Amino acid dipepetide frequency for Hubei narna-like virus 21

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.37AlaAla: 13.37 ± 4.436
1.114AlaCys: 1.114 ± 0.045
3.9AlaAsp: 3.9 ± 0.547
9.471AlaGlu: 9.471 ± 4.667
3.9AlaPhe: 3.9 ± 1.01
10.585AlaGly: 10.585 ± 2.376
5.014AlaHis: 5.014 ± 0.965
4.457AlaIle: 4.457 ± 2.517
2.786AlaLys: 2.786 ± 2.06
10.585AlaLeu: 10.585 ± 2.376
1.114AlaMet: 1.114 ± 0.824
1.114AlaAsn: 1.114 ± 0.824
6.685AlaPro: 6.685 ± 0.271
3.343AlaGln: 3.343 ± 0.643
8.914AlaArg: 8.914 ± 1.919
1.671AlaSer: 1.671 ± 0.457
6.128AlaThr: 6.128 ± 0.638
5.014AlaVal: 5.014 ± 1.371
0.0AlaTrp: 0.0 ± 0.0
2.228AlaTyr: 2.228 ± 0.869
0.0AlaXaa: 0.0 ± 0.0
Cys
2.228CysAla: 2.228 ± 0.689
0.557CysCys: 0.557 ± 0.367
0.557CysAsp: 0.557 ± 0.412
0.557CysGlu: 0.557 ± 0.367
0.557CysPhe: 0.557 ± 0.367
0.557CysGly: 0.557 ± 0.367
0.557CysHis: 0.557 ± 0.367
0.0CysIle: 0.0 ± 0.0
1.671CysLys: 1.671 ± 0.322
0.557CysLeu: 0.557 ± 0.412
0.557CysMet: 0.557 ± 0.412
1.114CysAsn: 1.114 ± 0.045
2.228CysPro: 2.228 ± 0.689
0.0CysGln: 0.0 ± 0.0
5.571CysArg: 5.571 ± 2.89
4.457CysSer: 4.457 ± 1.377
0.0CysThr: 0.0 ± 0.0
1.671CysVal: 1.671 ± 1.101
0.0CysTrp: 0.0 ± 0.0
0.557CysTyr: 0.557 ± 0.412
0.0CysXaa: 0.0 ± 0.0
Asp
4.457AspAla: 4.457 ± 0.959
1.114AspCys: 1.114 ± 0.734
5.014AspAsp: 5.014 ± 1.371
2.786AspGlu: 2.786 ± 0.502
2.786AspPhe: 2.786 ± 1.055
1.671AspGly: 1.671 ± 1.101
0.557AspHis: 0.557 ± 0.367
3.343AspIle: 3.343 ± 0.135
0.557AspLys: 0.557 ± 0.412
6.128AspLeu: 6.128 ± 4.532
0.0AspMet: 0.0 ± 0.0
1.114AspAsn: 1.114 ± 0.734
2.786AspPro: 2.786 ± 0.502
1.671AspGln: 1.671 ± 1.101
7.242AspArg: 7.242 ± 0.875
1.114AspSer: 1.114 ± 0.045
0.557AspThr: 0.557 ± 0.412
3.343AspVal: 3.343 ± 1.693
0.0AspTrp: 0.0 ± 0.0
0.557AspTyr: 0.557 ± 0.412
0.0AspXaa: 0.0 ± 0.0
Glu
6.685GluAla: 6.685 ± 1.829
1.671GluCys: 1.671 ± 1.101
1.671GluAsp: 1.671 ± 0.457
3.9GluGlu: 3.9 ± 2.105
2.786GluPhe: 2.786 ± 0.277
5.571GluGly: 5.571 ± 1.005
1.671GluHis: 1.671 ± 0.322
3.343GluIle: 3.343 ± 1.693
1.114GluLys: 1.114 ± 0.734
7.799GluLeu: 7.799 ± 0.463
0.557GluMet: 0.557 ± 0.412
0.0GluAsn: 0.0 ± 0.0
2.228GluPro: 2.228 ± 0.689
0.557GluGln: 0.557 ± 0.367
6.128GluArg: 6.128 ± 1.417
3.9GluSer: 3.9 ± 0.231
2.228GluThr: 2.228 ± 0.09
5.571GluVal: 5.571 ± 0.553
0.0GluTrp: 0.0 ± 0.0
1.671GluTyr: 1.671 ± 0.322
0.0GluXaa: 0.0 ± 0.0
Phe
0.557PheAla: 0.557 ± 0.367
0.0PheCys: 0.0 ± 0.0
1.671PheAsp: 1.671 ± 0.322
2.228PheGlu: 2.228 ± 0.869
1.114PhePhe: 1.114 ± 0.734
2.786PheGly: 2.786 ± 0.277
1.671PheHis: 1.671 ± 0.322
1.114PheIle: 1.114 ± 0.045
2.786PheLys: 2.786 ± 0.277
3.343PheLeu: 3.343 ± 0.135
0.557PheMet: 0.557 ± 0.367
2.228PheAsn: 2.228 ± 0.09
3.343PhePro: 3.343 ± 0.135
1.114PheGln: 1.114 ± 0.734
2.786PheArg: 2.786 ± 1.055
2.228PheSer: 2.228 ± 0.689
2.786PheThr: 2.786 ± 0.277
0.557PheVal: 0.557 ± 0.367
0.0PheTrp: 0.0 ± 0.0
1.671PheTyr: 1.671 ± 1.236
0.0PheXaa: 0.0 ± 0.0
Gly
8.357GlyAla: 8.357 ± 1.507
1.114GlyCys: 1.114 ± 0.045
2.228GlyAsp: 2.228 ± 0.869
2.786GlyGlu: 2.786 ± 0.277
3.9GlyPhe: 3.9 ± 1.326
7.242GlyGly: 7.242 ± 1.462
1.671GlyHis: 1.671 ± 0.322
2.228GlyIle: 2.228 ± 0.869
2.228GlyLys: 2.228 ± 0.09
10.028GlyLeu: 10.028 ± 0.406
0.557GlyMet: 0.557 ± 0.412
3.343GlyAsn: 3.343 ± 1.422
7.242GlyPro: 7.242 ± 0.875
4.457GlyGln: 4.457 ± 0.181
8.357GlyArg: 8.357 ± 1.507
4.457GlySer: 4.457 ± 0.598
2.786GlyThr: 2.786 ± 0.277
4.457GlyVal: 4.457 ± 0.598
1.671GlyTrp: 1.671 ± 0.322
0.557GlyTyr: 0.557 ± 0.412
0.0GlyXaa: 0.0 ± 0.0
His
1.671HisAla: 1.671 ± 0.457
1.671HisCys: 1.671 ± 0.322
1.671HisAsp: 1.671 ± 0.457
1.671HisGlu: 1.671 ± 0.322
0.557HisPhe: 0.557 ± 0.412
0.557HisGly: 0.557 ± 0.412
1.671HisHis: 1.671 ± 0.322
0.557HisIle: 0.557 ± 0.367
1.671HisLys: 1.671 ± 0.457
2.786HisLeu: 2.786 ± 0.502
0.0HisMet: 0.0 ± 0.0
1.671HisAsn: 1.671 ± 1.101
2.786HisPro: 2.786 ± 0.502
2.786HisGln: 2.786 ± 1.834
5.014HisArg: 5.014 ± 2.523
0.557HisSer: 0.557 ± 0.367
1.671HisThr: 1.671 ± 0.322
0.557HisVal: 0.557 ± 0.367
1.114HisTrp: 1.114 ± 0.045
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.9IleAla: 3.9 ± 1.01
1.671IleCys: 1.671 ± 0.457
3.9IleAsp: 3.9 ± 2.105
3.9IleGlu: 3.9 ± 1.01
1.671IlePhe: 1.671 ± 0.322
2.228IleGly: 2.228 ± 0.689
0.0IleHis: 0.0 ± 0.0
2.228IleIle: 2.228 ± 0.09
1.114IleLys: 1.114 ± 0.824
2.786IleLeu: 2.786 ± 0.502
0.0IleMet: 0.0 ± 0.0
0.557IleAsn: 0.557 ± 0.367
2.786IlePro: 2.786 ± 0.277
1.114IleGln: 1.114 ± 0.045
6.128IleArg: 6.128 ± 1.417
0.557IleSer: 0.557 ± 0.367
1.114IleThr: 1.114 ± 0.045
1.671IleVal: 1.671 ± 0.322
0.557IleTrp: 0.557 ± 0.412
0.557IleTyr: 0.557 ± 0.412
0.0IleXaa: 0.0 ± 0.0
Lys
1.671LysAla: 1.671 ± 0.457
1.671LysCys: 1.671 ± 0.457
1.114LysAsp: 1.114 ± 0.045
1.114LysGlu: 1.114 ± 0.045
1.671LysPhe: 1.671 ± 0.457
5.571LysGly: 5.571 ± 2.562
0.0LysHis: 0.0 ± 0.0
1.114LysIle: 1.114 ± 0.045
1.114LysLys: 1.114 ± 0.045
0.557LysLeu: 0.557 ± 0.367
0.557LysMet: 0.557 ± 0.367
0.557LysAsn: 0.557 ± 0.367
1.114LysPro: 1.114 ± 0.734
1.671LysGln: 1.671 ± 0.457
5.014LysArg: 5.014 ± 0.186
1.671LysSer: 1.671 ± 0.457
0.0LysThr: 0.0 ± 0.0
2.786LysVal: 2.786 ± 1.055
0.0LysTrp: 0.0 ± 0.0
0.557LysTyr: 0.557 ± 0.412
0.0LysXaa: 0.0 ± 0.0
Leu
9.471LeuAla: 9.471 ± 3.889
3.343LeuCys: 3.343 ± 1.422
5.014LeuAsp: 5.014 ± 0.186
3.9LeuGlu: 3.9 ± 1.326
1.671LeuPhe: 1.671 ± 1.101
6.685LeuGly: 6.685 ± 1.829
1.114LeuHis: 1.114 ± 0.824
3.343LeuIle: 3.343 ± 0.135
1.114LeuLys: 1.114 ± 0.045
7.242LeuLeu: 7.242 ± 0.875
3.343LeuMet: 3.343 ± 1.501
1.671LeuAsn: 1.671 ± 0.322
6.685LeuPro: 6.685 ± 1.287
3.343LeuGln: 3.343 ± 2.201
10.585LeuArg: 10.585 ± 3.076
9.471LeuSer: 9.471 ± 0.773
5.014LeuThr: 5.014 ± 0.593
3.9LeuVal: 3.9 ± 0.231
1.671LeuTrp: 1.671 ± 1.236
1.114LeuTyr: 1.114 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
1.114MetAla: 1.114 ± 0.045
0.557MetCys: 0.557 ± 0.367
0.557MetAsp: 0.557 ± 0.412
0.557MetGlu: 0.557 ± 0.412
0.557MetPhe: 0.557 ± 0.412
2.228MetGly: 2.228 ± 0.869
1.114MetHis: 1.114 ± 0.045
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
2.228MetLeu: 2.228 ± 0.869
1.114MetMet: 1.114 ± 0.045
0.557MetAsn: 0.557 ± 0.367
2.228MetPro: 2.228 ± 0.869
0.557MetGln: 0.557 ± 0.367
1.114MetArg: 1.114 ± 0.734
0.557MetSer: 0.557 ± 0.367
1.114MetThr: 1.114 ± 0.045
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.343AsnAla: 3.343 ± 0.643
1.114AsnCys: 1.114 ± 0.734
0.557AsnAsp: 0.557 ± 0.367
0.557AsnGlu: 0.557 ± 0.412
1.114AsnPhe: 1.114 ± 0.045
1.671AsnGly: 1.671 ± 1.101
0.557AsnHis: 0.557 ± 0.367
0.557AsnIle: 0.557 ± 0.367
0.557AsnLys: 0.557 ± 0.367
5.571AsnLeu: 5.571 ± 0.553
0.0AsnMet: 0.0 ± 0.0
0.557AsnAsn: 0.557 ± 0.367
4.457AsnPro: 4.457 ± 1.377
0.0AsnGln: 0.0 ± 0.0
2.228AsnArg: 2.228 ± 0.689
0.557AsnSer: 0.557 ± 0.367
1.671AsnThr: 1.671 ± 0.322
0.557AsnVal: 0.557 ± 0.367
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
5.014ProAla: 5.014 ± 1.371
1.114ProCys: 1.114 ± 0.734
3.9ProAsp: 3.9 ± 0.547
3.343ProGlu: 3.343 ± 1.422
2.228ProPhe: 2.228 ± 0.689
3.9ProGly: 3.9 ± 1.01
3.9ProHis: 3.9 ± 0.547
2.786ProIle: 2.786 ± 1.055
3.343ProLys: 3.343 ± 0.643
7.242ProLeu: 7.242 ± 0.875
0.557ProMet: 0.557 ± 0.367
1.671ProAsn: 1.671 ± 1.101
3.343ProPro: 3.343 ± 0.643
2.786ProGln: 2.786 ± 1.055
10.028ProArg: 10.028 ± 0.406
4.457ProSer: 4.457 ± 1.377
2.228ProThr: 2.228 ± 0.09
5.571ProVal: 5.571 ± 0.226
1.114ProTrp: 1.114 ± 0.045
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
2.786GlnAla: 2.786 ± 1.281
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
1.114GlnGlu: 1.114 ± 0.734
1.114GlnPhe: 1.114 ± 0.045
3.343GlnGly: 3.343 ± 0.643
1.671GlnHis: 1.671 ± 1.101
1.671GlnIle: 1.671 ± 1.101
0.0GlnLys: 0.0 ± 0.0
2.786GlnLeu: 2.786 ± 0.502
1.114GlnMet: 1.114 ± 0.734
1.671GlnAsn: 1.671 ± 0.322
2.786GlnPro: 2.786 ± 1.834
1.114GlnGln: 1.114 ± 0.045
3.343GlnArg: 3.343 ± 0.135
3.9GlnSer: 3.9 ± 1.789
2.786GlnThr: 2.786 ± 1.055
3.9GlnVal: 3.9 ± 1.01
0.0GlnTrp: 0.0 ± 0.0
0.557GlnTyr: 0.557 ± 0.412
0.0GlnXaa: 0.0 ± 0.0
Arg
13.928ArgAla: 13.928 ± 4.848
2.228ArgCys: 2.228 ± 0.689
3.9ArgAsp: 3.9 ± 1.326
9.471ArgGlu: 9.471 ± 0.006
2.786ArgPhe: 2.786 ± 0.277
12.813ArgGly: 12.813 ± 2.207
3.9ArgHis: 3.9 ± 1.789
6.685ArgIle: 6.685 ± 1.287
4.457ArgLys: 4.457 ± 0.959
7.242ArgLeu: 7.242 ± 0.096
1.671ArgMet: 1.671 ± 1.101
2.228ArgAsn: 2.228 ± 1.467
3.9ArgPro: 3.9 ± 0.547
6.128ArgGln: 6.128 ± 0.141
12.256ArgArg: 12.256 ± 0.282
11.699ArgSer: 11.699 ± 1.473
6.128ArgThr: 6.128 ± 1.699
7.799ArgVal: 7.799 ± 0.463
1.114ArgTrp: 1.114 ± 0.734
1.671ArgTyr: 1.671 ± 0.322
0.0ArgXaa: 0.0 ± 0.0
Ser
8.357SerAla: 8.357 ± 1.507
2.228SerCys: 2.228 ± 0.689
3.9SerAsp: 3.9 ± 0.231
3.9SerGlu: 3.9 ± 1.01
2.228SerPhe: 2.228 ± 0.689
5.014SerGly: 5.014 ± 0.186
0.557SerHis: 0.557 ± 0.367
1.114SerIle: 1.114 ± 0.824
2.228SerLys: 2.228 ± 0.689
4.457SerLeu: 4.457 ± 2.935
1.114SerMet: 1.114 ± 0.045
0.557SerAsn: 0.557 ± 0.367
4.457SerPro: 4.457 ± 2.156
1.671SerGln: 1.671 ± 1.101
9.471SerArg: 9.471 ± 0.785
5.571SerSer: 5.571 ± 1.332
1.671SerThr: 1.671 ± 0.322
3.343SerVal: 3.343 ± 1.693
0.557SerTrp: 0.557 ± 0.412
1.114SerTyr: 1.114 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
6.128ThrAla: 6.128 ± 1.417
1.114ThrCys: 1.114 ± 0.734
2.228ThrAsp: 2.228 ± 0.689
0.557ThrGlu: 0.557 ± 0.367
3.343ThrPhe: 3.343 ± 0.135
2.786ThrGly: 2.786 ± 0.502
2.228ThrHis: 2.228 ± 0.869
0.557ThrIle: 0.557 ± 0.367
0.557ThrLys: 0.557 ± 0.412
3.9ThrLeu: 3.9 ± 0.231
0.557ThrMet: 0.557 ± 0.412
0.0ThrAsn: 0.0 ± 0.0
3.9ThrPro: 3.9 ± 1.789
1.671ThrGln: 1.671 ± 0.457
4.457ThrArg: 4.457 ± 0.598
2.228ThrSer: 2.228 ± 0.689
2.228ThrThr: 2.228 ± 0.09
5.571ThrVal: 5.571 ± 0.226
1.114ThrTrp: 1.114 ± 0.824
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
5.571ValAla: 5.571 ± 1.005
1.114ValCys: 1.114 ± 0.734
3.343ValAsp: 3.343 ± 1.422
6.128ValGlu: 6.128 ± 0.92
0.557ValPhe: 0.557 ± 0.412
2.786ValGly: 2.786 ± 0.277
2.786ValHis: 2.786 ± 0.277
1.114ValIle: 1.114 ± 0.045
2.228ValLys: 2.228 ± 0.09
3.343ValLeu: 3.343 ± 1.422
1.671ValMet: 1.671 ± 0.457
3.9ValAsn: 3.9 ± 0.231
3.9ValPro: 3.9 ± 1.326
0.557ValGln: 0.557 ± 0.412
10.028ValArg: 10.028 ± 0.373
3.343ValSer: 3.343 ± 0.135
3.343ValThr: 3.343 ± 1.693
7.799ValVal: 7.799 ± 1.874
0.557ValTrp: 0.557 ± 0.367
1.114ValTyr: 1.114 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.114TrpAla: 1.114 ± 0.045
0.0TrpCys: 0.0 ± 0.0
0.557TrpAsp: 0.557 ± 0.412
0.557TrpGlu: 0.557 ± 0.367
0.0TrpPhe: 0.0 ± 0.0
0.557TrpGly: 0.557 ± 0.412
0.0TrpHis: 0.0 ± 0.0
0.557TrpIle: 0.557 ± 0.412
0.0TrpLys: 0.0 ± 0.0
0.557TrpLeu: 0.557 ± 0.367
0.557TrpMet: 0.557 ± 0.302
0.557TrpAsn: 0.557 ± 0.367
0.557TrpPro: 0.557 ± 0.412
0.557TrpGln: 0.557 ± 0.367
1.114TrpArg: 1.114 ± 0.045
0.0TrpSer: 0.0 ± 0.0
1.114TrpThr: 1.114 ± 0.824
0.557TrpVal: 0.557 ± 0.412
0.0TrpTrp: 0.0 ± 0.0
0.557TrpTyr: 0.557 ± 0.412
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.671TyrAla: 1.671 ± 1.236
0.557TyrCys: 0.557 ± 0.412
1.114TyrAsp: 1.114 ± 0.734
0.557TyrGlu: 0.557 ± 0.412
0.0TyrPhe: 0.0 ± 0.0
1.114TyrGly: 1.114 ± 0.824
0.0TyrHis: 0.0 ± 0.0
1.671TyrIle: 1.671 ± 0.322
0.0TyrLys: 0.0 ± 0.0
0.557TyrLeu: 0.557 ± 0.367
0.0TyrMet: 0.0 ± 0.0
0.557TyrAsn: 0.557 ± 0.412
1.114TyrPro: 1.114 ± 0.045
0.557TyrGln: 0.557 ± 0.412
2.228TyrArg: 2.228 ± 0.869
1.114TyrSer: 1.114 ± 0.824
0.557TyrThr: 0.557 ± 0.367
0.557TyrVal: 0.557 ± 0.412
0.557TyrTrp: 0.557 ± 0.412
0.557TyrTyr: 0.557 ± 0.412
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (1796 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski