Amino acid dipepetide frequency for Hasllibacter halocynthiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.852AlaAla: 23.852 ± 0.29
1.14AlaCys: 1.14 ± 0.043
7.728AlaAsp: 7.728 ± 0.119
10.169AlaGlu: 10.169 ± 0.144
5.055AlaPhe: 5.055 ± 0.096
14.188AlaGly: 14.188 ± 0.175
2.443AlaHis: 2.443 ± 0.061
5.586AlaIle: 5.586 ± 0.079
2.696AlaLys: 2.696 ± 0.07
17.424AlaLeu: 17.424 ± 0.205
4.095AlaMet: 4.095 ± 0.072
2.156AlaAsn: 2.156 ± 0.055
8.562AlaPro: 8.562 ± 0.144
3.447AlaGln: 3.447 ± 0.068
12.896AlaArg: 12.896 ± 0.165
5.481AlaSer: 5.481 ± 0.087
6.11AlaThr: 6.11 ± 0.092
10.352AlaVal: 10.352 ± 0.117
1.863AlaTrp: 1.863 ± 0.049
2.234AlaTyr: 2.234 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
1.122CysAla: 1.122 ± 0.039
0.08CysCys: 0.08 ± 0.009
0.515CysAsp: 0.515 ± 0.024
0.483CysGlu: 0.483 ± 0.025
0.246CysPhe: 0.246 ± 0.015
0.975CysGly: 0.975 ± 0.041
0.225CysHis: 0.225 ± 0.02
0.29CysIle: 0.29 ± 0.021
0.113CysLys: 0.113 ± 0.012
0.726CysLeu: 0.726 ± 0.03
0.145CysMet: 0.145 ± 0.012
0.143CysAsn: 0.143 ± 0.013
0.474CysPro: 0.474 ± 0.028
0.152CysGln: 0.152 ± 0.013
0.572CysArg: 0.572 ± 0.028
0.3CysSer: 0.3 ± 0.019
0.352CysThr: 0.352 ± 0.022
0.582CysVal: 0.582 ± 0.027
0.097CysTrp: 0.097 ± 0.011
0.147CysTyr: 0.147 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
9.401AspAla: 9.401 ± 0.148
0.422AspCys: 0.422 ± 0.023
3.333AspAsp: 3.333 ± 0.083
3.867AspGlu: 3.867 ± 0.075
1.89AspPhe: 1.89 ± 0.046
6.673AspGly: 6.673 ± 0.114
1.267AspHis: 1.267 ± 0.039
1.96AspIle: 1.96 ± 0.048
0.786AspLys: 0.786 ± 0.035
6.56AspLeu: 6.56 ± 0.103
1.385AspMet: 1.385 ± 0.04
0.712AspAsn: 0.712 ± 0.031
4.559AspPro: 4.559 ± 0.083
1.204AspGln: 1.204 ± 0.04
5.249AspArg: 5.249 ± 0.09
1.396AspSer: 1.396 ± 0.037
2.127AspThr: 2.127 ± 0.058
4.699AspVal: 4.699 ± 0.083
1.147AspTrp: 1.147 ± 0.039
1.253AspTyr: 1.253 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
10.997GluAla: 10.997 ± 0.142
0.334GluCys: 0.334 ± 0.017
3.906GluAsp: 3.906 ± 0.073
4.748GluGlu: 4.748 ± 0.088
1.475GluPhe: 1.475 ± 0.039
8.126GluGly: 8.126 ± 0.129
1.07GluHis: 1.07 ± 0.035
2.814GluIle: 2.814 ± 0.062
1.419GluLys: 1.419 ± 0.053
4.535GluLeu: 4.535 ± 0.071
1.712GluMet: 1.712 ± 0.037
1.214GluAsn: 1.214 ± 0.036
2.763GluPro: 2.763 ± 0.067
1.343GluGln: 1.343 ± 0.042
5.87GluArg: 5.87 ± 0.088
1.777GluSer: 1.777 ± 0.048
3.299GluThr: 3.299 ± 0.069
5.55GluVal: 5.55 ± 0.083
0.895GluTrp: 0.895 ± 0.033
0.903GluTyr: 0.903 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.673PheAla: 4.673 ± 0.082
0.322PheCys: 0.322 ± 0.017
2.506PheAsp: 2.506 ± 0.057
2.289PheGlu: 2.289 ± 0.052
1.128PhePhe: 1.128 ± 0.041
3.693PheGly: 3.693 ± 0.073
0.632PheHis: 0.632 ± 0.028
0.957PheIle: 0.957 ± 0.033
0.502PheLys: 0.502 ± 0.027
3.463PheLeu: 3.463 ± 0.068
0.649PheMet: 0.649 ± 0.028
0.625PheAsn: 0.625 ± 0.028
1.585PhePro: 1.585 ± 0.051
0.73PheGln: 0.73 ± 0.031
2.337PheArg: 2.337 ± 0.054
1.403PheSer: 1.403 ± 0.045
1.558PheThr: 1.558 ± 0.052
2.722PheVal: 2.722 ± 0.056
0.517PheTrp: 0.517 ± 0.028
0.775PheTyr: 0.775 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
14.154GlyAla: 14.154 ± 0.157
0.918GlyCys: 0.918 ± 0.036
5.407GlyAsp: 5.407 ± 0.092
6.406GlyGlu: 6.406 ± 0.1
3.725GlyPhe: 3.725 ± 0.074
10.506GlyGly: 10.506 ± 0.17
1.938GlyHis: 1.938 ± 0.051
4.373GlyIle: 4.373 ± 0.076
2.098GlyLys: 2.098 ± 0.06
9.729GlyLeu: 9.729 ± 0.116
2.79GlyMet: 2.79 ± 0.061
1.646GlyAsn: 1.646 ± 0.044
5.531GlyPro: 5.531 ± 0.088
2.398GlyGln: 2.398 ± 0.055
9.028GlyArg: 9.028 ± 0.121
3.673GlySer: 3.673 ± 0.073
5.776GlyThr: 5.776 ± 0.11
6.878GlyVal: 6.878 ± 0.087
1.859GlyTrp: 1.859 ± 0.056
2.04GlyTyr: 2.04 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
2.547HisAla: 2.547 ± 0.056
0.189HisCys: 0.189 ± 0.016
1.234HisAsp: 1.234 ± 0.04
1.127HisGlu: 1.127 ± 0.036
0.619HisPhe: 0.619 ± 0.03
1.989HisGly: 1.989 ± 0.048
0.492HisHis: 0.492 ± 0.027
0.517HisIle: 0.517 ± 0.027
0.253HisLys: 0.253 ± 0.018
2.074HisLeu: 2.074 ± 0.051
0.423HisMet: 0.423 ± 0.02
0.305HisAsn: 0.305 ± 0.02
1.512HisPro: 1.512 ± 0.045
0.398HisGln: 0.398 ± 0.02
1.501HisArg: 1.501 ± 0.049
0.711HisSer: 0.711 ± 0.032
0.615HisThr: 0.615 ± 0.029
1.643HisVal: 1.643 ± 0.042
0.316HisTrp: 0.316 ± 0.02
0.447HisTyr: 0.447 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.098IleAla: 6.098 ± 0.089
0.386IleCys: 0.386 ± 0.021
2.916IleAsp: 2.916 ± 0.071
3.117IleGlu: 3.117 ± 0.064
1.146IlePhe: 1.146 ± 0.041
4.301IleGly: 4.301 ± 0.076
0.726IleHis: 0.726 ± 0.029
1.025IleIle: 1.025 ± 0.046
0.645IleLys: 0.645 ± 0.027
3.97IleLeu: 3.97 ± 0.078
0.723IleMet: 0.723 ± 0.031
0.648IleAsn: 0.648 ± 0.027
2.072IlePro: 2.072 ± 0.056
0.732IleGln: 0.732 ± 0.029
3.058IleArg: 3.058 ± 0.058
1.58IleSer: 1.58 ± 0.046
1.813IleThr: 1.813 ± 0.054
3.46IleVal: 3.46 ± 0.078
0.574IleTrp: 0.574 ± 0.029
0.819IleTyr: 0.819 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
2.852LysAla: 2.852 ± 0.066
0.095LysCys: 0.095 ± 0.011
1.25LysAsp: 1.25 ± 0.043
1.013LysGlu: 1.013 ± 0.039
0.472LysPhe: 0.472 ± 0.025
2.081LysGly: 2.081 ± 0.055
0.37LysHis: 0.37 ± 0.022
0.777LysIle: 0.777 ± 0.033
0.657LysLys: 0.657 ± 0.036
1.746LysLeu: 1.746 ± 0.052
0.484LysMet: 0.484 ± 0.027
0.379LysAsn: 0.379 ± 0.025
1.123LysPro: 1.123 ± 0.04
0.416LysGln: 0.416 ± 0.025
1.595LysArg: 1.595 ± 0.05
0.89LysSer: 0.89 ± 0.033
0.949LysThr: 0.949 ± 0.031
1.645LysVal: 1.645 ± 0.051
0.21LysTrp: 0.21 ± 0.018
0.33LysTyr: 0.33 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
15.698LeuAla: 15.698 ± 0.192
0.815LeuCys: 0.815 ± 0.032
6.188LeuAsp: 6.188 ± 0.099
5.665LeuGlu: 5.665 ± 0.088
3.183LeuPhe: 3.183 ± 0.064
9.504LeuGly: 9.504 ± 0.111
1.879LeuHis: 1.879 ± 0.05
3.927LeuIle: 3.927 ± 0.079
2.04LeuLys: 2.04 ± 0.064
9.725LeuLeu: 9.725 ± 0.144
2.264LeuMet: 2.264 ± 0.054
1.928LeuAsn: 1.928 ± 0.046
6.132LeuPro: 6.132 ± 0.097
2.109LeuGln: 2.109 ± 0.054
8.881LeuArg: 8.881 ± 0.118
5.827LeuSer: 5.827 ± 0.09
5.12LeuThr: 5.12 ± 0.093
7.404LeuVal: 7.404 ± 0.101
1.536LeuTrp: 1.536 ± 0.049
1.72LeuTyr: 1.72 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
3.354MetAla: 3.354 ± 0.064
0.136MetCys: 0.136 ± 0.013
1.456MetAsp: 1.456 ± 0.04
1.302MetGlu: 1.302 ± 0.041
0.541MetPhe: 0.541 ± 0.026
2.228MetGly: 2.228 ± 0.05
0.389MetHis: 0.389 ± 0.023
1.176MetIle: 1.176 ± 0.042
0.692MetLys: 0.692 ± 0.029
2.256MetLeu: 2.256 ± 0.053
0.609MetMet: 0.609 ± 0.027
0.623MetAsn: 0.623 ± 0.024
1.689MetPro: 1.689 ± 0.043
0.649MetGln: 0.649 ± 0.029
2.323MetArg: 2.323 ± 0.06
1.22MetSer: 1.22 ± 0.036
1.873MetThr: 1.873 ± 0.043
1.565MetVal: 1.565 ± 0.045
0.21MetTrp: 0.21 ± 0.015
0.251MetTyr: 0.251 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.461AsnAla: 2.461 ± 0.057
0.165AsnCys: 0.165 ± 0.015
1.001AsnAsp: 1.001 ± 0.035
0.924AsnGlu: 0.924 ± 0.039
0.64AsnPhe: 0.64 ± 0.022
1.705AsnGly: 1.705 ± 0.049
0.355AsnHis: 0.355 ± 0.023
0.675AsnIle: 0.675 ± 0.033
0.3AsnLys: 0.3 ± 0.019
1.92AsnLeu: 1.92 ± 0.049
0.403AsnMet: 0.403 ± 0.022
0.346AsnAsn: 0.346 ± 0.022
1.42AsnPro: 1.42 ± 0.044
0.421AsnGln: 0.421 ± 0.023
1.338AsnArg: 1.338 ± 0.044
0.636AsnSer: 0.636 ± 0.032
0.743AsnThr: 0.743 ± 0.029
1.633AsnVal: 1.633 ± 0.054
0.266AsnTrp: 0.266 ± 0.018
0.42AsnTyr: 0.42 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
8.419ProAla: 8.419 ± 0.144
0.391ProCys: 0.391 ± 0.02
4.265ProAsp: 4.265 ± 0.074
5.006ProGlu: 5.006 ± 0.092
2.098ProPhe: 2.098 ± 0.054
6.459ProGly: 6.459 ± 0.095
1.11ProHis: 1.11 ± 0.037
1.936ProIle: 1.936 ± 0.044
1.254ProLys: 1.254 ± 0.045
5.357ProLeu: 5.357 ± 0.086
1.289ProMet: 1.289 ± 0.042
1.012ProAsn: 1.012 ± 0.035
3.66ProPro: 3.66 ± 0.091
1.245ProGln: 1.245 ± 0.039
4.019ProArg: 4.019 ± 0.08
2.71ProSer: 2.71 ± 0.067
2.179ProThr: 2.179 ± 0.047
4.821ProVal: 4.821 ± 0.087
0.856ProTrp: 0.856 ± 0.032
0.994ProTyr: 0.994 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.271GlnAla: 3.271 ± 0.062
0.145GlnCys: 0.145 ± 0.013
1.371GlnAsp: 1.371 ± 0.037
1.254GlnGlu: 1.254 ± 0.044
0.718GlnPhe: 0.718 ± 0.033
2.253GlnGly: 2.253 ± 0.057
0.38GlnHis: 0.38 ± 0.023
1.245GlnIle: 1.245 ± 0.041
0.559GlnLys: 0.559 ± 0.028
1.921GlnLeu: 1.921 ± 0.048
0.636GlnMet: 0.636 ± 0.027
0.478GlnAsn: 0.478 ± 0.024
1.19GlnPro: 1.19 ± 0.044
0.713GlnGln: 0.713 ± 0.032
1.876GlnArg: 1.876 ± 0.055
1.111GlnSer: 1.111 ± 0.038
1.088GlnThr: 1.088 ± 0.036
1.878GlnVal: 1.878 ± 0.05
0.277GlnTrp: 0.277 ± 0.017
0.393GlnTyr: 0.393 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
12.222ArgAla: 12.222 ± 0.167
0.544ArgCys: 0.544 ± 0.029
4.895ArgAsp: 4.895 ± 0.07
5.343ArgGlu: 5.343 ± 0.088
2.949ArgPhe: 2.949 ± 0.061
6.805ArgGly: 6.805 ± 0.109
1.832ArgHis: 1.832 ± 0.048
4.091ArgIle: 4.091 ± 0.074
1.577ArgLys: 1.577 ± 0.037
8.957ArgLeu: 8.957 ± 0.135
2.322ArgMet: 2.322 ± 0.06
1.43ArgAsn: 1.43 ± 0.043
4.92ArgPro: 4.92 ± 0.103
2.149ArgGln: 2.149 ± 0.046
8.116ArgArg: 8.116 ± 0.128
3.171ArgSer: 3.171 ± 0.068
4.1ArgThr: 4.1 ± 0.065
5.85ArgVal: 5.85 ± 0.09
1.315ArgTrp: 1.315 ± 0.044
1.552ArgTyr: 1.552 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
5.266SerAla: 5.266 ± 0.09
0.326SerCys: 0.326 ± 0.021
2.443SerAsp: 2.443 ± 0.057
2.426SerGlu: 2.426 ± 0.059
1.639SerPhe: 1.639 ± 0.052
4.755SerGly: 4.755 ± 0.082
0.75SerHis: 0.75 ± 0.034
1.701SerIle: 1.701 ± 0.045
0.89SerLys: 0.89 ± 0.035
3.838SerLeu: 3.838 ± 0.072
0.998SerMet: 0.998 ± 0.033
0.858SerAsn: 0.858 ± 0.033
2.316SerPro: 2.316 ± 0.054
1.006SerGln: 1.006 ± 0.036
3.016SerArg: 3.016 ± 0.059
1.79SerSer: 1.79 ± 0.051
1.929SerThr: 1.929 ± 0.054
3.13SerVal: 3.13 ± 0.067
0.61SerTrp: 0.61 ± 0.028
0.926SerTyr: 0.926 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
6.023ThrAla: 6.023 ± 0.095
0.407ThrCys: 0.407 ± 0.021
2.792ThrAsp: 2.792 ± 0.061
2.577ThrGlu: 2.577 ± 0.056
1.794ThrPhe: 1.794 ± 0.055
5.472ThrGly: 5.472 ± 0.097
0.869ThrHis: 0.869 ± 0.037
2.1ThrIle: 2.1 ± 0.05
0.874ThrLys: 0.874 ± 0.033
5.531ThrLeu: 5.531 ± 0.085
1.072ThrMet: 1.072 ± 0.037
0.905ThrAsn: 0.905 ± 0.038
3.17ThrPro: 3.17 ± 0.066
1.042ThrGln: 1.042 ± 0.036
3.426ThrArg: 3.426 ± 0.061
2.078ThrSer: 2.078 ± 0.057
2.331ThrThr: 2.331 ± 0.066
4.326ThrVal: 4.326 ± 0.083
0.59ThrTrp: 0.59 ± 0.031
0.869ThrTyr: 0.869 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
10.925ValAla: 10.925 ± 0.122
0.586ValCys: 0.586 ± 0.027
4.36ValAsp: 4.36 ± 0.07
5.072ValGlu: 5.072 ± 0.088
2.593ValPhe: 2.593 ± 0.059
6.05ValGly: 6.05 ± 0.089
1.479ValHis: 1.479 ± 0.045
3.516ValIle: 3.516 ± 0.077
1.337ValLys: 1.337 ± 0.042
8.375ValLeu: 8.375 ± 0.12
1.812ValMet: 1.812 ± 0.057
1.62ValAsn: 1.62 ± 0.049
4.768ValPro: 4.768 ± 0.078
1.733ValGln: 1.733 ± 0.05
6.135ValArg: 6.135 ± 0.099
3.357ValSer: 3.357 ± 0.061
4.62ValThr: 4.62 ± 0.096
6.307ValVal: 6.307 ± 0.103
1.01ValTrp: 1.01 ± 0.033
1.164ValTyr: 1.164 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.695TrpAla: 1.695 ± 0.049
0.156TrpCys: 0.156 ± 0.013
0.886TrpAsp: 0.886 ± 0.038
0.738TrpGlu: 0.738 ± 0.031
0.486TrpPhe: 0.486 ± 0.027
1.201TrpGly: 1.201 ± 0.04
0.317TrpHis: 0.317 ± 0.016
0.679TrpIle: 0.679 ± 0.029
0.332TrpLys: 0.332 ± 0.02
1.693TrpLeu: 1.693 ± 0.05
0.391TrpMet: 0.391 ± 0.025
0.393TrpAsn: 0.393 ± 0.021
0.795TrpPro: 0.795 ± 0.034
0.446TrpGln: 0.446 ± 0.025
1.42TrpArg: 1.42 ± 0.045
0.792TrpSer: 0.792 ± 0.034
0.908TrpThr: 0.908 ± 0.031
0.864TrpVal: 0.864 ± 0.033
0.334TrpTrp: 0.334 ± 0.02
0.231TrpTyr: 0.231 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.446TyrAla: 2.446 ± 0.06
0.182TyrCys: 0.182 ± 0.016
1.438TyrAsp: 1.438 ± 0.046
1.223TyrGlu: 1.223 ± 0.039
0.668TyrPhe: 0.668 ± 0.03
1.911TyrGly: 1.911 ± 0.046
0.39TyrHis: 0.39 ± 0.024
0.464TyrIle: 0.464 ± 0.023
0.313TyrLys: 0.313 ± 0.02
1.745TyrLeu: 1.745 ± 0.047
0.339TyrMet: 0.339 ± 0.022
0.349TyrAsn: 0.349 ± 0.019
0.839TyrPro: 0.839 ± 0.03
0.423TyrGln: 0.423 ± 0.022
1.485TyrArg: 1.485 ± 0.046
0.711TyrSer: 0.711 ± 0.029
0.758TyrThr: 0.758 ± 0.032
1.51TyrVal: 1.51 ± 0.04
0.273TyrTrp: 0.273 ± 0.018
0.415TyrTyr: 0.415 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2723 proteins (841267 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski