307TyrTrp: 0.307 ± 0.025
1.129TyrTyr: 1.129 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1376 proteins (419917 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski