Amino acid dipepetide frequency for Aspergillus novoparasiticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.96AlaAla: 7.96 ± 0.049	1.171AlaCys: 1.171 ± 0.015	3.995AlaAsp: 3.995 ± 0.028	4.772AlaGlu: 4.772 ± 0.033	3.187AlaPhe: 3.187 ± 0.026	5.501AlaGly: 5.501 ± 0.033	1.758AlaHis: 1.758 ± 0.016	4.426AlaIle: 4.426 ± 0.032	3.665AlaLys: 3.665 ± 0.029	7.755AlaLeu: 7.755 ± 0.039	1.958AlaMet: 1.958 ± 0.02	2.849AlaAsn: 2.849 ± 0.021	4.25AlaPro: 4.25 ± 0.038	3.193AlaGln: 3.193 ± 0.027	4.577AlaArg: 4.577 ± 0.032	6.824AlaSer: 6.824 ± 0.036	5.058AlaThr: 5.058 ± 0.033	5.325AlaVal: 5.325 ± 0.036	1.188AlaTrp: 1.188 ± 0.018	2.264AlaTyr: 2.264 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	1.035CysAla: 1.035 ± 0.013	0.282CysCys: 0.282 ± 0.007	0.737CysAsp: 0.737 ± 0.012	0.662CysGlu: 0.662 ± 0.011	0.608CysPhe: 0.608 ± 0.01	0.993CysGly: 0.993 ± 0.014	0.382CysHis: 0.382 ± 0.008	0.808CysIle: 0.808 ± 0.013	0.53CysLys: 0.53 ± 0.01	1.478CysLeu: 1.478 ± 0.017	0.314CysMet: 0.314 ± 0.007	0.483CysAsn: 0.483 ± 0.009	0.729CysPro: 0.729 ± 0.014	0.531CysGln: 0.531 ± 0.01	0.865CysArg: 0.865 ± 0.012	1.076CysSer: 1.076 ± 0.014	0.774CysThr: 0.774 ± 0.013	0.895CysVal: 0.895 ± 0.014	0.23CysTrp: 0.23 ± 0.006	0.418CysTyr: 0.418 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.344AspAla: 4.344 ± 0.027	0.685AspCys: 0.685 ± 0.011	3.716AspAsp: 3.716 ± 0.036	4.042AspGlu: 4.042 ± 0.036	2.148AspPhe: 2.148 ± 0.019	3.929AspGly: 3.929 ± 0.028	1.291AspHis: 1.291 ± 0.015	3.292AspIle: 3.292 ± 0.023	2.247AspLys: 2.247 ± 0.024	5.146AspLeu: 5.146 ± 0.03	1.273AspMet: 1.273 ± 0.015	1.96AspAsn: 1.96 ± 0.019	3.302AspPro: 3.302 ± 0.024	1.932AspGln: 1.932 ± 0.019	3.077AspArg: 3.077 ± 0.025	4.118AspSer: 4.118 ± 0.027	3.04AspThr: 3.04 ± 0.023	3.62AspVal: 3.62 ± 0.025	0.904AspTrp: 0.904 ± 0.011	1.691AspTyr: 1.691 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.005GluAla: 5.005 ± 0.034	0.706GluCys: 0.706 ± 0.013	3.902GluAsp: 3.902 ± 0.03	5.066GluGlu: 5.066 ± 0.042	1.959GluPhe: 1.959 ± 0.019	3.636GluGly: 3.636 ± 0.026	1.402GluHis: 1.402 ± 0.016	3.105GluIle: 3.105 ± 0.023	3.554GluLys: 3.554 ± 0.028	5.189GluLeu: 5.189 ± 0.029	1.39GluMet: 1.39 ± 0.013	2.364GluAsn: 2.364 ± 0.019	2.724GluPro: 2.724 ± 0.038	2.452GluGln: 2.452 ± 0.022	3.789GluArg: 3.789 ± 0.031	4.333GluSer: 4.333 ± 0.034	3.482GluThr: 3.482 ± 0.028	3.522GluVal: 3.522 ± 0.027	0.909GluTrp: 0.909 ± 0.013	1.794GluTyr: 1.794 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.028PheAla: 3.028 ± 0.023	0.624PheCys: 0.624 ± 0.01	2.275PheAsp: 2.275 ± 0.021	2.084PheGlu: 2.084 ± 0.018	1.762PhePhe: 1.762 ± 0.019	2.858PheGly: 2.858 ± 0.024	1.017PheHis: 1.017 ± 0.012	1.996PheIle: 1.996 ± 0.021	1.468PheLys: 1.468 ± 0.017	3.803PheLeu: 3.803 ± 0.029	0.821PheMet: 0.821 ± 0.012	1.489PheAsn: 1.489 ± 0.016	2.072PhePro: 2.072 ± 0.018	1.501PheGln: 1.501 ± 0.017	2.049PheArg: 2.049 ± 0.018	3.101PheSer: 3.101 ± 0.026	2.262PheThr: 2.262 ± 0.02	2.451PheVal: 2.451 ± 0.022	0.687PheTrp: 0.687 ± 0.011	1.244PheTyr: 1.244 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.082GlyAla: 5.082 ± 0.036	0.978GlyCys: 0.978 ± 0.013	3.563GlyAsp: 3.563 ± 0.027	3.523GlyGlu: 3.523 ± 0.029	2.9GlyPhe: 2.9 ± 0.02	5.244GlyGly: 5.244 ± 0.043	1.7GlyHis: 1.7 ± 0.021	3.766GlyIle: 3.766 ± 0.03	3.278GlyLys: 3.278 ± 0.025	6.343GlyLeu: 6.343 ± 0.032	1.553GlyMet: 1.553 ± 0.017	2.587GlyAsn: 2.587 ± 0.022	3.286GlyPro: 3.286 ± 0.026	2.579GlyGln: 2.579 ± 0.021	3.921GlyArg: 3.921 ± 0.028	5.657GlySer: 5.657 ± 0.033	3.977GlyThr: 3.977 ± 0.025	4.515GlyVal: 4.515 ± 0.03	1.232GlyTrp: 1.232 ± 0.015	2.282GlyTyr: 2.282 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	1.816HisAla: 1.816 ± 0.018	0.399HisCys: 0.399 ± 0.009	1.341HisAsp: 1.341 ± 0.014	1.336HisGlu: 1.336 ± 0.015	0.963HisPhe: 0.963 ± 0.013	1.762HisGly: 1.762 ± 0.017	0.857HisHis: 0.857 ± 0.015	1.342HisIle: 1.342 ± 0.014	0.886HisLys: 0.886 ± 0.012	2.36HisLeu: 2.36 ± 0.02	0.519HisMet: 0.519 ± 0.01	0.876HisAsn: 0.876 ± 0.012	1.712HisPro: 1.712 ± 0.018	0.971HisGln: 0.971 ± 0.014	1.596HisArg: 1.596 ± 0.018	1.955HisSer: 1.955 ± 0.019	1.333HisThr: 1.333 ± 0.015	1.472HisVal: 1.472 ± 0.015	0.398HisTrp: 0.398 ± 0.009	0.758HisTyr: 0.758 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.34IleAla: 4.34 ± 0.031	0.881IleCys: 0.881 ± 0.012	2.906IleAsp: 2.906 ± 0.023	2.918IleGlu: 2.918 ± 0.019	2.185IlePhe: 2.185 ± 0.022	3.433IleGly: 3.433 ± 0.031	1.335IleHis: 1.335 ± 0.015	2.775IleIle: 2.775 ± 0.024	2.063IleLys: 2.063 ± 0.02	5.0IleLeu: 5.0 ± 0.032	1.074IleMet: 1.074 ± 0.013	1.896IleAsn: 1.896 ± 0.017	3.246IlePro: 3.246 ± 0.023	2.053IleGln: 2.053 ± 0.019	2.925IleArg: 2.925 ± 0.02	4.152IleSer: 4.152 ± 0.027	2.975IleThr: 2.975 ± 0.022	3.396IleVal: 3.396 ± 0.027	0.773IleTrp: 0.773 ± 0.011	1.61IleTyr: 1.61 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.913LysAla: 3.913 ± 0.03	0.558LysCys: 0.558 ± 0.01	2.723LysAsp: 2.723 ± 0.023	3.225LysGlu: 3.225 ± 0.026	1.402LysPhe: 1.402 ± 0.016	2.877LysGly: 2.877 ± 0.023	1.097LysHis: 1.097 ± 0.013	2.179LysIle: 2.179 ± 0.022	2.834LysLys: 2.834 ± 0.035	3.957LysLeu: 3.957 ± 0.026	0.917LysMet: 0.917 ± 0.013	1.692LysAsn: 1.692 ± 0.018	2.534LysPro: 2.534 ± 0.021	1.785LysGln: 1.785 ± 0.019	3.149LysArg: 3.149 ± 0.026	3.307LysSer: 3.307 ± 0.026	2.603LysThr: 2.603 ± 0.021	2.795LysVal: 2.795 ± 0.02	0.671LysTrp: 0.671 ± 0.011	1.402LysTyr: 1.402 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	7.738LeuAla: 7.738 ± 0.04	1.382LeuCys: 1.382 ± 0.015	5.216LeuAsp: 5.216 ± 0.033	5.57LeuGlu: 5.57 ± 0.039	3.609LeuPhe: 3.609 ± 0.03	6.206LeuGly: 6.206 ± 0.035	2.386LeuHis: 2.386 ± 0.02	4.305LeuIle: 4.305 ± 0.03	4.053LeuLys: 4.053 ± 0.026	8.903LeuLeu: 8.903 ± 0.054	1.902LeuMet: 1.902 ± 0.019	3.363LeuAsn: 3.363 ± 0.022	5.565LeuPro: 5.565 ± 0.034	3.989LeuGln: 3.989 ± 0.031	5.832LeuArg: 5.832 ± 0.032	7.774LeuSer: 7.774 ± 0.037	4.972LeuThr: 4.972 ± 0.031	5.728LeuVal: 5.728 ± 0.031	1.305LeuTrp: 1.305 ± 0.016	2.647LeuTyr: 2.647 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.131MetAla: 2.131 ± 0.02	0.284MetCys: 0.284 ± 0.007	1.221MetAsp: 1.221 ± 0.013	1.285MetGlu: 1.285 ± 0.014	0.761MetPhe: 0.761 ± 0.013	1.484MetGly: 1.484 ± 0.016	0.489MetHis: 0.489 ± 0.008	1.071MetIle: 1.071 ± 0.014	1.011MetLys: 1.011 ± 0.013	1.903MetLeu: 1.903 ± 0.017	0.551MetMet: 0.551 ± 0.01	0.826MetAsn: 0.826 ± 0.011	1.19MetPro: 1.19 ± 0.014	0.857MetGln: 0.857 ± 0.013	1.248MetArg: 1.248 ± 0.015	1.861MetSer: 1.861 ± 0.018	1.308MetThr: 1.308 ± 0.014	1.395MetVal: 1.395 ± 0.015	0.28MetTrp: 0.28 ± 0.007	0.56MetTyr: 0.56 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.07AsnAla: 3.07 ± 0.024	0.51AsnCys: 0.51 ± 0.01	1.983AsnAsp: 1.983 ± 0.017	2.064AsnGlu: 2.064 ± 0.017	1.387AsnPhe: 1.387 ± 0.014	2.955AsnGly: 2.955 ± 0.023	0.914AsnHis: 0.914 ± 0.011	2.215AsnIle: 2.215 ± 0.02	1.5AsnLys: 1.5 ± 0.015	3.321AsnLeu: 3.321 ± 0.024	0.88AsnMet: 0.88 ± 0.013	1.503AsnAsn: 1.503 ± 0.017	2.481AsnPro: 2.481 ± 0.022	1.37AsnGln: 1.37 ± 0.015	1.98AsnArg: 1.98 ± 0.018	2.779AsnSer: 2.779 ± 0.02	2.25AsnThr: 2.25 ± 0.019	2.403AsnVal: 2.403 ± 0.021	0.592AsnTrp: 0.592 ± 0.01	1.131AsnTyr: 1.131 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	4.614ProAla: 4.614 ± 0.038	0.62ProCys: 0.62 ± 0.012	3.184ProAsp: 3.184 ± 0.025	3.84ProGlu: 3.84 ± 0.038	2.15ProPhe: 2.15 ± 0.018	3.835ProGly: 3.835 ± 0.029	1.317ProHis: 1.317 ± 0.017	2.591ProIle: 2.591 ± 0.022	2.489ProLys: 2.489 ± 0.022	4.774ProLeu: 4.774 ± 0.032	1.054ProMet: 1.054 ± 0.015	2.183ProAsn: 2.183 ± 0.019	4.365ProPro: 4.365 ± 0.063	2.36ProGln: 2.36 ± 0.023	3.299ProArg: 3.299 ± 0.031	5.842ProSer: 5.842 ± 0.049	3.838ProThr: 3.838 ± 0.029	3.626ProVal: 3.626 ± 0.028	0.81ProTrp: 0.81 ± 0.012	1.586ProTyr: 1.586 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.255GlnAla: 3.255 ± 0.025	0.514GlnCys: 0.514 ± 0.01	2.068GlnAsp: 2.068 ± 0.015	2.444GlnGlu: 2.444 ± 0.024	1.342GlnPhe: 1.342 ± 0.013	2.508GlnGly: 2.508 ± 0.022	1.053GlnHis: 1.053 ± 0.014	1.967GlnIle: 1.967 ± 0.017	1.983GlnLys: 1.983 ± 0.018	3.564GlnLeu: 3.564 ± 0.027	0.879GlnMet: 0.879 ± 0.013	1.585GlnAsn: 1.585 ± 0.016	2.443GlnPro: 2.443 ± 0.03	2.177GlnGln: 2.177 ± 0.032	2.593GlnArg: 2.593 ± 0.022	3.202GlnSer: 3.202 ± 0.028	2.355GlnThr: 2.355 ± 0.019	2.251GlnVal: 2.251 ± 0.018	0.622GlnTrp: 0.622 ± 0.009	1.229GlnTyr: 1.229 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.412ArgAla: 4.412 ± 0.03	0.788ArgCys: 0.788 ± 0.013	3.265ArgAsp: 3.265 ± 0.03	3.7ArgGlu: 3.7 ± 0.03	2.248ArgPhe: 2.248 ± 0.019	3.581ArgGly: 3.581 ± 0.031	1.576ArgHis: 1.576 ± 0.017	2.952ArgIle: 2.952 ± 0.023	3.253ArgLys: 3.253 ± 0.028	5.666ArgLeu: 5.666 ± 0.031	1.285ArgMet: 1.285 ± 0.013	2.254ArgAsn: 2.254 ± 0.021	3.315ArgPro: 3.315 ± 0.029	2.554ArgGln: 2.554 ± 0.027	4.827ArgArg: 4.827 ± 0.044	4.707ArgSer: 4.707 ± 0.035	3.244ArgThr: 3.244 ± 0.024	3.465ArgVal: 3.465 ± 0.025	0.998ArgTrp: 0.998 ± 0.013	1.81ArgTyr: 1.81 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.37SerAla: 6.37 ± 0.039	1.029SerCys: 1.029 ± 0.013	4.272SerAsp: 4.272 ± 0.028	4.252SerGlu: 4.252 ± 0.031	3.2SerPhe: 3.2 ± 0.025	5.503SerGly: 5.503 ± 0.029	2.042SerHis: 2.042 ± 0.018	4.227SerIle: 4.227 ± 0.027	3.561SerLys: 3.561 ± 0.029	7.657SerLeu: 7.657 ± 0.037	1.723SerMet: 1.723 ± 0.019	3.051SerAsn: 3.051 ± 0.024	5.21SerPro: 5.21 ± 0.045	3.364SerGln: 3.364 ± 0.027	4.937SerArg: 4.937 ± 0.038	8.5SerSer: 8.5 ± 0.058	5.491SerThr: 5.491 ± 0.036	4.763SerVal: 4.763 ± 0.026	1.23SerTrp: 1.23 ± 0.014	2.214SerTyr: 2.214 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.007ThrAla: 5.007 ± 0.032	0.821ThrCys: 0.821 ± 0.013	2.946ThrAsp: 2.946 ± 0.024	3.205ThrGlu: 3.205 ± 0.024	2.317ThrPhe: 2.317 ± 0.019	4.289ThrGly: 4.289 ± 0.028	1.331ThrHis: 1.331 ± 0.013	3.24ThrIle: 3.24 ± 0.026	2.499ThrLys: 2.499 ± 0.02	5.413ThrLeu: 5.413 ± 0.032	1.211ThrMet: 1.211 ± 0.015	2.112ThrAsn: 2.112 ± 0.019	4.062ThrPro: 4.062 ± 0.031	2.094ThrGln: 2.094 ± 0.02	3.02ThrArg: 3.02 ± 0.021	5.192ThrSer: 5.192 ± 0.038	4.085ThrThr: 4.085 ± 0.033	3.948ThrVal: 3.948 ± 0.025	0.929ThrTrp: 0.929 ± 0.014	1.717ThrTyr: 1.717 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.158ValAla: 5.158 ± 0.032	0.922ValCys: 0.922 ± 0.013	3.772ValAsp: 3.772 ± 0.024	3.778ValGlu: 3.778 ± 0.029	2.601ValPhe: 2.601 ± 0.023	4.138ValGly: 4.138 ± 0.033	1.483ValHis: 1.483 ± 0.015	3.21ValIle: 3.21 ± 0.024	2.782ValLys: 2.782 ± 0.023	5.832ValLeu: 5.832 ± 0.033	1.355ValMet: 1.355 ± 0.013	2.324ValAsn: 2.324 ± 0.02	3.615ValPro: 3.615 ± 0.022	2.462ValGln: 2.462 ± 0.02	3.467ValArg: 3.467 ± 0.021	4.903ValSer: 4.903 ± 0.026	3.659ValThr: 3.659 ± 0.029	4.353ValVal: 4.353 ± 0.033	0.912ValTrp: 0.912 ± 0.014	1.914ValTyr: 1.914 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.149TrpAla: 1.149 ± 0.016	0.219TrpCys: 0.219 ± 0.006	0.953TrpAsp: 0.953 ± 0.015	0.894TrpGlu: 0.894 ± 0.014	0.578TrpPhe: 0.578 ± 0.011	0.992TrpGly: 0.992 ± 0.013	0.389TrpHis: 0.389 ± 0.009	0.843TrpIle: 0.843 ± 0.012	0.845TrpLys: 0.845 ± 0.012	1.475TrpLeu: 1.475 ± 0.018	0.388TrpMet: 0.388 ± 0.008	0.684TrpAsn: 0.684 ± 0.011	0.641TrpPro: 0.641 ± 0.01	0.599TrpGln: 0.599 ± 0.01	0.985TrpArg: 0.985 ± 0.015	1.116TrpSer: 1.116 ± 0.014	0.974TrpThr: 0.974 ± 0.013	0.961TrpVal: 0.961 ± 0.014	0.293TrpTrp: 0.293 ± 0.008	0.485TrpTyr: 0.485 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.247TyrAla: 2.247 ± 0.02	0.458TyrCys: 0.458 ± 0.009	1.722TyrAsp: 1.722 ± 0.018	1.622TyrGlu: 1.622 ± 0.017	1.285TyrPhe: 1.285 ± 0.017	2.241TyrGly: 2.241 ± 0.022	0.833TyrHis: 0.833 ± 0.012	1.625TyrIle: 1.625 ± 0.016	1.12TyrLys: 1.12 ± 0.014	2.907TyrLeu: 2.907 ± 0.023	0.67TyrMet: 0.67 ± 0.011	1.206TyrAsn: 1.206 ± 0.014	1.635TyrPro: 1.635 ± 0.018	1.21TyrGln: 1.21 ± 0.017	1.767TyrArg: 1.767 ± 0.015	2.195TyrSer: 2.195 ± 0.022	1.759TyrThr: 1.759 ± 0.019	1.756TyrVal: 1.756 ± 0.016	0.498TyrTrp: 0.498 ± 0.009	1.038TyrTyr: 1.038 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 14181 proteins (6421159 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---