Amino acid dipepetide frequency for Meiothermus luteus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.656AlaAla: 11.656 ± 0.167
0.738AlaCys: 0.738 ± 0.035
3.665AlaAsp: 3.665 ± 0.065
7.796AlaGlu: 7.796 ± 0.132
4.295AlaPhe: 4.295 ± 0.075
8.68AlaGly: 8.68 ± 0.107
2.393AlaHis: 2.393 ± 0.053
4.08AlaIle: 4.08 ± 0.081
3.201AlaLys: 3.201 ± 0.072
17.397AlaLeu: 17.397 ± 0.197
2.196AlaMet: 2.196 ± 0.056
2.0AlaAsn: 2.0 ± 0.06
4.827AlaPro: 4.827 ± 0.074
6.053AlaGln: 6.053 ± 0.088
9.148AlaArg: 9.148 ± 0.105
4.699AlaSer: 4.699 ± 0.086
4.195AlaThr: 4.195 ± 0.081
8.005AlaVal: 8.005 ± 0.12
1.989AlaTrp: 1.989 ± 0.051
3.572AlaTyr: 3.572 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.598CysAla: 0.598 ± 0.029
0.061CysCys: 0.061 ± 0.008
0.263CysAsp: 0.263 ± 0.02
0.307CysGlu: 0.307 ± 0.02
0.197CysPhe: 0.197 ± 0.017
0.609CysGly: 0.609 ± 0.027
0.145CysHis: 0.145 ± 0.012
0.208CysIle: 0.208 ± 0.017
0.148CysLys: 0.148 ± 0.012
0.611CysLeu: 0.611 ± 0.028
0.087CysMet: 0.087 ± 0.01
0.153CysAsn: 0.153 ± 0.013
0.492CysPro: 0.492 ± 0.032
0.175CysGln: 0.175 ± 0.016
0.473CysArg: 0.473 ± 0.025
0.292CysSer: 0.292 ± 0.017
0.338CysThr: 0.338 ± 0.021
0.34CysVal: 0.34 ± 0.018
0.073CysTrp: 0.073 ± 0.01
0.181CysTyr: 0.181 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.344AspAla: 3.344 ± 0.065
0.211AspCys: 0.211 ± 0.017
1.311AspAsp: 1.311 ± 0.042
2.531AspGlu: 2.531 ± 0.07
1.55AspPhe: 1.55 ± 0.046
3.275AspGly: 3.275 ± 0.067
0.83AspHis: 0.83 ± 0.028
1.427AspIle: 1.427 ± 0.048
1.047AspLys: 1.047 ± 0.041
5.489AspLeu: 5.489 ± 0.084
0.605AspMet: 0.605 ± 0.032
0.728AspAsn: 0.728 ± 0.029
3.435AspPro: 3.435 ± 0.073
1.224AspGln: 1.224 ± 0.045
2.633AspArg: 2.633 ± 0.069
1.238AspSer: 1.238 ± 0.044
1.606AspThr: 1.606 ± 0.04
2.412AspVal: 2.412 ± 0.063
0.794AspTrp: 0.794 ± 0.037
1.264AspTyr: 1.264 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
11.374GluAla: 11.374 ± 0.16
0.253GluCys: 0.253 ± 0.02
2.457GluAsp: 2.457 ± 0.058
6.043GluGlu: 6.043 ± 0.109
1.966GluPhe: 1.966 ± 0.053
7.165GluGly: 7.165 ± 0.098
1.213GluHis: 1.213 ± 0.042
2.744GluIle: 2.744 ± 0.057
2.386GluLys: 2.386 ± 0.055
8.124GluLeu: 8.124 ± 0.109
1.258GluMet: 1.258 ± 0.042
1.546GluAsn: 1.546 ± 0.039
3.626GluPro: 3.626 ± 0.073
2.458GluGln: 2.458 ± 0.056
7.014GluArg: 7.014 ± 0.123
2.154GluSer: 2.154 ± 0.058
2.593GluThr: 2.593 ± 0.063
6.928GluVal: 6.928 ± 0.102
0.923GluTrp: 0.923 ± 0.034
1.416GluTyr: 1.416 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.714PheAla: 3.714 ± 0.074
0.243PheCys: 0.243 ± 0.018
1.57PheAsp: 1.57 ± 0.044
2.173PheGlu: 2.173 ± 0.057
1.573PhePhe: 1.573 ± 0.053
3.201PheGly: 3.201 ± 0.071
0.722PheHis: 0.722 ± 0.026
1.392PheIle: 1.392 ± 0.045
1.01PheLys: 1.01 ± 0.035
4.387PheLeu: 4.387 ± 0.092
0.541PheMet: 0.541 ± 0.027
0.901PheAsn: 0.901 ± 0.038
2.059PhePro: 2.059 ± 0.055
1.237PheGln: 1.237 ± 0.038
2.616PheArg: 2.616 ± 0.056
2.186PheSer: 2.186 ± 0.057
1.868PheThr: 1.868 ± 0.048
2.563PheVal: 2.563 ± 0.067
0.803PheTrp: 0.803 ± 0.041
1.201PheTyr: 1.201 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
8.107GlyAla: 8.107 ± 0.132
0.585GlyCys: 0.585 ± 0.028
2.859GlyAsp: 2.859 ± 0.054
5.843GlyGlu: 5.843 ± 0.086
3.884GlyPhe: 3.884 ± 0.077
7.644GlyGly: 7.644 ± 0.105
1.789GlyHis: 1.789 ± 0.052
3.459GlyIle: 3.459 ± 0.067
3.133GlyLys: 3.133 ± 0.068
13.049GlyLeu: 13.049 ± 0.174
2.013GlyMet: 2.013 ± 0.053
1.868GlyAsn: 1.868 ± 0.056
4.244GlyPro: 4.244 ± 0.066
3.654GlyGln: 3.654 ± 0.076
7.143GlyArg: 7.143 ± 0.104
4.333GlySer: 4.333 ± 0.081
3.495GlyThr: 3.495 ± 0.066
7.741GlyVal: 7.741 ± 0.117
1.683GlyTrp: 1.683 ± 0.051
3.004GlyTyr: 3.004 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
1.686HisAla: 1.686 ± 0.044
0.138HisCys: 0.138 ± 0.013
0.7HisAsp: 0.7 ± 0.029
0.899HisGlu: 0.899 ± 0.034
0.701HisPhe: 0.701 ± 0.032
1.474HisGly: 1.474 ± 0.044
0.612HisHis: 0.612 ± 0.031
0.778HisIle: 0.778 ± 0.031
0.588HisLys: 0.588 ± 0.027
3.014HisLeu: 3.014 ± 0.068
0.292HisMet: 0.292 ± 0.02
0.457HisAsn: 0.457 ± 0.022
1.908HisPro: 1.908 ± 0.049
0.828HisGln: 0.828 ± 0.03
1.575HisArg: 1.575 ± 0.046
0.79HisSer: 0.79 ± 0.03
0.998HisThr: 0.998 ± 0.035
0.962HisVal: 0.962 ± 0.034
0.301HisTrp: 0.301 ± 0.02
0.672HisTyr: 0.672 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
4.464IleAla: 4.464 ± 0.077
0.236IleCys: 0.236 ± 0.016
1.389IleAsp: 1.389 ± 0.041
2.451IleGlu: 2.451 ± 0.067
1.172IlePhe: 1.172 ± 0.044
3.291IleGly: 3.291 ± 0.074
0.77IleHis: 0.77 ± 0.029
1.167IleIle: 1.167 ± 0.047
1.002IleLys: 1.002 ± 0.041
4.32IleLeu: 4.32 ± 0.087
0.466IleMet: 0.466 ± 0.023
0.94IleAsn: 0.94 ± 0.041
2.632IlePro: 2.632 ± 0.059
1.345IleGln: 1.345 ± 0.038
2.69IleArg: 2.69 ± 0.062
1.588IleSer: 1.588 ± 0.046
1.947IleThr: 1.947 ± 0.051
2.517IleVal: 2.517 ± 0.071
0.483IleTrp: 0.483 ± 0.026
1.028IleTyr: 1.028 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.113LysAla: 4.113 ± 0.077
0.113LysCys: 0.113 ± 0.011
1.434LysAsp: 1.434 ± 0.048
2.509LysGlu: 2.509 ± 0.058
0.599LysPhe: 0.599 ± 0.032
3.017LysGly: 3.017 ± 0.06
0.537LysHis: 0.537 ± 0.028
1.032LysIle: 1.032 ± 0.038
1.224LysLys: 1.224 ± 0.041
2.804LysLeu: 2.804 ± 0.062
0.456LysMet: 0.456 ± 0.023
0.861LysAsn: 0.861 ± 0.034
2.101LysPro: 2.101 ± 0.05
0.884LysGln: 0.884 ± 0.033
2.411LysArg: 2.411 ± 0.062
1.371LysSer: 1.371 ± 0.042
1.706LysThr: 1.706 ± 0.043
2.392LysVal: 2.392 ± 0.057
0.299LysTrp: 0.299 ± 0.019
0.677LysTyr: 0.677 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
15.937LeuAla: 15.937 ± 0.159
0.769LeuCys: 0.769 ± 0.032
4.839LeuAsp: 4.839 ± 0.081
12.541LeuGlu: 12.541 ± 0.16
4.129LeuPhe: 4.129 ± 0.097
12.475LeuGly: 12.475 ± 0.179
2.178LeuHis: 2.178 ± 0.052
3.902LeuIle: 3.902 ± 0.074
4.135LeuLys: 4.135 ± 0.075
16.033LeuLeu: 16.033 ± 0.262
2.142LeuMet: 2.142 ± 0.054
2.471LeuAsn: 2.471 ± 0.062
7.72LeuPro: 7.72 ± 0.101
4.286LeuGln: 4.286 ± 0.084
10.44LeuArg: 10.44 ± 0.144
7.279LeuSer: 7.279 ± 0.096
5.38LeuThr: 5.38 ± 0.077
9.491LeuVal: 9.491 ± 0.135
2.074LeuTrp: 2.074 ± 0.058
3.242LeuTyr: 3.242 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
2.087MetAla: 2.087 ± 0.056
0.082MetCys: 0.082 ± 0.009
0.711MetAsp: 0.711 ± 0.03
1.251MetGlu: 1.251 ± 0.04
0.444MetPhe: 0.444 ± 0.023
1.933MetGly: 1.933 ± 0.05
0.278MetHis: 0.278 ± 0.018
0.551MetIle: 0.551 ± 0.028
0.713MetLys: 0.713 ± 0.029
1.979MetLeu: 1.979 ± 0.052
0.323MetMet: 0.323 ± 0.023
0.502MetAsn: 0.502 ± 0.024
1.03MetPro: 1.03 ± 0.039
0.664MetGln: 0.664 ± 0.027
1.669MetArg: 1.669 ± 0.037
0.881MetSer: 0.881 ± 0.033
0.803MetThr: 0.803 ± 0.029
1.478MetVal: 1.478 ± 0.048
0.181MetTrp: 0.181 ± 0.016
0.365MetTyr: 0.365 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
2.305AsnAla: 2.305 ± 0.06
0.132AsnCys: 0.132 ± 0.013
0.747AsnAsp: 0.747 ± 0.029
0.929AsnGlu: 0.929 ± 0.035
0.831AsnPhe: 0.831 ± 0.035
1.648AsnGly: 1.648 ± 0.056
0.429AsnHis: 0.429 ± 0.023
0.88AsnIle: 0.88 ± 0.039
0.512AsnLys: 0.512 ± 0.03
3.359AsnLeu: 3.359 ± 0.068
0.293AsnMet: 0.293 ± 0.017
0.543AsnAsn: 0.543 ± 0.031
2.512AsnPro: 2.512 ± 0.066
0.826AsnGln: 0.826 ± 0.034
1.742AsnArg: 1.742 ± 0.045
0.749AsnSer: 0.749 ± 0.034
1.055AsnThr: 1.055 ± 0.042
1.376AsnVal: 1.376 ± 0.044
0.332AsnTrp: 0.332 ± 0.023
0.636AsnTyr: 0.636 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
5.276ProAla: 5.276 ± 0.084
0.28ProCys: 0.28 ± 0.019
2.768ProAsp: 2.768 ± 0.058
5.817ProGlu: 5.817 ± 0.096
2.183ProPhe: 2.183 ± 0.05
5.751ProGly: 5.751 ± 0.093
1.378ProHis: 1.378 ± 0.039
2.06ProIle: 2.06 ± 0.053
2.191ProLys: 2.191 ± 0.054
7.037ProLeu: 7.037 ± 0.109
1.047ProMet: 1.047 ± 0.035
1.426ProAsn: 1.426 ± 0.048
3.967ProPro: 3.967 ± 0.082
2.611ProGln: 2.611 ± 0.062
3.822ProArg: 3.822 ± 0.068
3.265ProSer: 3.265 ± 0.071
2.822ProThr: 2.822 ± 0.061
4.257ProVal: 4.257 ± 0.08
1.029ProTrp: 1.029 ± 0.036
1.768ProTyr: 1.768 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
5.841GlnAla: 5.841 ± 0.097
0.135GlnCys: 0.135 ± 0.011
1.531GlnAsp: 1.531 ± 0.04
2.935GlnGlu: 2.935 ± 0.071
0.927GlnPhe: 0.927 ± 0.033
4.173GlnGly: 4.173 ± 0.07
0.671GlnHis: 0.671 ± 0.031
1.524GlnIle: 1.524 ± 0.045
1.348GlnLys: 1.348 ± 0.039
3.029GlnLeu: 3.029 ± 0.063
0.782GlnMet: 0.782 ± 0.034
1.148GlnAsn: 1.148 ± 0.046
2.03GlnPro: 2.03 ± 0.054
1.452GlnGln: 1.452 ± 0.049
2.909GlnArg: 2.909 ± 0.066
1.665GlnSer: 1.665 ± 0.054
1.851GlnThr: 1.851 ± 0.051
3.61GlnVal: 3.61 ± 0.071
0.353GlnTrp: 0.353 ± 0.02
0.738GlnTyr: 0.738 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
8.289ArgAla: 8.289 ± 0.111
0.42ArgCys: 0.42 ± 0.022
2.519ArgAsp: 2.519 ± 0.06
5.913ArgGlu: 5.913 ± 0.115
3.571ArgPhe: 3.571 ± 0.075
5.841ArgGly: 5.841 ± 0.09
1.417ArgHis: 1.417 ± 0.041
3.591ArgIle: 3.591 ± 0.064
2.465ArgLys: 2.465 ± 0.068
11.145ArgLeu: 11.145 ± 0.136
1.864ArgMet: 1.864 ± 0.047
1.592ArgAsn: 1.592 ± 0.044
4.445ArgPro: 4.445 ± 0.071
2.836ArgGln: 2.836 ± 0.064
6.395ArgArg: 6.395 ± 0.107
3.262ArgSer: 3.262 ± 0.066
3.122ArgThr: 3.122 ± 0.066
6.895ArgVal: 6.895 ± 0.106
1.431ArgTrp: 1.431 ± 0.045
2.867ArgTyr: 2.867 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
4.233SerAla: 4.233 ± 0.08
0.274SerCys: 0.274 ± 0.02
1.663SerAsp: 1.663 ± 0.04
2.794SerGlu: 2.794 ± 0.054
1.878SerPhe: 1.878 ± 0.049
4.504SerGly: 4.504 ± 0.079
0.745SerHis: 0.745 ± 0.03
1.539SerIle: 1.539 ± 0.05
1.311SerLys: 1.311 ± 0.041
6.615SerLeu: 6.615 ± 0.098
0.79SerMet: 0.79 ± 0.03
0.974SerAsn: 0.974 ± 0.039
3.322SerPro: 3.322 ± 0.065
1.692SerGln: 1.692 ± 0.052
3.422SerArg: 3.422 ± 0.062
2.378SerSer: 2.378 ± 0.055
2.035SerThr: 2.035 ± 0.05
3.154SerVal: 3.154 ± 0.069
0.701SerTrp: 0.701 ± 0.032
1.271SerTyr: 1.271 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
4.243ThrAla: 4.243 ± 0.075
0.27ThrCys: 0.27 ± 0.016
1.702ThrAsp: 1.702 ± 0.047
2.198ThrGlu: 2.198 ± 0.054
1.668ThrPhe: 1.668 ± 0.044
3.901ThrGly: 3.901 ± 0.082
0.969ThrHis: 0.969 ± 0.032
1.444ThrIle: 1.444 ± 0.045
0.933ThrLys: 0.933 ± 0.039
6.724ThrLeu: 6.724 ± 0.108
0.511ThrMet: 0.511 ± 0.031
0.9ThrAsn: 0.9 ± 0.036
3.71ThrPro: 3.71 ± 0.064
1.698ThrGln: 1.698 ± 0.049
2.858ThrArg: 2.858 ± 0.056
1.951ThrSer: 1.951 ± 0.051
2.085ThrThr: 2.085 ± 0.056
3.19ThrVal: 3.19 ± 0.07
0.616ThrTrp: 0.616 ± 0.029
1.354ThrTyr: 1.354 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
8.398ValAla: 8.398 ± 0.104
0.544ValCys: 0.544 ± 0.026
3.06ValAsp: 3.06 ± 0.075
5.982ValGlu: 5.982 ± 0.099
2.817ValPhe: 2.817 ± 0.068
7.02ValGly: 7.02 ± 0.112
1.405ValHis: 1.405 ± 0.041
2.626ValIle: 2.626 ± 0.055
1.931ValLys: 1.931 ± 0.054
10.181ValLeu: 10.181 ± 0.124
1.492ValMet: 1.492 ± 0.043
1.763ValAsn: 1.763 ± 0.051
3.977ValPro: 3.977 ± 0.065
2.795ValGln: 2.795 ± 0.06
6.815ValArg: 6.815 ± 0.093
3.398ValSer: 3.398 ± 0.062
2.772ValThr: 2.772 ± 0.063
7.49ValVal: 7.49 ± 0.116
1.279ValTrp: 1.279 ± 0.035
2.312ValTyr: 2.312 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
1.828TrpAla: 1.828 ± 0.048
0.095TrpCys: 0.095 ± 0.01
0.569TrpAsp: 0.569 ± 0.025
1.145TrpGlu: 1.145 ± 0.037
0.571TrpPhe: 0.571 ± 0.028
1.39TrpGly: 1.39 ± 0.044
0.261TrpHis: 0.261 ± 0.015
0.523TrpIle: 0.523 ± 0.024
0.511TrpLys: 0.511 ± 0.027
2.154TrpLeu: 2.154 ± 0.057
0.382TrpMet: 0.382 ± 0.022
0.407TrpAsn: 0.407 ± 0.023
0.847TrpPro: 0.847 ± 0.033
0.704TrpGln: 0.704 ± 0.027
1.278TrpArg: 1.278 ± 0.042
0.645TrpSer: 0.645 ± 0.032
0.627TrpThr: 0.627 ± 0.031
1.525TrpVal: 1.525 ± 0.048
0.312TrpTrp: 0.312 ± 0.019
0.363TrpTyr: 0.363 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.094TyrAla: 3.094 ± 0.055
0.173TyrCys: 0.173 ± 0.014
1.199TyrAsp: 1.199 ± 0.038
1.588TyrGlu: 1.588 ± 0.045
1.002TyrPhe: 1.002 ± 0.034
2.54TyrGly: 2.54 ± 0.058
0.63TyrHis: 0.63 ± 0.028
0.968TyrIle: 0.968 ± 0.031
0.751TyrLys: 0.751 ± 0.031
4.014TyrLeu: 4.014 ± 0.077
0.383TyrMet: 0.383 ± 0.02
0.655TyrAsn: 0.655 ± 0.028
1.868TyrPro: 1.868 ± 0.045
1.232TyrGln: 1.232 ± 0.045
2.828TyrArg: 2.828 ± 0.064
1.172TyrSer: 1.172 ± 0.039
1.625TyrThr: 1.625 ± 0.041
1.731TyrVal: 1.731 ± 0.051
0.479TyrTrp: 0.479 ± 0.027
0.906TyrTyr: 0.906 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2850 proteins (849109 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski