Amino acid dipepetide frequency for Faecalitalea cylindroides T2-87

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.073AlaAla: 5.073 ± 0.177
1.161AlaCys: 1.161 ± 0.051
3.667AlaAsp: 3.667 ± 0.131
3.576AlaGlu: 3.576 ± 0.14
2.76AlaPhe: 2.76 ± 0.088
4.627AlaGly: 4.627 ± 0.146
1.153AlaHis: 1.153 ± 0.06
5.33AlaIle: 5.33 ± 0.14
5.214AlaLys: 5.214 ± 0.15
6.882AlaLeu: 6.882 ± 0.144
2.181AlaMet: 2.181 ± 0.078
2.867AlaAsn: 2.867 ± 0.095
1.72AlaPro: 1.72 ± 0.081
2.539AlaGln: 2.539 ± 0.108
2.55AlaArg: 2.55 ± 0.097
4.092AlaSer: 4.092 ± 0.119
3.174AlaThr: 3.174 ± 0.114
4.257AlaVal: 4.257 ± 0.127
0.452AlaTrp: 0.452 ± 0.033
2.807AlaTyr: 2.807 ± 0.086
0.0AlaXaa: 0.0 ± 0.0
Cys
1.092CysAla: 1.092 ± 0.057
0.245CysCys: 0.245 ± 0.026
0.929CysAsp: 0.929 ± 0.056
0.863CysGlu: 0.863 ± 0.045
0.673CysPhe: 0.673 ± 0.044
1.13CysGly: 1.13 ± 0.058
0.353CysHis: 0.353 ± 0.034
1.23CysIle: 1.23 ± 0.06
0.932CysLys: 0.932 ± 0.056
1.39CysLeu: 1.39 ± 0.067
0.447CysMet: 0.447 ± 0.04
0.568CysAsn: 0.568 ± 0.039
0.653CysPro: 0.653 ± 0.046
0.499CysGln: 0.499 ± 0.035
0.648CysArg: 0.648 ± 0.05
0.94CysSer: 0.94 ± 0.051
0.764CysThr: 0.764 ± 0.046
1.067CysVal: 1.067 ± 0.059
0.127CysTrp: 0.127 ± 0.016
0.505CysTyr: 0.505 ± 0.04
0.0CysXaa: 0.0 ± 0.0
Asp
3.912AspAla: 3.912 ± 0.12
0.888AspCys: 0.888 ± 0.049
3.317AspAsp: 3.317 ± 0.093
5.145AspGlu: 5.145 ± 0.135
2.854AspPhe: 2.854 ± 0.101
3.83AspGly: 3.83 ± 0.126
1.304AspHis: 1.304 ± 0.062
4.88AspIle: 4.88 ± 0.115
4.219AspLys: 4.219 ± 0.106
5.597AspLeu: 5.597 ± 0.12
1.795AspMet: 1.795 ± 0.064
2.294AspAsn: 2.294 ± 0.065
2.142AspPro: 2.142 ± 0.081
1.999AspGln: 1.999 ± 0.07
2.305AspArg: 2.305 ± 0.107
3.245AspSer: 3.245 ± 0.092
3.309AspThr: 3.309 ± 0.098
4.053AspVal: 4.053 ± 0.095
0.582AspTrp: 0.582 ± 0.039
2.903AspTyr: 2.903 ± 0.094
0.0AspXaa: 0.0 ± 0.0
Glu
4.676GluAla: 4.676 ± 0.123
0.874GluCys: 0.874 ± 0.043
4.541GluAsp: 4.541 ± 0.132
6.427GluGlu: 6.427 ± 0.182
2.592GluPhe: 2.592 ± 0.092
3.637GluGly: 3.637 ± 0.093
1.381GluHis: 1.381 ± 0.055
5.823GluIle: 5.823 ± 0.146
6.366GluLys: 6.366 ± 0.134
6.535GluLeu: 6.535 ± 0.161
2.44GluMet: 2.44 ± 0.081
4.682GluAsn: 4.682 ± 0.116
1.883GluPro: 1.883 ± 0.095
3.047GluGln: 3.047 ± 0.111
3.088GluArg: 3.088 ± 0.109
3.295GluSer: 3.295 ± 0.093
3.695GluThr: 3.695 ± 0.117
4.673GluVal: 4.673 ± 0.132
0.678GluTrp: 0.678 ± 0.047
3.107GluTyr: 3.107 ± 0.103
0.0GluXaa: 0.0 ± 0.0
Phe
2.73PheAla: 2.73 ± 0.086
0.667PheCys: 0.667 ± 0.043
2.912PheAsp: 2.912 ± 0.099
3.027PheGlu: 3.027 ± 0.087
1.803PhePhe: 1.803 ± 0.08
2.807PheGly: 2.807 ± 0.1
0.866PheHis: 0.866 ± 0.05
3.322PheIle: 3.322 ± 0.106
2.636PheLys: 2.636 ± 0.079
3.882PheLeu: 3.882 ± 0.133
1.26PheMet: 1.26 ± 0.069
1.936PheAsn: 1.936 ± 0.079
1.191PhePro: 1.191 ± 0.056
1.312PheGln: 1.312 ± 0.067
1.387PheArg: 1.387 ± 0.059
3.091PheSer: 3.091 ± 0.095
2.123PheThr: 2.123 ± 0.087
2.876PheVal: 2.876 ± 0.102
0.353PheTrp: 0.353 ± 0.032
1.787PheTyr: 1.787 ± 0.069
0.0PheXaa: 0.0 ± 0.0
Gly
3.912GlyAla: 3.912 ± 0.12
1.186GlyCys: 1.186 ± 0.066
2.953GlyAsp: 2.953 ± 0.096
3.248GlyGlu: 3.248 ± 0.112
2.947GlyPhe: 2.947 ± 0.083
3.998GlyGly: 3.998 ± 0.141
1.238GlyHis: 1.238 ± 0.066
5.561GlyIle: 5.561 ± 0.135
4.919GlyLys: 4.919 ± 0.135
5.498GlyLeu: 5.498 ± 0.126
2.14GlyMet: 2.14 ± 0.083
2.909GlyAsn: 2.909 ± 0.096
1.175GlyPro: 1.175 ± 0.052
2.101GlyGln: 2.101 ± 0.09
2.283GlyArg: 2.283 ± 0.099
3.639GlySer: 3.639 ± 0.114
3.584GlyThr: 3.584 ± 0.107
4.155GlyVal: 4.155 ± 0.117
0.609GlyTrp: 0.609 ± 0.046
3.223GlyTyr: 3.223 ± 0.117
0.0GlyXaa: 0.0 ± 0.0
His
1.235HisAla: 1.235 ± 0.063
0.317HisCys: 0.317 ± 0.029
1.232HisAsp: 1.232 ± 0.056
1.301HisGlu: 1.301 ± 0.057
0.932HisPhe: 0.932 ± 0.05
1.312HisGly: 1.312 ± 0.062
0.433HisHis: 0.433 ± 0.039
1.511HisIle: 1.511 ± 0.067
1.23HisLys: 1.23 ± 0.057
1.69HisLeu: 1.69 ± 0.066
0.576HisMet: 0.576 ± 0.04
0.766HisAsn: 0.766 ± 0.045
0.954HisPro: 0.954 ± 0.056
0.703HisGln: 0.703 ± 0.045
0.783HisArg: 0.783 ± 0.05
0.987HisSer: 0.987 ± 0.058
1.048HisThr: 1.048 ± 0.053
1.307HisVal: 1.307 ± 0.069
0.176HisTrp: 0.176 ± 0.021
0.855HisTyr: 0.855 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
5.454IleAla: 5.454 ± 0.133
1.351IleCys: 1.351 ± 0.063
5.178IleAsp: 5.178 ± 0.115
6.217IleGlu: 6.217 ± 0.153
3.146IlePhe: 3.146 ± 0.122
4.789IleGly: 4.789 ± 0.128
1.561IleHis: 1.561 ± 0.064
5.964IleIle: 5.964 ± 0.143
5.321IleLys: 5.321 ± 0.144
7.693IleLeu: 7.693 ± 0.205
2.189IleMet: 2.189 ± 0.082
3.626IleAsn: 3.626 ± 0.124
2.975IlePro: 2.975 ± 0.097
3.32IleGln: 3.32 ± 0.1
3.245IleArg: 3.245 ± 0.108
4.966IleSer: 4.966 ± 0.115
4.037IleThr: 4.037 ± 0.115
5.509IleVal: 5.509 ± 0.155
0.64IleTrp: 0.64 ± 0.039
2.923IleTyr: 2.923 ± 0.094
0.0IleXaa: 0.0 ± 0.0
Lys
4.905LysAla: 4.905 ± 0.144
0.7LysCys: 0.7 ± 0.044
5.018LysAsp: 5.018 ± 0.142
8.181LysGlu: 8.181 ± 0.175
1.897LysPhe: 1.897 ± 0.063
4.111LysGly: 4.111 ± 0.109
1.461LysHis: 1.461 ± 0.063
5.52LysIle: 5.52 ± 0.133
7.001LysLys: 7.001 ± 0.176
5.567LysLeu: 5.567 ± 0.123
2.517LysMet: 2.517 ± 0.078
4.059LysAsn: 4.059 ± 0.12
2.247LysPro: 2.247 ± 0.083
3.091LysGln: 3.091 ± 0.1
3.234LysArg: 3.234 ± 0.092
3.733LysSer: 3.733 ± 0.106
4.224LysThr: 4.224 ± 0.104
4.629LysVal: 4.629 ± 0.13
0.568LysTrp: 0.568 ± 0.041
2.873LysTyr: 2.873 ± 0.092
0.0LysXaa: 0.0 ± 0.0
Leu
6.151LeuAla: 6.151 ± 0.156
1.572LeuCys: 1.572 ± 0.068
5.956LeuAsp: 5.956 ± 0.128
6.435LeuGlu: 6.435 ± 0.147
4.072LeuPhe: 4.072 ± 0.144
5.368LeuGly: 5.368 ± 0.137
1.676LeuHis: 1.676 ± 0.079
6.973LeuIle: 6.973 ± 0.174
7.243LeuLys: 7.243 ± 0.146
8.12LeuLeu: 8.12 ± 0.179
2.958LeuMet: 2.958 ± 0.105
4.483LeuAsn: 4.483 ± 0.125
3.262LeuPro: 3.262 ± 0.1
3.008LeuGln: 3.008 ± 0.114
3.491LeuArg: 3.491 ± 0.117
6.504LeuSer: 6.504 ± 0.148
4.624LeuThr: 4.624 ± 0.12
5.611LeuVal: 5.611 ± 0.138
0.758LeuTrp: 0.758 ± 0.046
3.361LeuTyr: 3.361 ± 0.112
0.0LeuXaa: 0.0 ± 0.0
Met
2.396MetAla: 2.396 ± 0.079
0.4MetCys: 0.4 ± 0.029
2.046MetAsp: 2.046 ± 0.07
2.393MetGlu: 2.393 ± 0.068
1.086MetPhe: 1.086 ± 0.061
1.751MetGly: 1.751 ± 0.077
0.529MetHis: 0.529 ± 0.039
2.559MetIle: 2.559 ± 0.097
2.785MetLys: 2.785 ± 0.101
2.622MetLeu: 2.622 ± 0.109
1.153MetMet: 1.153 ± 0.06
1.886MetAsn: 1.886 ± 0.072
1.169MetPro: 1.169 ± 0.057
1.13MetGln: 1.13 ± 0.067
1.114MetArg: 1.114 ± 0.051
1.817MetSer: 1.817 ± 0.083
1.61MetThr: 1.61 ± 0.06
1.93MetVal: 1.93 ± 0.073
0.185MetTrp: 0.185 ± 0.019
0.94MetTyr: 0.94 ± 0.052
0.0MetXaa: 0.0 ± 0.0
Asn
3.267AsnAla: 3.267 ± 0.097
0.659AsnCys: 0.659 ± 0.051
2.867AsnAsp: 2.867 ± 0.104
3.673AsnGlu: 3.673 ± 0.099
1.789AsnPhe: 1.789 ± 0.073
3.22AsnGly: 3.22 ± 0.107
1.001AsnHis: 1.001 ± 0.05
4.07AsnIle: 4.07 ± 0.111
3.231AsnLys: 3.231 ± 0.108
4.108AsnLeu: 4.108 ± 0.111
1.417AsnMet: 1.417 ± 0.064
2.021AsnAsn: 2.021 ± 0.082
1.889AsnPro: 1.889 ± 0.08
1.993AsnGln: 1.993 ± 0.081
1.853AsnArg: 1.853 ± 0.071
2.333AsnSer: 2.333 ± 0.075
2.561AsnThr: 2.561 ± 0.086
3.262AsnVal: 3.262 ± 0.084
0.422AsnTrp: 0.422 ± 0.033
1.913AsnTyr: 1.913 ± 0.08
0.0AsnXaa: 0.0 ± 0.0
Pro
1.897ProAla: 1.897 ± 0.083
0.414ProCys: 0.414 ± 0.035
2.027ProAsp: 2.027 ± 0.09
3.014ProGlu: 3.014 ± 0.11
1.583ProPhe: 1.583 ± 0.069
1.853ProGly: 1.853 ± 0.072
0.54ProHis: 0.54 ± 0.037
2.446ProIle: 2.446 ± 0.076
2.082ProLys: 2.082 ± 0.074
2.459ProLeu: 2.459 ± 0.084
0.921ProMet: 0.921 ± 0.044
1.533ProAsn: 1.533 ± 0.065
0.573ProPro: 0.573 ± 0.046
1.119ProGln: 1.119 ± 0.074
0.954ProArg: 0.954 ± 0.055
2.032ProSer: 2.032 ± 0.071
1.679ProThr: 1.679 ± 0.067
2.661ProVal: 2.661 ± 0.108
0.24ProTrp: 0.24 ± 0.026
1.448ProTyr: 1.448 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
2.873GlnAla: 2.873 ± 0.086
0.392GlnCys: 0.392 ± 0.032
2.2GlnAsp: 2.2 ± 0.08
2.843GlnGlu: 2.843 ± 0.084
1.431GlnPhe: 1.431 ± 0.072
1.98GlnGly: 1.98 ± 0.068
0.529GlnHis: 0.529 ± 0.037
3.058GlnIle: 3.058 ± 0.092
3.424GlnLys: 3.424 ± 0.108
3.259GlnLeu: 3.259 ± 0.12
1.208GlnMet: 1.208 ± 0.056
1.861GlnAsn: 1.861 ± 0.08
0.998GlnPro: 0.998 ± 0.056
1.348GlnGln: 1.348 ± 0.083
1.696GlnArg: 1.696 ± 0.07
2.051GlnSer: 2.051 ± 0.078
1.98GlnThr: 1.98 ± 0.078
2.151GlnVal: 2.151 ± 0.075
0.32GlnTrp: 0.32 ± 0.033
1.456GlnTyr: 1.456 ± 0.065
0.0GlnXaa: 0.0 ± 0.0
Arg
2.195ArgAla: 2.195 ± 0.092
0.521ArgCys: 0.521 ± 0.033
1.96ArgAsp: 1.96 ± 0.076
2.763ArgGlu: 2.763 ± 0.112
1.858ArgPhe: 1.858 ± 0.074
1.985ArgGly: 1.985 ± 0.08
0.816ArgHis: 0.816 ± 0.05
3.325ArgIle: 3.325 ± 0.104
3.317ArgLys: 3.317 ± 0.103
3.739ArgLeu: 3.739 ± 0.133
1.594ArgMet: 1.594 ± 0.069
1.98ArgAsn: 1.98 ± 0.077
1.227ArgPro: 1.227 ± 0.073
1.698ArgGln: 1.698 ± 0.071
1.938ArgArg: 1.938 ± 0.089
2.231ArgSer: 2.231 ± 0.09
1.889ArgThr: 1.889 ± 0.073
2.429ArgVal: 2.429 ± 0.086
0.29ArgTrp: 0.29 ± 0.031
1.767ArgTyr: 1.767 ± 0.08
0.0ArgXaa: 0.0 ± 0.0
Ser
3.565SerAla: 3.565 ± 0.113
0.907SerCys: 0.907 ± 0.051
3.356SerAsp: 3.356 ± 0.1
3.488SerGlu: 3.488 ± 0.107
3.055SerPhe: 3.055 ± 0.09
4.219SerGly: 4.219 ± 0.119
1.164SerHis: 1.164 ± 0.056
4.811SerIle: 4.811 ± 0.129
4.409SerLys: 4.409 ± 0.117
6.115SerLeu: 6.115 ± 0.151
1.85SerMet: 1.85 ± 0.076
2.793SerAsn: 2.793 ± 0.102
1.511SerPro: 1.511 ± 0.065
2.018SerGln: 2.018 ± 0.073
2.355SerArg: 2.355 ± 0.083
3.681SerSer: 3.681 ± 0.108
3.105SerThr: 3.105 ± 0.089
4.025SerVal: 4.025 ± 0.109
0.554SerTrp: 0.554 ± 0.041
2.495SerTyr: 2.495 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
3.201ThrAla: 3.201 ± 0.132
0.75ThrCys: 0.75 ± 0.045
2.992ThrAsp: 2.992 ± 0.117
2.903ThrGlu: 2.903 ± 0.109
2.33ThrPhe: 2.33 ± 0.094
3.722ThrGly: 3.722 ± 0.115
0.984ThrHis: 0.984 ± 0.048
4.605ThrIle: 4.605 ± 0.125
3.722ThrLys: 3.722 ± 0.089
5.098ThrLeu: 5.098 ± 0.111
1.516ThrMet: 1.516 ± 0.061
2.324ThrAsn: 2.324 ± 0.082
2.073ThrPro: 2.073 ± 0.08
1.704ThrGln: 1.704 ± 0.064
1.958ThrArg: 1.958 ± 0.077
3.328ThrSer: 3.328 ± 0.094
2.981ThrThr: 2.981 ± 0.126
3.703ThrVal: 3.703 ± 0.117
0.425ThrTrp: 0.425 ± 0.032
2.272ThrTyr: 2.272 ± 0.093
0.0ThrXaa: 0.0 ± 0.0
Val
4.232ValAla: 4.232 ± 0.13
1.21ValCys: 1.21 ± 0.06
4.169ValAsp: 4.169 ± 0.106
4.48ValGlu: 4.48 ± 0.147
2.928ValPhe: 2.928 ± 0.094
3.758ValGly: 3.758 ± 0.102
1.255ValHis: 1.255 ± 0.069
5.266ValIle: 5.266 ± 0.132
4.37ValLys: 4.37 ± 0.144
6.601ValLeu: 6.601 ± 0.16
1.955ValMet: 1.955 ± 0.077
2.826ValAsn: 2.826 ± 0.09
2.084ValPro: 2.084 ± 0.067
2.173ValGln: 2.173 ± 0.079
2.589ValArg: 2.589 ± 0.097
4.657ValSer: 4.657 ± 0.104
3.488ValThr: 3.488 ± 0.171
4.624ValVal: 4.624 ± 0.143
0.474ValTrp: 0.474 ± 0.035
2.856ValTyr: 2.856 ± 0.094
0.0ValXaa: 0.0 ± 0.0
Trp
0.452TrpAla: 0.452 ± 0.038
0.149TrpCys: 0.149 ± 0.019
0.494TrpAsp: 0.494 ± 0.038
0.455TrpGlu: 0.455 ± 0.038
0.369TrpPhe: 0.369 ± 0.035
0.425TrpGly: 0.425 ± 0.033
0.135TrpHis: 0.135 ± 0.019
0.893TrpIle: 0.893 ± 0.053
0.645TrpLys: 0.645 ± 0.044
0.871TrpLeu: 0.871 ± 0.049
0.273TrpMet: 0.273 ± 0.028
0.469TrpAsn: 0.469 ± 0.036
0.174TrpPro: 0.174 ± 0.026
0.441TrpGln: 0.441 ± 0.034
0.35TrpArg: 0.35 ± 0.031
0.411TrpSer: 0.411 ± 0.035
0.425TrpThr: 0.425 ± 0.035
0.4TrpVal: 0.4 ± 0.034
0.08TrpTrp: 0.08 ± 0.013
0.306TrpTyr: 0.306 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.862TyrAla: 2.862 ± 0.09
0.692TyrCys: 0.692 ± 0.045
2.76TyrAsp: 2.76 ± 0.095
3.008TyrGlu: 3.008 ± 0.076
1.861TyrPhe: 1.861 ± 0.078
2.757TyrGly: 2.757 ± 0.089
0.971TyrHis: 0.971 ± 0.056
2.958TyrIle: 2.958 ± 0.092
2.47TyrLys: 2.47 ± 0.083
3.901TyrLeu: 3.901 ± 0.118
1.108TyrMet: 1.108 ± 0.056
1.668TyrAsn: 1.668 ± 0.073
1.572TyrPro: 1.572 ± 0.063
1.811TyrGln: 1.811 ± 0.075
1.701TyrArg: 1.701 ± 0.067
2.443TyrSer: 2.443 ± 0.081
2.294TyrThr: 2.294 ± 0.086
2.674TyrVal: 2.674 ± 0.099
0.284TyrTrp: 0.284 ± 0.034
1.811TyrTyr: 1.811 ± 0.088
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1442 proteins (362689 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski