Amino acid dipepetide frequency for Amycolatopsis marina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.224AlaAla: 19.224 ± 0.164	1.012AlaCys: 1.012 ± 0.024	8.179AlaAsp: 8.179 ± 0.073	9.577AlaGlu: 9.577 ± 0.081	3.365AlaPhe: 3.365 ± 0.042	12.879AlaGly: 12.879 ± 0.099	2.567AlaHis: 2.567 ± 0.04	4.288AlaIle: 4.288 ± 0.05	2.709AlaLys: 2.709 ± 0.042	13.596AlaLeu: 13.596 ± 0.102	2.58AlaMet: 2.58 ± 0.038	2.227AlaAsn: 2.227 ± 0.033	5.989AlaPro: 5.989 ± 0.063	3.672AlaGln: 3.672 ± 0.043	9.282AlaArg: 9.282 ± 0.092	5.768AlaSer: 5.768 ± 0.051	7.12AlaThr: 7.12 ± 0.063	11.689AlaVal: 11.689 ± 0.096	1.657AlaTrp: 1.657 ± 0.029	2.213AlaTyr: 2.213 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.077CysAla: 1.077 ± 0.027	0.118CysCys: 0.118 ± 0.008	0.437CysAsp: 0.437 ± 0.014	0.377CysGlu: 0.377 ± 0.016	0.215CysPhe: 0.215 ± 0.01	0.951CysGly: 0.951 ± 0.019	0.194CysHis: 0.194 ± 0.01	0.185CysIle: 0.185 ± 0.009	0.118CysLys: 0.118 ± 0.009	0.723CysLeu: 0.723 ± 0.021	0.123CysMet: 0.123 ± 0.009	0.13CysAsn: 0.13 ± 0.009	0.462CysPro: 0.462 ± 0.017	0.187CysGln: 0.187 ± 0.009	0.583CysArg: 0.583 ± 0.02	0.471CysSer: 0.471 ± 0.019	0.486CysThr: 0.486 ± 0.016	0.686CysVal: 0.686 ± 0.021	0.127CysTrp: 0.127 ± 0.009	0.175CysTyr: 0.175 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.101AspAla: 7.101 ± 0.07	0.41AspCys: 0.41 ± 0.015	3.604AspAsp: 3.604 ± 0.047	4.223AspGlu: 4.223 ± 0.045	1.596AspPhe: 1.596 ± 0.028	5.764AspGly: 5.764 ± 0.073	1.267AspHis: 1.267 ± 0.027	2.076AspIle: 2.076 ± 0.032	1.076AspLys: 1.076 ± 0.029	6.347AspLeu: 6.347 ± 0.062	0.817AspMet: 0.817 ± 0.022	1.189AspAsn: 1.189 ± 0.03	4.328AspPro: 4.328 ± 0.05	1.693AspGln: 1.693 ± 0.025	4.816AspArg: 4.816 ± 0.054	2.919AspSer: 2.919 ± 0.042	3.246AspThr: 3.246 ± 0.039	5.212AspVal: 5.212 ± 0.056	0.928AspTrp: 0.928 ± 0.021	1.211AspTyr: 1.211 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	6.599GluAla: 6.599 ± 0.069	0.391GluCys: 0.391 ± 0.016	2.765GluAsp: 2.765 ± 0.041	3.063GluGlu: 3.063 ± 0.047	1.84GluPhe: 1.84 ± 0.028	4.005GluGly: 4.005 ± 0.048	1.913GluHis: 1.913 ± 0.029	2.565GluIle: 2.565 ± 0.036	1.276GluLys: 1.276 ± 0.03	7.754GluLeu: 7.754 ± 0.074	0.967GluMet: 0.967 ± 0.024	1.27GluAsn: 1.27 ± 0.027	3.548GluPro: 3.548 ± 0.049	2.94GluGln: 2.94 ± 0.039	5.556GluArg: 5.556 ± 0.056	2.974GluSer: 2.974 ± 0.04	2.946GluThr: 2.946 ± 0.041	5.09GluVal: 5.09 ± 0.064	0.868GluTrp: 0.868 ± 0.02	1.169GluTyr: 1.169 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.929PheAla: 3.929 ± 0.051	0.259PheCys: 0.259 ± 0.011	2.111PheAsp: 2.111 ± 0.029	1.491PheGlu: 1.491 ± 0.028	0.891PhePhe: 0.891 ± 0.027	3.295PheGly: 3.295 ± 0.047	0.609PheHis: 0.609 ± 0.016	0.769PheIle: 0.769 ± 0.022	0.368PheLys: 0.368 ± 0.014	2.68PheLeu: 2.68 ± 0.043	0.383PheMet: 0.383 ± 0.014	0.584PheAsn: 0.584 ± 0.017	1.333PhePro: 1.333 ± 0.024	0.659PheGln: 0.659 ± 0.017	1.81PheArg: 1.81 ± 0.028	1.565PheSer: 1.565 ± 0.027	1.982PheThr: 1.982 ± 0.031	2.552PheVal: 2.552 ± 0.036	0.421PheTrp: 0.421 ± 0.016	0.618PheTyr: 0.618 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	10.497GlyAla: 10.497 ± 0.088	0.82GlyCys: 0.82 ± 0.022	5.007GlyAsp: 5.007 ± 0.049	5.528GlyGlu: 5.528 ± 0.062	2.929GlyPhe: 2.929 ± 0.037	8.287GlyGly: 8.287 ± 0.087	2.075GlyHis: 2.075 ± 0.037	3.743GlyIle: 3.743 ± 0.043	2.391GlyLys: 2.391 ± 0.04	9.368GlyLeu: 9.368 ± 0.082	2.101GlyMet: 2.101 ± 0.032	1.953GlyAsn: 1.953 ± 0.035	4.53GlyPro: 4.53 ± 0.05	2.92GlyGln: 2.92 ± 0.048	6.898GlyArg: 6.898 ± 0.059	5.443GlySer: 5.443 ± 0.047	5.783GlyThr: 5.783 ± 0.054	7.936GlyVal: 7.936 ± 0.073	1.681GlyTrp: 1.681 ± 0.032	2.319GlyTyr: 2.319 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.59HisAla: 2.59 ± 0.037	0.223HisCys: 0.223 ± 0.011	1.318HisAsp: 1.318 ± 0.025	1.284HisGlu: 1.284 ± 0.028	0.634HisPhe: 0.634 ± 0.017	2.338HisGly: 2.338 ± 0.036	0.667HisHis: 0.667 ± 0.022	0.68HisIle: 0.68 ± 0.02	0.334HisLys: 0.334 ± 0.014	2.308HisLeu: 2.308 ± 0.033	0.3HisMet: 0.3 ± 0.012	0.458HisAsn: 0.458 ± 0.016	1.585HisPro: 1.585 ± 0.03	0.647HisGln: 0.647 ± 0.018	1.958HisArg: 1.958 ± 0.036	1.122HisSer: 1.122 ± 0.021	1.22HisThr: 1.22 ± 0.027	1.747HisVal: 1.747 ± 0.032	0.359HisTrp: 0.359 ± 0.014	0.524HisTyr: 0.524 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.407IleAla: 5.407 ± 0.066	0.3IleCys: 0.3 ± 0.012	2.564IleAsp: 2.564 ± 0.037	2.385IleGlu: 2.385 ± 0.036	0.828IlePhe: 0.828 ± 0.022	3.992IleGly: 3.992 ± 0.049	0.623IleHis: 0.623 ± 0.016	1.067IleIle: 1.067 ± 0.026	0.671IleLys: 0.671 ± 0.021	2.62IleLeu: 2.62 ± 0.037	0.488IleMet: 0.488 ± 0.013	0.857IleAsn: 0.857 ± 0.02	1.923IlePro: 1.923 ± 0.032	0.807IleGln: 0.807 ± 0.018	2.459IleArg: 2.459 ± 0.033	2.061IleSer: 2.061 ± 0.028	2.434IleThr: 2.434 ± 0.035	3.078IleVal: 3.078 ± 0.038	0.434IleTrp: 0.434 ± 0.015	0.664IleTyr: 0.664 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.418LysAla: 2.418 ± 0.042	0.103LysCys: 0.103 ± 0.007	1.044LysAsp: 1.044 ± 0.025	0.99LysGlu: 0.99 ± 0.024	0.489LysPhe: 0.489 ± 0.015	1.484LysGly: 1.484 ± 0.03	0.484LysHis: 0.484 ± 0.016	0.862LysIle: 0.862 ± 0.025	0.558LysLys: 0.558 ± 0.019	2.031LysLeu: 2.031 ± 0.037	0.379LysMet: 0.379 ± 0.013	0.435LysAsn: 0.435 ± 0.015	1.328LysPro: 1.328 ± 0.03	0.715LysGln: 0.715 ± 0.02	1.419LysArg: 1.419 ± 0.028	1.063LysSer: 1.063 ± 0.026	1.162LysThr: 1.162 ± 0.024	1.803LysVal: 1.803 ± 0.034	0.253LysTrp: 0.253 ± 0.011	0.402LysTyr: 0.402 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.454LeuAla: 15.454 ± 0.104	0.818LeuCys: 0.818 ± 0.023	6.983LeuAsp: 6.983 ± 0.072	4.787LeuGlu: 4.787 ± 0.056	2.7LeuPhe: 2.7 ± 0.039	9.635LeuGly: 9.635 ± 0.082	2.237LeuHis: 2.237 ± 0.029	3.621LeuIle: 3.621 ± 0.05	1.492LeuLys: 1.492 ± 0.034	11.494LeuLeu: 11.494 ± 0.102	1.461LeuMet: 1.461 ± 0.027	1.856LeuAsn: 1.856 ± 0.029	6.266LeuPro: 6.266 ± 0.052	2.127LeuGln: 2.127 ± 0.031	9.182LeuArg: 9.182 ± 0.067	5.735LeuSer: 5.735 ± 0.056	6.575LeuThr: 6.575 ± 0.056	9.47LeuVal: 9.47 ± 0.091	1.237LeuTrp: 1.237 ± 0.024	1.72LeuTyr: 1.72 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.162MetAla: 2.162 ± 0.033	0.122MetCys: 0.122 ± 0.008	0.875MetAsp: 0.875 ± 0.018	0.682MetGlu: 0.682 ± 0.02	0.533MetPhe: 0.533 ± 0.017	1.266MetGly: 1.266 ± 0.023	0.357MetHis: 0.357 ± 0.013	0.753MetIle: 0.753 ± 0.019	0.352MetLys: 0.352 ± 0.013	1.89MetLeu: 1.89 ± 0.029	0.312MetMet: 0.312 ± 0.013	0.45MetAsn: 0.45 ± 0.015	1.117MetPro: 1.117 ± 0.023	0.442MetGln: 0.442 ± 0.015	1.517MetArg: 1.517 ± 0.027	1.449MetSer: 1.449 ± 0.027	1.553MetThr: 1.553 ± 0.026	1.383MetVal: 1.383 ± 0.027	0.218MetTrp: 0.218 ± 0.01	0.298MetTyr: 0.298 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.35AsnAla: 2.35 ± 0.034	0.196AsnCys: 0.196 ± 0.01	1.106AsnAsp: 1.106 ± 0.02	1.045AsnGlu: 1.045 ± 0.025	0.557AsnPhe: 0.557 ± 0.017	1.965AsnGly: 1.965 ± 0.03	0.424AsnHis: 0.424 ± 0.014	0.706AsnIle: 0.706 ± 0.019	0.365AsnLys: 0.365 ± 0.015	1.947AsnLeu: 1.947 ± 0.029	0.342AsnMet: 0.342 ± 0.014	0.478AsnAsn: 0.478 ± 0.015	1.469AsnPro: 1.469 ± 0.025	0.625AsnGln: 0.625 ± 0.019	1.436AsnArg: 1.436 ± 0.025	1.164AsnSer: 1.164 ± 0.025	1.222AsnThr: 1.222 ± 0.027	1.565AsnVal: 1.565 ± 0.03	0.357AsnTrp: 0.357 ± 0.013	0.495AsnTyr: 0.495 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	7.509ProAla: 7.509 ± 0.073	0.339ProCys: 0.339 ± 0.014	4.331ProAsp: 4.331 ± 0.047	4.394ProGlu: 4.394 ± 0.046	1.533ProPhe: 1.533 ± 0.029	5.991ProGly: 5.991 ± 0.06	1.199ProHis: 1.199 ± 0.024	1.675ProIle: 1.675 ± 0.028	1.148ProLys: 1.148 ± 0.025	4.972ProLeu: 4.972 ± 0.057	1.048ProMet: 1.048 ± 0.024	1.127ProAsn: 1.127 ± 0.023	3.363ProPro: 3.363 ± 0.068	1.675ProGln: 1.675 ± 0.032	3.753ProArg: 3.753 ± 0.044	3.021ProSer: 3.021 ± 0.041	3.109ProThr: 3.109 ± 0.053	5.217ProVal: 5.217 ± 0.05	0.83ProTrp: 0.83 ± 0.019	1.068ProTyr: 1.068 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.716GlnAla: 3.716 ± 0.047	0.18GlnCys: 0.18 ± 0.009	1.411GlnAsp: 1.411 ± 0.027	1.457GlnGlu: 1.457 ± 0.027	0.824GlnPhe: 0.824 ± 0.02	2.184GlnGly: 2.184 ± 0.04	0.775GlnHis: 0.775 ± 0.02	1.2GlnIle: 1.2 ± 0.023	0.473GlnLys: 0.473 ± 0.018	3.446GlnLeu: 3.446 ± 0.044	0.445GlnMet: 0.445 ± 0.016	0.544GlnAsn: 0.544 ± 0.017	1.892GlnPro: 1.892 ± 0.041	1.434GlnGln: 1.434 ± 0.036	2.862GlnArg: 2.862 ± 0.044	1.363GlnSer: 1.363 ± 0.027	1.341GlnThr: 1.341 ± 0.022	2.673GlnVal: 2.673 ± 0.038	0.448GlnTrp: 0.448 ± 0.015	0.581GlnTyr: 0.581 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	9.35ArgAla: 9.35 ± 0.088	0.591ArgCys: 0.591 ± 0.02	4.272ArgAsp: 4.272 ± 0.051	4.76ArgGlu: 4.76 ± 0.053	2.382ArgPhe: 2.382 ± 0.036	5.818ArgGly: 5.818 ± 0.057	2.002ArgHis: 2.002 ± 0.035	3.287ArgIle: 3.287 ± 0.041	1.837ArgLys: 1.837 ± 0.033	8.436ArgLeu: 8.436 ± 0.072	1.857ArgMet: 1.857 ± 0.03	1.554ArgAsn: 1.554 ± 0.026	4.43ArgPro: 4.43 ± 0.05	2.539ArgGln: 2.539 ± 0.037	7.545ArgArg: 7.545 ± 0.07	4.454ArgSer: 4.454 ± 0.04	4.967ArgThr: 4.967 ± 0.049	6.053ArgVal: 6.053 ± 0.057	1.46ArgTrp: 1.46 ± 0.031	1.848ArgTyr: 1.848 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	7.132SerAla: 7.132 ± 0.053	0.454SerCys: 0.454 ± 0.014	2.854SerAsp: 2.854 ± 0.04	2.876SerGlu: 2.876 ± 0.042	1.627SerPhe: 1.627 ± 0.027	6.28SerGly: 6.28 ± 0.065	0.934SerHis: 0.934 ± 0.02	1.807SerIle: 1.807 ± 0.028	1.052SerLys: 1.052 ± 0.023	4.779SerLeu: 4.779 ± 0.048	1.217SerMet: 1.217 ± 0.024	0.996SerAsn: 0.996 ± 0.026	3.082SerPro: 3.082 ± 0.038	1.304SerGln: 1.304 ± 0.022	3.96SerArg: 3.96 ± 0.039	3.111SerSer: 3.111 ± 0.04	3.536SerThr: 3.536 ± 0.043	4.677SerVal: 4.677 ± 0.048	0.958SerTrp: 0.958 ± 0.023	1.218SerTyr: 1.218 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	7.945ThrAla: 7.945 ± 0.069	0.425ThrCys: 0.425 ± 0.015	3.4ThrAsp: 3.4 ± 0.038	3.858ThrGlu: 3.858 ± 0.045	1.682ThrPhe: 1.682 ± 0.03	6.261ThrGly: 6.261 ± 0.054	1.142ThrHis: 1.142 ± 0.024	2.118ThrIle: 2.118 ± 0.041	1.199ThrLys: 1.199 ± 0.025	5.57ThrLeu: 5.57 ± 0.057	1.128ThrMet: 1.128 ± 0.022	1.075ThrAsn: 1.075 ± 0.025	3.613ThrPro: 3.613 ± 0.039	1.425ThrGln: 1.425 ± 0.027	3.851ThrArg: 3.851 ± 0.046	3.368ThrSer: 3.368 ± 0.049	3.873ThrThr: 3.873 ± 0.055	6.026ThrVal: 6.026 ± 0.052	0.911ThrTrp: 0.911 ± 0.02	1.192ThrTyr: 1.192 ± 0.028	0.0ThrXaa: 0.0 ± 0.001
Val	11.296ValAla: 11.296 ± 0.086	0.719ValCys: 0.719 ± 0.021	5.479ValAsp: 5.479 ± 0.057	4.987ValGlu: 4.987 ± 0.056	2.491ValPhe: 2.491 ± 0.037	6.876ValGly: 6.876 ± 0.066	1.998ValHis: 1.998 ± 0.034	3.175ValIle: 3.175 ± 0.045	1.411ValLys: 1.411 ± 0.029	10.683ValLeu: 10.683 ± 0.082	1.245ValMet: 1.245 ± 0.024	1.822ValAsn: 1.822 ± 0.029	5.127ValPro: 5.127 ± 0.056	2.146ValGln: 2.146 ± 0.031	7.268ValArg: 7.268 ± 0.075	4.758ValSer: 4.758 ± 0.045	5.479ValThr: 5.479 ± 0.053	8.663ValVal: 8.663 ± 0.087	1.049ValTrp: 1.049 ± 0.027	1.502ValTyr: 1.502 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.55TrpAla: 1.55 ± 0.029	0.157TrpCys: 0.157 ± 0.01	0.763TrpAsp: 0.763 ± 0.02	0.663TrpGlu: 0.663 ± 0.019	0.537TrpPhe: 0.537 ± 0.017	0.95TrpGly: 0.95 ± 0.022	0.367TrpHis: 0.367 ± 0.014	0.6TrpIle: 0.6 ± 0.017	0.271TrpLys: 0.271 ± 0.011	1.893TrpLeu: 1.893 ± 0.036	0.313TrpMet: 0.313 ± 0.013	0.382TrpAsn: 0.382 ± 0.014	0.799TrpPro: 0.799 ± 0.023	0.662TrpGln: 0.662 ± 0.019	1.413TrpArg: 1.413 ± 0.027	0.927TrpSer: 0.927 ± 0.022	0.952TrpThr: 0.952 ± 0.021	1.026TrpVal: 1.026 ± 0.025	0.363TrpTrp: 0.363 ± 0.014	0.304TrpTyr: 0.304 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.285TyrAla: 2.285 ± 0.032	0.188TyrCys: 0.188 ± 0.01	1.322TyrAsp: 1.322 ± 0.035	1.072TyrGlu: 1.072 ± 0.024	0.654TyrPhe: 0.654 ± 0.02	1.986TyrGly: 1.986 ± 0.035	0.462TyrHis: 0.462 ± 0.013	0.485TyrIle: 0.485 ± 0.016	0.324TyrLys: 0.324 ± 0.015	2.311TyrLeu: 2.311 ± 0.036	0.225TyrMet: 0.225 ± 0.01	0.427TyrAsn: 0.427 ± 0.016	1.117TyrPro: 1.117 ± 0.025	0.634TyrGln: 0.634 ± 0.016	1.874TyrArg: 1.874 ± 0.032	1.115TyrSer: 1.115 ± 0.023	1.077TyrThr: 1.077 ± 0.024	1.629TyrVal: 1.629 ± 0.03	0.334TyrTrp: 0.334 ± 0.012	0.468TyrTyr: 0.468 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 6643 proteins (2101265 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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