Amino acid dipepetide frequency for Bradymonas sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.223AlaAla: 12.223 ± 0.14	1.397AlaCys: 1.397 ± 0.047	7.041AlaAsp: 7.041 ± 0.092	7.792AlaGlu: 7.792 ± 0.097	3.61AlaPhe: 3.61 ± 0.051	8.435AlaGly: 8.435 ± 0.097	2.295AlaHis: 2.295 ± 0.042	5.035AlaIle: 5.035 ± 0.069	3.953AlaLys: 3.953 ± 0.065	11.476AlaLeu: 11.476 ± 0.117	2.496AlaMet: 2.496 ± 0.047	3.017AlaAsn: 3.017 ± 0.048	5.885AlaPro: 5.885 ± 0.087	4.971AlaGln: 4.971 ± 0.069	7.608AlaArg: 7.608 ± 0.097	6.491AlaSer: 6.491 ± 0.072	5.399AlaThr: 5.399 ± 0.07	6.484AlaVal: 6.484 ± 0.077	1.236AlaTrp: 1.236 ± 0.033	2.476AlaTyr: 2.476 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.49CysAla: 1.49 ± 0.054	0.138CysCys: 0.138 ± 0.012	1.009CysAsp: 1.009 ± 0.052	0.908CysGlu: 0.908 ± 0.035	0.333CysPhe: 0.333 ± 0.016	1.243CysGly: 1.243 ± 0.045	0.23CysHis: 0.23 ± 0.015	0.442CysIle: 0.442 ± 0.021	0.286CysLys: 0.286 ± 0.012	0.838CysLeu: 0.838 ± 0.027	0.197CysMet: 0.197 ± 0.013	0.349CysAsn: 0.349 ± 0.022	0.688CysPro: 0.688 ± 0.04	0.382CysGln: 0.382 ± 0.023	0.553CysArg: 0.553 ± 0.025	0.729CysSer: 0.729 ± 0.029	0.649CysThr: 0.649 ± 0.031	0.925CysVal: 0.925 ± 0.042	0.227CysTrp: 0.227 ± 0.024	0.232CysTyr: 0.232 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	9.083AspAla: 9.083 ± 0.111	0.782AspCys: 0.782 ± 0.044	4.302AspAsp: 4.302 ± 0.084	4.736AspGlu: 4.736 ± 0.072	2.853AspPhe: 2.853 ± 0.045	5.656AspGly: 5.656 ± 0.101	1.065AspHis: 1.065 ± 0.022	3.582AspIle: 3.582 ± 0.057	2.002AspLys: 2.002 ± 0.041	5.974AspLeu: 5.974 ± 0.075	1.255AspMet: 1.255 ± 0.029	1.753AspAsn: 1.753 ± 0.047	3.761AspPro: 3.761 ± 0.06	1.84AspGln: 1.84 ± 0.039	3.155AspArg: 3.155 ± 0.052	3.537AspSer: 3.537 ± 0.063	3.36AspThr: 3.36 ± 0.064	4.11AspVal: 4.11 ± 0.066	0.918AspTrp: 0.918 ± 0.023	1.828AspTyr: 1.828 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	7.63GluAla: 7.63 ± 0.09	0.76GluCys: 0.76 ± 0.04	4.443GluAsp: 4.443 ± 0.07	4.548GluGlu: 4.548 ± 0.091	2.714GluPhe: 2.714 ± 0.043	4.372GluGly: 4.372 ± 0.058	1.503GluHis: 1.503 ± 0.036	3.82GluIle: 3.82 ± 0.066	2.799GluLys: 2.799 ± 0.056	7.193GluLeu: 7.193 ± 0.103	1.884GluMet: 1.884 ± 0.039	2.121GluAsn: 2.121 ± 0.041	3.199GluPro: 3.199 ± 0.06	2.915GluGln: 2.915 ± 0.046	5.2GluArg: 5.2 ± 0.071	3.838GluSer: 3.838 ± 0.058	3.238GluThr: 3.238 ± 0.043	5.401GluVal: 5.401 ± 0.07	0.709GluTrp: 0.709 ± 0.024	1.691GluTyr: 1.691 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.802PheAla: 3.802 ± 0.062	0.491PheCys: 0.491 ± 0.02	3.086PheAsp: 3.086 ± 0.044	3.268PheGlu: 3.268 ± 0.057	1.523PhePhe: 1.523 ± 0.036	3.578PheGly: 3.578 ± 0.055	0.744PheHis: 0.744 ± 0.022	1.659PheIle: 1.659 ± 0.034	1.312PheLys: 1.312 ± 0.03	3.227PheLeu: 3.227 ± 0.049	0.835PheMet: 0.835 ± 0.022	1.214PheAsn: 1.214 ± 0.03	1.395PhePro: 1.395 ± 0.032	1.09PheGln: 1.09 ± 0.03	2.154PheArg: 2.154 ± 0.034	2.566PheSer: 2.566 ± 0.044	1.615PheThr: 1.615 ± 0.037	2.708PheVal: 2.708 ± 0.047	0.525PheTrp: 0.525 ± 0.02	1.071PheTyr: 1.071 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	8.325GlyAla: 8.325 ± 0.091	1.16GlyCys: 1.16 ± 0.037	5.431GlyAsp: 5.431 ± 0.09	6.021GlyGlu: 6.021 ± 0.077	3.237GlyPhe: 3.237 ± 0.054	6.521GlyGly: 6.521 ± 0.111	1.661GlyHis: 1.661 ± 0.034	3.749GlyIle: 3.749 ± 0.064	2.912GlyLys: 2.912 ± 0.045	7.305GlyLeu: 7.305 ± 0.082	1.855GlyMet: 1.855 ± 0.037	2.222GlyAsn: 2.222 ± 0.047	2.942GlyPro: 2.942 ± 0.05	2.95GlyGln: 2.95 ± 0.055	4.81GlyArg: 4.81 ± 0.064	4.537GlySer: 4.537 ± 0.07	4.018GlyThr: 4.018 ± 0.067	6.18GlyVal: 6.18 ± 0.091	1.155GlyTrp: 1.155 ± 0.03	2.233GlyTyr: 2.233 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.098HisAla: 2.098 ± 0.041	0.238HisCys: 0.238 ± 0.013	1.133HisAsp: 1.133 ± 0.028	1.14HisGlu: 1.14 ± 0.028	0.93HisPhe: 0.93 ± 0.028	1.542HisGly: 1.542 ± 0.036	0.571HisHis: 0.571 ± 0.024	1.156HisIle: 1.156 ± 0.032	0.597HisLys: 0.597 ± 0.02	2.173HisLeu: 2.173 ± 0.034	0.375HisMet: 0.375 ± 0.018	0.5HisAsn: 0.5 ± 0.02	1.307HisPro: 1.307 ± 0.026	0.752HisGln: 0.752 ± 0.026	1.406HisArg: 1.406 ± 0.03	1.035HisSer: 1.035 ± 0.029	1.052HisThr: 1.052 ± 0.029	1.064HisVal: 1.064 ± 0.029	0.314HisTrp: 0.314 ± 0.015	0.642HisTyr: 0.642 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.436IleAla: 5.436 ± 0.061	0.666IleCys: 0.666 ± 0.027	3.803IleAsp: 3.803 ± 0.059	3.981IleGlu: 3.981 ± 0.056	2.118IlePhe: 2.118 ± 0.037	3.912IleGly: 3.912 ± 0.06	0.994IleHis: 0.994 ± 0.025	2.394IleIle: 2.394 ± 0.045	1.683IleLys: 1.683 ± 0.031	4.468IleLeu: 4.468 ± 0.066	0.896IleMet: 0.896 ± 0.026	1.563IleAsn: 1.563 ± 0.036	2.329IlePro: 2.329 ± 0.042	1.55IleGln: 1.55 ± 0.033	2.934IleArg: 2.934 ± 0.048	3.122IleSer: 3.122 ± 0.044	2.527IleThr: 2.527 ± 0.048	3.274IleVal: 3.274 ± 0.056	0.584IleTrp: 0.584 ± 0.022	1.377IleTyr: 1.377 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.544LysAla: 3.544 ± 0.07	0.236LysCys: 0.236 ± 0.014	1.982LysAsp: 1.982 ± 0.043	2.044LysGlu: 2.044 ± 0.051	1.263LysPhe: 1.263 ± 0.031	2.257LysGly: 2.257 ± 0.044	0.692LysHis: 0.692 ± 0.027	2.185LysIle: 2.185 ± 0.044	2.187LysLys: 2.187 ± 0.06	3.692LysLeu: 3.692 ± 0.053	1.075LysMet: 1.075 ± 0.031	1.256LysAsn: 1.256 ± 0.034	1.984LysPro: 1.984 ± 0.049	1.121LysGln: 1.121 ± 0.027	2.511LysArg: 2.511 ± 0.048	2.451LysSer: 2.451 ± 0.059	2.17LysThr: 2.17 ± 0.043	2.549LysVal: 2.549 ± 0.041	0.406LysTrp: 0.406 ± 0.017	1.007LysTyr: 1.007 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	10.507LeuAla: 10.507 ± 0.106	0.983LeuCys: 0.983 ± 0.026	6.397LeuAsp: 6.397 ± 0.071	7.016LeuGlu: 7.016 ± 0.112	3.489LeuPhe: 3.489 ± 0.057	8.211LeuGly: 8.211 ± 0.089	1.865LeuHis: 1.865 ± 0.041	4.465LeuIle: 4.465 ± 0.062	3.92LeuLys: 3.92 ± 0.055	9.426LeuLeu: 9.426 ± 0.113	2.045LeuMet: 2.045 ± 0.038	3.194LeuAsn: 3.194 ± 0.045	4.475LeuPro: 4.475 ± 0.064	3.097LeuGln: 3.097 ± 0.048	6.675LeuArg: 6.675 ± 0.078	6.756LeuSer: 6.756 ± 0.073	4.628LeuThr: 4.628 ± 0.06	6.602LeuVal: 6.602 ± 0.082	1.036LeuTrp: 1.036 ± 0.032	2.273LeuTyr: 2.273 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.284MetAla: 2.284 ± 0.046	0.186MetCys: 0.186 ± 0.013	1.045MetAsp: 1.045 ± 0.028	1.161MetGlu: 1.161 ± 0.027	0.522MetPhe: 0.522 ± 0.022	1.804MetGly: 1.804 ± 0.037	0.428MetHis: 0.428 ± 0.02	1.122MetIle: 1.122 ± 0.028	0.979MetLys: 0.979 ± 0.026	2.403MetLeu: 2.403 ± 0.041	0.638MetMet: 0.638 ± 0.024	0.798MetAsn: 0.798 ± 0.026	1.238MetPro: 1.238 ± 0.034	0.807MetGln: 0.807 ± 0.026	1.711MetArg: 1.711 ± 0.035	1.729MetSer: 1.729 ± 0.034	1.403MetThr: 1.403 ± 0.034	1.569MetVal: 1.569 ± 0.036	0.214MetTrp: 0.214 ± 0.012	0.352MetTyr: 0.352 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.275AsnAla: 3.275 ± 0.044	0.451AsnCys: 0.451 ± 0.03	1.73AsnAsp: 1.73 ± 0.036	1.669AsnGlu: 1.669 ± 0.039	1.24AsnPhe: 1.24 ± 0.032	2.376AsnGly: 2.376 ± 0.051	0.618AsnHis: 0.618 ± 0.021	1.75AsnIle: 1.75 ± 0.034	0.98AsnLys: 0.98 ± 0.025	2.99AsnLeu: 2.99 ± 0.045	0.632AsnMet: 0.632 ± 0.02	1.122AsnAsn: 1.122 ± 0.033	2.24AsnPro: 2.24 ± 0.044	1.123AsnGln: 1.123 ± 0.026	1.817AsnArg: 1.817 ± 0.037	1.768AsnSer: 1.768 ± 0.037	1.727AsnThr: 1.727 ± 0.04	1.729AsnVal: 1.729 ± 0.036	0.417AsnTrp: 0.417 ± 0.018	0.91AsnTyr: 0.91 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.638ProAla: 5.638 ± 0.076	0.382ProCys: 0.382 ± 0.016	3.71ProAsp: 3.71 ± 0.062	4.304ProGlu: 4.304 ± 0.067	1.632ProPhe: 1.632 ± 0.035	4.215ProGly: 4.215 ± 0.067	0.923ProHis: 0.923 ± 0.027	2.218ProIle: 2.218 ± 0.042	1.979ProLys: 1.979 ± 0.039	3.955ProLeu: 3.955 ± 0.066	1.147ProMet: 1.147 ± 0.025	1.732ProAsn: 1.732 ± 0.039	2.374ProPro: 2.374 ± 0.053	1.813ProGln: 1.813 ± 0.038	2.64ProArg: 2.64 ± 0.045	3.212ProSer: 3.212 ± 0.05	2.936ProThr: 2.936 ± 0.047	3.333ProVal: 3.333 ± 0.052	0.557ProTrp: 0.557 ± 0.021	1.141ProTyr: 1.141 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.065GlnAla: 4.065 ± 0.063	0.4GlnCys: 0.4 ± 0.024	1.866GlnAsp: 1.866 ± 0.04	1.964GlnGlu: 1.964 ± 0.038	1.23GlnPhe: 1.23 ± 0.028	2.464GlnGly: 2.464 ± 0.038	0.635GlnHis: 0.635 ± 0.02	2.049GlnIle: 2.049 ± 0.037	1.684GlnLys: 1.684 ± 0.036	3.504GlnLeu: 3.504 ± 0.059	0.924GlnMet: 0.924 ± 0.027	1.301GlnAsn: 1.301 ± 0.03	1.855GlnPro: 1.855 ± 0.036	1.423GlnGln: 1.423 ± 0.041	2.615GlnArg: 2.615 ± 0.048	2.074GlnSer: 2.074 ± 0.038	2.06GlnThr: 2.06 ± 0.039	2.696GlnVal: 2.696 ± 0.047	0.472GlnTrp: 0.472 ± 0.019	0.802GlnTyr: 0.802 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.426ArgAla: 7.426 ± 0.099	0.644ArgCys: 0.644 ± 0.024	4.043ArgAsp: 4.043 ± 0.053	4.55ArgGlu: 4.55 ± 0.07	2.527ArgPhe: 2.527 ± 0.04	4.459ArgGly: 4.459 ± 0.065	1.353ArgHis: 1.353 ± 0.037	3.346ArgIle: 3.346 ± 0.049	2.23ArgLys: 2.23 ± 0.046	6.553ArgLeu: 6.553 ± 0.088	1.449ArgMet: 1.449 ± 0.033	1.752ArgAsn: 1.752 ± 0.036	2.93ArgPro: 2.93 ± 0.043	2.462ArgGln: 2.462 ± 0.04	4.882ArgArg: 4.882 ± 0.085	3.433ArgSer: 3.433 ± 0.053	2.779ArgThr: 2.779 ± 0.053	5.093ArgVal: 5.093 ± 0.064	0.951ArgTrp: 0.951 ± 0.03	1.807ArgTyr: 1.807 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	7.005SerAla: 7.005 ± 0.077	0.747SerCys: 0.747 ± 0.038	4.049SerAsp: 4.049 ± 0.073	3.855SerGlu: 3.855 ± 0.055	2.251SerPhe: 2.251 ± 0.035	5.52SerGly: 5.52 ± 0.076	1.098SerHis: 1.098 ± 0.027	2.794SerIle: 2.794 ± 0.046	2.199SerLys: 2.199 ± 0.043	5.615SerLeu: 5.615 ± 0.066	1.343SerMet: 1.343 ± 0.033	1.967SerAsn: 1.967 ± 0.034	3.222SerPro: 3.222 ± 0.055	2.088SerGln: 2.088 ± 0.04	3.483SerArg: 3.483 ± 0.052	3.849SerSer: 3.849 ± 0.059	3.386SerThr: 3.386 ± 0.059	4.282SerVal: 4.282 ± 0.054	0.741SerTrp: 0.741 ± 0.023	1.506SerTyr: 1.506 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	4.404ThrAla: 4.404 ± 0.058	0.767ThrCys: 0.767 ± 0.044	2.969ThrAsp: 2.969 ± 0.054	2.794ThrGlu: 2.794 ± 0.049	1.946ThrPhe: 1.946 ± 0.044	4.095ThrGly: 4.095 ± 0.062	1.17ThrHis: 1.17 ± 0.032	2.681ThrIle: 2.681 ± 0.051	1.493ThrLys: 1.493 ± 0.037	5.659ThrLeu: 5.659 ± 0.066	1.045ThrMet: 1.045 ± 0.026	1.531ThrAsn: 1.531 ± 0.035	3.492ThrPro: 3.492 ± 0.056	1.953ThrGln: 1.953 ± 0.038	3.459ThrArg: 3.459 ± 0.048	3.122ThrSer: 3.122 ± 0.047	2.77ThrThr: 2.77 ± 0.054	3.701ThrVal: 3.701 ± 0.07	0.61ThrTrp: 0.61 ± 0.025	1.41ThrTyr: 1.41 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	7.57ValAla: 7.57 ± 0.08	0.894ValCys: 0.894 ± 0.034	5.224ValAsp: 5.224 ± 0.063	5.819ValGlu: 5.819 ± 0.069	2.698ValPhe: 2.698 ± 0.043	5.693ValGly: 5.693 ± 0.08	1.348ValHis: 1.348 ± 0.034	3.383ValIle: 3.383 ± 0.057	2.102ValLys: 2.102 ± 0.049	6.543ValLeu: 6.543 ± 0.062	1.407ValMet: 1.407 ± 0.034	1.976ValAsn: 1.976 ± 0.035	2.874ValPro: 2.874 ± 0.047	2.102ValGln: 2.102 ± 0.038	4.194ValArg: 4.194 ± 0.061	4.359ValSer: 4.359 ± 0.063	3.426ValThr: 3.426 ± 0.064	5.2ValVal: 5.2 ± 0.07	0.773ValTrp: 0.773 ± 0.023	1.684ValTyr: 1.684 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.149TrpAla: 1.149 ± 0.032	0.144TrpCys: 0.144 ± 0.011	0.641TrpAsp: 0.641 ± 0.024	0.738TrpGlu: 0.738 ± 0.026	0.457TrpPhe: 0.457 ± 0.019	0.973TrpGly: 0.973 ± 0.037	0.267TrpHis: 0.267 ± 0.015	0.533TrpIle: 0.533 ± 0.02	0.506TrpLys: 0.506 ± 0.017	1.318TrpLeu: 1.318 ± 0.038	0.351TrpMet: 0.351 ± 0.017	0.375TrpAsn: 0.375 ± 0.018	0.522TrpPro: 0.522 ± 0.02	0.54TrpGln: 0.54 ± 0.02	0.933TrpArg: 0.933 ± 0.027	0.85TrpSer: 0.85 ± 0.025	0.673TrpThr: 0.673 ± 0.022	0.936TrpVal: 0.936 ± 0.027	0.208TrpTrp: 0.208 ± 0.013	0.301TrpTyr: 0.301 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.367TyrAla: 2.367 ± 0.041	0.379TyrCys: 0.379 ± 0.02	1.648TyrAsp: 1.648 ± 0.039	1.671TyrGlu: 1.671 ± 0.041	1.289TyrPhe: 1.289 ± 0.034	1.899TyrGly: 1.899 ± 0.037	0.564TyrHis: 0.564 ± 0.023	1.25TyrIle: 1.25 ± 0.033	0.811TyrLys: 0.811 ± 0.022	2.746TyrLeu: 2.746 ± 0.05	0.542TyrMet: 0.542 ± 0.019	0.822TyrAsn: 0.822 ± 0.025	1.127TyrPro: 1.127 ± 0.028	1.104TyrGln: 1.104 ± 0.032	1.926TyrArg: 1.926 ± 0.04	1.546TyrSer: 1.546 ± 0.04	1.257TyrThr: 1.257 ± 0.032	1.434TyrVal: 1.434 ± 0.031	0.36TyrTrp: 0.36 ± 0.016	0.858TyrTyr: 0.858 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3697 proteins (1449336 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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