Amino acid dipepetide frequency for Abyssibacter profundi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.641AlaAla: 15.641 ± 0.178	1.322AlaCys: 1.322 ± 0.04	7.597AlaAsp: 7.597 ± 0.085	7.625AlaGlu: 7.625 ± 0.103	3.716AlaPhe: 3.716 ± 0.066	10.59AlaGly: 10.59 ± 0.113	2.189AlaHis: 2.189 ± 0.047	5.164AlaIle: 5.164 ± 0.068	2.58AlaLys: 2.58 ± 0.059	13.502AlaLeu: 13.502 ± 0.135	3.102AlaMet: 3.102 ± 0.055	2.785AlaAsn: 2.785 ± 0.061	5.436AlaPro: 5.436 ± 0.073	4.918AlaGln: 4.918 ± 0.077	8.507AlaArg: 8.507 ± 0.109	6.547AlaSer: 6.547 ± 0.092	6.214AlaThr: 6.214 ± 0.096	8.921AlaVal: 8.921 ± 0.094	1.783AlaTrp: 1.783 ± 0.046	2.602AlaTyr: 2.602 ± 0.046	0.001AlaXaa: 0.001 ± 0.001
Cys	1.07CysAla: 1.07 ± 0.032	0.131CysCys: 0.131 ± 0.011	0.571CysAsp: 0.571 ± 0.023	0.551CysGlu: 0.551 ± 0.022	0.278CysPhe: 0.278 ± 0.018	0.941CysGly: 0.941 ± 0.029	0.254CysHis: 0.254 ± 0.018	0.386CysIle: 0.386 ± 0.02	0.163CysLys: 0.163 ± 0.012	0.975CysLeu: 0.975 ± 0.031	0.184CysMet: 0.184 ± 0.013	0.231CysAsn: 0.231 ± 0.016	0.527CysPro: 0.527 ± 0.026	0.356CysGln: 0.356 ± 0.02	0.718CysArg: 0.718 ± 0.029	0.596CysSer: 0.596 ± 0.026	0.462CysThr: 0.462 ± 0.022	0.745CysVal: 0.745 ± 0.024	0.135CysTrp: 0.135 ± 0.01	0.202CysTyr: 0.202 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.276AspAla: 8.276 ± 0.105	0.585AspCys: 0.585 ± 0.025	4.234AspAsp: 4.234 ± 0.075	3.68AspGlu: 3.68 ± 0.067	2.088AspPhe: 2.088 ± 0.044	5.755AspGly: 5.755 ± 0.099	1.466AspHis: 1.466 ± 0.037	2.615AspIle: 2.615 ± 0.048	1.315AspLys: 1.315 ± 0.04	6.067AspLeu: 6.067 ± 0.075	1.294AspMet: 1.294 ± 0.035	1.517AspAsn: 1.517 ± 0.04	3.721AspPro: 3.721 ± 0.066	2.663AspGln: 2.663 ± 0.052	4.5AspArg: 4.5 ± 0.071	3.046AspSer: 3.046 ± 0.062	3.117AspThr: 3.117 ± 0.066	4.557AspVal: 4.557 ± 0.075	1.128AspTrp: 1.128 ± 0.031	1.737AspTyr: 1.737 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	7.481GluAla: 7.481 ± 0.107	0.36GluCys: 0.36 ± 0.018	3.048GluAsp: 3.048 ± 0.061	2.637GluGlu: 2.637 ± 0.056	1.882GluPhe: 1.882 ± 0.04	3.706GluGly: 3.706 ± 0.066	1.456GluHis: 1.456 ± 0.042	2.778GluIle: 2.778 ± 0.057	1.08GluLys: 1.08 ± 0.039	6.331GluLeu: 6.331 ± 0.084	1.162GluMet: 1.162 ± 0.033	1.173GluAsn: 1.173 ± 0.033	3.134GluPro: 3.134 ± 0.059	3.503GluGln: 3.503 ± 0.069	5.011GluArg: 5.011 ± 0.073	3.437GluSer: 3.437 ± 0.065	3.345GluThr: 3.345 ± 0.061	3.803GluVal: 3.803 ± 0.067	0.697GluTrp: 0.697 ± 0.024	1.205GluTyr: 1.205 ± 0.033	0.003GluXaa: 0.003 ± 0.002
Phe	3.779PheAla: 3.779 ± 0.061	0.339PheCys: 0.339 ± 0.019	2.709PheAsp: 2.709 ± 0.051	2.252PheGlu: 2.252 ± 0.052	1.129PhePhe: 1.129 ± 0.032	3.21PheGly: 3.21 ± 0.059	0.681PheHis: 0.681 ± 0.021	1.339PheIle: 1.339 ± 0.034	0.81PheLys: 0.81 ± 0.026	2.715PheLeu: 2.715 ± 0.059	0.696PheMet: 0.696 ± 0.023	1.081PheAsn: 1.081 ± 0.031	1.418PhePro: 1.418 ± 0.042	1.052PheGln: 1.052 ± 0.032	2.021PheArg: 2.021 ± 0.041	2.048PheSer: 2.048 ± 0.046	1.736PheThr: 1.736 ± 0.049	2.677PheVal: 2.677 ± 0.049	0.504PheTrp: 0.504 ± 0.024	0.887PheTyr: 0.887 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	8.205GlyAla: 8.205 ± 0.104	0.98GlyCys: 0.98 ± 0.031	5.144GlyAsp: 5.144 ± 0.092	4.906GlyGlu: 4.906 ± 0.068	3.308GlyPhe: 3.308 ± 0.059	6.979GlyGly: 6.979 ± 0.136	1.969GlyHis: 1.969 ± 0.043	3.668GlyIle: 3.668 ± 0.061	2.043GlyLys: 2.043 ± 0.048	9.348GlyLeu: 9.348 ± 0.101	2.009GlyMet: 2.009 ± 0.049	2.084GlyAsn: 2.084 ± 0.056	3.307GlyPro: 3.307 ± 0.069	3.907GlyGln: 3.907 ± 0.064	5.963GlyArg: 5.963 ± 0.083	4.564GlySer: 4.564 ± 0.087	4.51GlyThr: 4.51 ± 0.102	6.362GlyVal: 6.362 ± 0.075	1.423GlyTrp: 1.423 ± 0.042	2.274GlyTyr: 2.274 ± 0.045	0.003GlyXaa: 0.003 ± 0.002
His	2.627HisAla: 2.627 ± 0.053	0.298HisCys: 0.298 ± 0.016	1.15HisAsp: 1.15 ± 0.026	1.063HisGlu: 1.063 ± 0.025	0.833HisPhe: 0.833 ± 0.031	1.964HisGly: 1.964 ± 0.051	0.638HisHis: 0.638 ± 0.02	0.853HisIle: 0.853 ± 0.029	0.425HisLys: 0.425 ± 0.019	2.215HisLeu: 2.215 ± 0.046	0.437HisMet: 0.437 ± 0.019	0.468HisAsn: 0.468 ± 0.022	1.572HisPro: 1.572 ± 0.036	0.842HisGln: 0.842 ± 0.029	1.826HisArg: 1.826 ± 0.042	1.027HisSer: 1.027 ± 0.032	0.921HisThr: 0.921 ± 0.027	1.57HisVal: 1.57 ± 0.038	0.471HisTrp: 0.471 ± 0.021	0.636HisTyr: 0.636 ± 0.023	0.001HisXaa: 0.001 ± 0.001
Ile	5.541IleAla: 5.541 ± 0.079	0.436IleCys: 0.436 ± 0.021	3.477IleAsp: 3.477 ± 0.056	3.398IleGlu: 3.398 ± 0.066	1.209IlePhe: 1.209 ± 0.036	4.168IleGly: 4.168 ± 0.071	0.984IleHis: 0.984 ± 0.028	1.751IleIle: 1.751 ± 0.043	1.195IleLys: 1.195 ± 0.031	3.155IleLeu: 3.155 ± 0.057	0.746IleMet: 0.746 ± 0.028	1.416IleAsn: 1.416 ± 0.04	2.079IlePro: 2.079 ± 0.047	1.592IleGln: 1.592 ± 0.035	3.38IleArg: 3.38 ± 0.059	2.328IleSer: 2.328 ± 0.047	2.513IleThr: 2.513 ± 0.051	3.347IleVal: 3.347 ± 0.063	0.539IleTrp: 0.539 ± 0.023	1.062IleTyr: 1.062 ± 0.026	0.001IleXaa: 0.001 ± 0.001
Lys	2.718LysAla: 2.718 ± 0.065	0.132LysCys: 0.132 ± 0.011	1.121LysAsp: 1.121 ± 0.042	0.957LysGlu: 0.957 ± 0.036	0.613LysPhe: 0.613 ± 0.025	1.544LysGly: 1.544 ± 0.046	0.52LysHis: 0.52 ± 0.021	1.026LysIle: 1.026 ± 0.033	0.709LysLys: 0.709 ± 0.036	2.49LysLeu: 2.49 ± 0.049	0.465LysMet: 0.465 ± 0.024	0.58LysAsn: 0.58 ± 0.028	1.552LysPro: 1.552 ± 0.051	1.142LysGln: 1.142 ± 0.034	2.013LysArg: 2.013 ± 0.053	1.305LysSer: 1.305 ± 0.04	1.462LysThr: 1.462 ± 0.043	1.511LysVal: 1.511 ± 0.047	0.208LysTrp: 0.208 ± 0.015	0.449LysTyr: 0.449 ± 0.021	0.001LysXaa: 0.001 ± 0.001
Leu	13.452LeuAla: 13.452 ± 0.136	1.006LeuCys: 1.006 ± 0.033	7.088LeuAsp: 7.088 ± 0.091	5.939LeuGlu: 5.939 ± 0.089	3.377LeuPhe: 3.377 ± 0.057	8.706LeuGly: 8.706 ± 0.103	2.187LeuHis: 2.187 ± 0.046	4.874LeuIle: 4.874 ± 0.079	2.582LeuLys: 2.582 ± 0.057	10.87LeuLeu: 10.87 ± 0.166	2.209LeuMet: 2.209 ± 0.054	2.709LeuAsn: 2.709 ± 0.053	5.737LeuPro: 5.737 ± 0.068	3.976LeuGln: 3.976 ± 0.063	7.844LeuArg: 7.844 ± 0.104	6.416LeuSer: 6.416 ± 0.088	5.837LeuThr: 5.837 ± 0.079	7.671LeuVal: 7.671 ± 0.105	1.227LeuTrp: 1.227 ± 0.035	2.082LeuTyr: 2.082 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.684MetAla: 2.684 ± 0.048	0.137MetCys: 0.137 ± 0.01	1.244MetAsp: 1.244 ± 0.035	1.068MetGlu: 1.068 ± 0.035	0.565MetPhe: 0.565 ± 0.024	1.588MetGly: 1.588 ± 0.037	0.49MetHis: 0.49 ± 0.019	1.02MetIle: 1.02 ± 0.031	0.683MetLys: 0.683 ± 0.024	2.411MetLeu: 2.411 ± 0.052	0.519MetMet: 0.519 ± 0.026	0.727MetAsn: 0.727 ± 0.023	1.322MetPro: 1.322 ± 0.03	0.961MetGln: 0.961 ± 0.03	1.712MetArg: 1.712 ± 0.035	1.491MetSer: 1.491 ± 0.036	1.612MetThr: 1.612 ± 0.041	1.434MetVal: 1.434 ± 0.034	0.189MetTrp: 0.189 ± 0.014	0.306MetTyr: 0.306 ± 0.018	0.001MetXaa: 0.001 ± 0.001
Asn	3.0AsnAla: 3.0 ± 0.059	0.268AsnCys: 0.268 ± 0.016	1.416AsnAsp: 1.416 ± 0.041	1.265AsnGlu: 1.265 ± 0.038	0.82AsnPhe: 0.82 ± 0.033	2.184AsnGly: 2.184 ± 0.063	0.544AsnHis: 0.544 ± 0.026	1.103AsnIle: 1.103 ± 0.033	0.553AsnLys: 0.553 ± 0.023	2.568AsnLeu: 2.568 ± 0.048	0.526AsnMet: 0.526 ± 0.02	0.766AsnAsn: 0.766 ± 0.04	1.859AsnPro: 1.859 ± 0.042	0.962AsnGln: 0.962 ± 0.035	1.949AsnArg: 1.949 ± 0.049	1.181AsnSer: 1.181 ± 0.036	1.416AsnThr: 1.416 ± 0.036	1.717AsnVal: 1.717 ± 0.043	0.397AsnTrp: 0.397 ± 0.019	0.597AsnTyr: 0.597 ± 0.024	0.002AsnXaa: 0.002 ± 0.001
Pro	6.707ProAla: 6.707 ± 0.084	0.336ProCys: 0.336 ± 0.018	4.277ProAsp: 4.277 ± 0.071	3.767ProGlu: 3.767 ± 0.057	1.531ProPhe: 1.531 ± 0.037	4.694ProGly: 4.694 ± 0.075	0.973ProHis: 0.973 ± 0.029	2.154ProIle: 2.154 ± 0.044	1.243ProLys: 1.243 ± 0.039	4.998ProLeu: 4.998 ± 0.065	1.188ProMet: 1.188 ± 0.032	1.31ProAsn: 1.31 ± 0.038	2.663ProPro: 2.663 ± 0.053	1.907ProGln: 1.907 ± 0.042	2.963ProArg: 2.963 ± 0.059	2.775ProSer: 2.775 ± 0.053	2.801ProThr: 2.801 ± 0.054	4.424ProVal: 4.424 ± 0.068	0.755ProTrp: 0.755 ± 0.027	1.159ProTyr: 1.159 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	6.41GlnAla: 6.41 ± 0.09	0.351GlnCys: 0.351 ± 0.018	1.965GlnAsp: 1.965 ± 0.042	1.44GlnGlu: 1.44 ± 0.039	1.398GlnPhe: 1.398 ± 0.035	3.005GlnGly: 3.005 ± 0.052	0.948GlnHis: 0.948 ± 0.028	1.879GlnIle: 1.879 ± 0.043	0.664GlnLys: 0.664 ± 0.025	4.481GlnLeu: 4.481 ± 0.078	0.842GlnMet: 0.842 ± 0.026	0.773GlnAsn: 0.773 ± 0.023	2.6GlnPro: 2.6 ± 0.054	2.176GlnGln: 2.176 ± 0.05	3.751GlnArg: 3.751 ± 0.068	2.293GlnSer: 2.293 ± 0.054	2.454GlnThr: 2.454 ± 0.05	3.086GlnVal: 3.086 ± 0.049	0.752GlnTrp: 0.752 ± 0.027	0.869GlnTyr: 0.869 ± 0.029	0.001GlnXaa: 0.001 ± 0.001
Arg	7.632ArgAla: 7.632 ± 0.103	0.755ArgCys: 0.755 ± 0.029	4.227ArgAsp: 4.227 ± 0.055	4.129ArgGlu: 4.129 ± 0.08	2.9ArgPhe: 2.9 ± 0.058	4.786ArgGly: 4.786 ± 0.061	1.884ArgHis: 1.884 ± 0.042	3.553ArgIle: 3.553 ± 0.064	1.86ArgLys: 1.86 ± 0.044	8.894ArgLeu: 8.894 ± 0.12	1.979ArgMet: 1.979 ± 0.04	1.78ArgAsn: 1.78 ± 0.046	3.744ArgPro: 3.744 ± 0.069	3.569ArgGln: 3.569 ± 0.061	6.273ArgArg: 6.273 ± 0.101	4.047ArgSer: 4.047 ± 0.058	3.161ArgThr: 3.161 ± 0.055	5.543ArgVal: 5.543 ± 0.073	1.338ArgTrp: 1.338 ± 0.038	2.234ArgTyr: 2.234 ± 0.043	0.001ArgXaa: 0.001 ± 0.001
Ser	6.254SerAla: 6.254 ± 0.09	0.468SerCys: 0.468 ± 0.018	3.531SerAsp: 3.531 ± 0.068	3.129SerGlu: 3.129 ± 0.06	1.876SerPhe: 1.876 ± 0.046	5.478SerGly: 5.478 ± 0.096	1.111SerHis: 1.111 ± 0.032	2.51SerIle: 2.51 ± 0.05	1.288SerLys: 1.288 ± 0.037	5.869SerLeu: 5.869 ± 0.07	1.379SerMet: 1.379 ± 0.036	1.481SerAsn: 1.481 ± 0.039	2.814SerPro: 2.814 ± 0.059	2.086SerGln: 2.086 ± 0.048	3.794SerArg: 3.794 ± 0.059	3.069SerSer: 3.069 ± 0.063	3.084SerThr: 3.084 ± 0.069	4.147SerVal: 4.147 ± 0.065	0.698SerTrp: 0.698 ± 0.026	1.212SerTyr: 1.212 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.573ThrAla: 6.573 ± 0.1	0.424ThrCys: 0.424 ± 0.021	3.252ThrAsp: 3.252 ± 0.062	2.863ThrGlu: 2.863 ± 0.049	1.484ThrPhe: 1.484 ± 0.04	5.151ThrGly: 5.151 ± 0.074	1.128ThrHis: 1.128 ± 0.032	2.291ThrIle: 2.291 ± 0.054	0.932ThrLys: 0.932 ± 0.033	6.439ThrLeu: 6.439 ± 0.076	0.948ThrMet: 0.948 ± 0.026	1.199ThrAsn: 1.199 ± 0.04	3.572ThrPro: 3.572 ± 0.061	2.065ThrGln: 2.065 ± 0.044	3.765ThrArg: 3.765 ± 0.062	2.617ThrSer: 2.617 ± 0.056	3.002ThrThr: 3.002 ± 0.075	4.657ThrVal: 4.657 ± 0.098	0.714ThrTrp: 0.714 ± 0.026	1.168ThrTyr: 1.168 ± 0.033	0.003ThrXaa: 0.003 ± 0.002
Val	8.747ValAla: 8.747 ± 0.096	0.746ValCys: 0.746 ± 0.027	5.127ValAsp: 5.127 ± 0.069	4.683ValGlu: 4.683 ± 0.073	2.573ValPhe: 2.573 ± 0.048	5.653ValGly: 5.653 ± 0.069	1.554ValHis: 1.554 ± 0.038	3.8ValIle: 3.8 ± 0.066	1.556ValLys: 1.556 ± 0.042	7.872ValLeu: 7.872 ± 0.097	1.647ValMet: 1.647 ± 0.04	2.007ValAsn: 2.007 ± 0.051	3.681ValPro: 3.681 ± 0.064	2.703ValGln: 2.703 ± 0.049	5.135ValArg: 5.135 ± 0.077	4.349ValSer: 4.349 ± 0.069	4.533ValThr: 4.533 ± 0.087	6.088ValVal: 6.088 ± 0.087	0.946ValTrp: 0.946 ± 0.035	1.623ValTyr: 1.623 ± 0.047	0.003ValXaa: 0.003 ± 0.002
Trp	1.325TrpAla: 1.325 ± 0.034	0.148TrpCys: 0.148 ± 0.011	0.674TrpAsp: 0.674 ± 0.027	0.573TrpGlu: 0.573 ± 0.024	0.523TrpPhe: 0.523 ± 0.021	0.92TrpGly: 0.92 ± 0.038	0.352TrpHis: 0.352 ± 0.018	0.717TrpIle: 0.717 ± 0.028	0.29TrpLys: 0.29 ± 0.017	2.15TrpLeu: 2.15 ± 0.055	0.445TrpMet: 0.445 ± 0.023	0.386TrpAsn: 0.386 ± 0.02	0.765TrpPro: 0.765 ± 0.032	0.735TrpGln: 0.735 ± 0.026	1.125TrpArg: 1.125 ± 0.036	0.935TrpSer: 0.935 ± 0.031	0.838TrpThr: 0.838 ± 0.029	1.068TrpVal: 1.068 ± 0.032	0.284TrpTrp: 0.284 ± 0.018	0.325TrpTyr: 0.325 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.621TyrAla: 2.621 ± 0.05	0.254TyrCys: 0.254 ± 0.017	1.507TyrAsp: 1.507 ± 0.041	1.301TyrGlu: 1.301 ± 0.036	0.977TyrPhe: 0.977 ± 0.031	1.935TyrGly: 1.935 ± 0.042	0.505TyrHis: 0.505 ± 0.02	0.834TyrIle: 0.834 ± 0.026	0.543TyrLys: 0.543 ± 0.023	2.439TyrLeu: 2.439 ± 0.044	0.386TyrMet: 0.386 ± 0.02	0.617TyrAsn: 0.617 ± 0.025	1.122TyrPro: 1.122 ± 0.034	1.026TyrGln: 1.026 ± 0.031	2.039TyrArg: 2.039 ± 0.045	1.204TyrSer: 1.204 ± 0.034	1.228TyrThr: 1.228 ± 0.029	1.699TyrVal: 1.699 ± 0.035	0.392TyrTrp: 0.392 ± 0.017	0.609TyrTyr: 0.609 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.002XaaAsp: 0.002 ± 0.001	0.003XaaGlu: 0.003 ± 0.002	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.004XaaLys: 0.004 ± 0.003	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3331 proteins (1138768 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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