Amino acid dipepetide frequency for Perkinsus marinus (strain ATCC 50983 / TXsc)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.351AlaAla: 9.351 ± 0.066	1.468AlaCys: 1.468 ± 0.019	4.554AlaAsp: 4.554 ± 0.024	5.523AlaGlu: 5.523 ± 0.037	2.858AlaPhe: 2.858 ± 0.02	5.455AlaGly: 5.455 ± 0.031	1.648AlaHis: 1.648 ± 0.018	3.87AlaIle: 3.87 ± 0.024	4.124AlaLys: 4.124 ± 0.032	7.858AlaLeu: 7.858 ± 0.039	2.263AlaMet: 2.263 ± 0.016	2.498AlaAsn: 2.498 ± 0.018	3.877AlaPro: 3.877 ± 0.039	2.775AlaGln: 2.775 ± 0.022	4.82AlaArg: 4.82 ± 0.028	6.449AlaSer: 6.449 ± 0.034	5.163AlaThr: 5.163 ± 0.038	6.588AlaVal: 6.588 ± 0.03	0.924AlaTrp: 0.924 ± 0.012	2.04AlaTyr: 2.04 ± 0.016	0.006AlaXaa: 0.006 ± 0.001
Cys	1.324CysAla: 1.324 ± 0.014	0.447CysCys: 0.447 ± 0.009	1.153CysAsp: 1.153 ± 0.013	1.037CysGlu: 1.037 ± 0.013	0.714CysPhe: 0.714 ± 0.01	1.604CysGly: 1.604 ± 0.017	0.465CysHis: 0.465 ± 0.009	1.014CysIle: 1.014 ± 0.012	0.854CysLys: 0.854 ± 0.012	1.71CysLeu: 1.71 ± 0.019	0.477CysMet: 0.477 ± 0.008	0.603CysAsn: 0.603 ± 0.01	1.031CysPro: 1.031 ± 0.015	0.634CysGln: 0.634 ± 0.011	1.315CysArg: 1.315 ± 0.014	1.439CysSer: 1.439 ± 0.015	0.994CysThr: 0.994 ± 0.012	1.277CysVal: 1.277 ± 0.016	0.287CysTrp: 0.287 ± 0.006	0.534CysTyr: 0.534 ± 0.008	0.001CysXaa: 0.001 ± 0.0
Asp	4.699AspAla: 4.699 ± 0.026	1.042AspCys: 1.042 ± 0.013	4.978AspAsp: 4.978 ± 0.036	4.69AspGlu: 4.69 ± 0.032	2.164AspPhe: 2.164 ± 0.019	4.532AspGly: 4.532 ± 0.033	1.328AspHis: 1.328 ± 0.015	3.055AspIle: 3.055 ± 0.023	2.779AspLys: 2.779 ± 0.024	5.117AspLeu: 5.117 ± 0.027	1.514AspMet: 1.514 ± 0.016	1.923AspAsn: 1.923 ± 0.018	2.949AspPro: 2.949 ± 0.023	1.722AspGln: 1.722 ± 0.018	3.255AspArg: 3.255 ± 0.018	4.2AspSer: 4.2 ± 0.028	2.985AspThr: 2.985 ± 0.023	4.279AspVal: 4.279 ± 0.029	0.816AspTrp: 0.816 ± 0.01	1.734AspTyr: 1.734 ± 0.019	0.003AspXaa: 0.003 ± 0.001
Glu	6.613GluAla: 6.613 ± 0.052	1.031GluCys: 1.031 ± 0.013	4.375GluAsp: 4.375 ± 0.026	6.828GluGlu: 6.828 ± 0.066	2.05GluPhe: 2.05 ± 0.017	4.544GluGly: 4.544 ± 0.029	1.407GluHis: 1.407 ± 0.012	2.975GluIle: 2.975 ± 0.022	3.863GluLys: 3.863 ± 0.034	5.891GluLeu: 5.891 ± 0.037	1.856GluMet: 1.856 ± 0.019	2.039GluAsn: 2.039 ± 0.017	2.38GluPro: 2.38 ± 0.022	2.241GluGln: 2.241 ± 0.023	4.028GluArg: 4.028 ± 0.032	4.373GluSer: 4.373 ± 0.038	2.97GluThr: 2.97 ± 0.03	5.07GluVal: 5.07 ± 0.037	0.86GluTrp: 0.86 ± 0.012	1.775GluTyr: 1.775 ± 0.02	0.003GluXaa: 0.003 ± 0.001
Phe	2.579PheAla: 2.579 ± 0.02	0.73PheCys: 0.73 ± 0.01	2.335PheAsp: 2.335 ± 0.019	2.069PheGlu: 2.069 ± 0.022	1.297PhePhe: 1.297 ± 0.017	2.81PheGly: 2.81 ± 0.026	0.77PheHis: 0.77 ± 0.011	1.731PheIle: 1.731 ± 0.016	1.539PheLys: 1.539 ± 0.015	2.89PheLeu: 2.89 ± 0.023	0.883PheMet: 0.883 ± 0.012	1.311PheAsn: 1.311 ± 0.013	1.533PhePro: 1.533 ± 0.015	1.039PheGln: 1.039 ± 0.013	1.818PheArg: 1.818 ± 0.017	2.422PheSer: 2.422 ± 0.021	1.994PheThr: 1.994 ± 0.017	2.496PheVal: 2.496 ± 0.021	0.474PheTrp: 0.474 ± 0.008	1.11PheTyr: 1.11 ± 0.013	0.001PheXaa: 0.001 ± 0.0
Gly	4.95GlyAla: 4.95 ± 0.027	1.3GlyCys: 1.3 ± 0.014	4.148GlyAsp: 4.148 ± 0.027	4.248GlyGlu: 4.248 ± 0.029	2.416GlyPhe: 2.416 ± 0.018	6.409GlyGly: 6.409 ± 0.067	1.705GlyHis: 1.705 ± 0.017	3.474GlyIle: 3.474 ± 0.023	3.805GlyLys: 3.805 ± 0.031	5.888GlyLeu: 5.888 ± 0.035	1.89GlyMet: 1.89 ± 0.018	2.295GlyAsn: 2.295 ± 0.018	3.13GlyPro: 3.13 ± 0.029	2.307GlyGln: 2.307 ± 0.019	4.473GlyArg: 4.473 ± 0.028	5.867GlySer: 5.867 ± 0.036	3.546GlyThr: 3.546 ± 0.024	5.238GlyVal: 5.238 ± 0.032	0.964GlyTrp: 0.964 ± 0.011	2.141GlyTyr: 2.141 ± 0.022	0.003GlyXaa: 0.003 ± 0.001
His	1.579HisAla: 1.579 ± 0.015	0.482HisCys: 0.482 ± 0.008	1.217HisAsp: 1.217 ± 0.014	1.222HisGlu: 1.222 ± 0.013	0.889HisPhe: 0.889 ± 0.012	1.576HisGly: 1.576 ± 0.015	0.86HisHis: 0.86 ± 0.015	1.084HisIle: 1.084 ± 0.011	1.031HisLys: 1.031 ± 0.013	2.084HisLeu: 2.084 ± 0.019	0.56HisMet: 0.56 ± 0.008	0.757HisAsn: 0.757 ± 0.011	1.336HisPro: 1.336 ± 0.014	0.854HisGln: 0.854 ± 0.013	1.588HisArg: 1.588 ± 0.017	1.613HisSer: 1.613 ± 0.015	1.125HisThr: 1.125 ± 0.015	1.495HisVal: 1.495 ± 0.012	0.354HisTrp: 0.354 ± 0.007	0.746HisTyr: 0.746 ± 0.01	0.001HisXaa: 0.001 ± 0.0
Ile	3.925IleAla: 3.925 ± 0.025	1.012IleCys: 1.012 ± 0.014	3.124IleAsp: 3.124 ± 0.019	3.063IleGlu: 3.063 ± 0.023	1.653IlePhe: 1.653 ± 0.017	3.224IleGly: 3.224 ± 0.026	1.08IleHis: 1.08 ± 0.013	2.428IleIle: 2.428 ± 0.021	2.144IleLys: 2.144 ± 0.021	4.092IleLeu: 4.092 ± 0.027	1.112IleMet: 1.112 ± 0.012	1.666IleAsn: 1.666 ± 0.015	2.608IlePro: 2.608 ± 0.02	1.585IleGln: 1.585 ± 0.014	2.92IleArg: 2.92 ± 0.018	3.415IleSer: 3.415 ± 0.024	2.808IleThr: 2.808 ± 0.023	3.397IleVal: 3.397 ± 0.025	0.548IleTrp: 0.548 ± 0.009	1.208IleTyr: 1.208 ± 0.011	0.003IleXaa: 0.003 ± 0.001
Lys	4.507LysAla: 4.507 ± 0.033	0.911LysCys: 0.911 ± 0.011	2.867LysAsp: 2.867 ± 0.026	3.886LysGlu: 3.886 ± 0.032	1.591LysPhe: 1.591 ± 0.017	3.307LysGly: 3.307 ± 0.028	1.152LysHis: 1.152 ± 0.012	2.271LysIle: 2.271 ± 0.02	3.407LysLys: 3.407 ± 0.036	4.564LysLeu: 4.564 ± 0.028	1.417LysMet: 1.417 ± 0.017	1.674LysAsn: 1.674 ± 0.018	2.157LysPro: 2.157 ± 0.017	1.78LysGln: 1.78 ± 0.019	3.341LysArg: 3.341 ± 0.026	3.378LysSer: 3.378 ± 0.025	2.562LysThr: 2.562 ± 0.02	3.541LysVal: 3.541 ± 0.026	0.677LysTrp: 0.677 ± 0.01	1.546LysTyr: 1.546 ± 0.015	0.003LysXaa: 0.003 ± 0.001
Leu	7.576LeuAla: 7.576 ± 0.04	1.825LeuCys: 1.825 ± 0.017	4.987LeuAsp: 4.987 ± 0.029	5.684LeuGlu: 5.684 ± 0.038	2.962LeuPhe: 2.962 ± 0.023	5.909LeuGly: 5.909 ± 0.029	1.983LeuHis: 1.983 ± 0.017	3.877LeuIle: 3.877 ± 0.023	4.613LeuLys: 4.613 ± 0.028	8.832LeuLeu: 8.832 ± 0.051	2.287LeuMet: 2.287 ± 0.016	2.921LeuAsn: 2.921 ± 0.021	4.979LeuPro: 4.979 ± 0.03	3.443LeuGln: 3.443 ± 0.027	6.237LeuArg: 6.237 ± 0.034	7.077LeuSer: 7.077 ± 0.032	4.815LeuThr: 4.815 ± 0.028	6.197LeuVal: 6.197 ± 0.031	1.18LeuTrp: 1.18 ± 0.015	2.447LeuTyr: 2.447 ± 0.021	0.007LeuXaa: 0.007 ± 0.001
Met	2.333MetAla: 2.333 ± 0.019	0.47MetCys: 0.47 ± 0.008	1.494MetAsp: 1.494 ± 0.016	1.657MetGlu: 1.657 ± 0.015	0.839MetPhe: 0.839 ± 0.012	1.683MetGly: 1.683 ± 0.016	0.504MetHis: 0.504 ± 0.008	1.18MetIle: 1.18 ± 0.014	1.431MetLys: 1.431 ± 0.016	2.415MetLeu: 2.415 ± 0.018	0.922MetMet: 0.922 ± 0.017	0.943MetAsn: 0.943 ± 0.012	1.331MetPro: 1.331 ± 0.014	1.0MetGln: 1.0 ± 0.012	1.572MetArg: 1.572 ± 0.013	2.127MetSer: 2.127 ± 0.02	1.461MetThr: 1.461 ± 0.016	1.911MetVal: 1.911 ± 0.018	0.295MetTrp: 0.295 ± 0.007	0.641MetTyr: 0.641 ± 0.009	0.001MetXaa: 0.001 ± 0.0
Asn	2.681AsnAla: 2.681 ± 0.024	0.643AsnCys: 0.643 ± 0.01	2.067AsnAsp: 2.067 ± 0.018	2.009AsnGlu: 2.009 ± 0.017	1.182AsnPhe: 1.182 ± 0.017	2.483AsnGly: 2.483 ± 0.022	0.691AsnHis: 0.691 ± 0.011	1.681AsnIle: 1.681 ± 0.016	1.688AsnLys: 1.688 ± 0.017	2.816AsnLeu: 2.816 ± 0.022	0.892AsnMet: 0.892 ± 0.012	1.385AsnAsn: 1.385 ± 0.024	1.796AsnPro: 1.796 ± 0.016	0.988AsnGln: 0.988 ± 0.011	1.907AsnArg: 1.907 ± 0.018	2.406AsnSer: 2.406 ± 0.021	1.927AsnThr: 1.927 ± 0.021	2.288AsnVal: 2.288 ± 0.021	0.441AsnTrp: 0.441 ± 0.008	1.002AsnTyr: 1.002 ± 0.013	0.001AsnXaa: 0.001 ± 0.0
Pro	3.733ProAla: 3.733 ± 0.025	0.815ProCys: 0.815 ± 0.012	2.721ProAsp: 2.721 ± 0.023	3.326ProGlu: 3.326 ± 0.025	1.614ProPhe: 1.614 ± 0.016	3.19ProGly: 3.19 ± 0.024	1.103ProHis: 1.103 ± 0.014	2.188ProIle: 2.188 ± 0.017	2.283ProLys: 2.283 ± 0.019	4.234ProLeu: 4.234 ± 0.032	1.156ProMet: 1.156 ± 0.014	1.62ProAsn: 1.62 ± 0.017	3.692ProPro: 3.692 ± 0.043	1.87ProGln: 1.87 ± 0.018	2.867ProArg: 2.867 ± 0.025	4.702ProSer: 4.702 ± 0.035	3.407ProThr: 3.407 ± 0.028	3.889ProVal: 3.889 ± 0.034	0.615ProTrp: 0.615 ± 0.01	1.358ProTyr: 1.358 ± 0.015	0.003ProXaa: 0.003 ± 0.001
Gln	2.895GlnAla: 2.895 ± 0.024	0.665GlnCys: 0.665 ± 0.01	1.58GlnAsp: 1.58 ± 0.014	2.278GlnGlu: 2.278 ± 0.021	1.128GlnPhe: 1.128 ± 0.013	2.184GlnGly: 2.184 ± 0.019	0.92GlnHis: 0.92 ± 0.01	1.422GlnIle: 1.422 ± 0.014	1.783GlnLys: 1.783 ± 0.018	3.633GlnLeu: 3.633 ± 0.027	0.996GlnMet: 0.996 ± 0.012	1.016GlnAsn: 1.016 ± 0.013	1.696GlnPro: 1.696 ± 0.018	2.537GlnGln: 2.537 ± 0.042	2.54GlnArg: 2.54 ± 0.021	2.332GlnSer: 2.332 ± 0.021	1.654GlnThr: 1.654 ± 0.016	2.249GlnVal: 2.249 ± 0.019	0.56GlnTrp: 0.56 ± 0.01	0.997GlnTyr: 0.997 ± 0.012	0.003GlnXaa: 0.003 ± 0.001
Arg	4.757ArgAla: 4.757 ± 0.023	1.204ArgCys: 1.204 ± 0.015	3.403ArgAsp: 3.403 ± 0.025	4.22ArgGlu: 4.22 ± 0.03	2.119ArgPhe: 2.119 ± 0.015	4.071ArgGly: 4.071 ± 0.025	1.497ArgHis: 1.497 ± 0.014	2.88ArgIle: 2.88 ± 0.021	3.489ArgLys: 3.489 ± 0.026	6.11ArgLeu: 6.11 ± 0.035	1.714ArgMet: 1.714 ± 0.015	1.936ArgAsn: 1.936 ± 0.017	2.885ArgPro: 2.885 ± 0.022	2.498ArgGln: 2.498 ± 0.02	5.188ArgArg: 5.188 ± 0.04	4.684ArgSer: 4.684 ± 0.034	2.87ArgThr: 2.87 ± 0.022	4.31ArgVal: 4.31 ± 0.027	0.906ArgTrp: 0.906 ± 0.013	1.809ArgTyr: 1.809 ± 0.016	0.005ArgXaa: 0.005 ± 0.001
Ser	6.125SerAla: 6.125 ± 0.028	1.348SerCys: 1.348 ± 0.015	4.273SerAsp: 4.273 ± 0.026	4.456SerGlu: 4.456 ± 0.028	2.407SerPhe: 2.407 ± 0.02	5.657SerGly: 5.657 ± 0.032	1.596SerHis: 1.596 ± 0.014	3.654SerIle: 3.654 ± 0.028	3.618SerLys: 3.618 ± 0.027	6.662SerLeu: 6.662 ± 0.031	1.89SerMet: 1.89 ± 0.015	2.545SerAsn: 2.545 ± 0.023	4.263SerPro: 4.263 ± 0.033	2.446SerGln: 2.446 ± 0.019	4.802SerArg: 4.802 ± 0.027	8.304SerSer: 8.304 ± 0.063	5.263SerThr: 5.263 ± 0.051	5.229SerVal: 5.229 ± 0.03	1.018SerTrp: 1.018 ± 0.014	1.891SerTyr: 1.891 ± 0.019	0.006SerXaa: 0.006 ± 0.001
Thr	5.157ThrAla: 5.157 ± 0.034	0.998ThrCys: 0.998 ± 0.013	2.968ThrAsp: 2.968 ± 0.02	3.452ThrGlu: 3.452 ± 0.042	1.87ThrPhe: 1.87 ± 0.015	3.959ThrGly: 3.959 ± 0.025	1.048ThrHis: 1.048 ± 0.012	2.939ThrIle: 2.939 ± 0.024	2.529ThrLys: 2.529 ± 0.019	4.898ThrLeu: 4.898 ± 0.026	1.394ThrMet: 1.394 ± 0.014	1.811ThrAsn: 1.811 ± 0.023	3.341ThrPro: 3.341 ± 0.025	1.679ThrGln: 1.679 ± 0.02	3.059ThrArg: 3.059 ± 0.023	4.503ThrSer: 4.503 ± 0.035	5.326ThrThr: 5.326 ± 0.116	4.438ThrVal: 4.438 ± 0.038	0.65ThrTrp: 0.65 ± 0.011	1.416ThrTyr: 1.416 ± 0.013	0.004ThrXaa: 0.004 ± 0.001
Val	6.326ValAla: 6.326 ± 0.037	1.495ValCys: 1.495 ± 0.016	4.915ValAsp: 4.915 ± 0.03	5.162ValGlu: 5.162 ± 0.038	2.494ValPhe: 2.494 ± 0.021	4.71ValGly: 4.71 ± 0.026	1.624ValHis: 1.624 ± 0.016	3.329ValIle: 3.329 ± 0.024	3.575ValLys: 3.575 ± 0.026	6.359ValLeu: 6.359 ± 0.032	1.911ValMet: 1.911 ± 0.017	2.468ValAsn: 2.468 ± 0.021	3.6ValPro: 3.6 ± 0.03	2.223ValGln: 2.223 ± 0.019	4.038ValArg: 4.038 ± 0.027	5.136ValSer: 5.136 ± 0.033	4.368ValThr: 4.368 ± 0.034	6.165ValVal: 6.165 ± 0.056	0.885ValTrp: 0.885 ± 0.012	2.055ValTyr: 2.055 ± 0.021	0.006ValXaa: 0.006 ± 0.001
Trp	0.98TrpAla: 0.98 ± 0.012	0.279TrpCys: 0.279 ± 0.007	0.743TrpAsp: 0.743 ± 0.011	0.742TrpGlu: 0.742 ± 0.01	0.466TrpPhe: 0.466 ± 0.008	0.785TrpGly: 0.785 ± 0.011	0.303TrpHis: 0.303 ± 0.006	0.636TrpIle: 0.636 ± 0.01	0.729TrpLys: 0.729 ± 0.011	1.348TrpLeu: 1.348 ± 0.015	0.388TrpMet: 0.388 ± 0.008	0.47TrpAsn: 0.47 ± 0.008	0.534TrpPro: 0.534 ± 0.01	0.507TrpGln: 0.507 ± 0.009	0.947TrpArg: 0.947 ± 0.011	1.066TrpSer: 1.066 ± 0.012	0.711TrpThr: 0.711 ± 0.011	0.852TrpVal: 0.852 ± 0.013	0.283TrpTrp: 0.283 ± 0.007	0.41TrpTyr: 0.41 ± 0.008	0.001TrpXaa: 0.001 ± 0.0
Tyr	2.019TyrAla: 2.019 ± 0.019	0.747TyrCys: 0.747 ± 0.012	1.86TyrAsp: 1.86 ± 0.019	1.616TyrGlu: 1.616 ± 0.018	1.114TyrPhe: 1.114 ± 0.014	2.102TyrGly: 2.102 ± 0.023	0.768TyrHis: 0.768 ± 0.012	1.32TyrIle: 1.32 ± 0.015	1.249TyrLys: 1.249 ± 0.014	2.432TyrLeu: 2.432 ± 0.022	0.687TyrMet: 0.687 ± 0.01	1.092TyrAsn: 1.092 ± 0.016	1.262TyrPro: 1.262 ± 0.013	0.939TyrGln: 0.939 ± 0.011	1.839TyrArg: 1.839 ± 0.017	1.949TyrSer: 1.949 ± 0.017	1.486TyrThr: 1.486 ± 0.016	1.935TyrVal: 1.935 ± 0.017	0.443TyrTrp: 0.443 ± 0.009	1.074TyrTyr: 1.074 ± 0.023	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.003XaaAsp: 0.003 ± 0.001	0.003XaaGlu: 0.003 ± 0.001	0.003XaaPhe: 0.003 ± 0.001	0.005XaaGly: 0.005 ± 0.001	0.002XaaHis: 0.002 ± 0.001	0.006XaaIle: 0.006 ± 0.001	0.003XaaLys: 0.003 ± 0.001	0.005XaaLeu: 0.005 ± 0.001	0.002XaaMet: 0.002 ± 0.001	0.002XaaAsn: 0.002 ± 0.0	0.004XaaPro: 0.004 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.003XaaArg: 0.003 ± 0.001	0.009XaaSer: 0.009 ± 0.001	0.004XaaThr: 0.004 ± 0.001	0.003XaaVal: 0.003 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.002XaaTyr: 0.002 ± 0.0	0.053XaaXaa: 0.053 ± 0.003

Statistics based on 23114 proteins (7493757 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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