Amino acid dipepetide frequency for Rhizobium straminoryzae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.887AlaAla: 16.887 ± 0.161
1.031AlaCys: 1.031 ± 0.024
6.85AlaAsp: 6.85 ± 0.077
7.678AlaGlu: 7.678 ± 0.091
4.578AlaPhe: 4.578 ± 0.051
10.868AlaGly: 10.868 ± 0.096
2.276AlaHis: 2.276 ± 0.037
6.709AlaIle: 6.709 ± 0.069
3.853AlaLys: 3.853 ± 0.057
13.428AlaLeu: 13.428 ± 0.128
3.612AlaMet: 3.612 ± 0.05
2.796AlaAsn: 2.796 ± 0.045
5.137AlaPro: 5.137 ± 0.07
3.546AlaGln: 3.546 ± 0.044
8.722AlaArg: 8.722 ± 0.082
6.667AlaSer: 6.667 ± 0.067
6.044AlaThr: 6.044 ± 0.063
8.667AlaVal: 8.667 ± 0.085
1.395AlaTrp: 1.395 ± 0.026
2.533AlaTyr: 2.533 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.823CysAla: 0.823 ± 0.024
0.115CysCys: 0.115 ± 0.009
0.48CysAsp: 0.48 ± 0.02
0.414CysGlu: 0.414 ± 0.016
0.286CysPhe: 0.286 ± 0.014
0.898CysGly: 0.898 ± 0.023
0.215CysHis: 0.215 ± 0.011
0.37CysIle: 0.37 ± 0.015
0.157CysLys: 0.157 ± 0.01
0.855CysLeu: 0.855 ± 0.022
0.153CysMet: 0.153 ± 0.011
0.19CysAsn: 0.19 ± 0.01
0.392CysPro: 0.392 ± 0.015
0.209CysGln: 0.209 ± 0.011
0.595CysArg: 0.595 ± 0.02
0.405CysSer: 0.405 ± 0.018
0.364CysThr: 0.364 ± 0.014
0.548CysVal: 0.548 ± 0.019
0.099CysTrp: 0.099 ± 0.008
0.172CysTyr: 0.172 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.441AspAla: 6.441 ± 0.067
0.485AspCys: 0.485 ± 0.018
2.787AspAsp: 2.787 ± 0.052
3.285AspGlu: 3.285 ± 0.053
2.274AspPhe: 2.274 ± 0.041
4.961AspGly: 4.961 ± 0.057
1.285AspHis: 1.285 ± 0.031
3.183AspIle: 3.183 ± 0.047
1.709AspLys: 1.709 ± 0.039
6.355AspLeu: 6.355 ± 0.077
1.411AspMet: 1.411 ± 0.03
1.364AspAsn: 1.364 ± 0.035
3.293AspPro: 3.293 ± 0.048
1.696AspGln: 1.696 ± 0.031
4.234AspArg: 4.234 ± 0.051
2.015AspSer: 2.015 ± 0.038
2.52AspThr: 2.52 ± 0.04
4.083AspVal: 4.083 ± 0.05
0.98AspTrp: 0.98 ± 0.027
1.52AspTyr: 1.52 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
7.701GluAla: 7.701 ± 0.083
0.308GluCys: 0.308 ± 0.012
2.875GluAsp: 2.875 ± 0.049
3.376GluGlu: 3.376 ± 0.063
1.643GluPhe: 1.643 ± 0.034
4.269GluGly: 4.269 ± 0.053
1.119GluHis: 1.119 ± 0.028
3.576GluIle: 3.576 ± 0.053
2.377GluLys: 2.377 ± 0.049
4.828GluLeu: 4.828 ± 0.055
1.455GluMet: 1.455 ± 0.029
1.644GluAsn: 1.644 ± 0.032
2.633GluPro: 2.633 ± 0.051
2.133GluGln: 2.133 ± 0.038
4.843GluArg: 4.843 ± 0.06
2.227GluSer: 2.227 ± 0.04
3.678GluThr: 3.678 ± 0.057
3.716GluVal: 3.716 ± 0.057
0.616GluTrp: 0.616 ± 0.019
0.854GluTyr: 0.854 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
4.65PheAla: 4.65 ± 0.051
0.377PheCys: 0.377 ± 0.014
2.67PheAsp: 2.67 ± 0.047
2.057PheGlu: 2.057 ± 0.038
1.552PhePhe: 1.552 ± 0.041
3.819PheGly: 3.819 ± 0.062
0.787PheHis: 0.787 ± 0.018
1.856PheIle: 1.856 ± 0.038
0.991PheLys: 0.991 ± 0.025
3.681PheLeu: 3.681 ± 0.058
0.861PheMet: 0.861 ± 0.024
1.085PheAsn: 1.085 ± 0.022
1.588PhePro: 1.588 ± 0.032
1.13PheGln: 1.13 ± 0.028
2.422PheArg: 2.422 ± 0.043
2.477PheSer: 2.477 ± 0.038
1.949PheThr: 1.949 ± 0.036
2.853PheVal: 2.853 ± 0.039
0.556PheTrp: 0.556 ± 0.019
0.927PheTyr: 0.927 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
8.798GlyAla: 8.798 ± 0.089
0.795GlyCys: 0.795 ± 0.022
4.162GlyAsp: 4.162 ± 0.056
4.831GlyGlu: 4.831 ± 0.06
3.814GlyPhe: 3.814 ± 0.049
6.965GlyGly: 6.965 ± 0.093
1.891GlyHis: 1.891 ± 0.036
4.935GlyIle: 4.935 ± 0.068
3.264GlyLys: 3.264 ± 0.048
9.276GlyLeu: 9.276 ± 0.086
2.324GlyMet: 2.324 ± 0.042
2.189GlyAsn: 2.189 ± 0.04
3.226GlyPro: 3.226 ± 0.052
2.925GlyGln: 2.925 ± 0.042
6.139GlyArg: 6.139 ± 0.066
4.685GlySer: 4.685 ± 0.059
4.597GlyThr: 4.597 ± 0.068
5.792GlyVal: 5.792 ± 0.054
1.287GlyTrp: 1.287 ± 0.028
2.336GlyTyr: 2.336 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.342HisAla: 2.342 ± 0.036
0.215HisCys: 0.215 ± 0.012
1.257HisAsp: 1.257 ± 0.033
0.997HisGlu: 0.997 ± 0.025
0.887HisPhe: 0.887 ± 0.023
1.93HisGly: 1.93 ± 0.039
0.605HisHis: 0.605 ± 0.025
0.946HisIle: 0.946 ± 0.025
0.456HisLys: 0.456 ± 0.016
2.224HisLeu: 2.224 ± 0.041
0.52HisMet: 0.52 ± 0.016
0.437HisAsn: 0.437 ± 0.018
1.356HisPro: 1.356 ± 0.032
0.646HisGln: 0.646 ± 0.021
1.492HisArg: 1.492 ± 0.028
0.903HisSer: 0.903 ± 0.023
0.794HisThr: 0.794 ± 0.023
1.585HisVal: 1.585 ± 0.031
0.323HisTrp: 0.323 ± 0.015
0.547HisTyr: 0.547 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
7.489IleAla: 7.489 ± 0.07
0.499IleCys: 0.499 ± 0.017
3.668IleAsp: 3.668 ± 0.051
3.466IleGlu: 3.466 ± 0.053
1.899IlePhe: 1.899 ± 0.039
5.327IleGly: 5.327 ± 0.06
0.944IleHis: 0.944 ± 0.025
2.574IleIle: 2.574 ± 0.04
1.371IleLys: 1.371 ± 0.039
5.033IleLeu: 5.033 ± 0.059
1.061IleMet: 1.061 ± 0.028
1.505IleAsn: 1.505 ± 0.031
2.351IlePro: 2.351 ± 0.035
1.256IleGln: 1.256 ± 0.03
3.736IleArg: 3.736 ± 0.049
3.168IleSer: 3.168 ± 0.049
2.827IleThr: 2.827 ± 0.038
4.245IleVal: 4.245 ± 0.057
0.612IleTrp: 0.612 ± 0.021
1.191IleTyr: 1.191 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
4.542LysAla: 4.542 ± 0.06
0.131LysCys: 0.131 ± 0.009
1.754LysAsp: 1.754 ± 0.041
1.601LysGlu: 1.601 ± 0.037
0.9LysPhe: 0.9 ± 0.029
2.745LysGly: 2.745 ± 0.048
0.544LysHis: 0.544 ± 0.018
1.782LysIle: 1.782 ± 0.04
1.257LysLys: 1.257 ± 0.033
3.133LysLeu: 3.133 ± 0.048
0.808LysMet: 0.808 ± 0.025
0.891LysAsn: 0.891 ± 0.025
2.13LysPro: 2.13 ± 0.036
0.998LysGln: 0.998 ± 0.03
2.21LysArg: 2.21 ± 0.04
1.835LysSer: 1.835 ± 0.036
2.072LysThr: 2.072 ± 0.036
2.527LysVal: 2.527 ± 0.051
0.332LysTrp: 0.332 ± 0.015
0.571LysTyr: 0.571 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
13.676LeuAla: 13.676 ± 0.116
0.897LeuCys: 0.897 ± 0.024
6.018LeuAsp: 6.018 ± 0.069
5.201LeuGlu: 5.201 ± 0.061
3.861LeuPhe: 3.861 ± 0.053
8.162LeuGly: 8.162 ± 0.087
1.811LeuHis: 1.811 ± 0.034
5.332LeuIle: 5.332 ± 0.067
3.984LeuLys: 3.984 ± 0.057
9.997LeuLeu: 9.997 ± 0.114
2.644LeuMet: 2.644 ± 0.049
2.694LeuAsn: 2.694 ± 0.039
5.698LeuPro: 5.698 ± 0.065
3.04LeuGln: 3.04 ± 0.043
6.494LeuArg: 6.494 ± 0.077
7.707LeuSer: 7.707 ± 0.092
5.872LeuThr: 5.872 ± 0.066
7.672LeuVal: 7.672 ± 0.075
1.145LeuTrp: 1.145 ± 0.028
2.138LeuTyr: 2.138 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
3.32MetAla: 3.32 ± 0.05
0.133MetCys: 0.133 ± 0.008
1.172MetAsp: 1.172 ± 0.028
1.191MetGlu: 1.191 ± 0.029
0.669MetPhe: 0.669 ± 0.021
1.757MetGly: 1.757 ± 0.035
0.446MetHis: 0.446 ± 0.017
1.489MetIle: 1.489 ± 0.034
0.989MetLys: 0.989 ± 0.027
2.638MetLeu: 2.638 ± 0.046
0.712MetMet: 0.712 ± 0.022
0.813MetAsn: 0.813 ± 0.023
1.61MetPro: 1.61 ± 0.033
0.92MetGln: 0.92 ± 0.022
1.851MetArg: 1.851 ± 0.034
1.739MetSer: 1.739 ± 0.033
1.994MetThr: 1.994 ± 0.033
1.794MetVal: 1.794 ± 0.035
0.18MetTrp: 0.18 ± 0.011
0.315MetTyr: 0.315 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.151AsnAla: 3.151 ± 0.041
0.205AsnCys: 0.205 ± 0.011
1.352AsnAsp: 1.352 ± 0.029
1.209AsnGlu: 1.209 ± 0.026
0.991AsnPhe: 0.991 ± 0.028
2.527AsnGly: 2.527 ± 0.041
0.554AsnHis: 0.554 ± 0.018
1.409AsnIle: 1.409 ± 0.031
0.64AsnLys: 0.64 ± 0.02
2.708AsnLeu: 2.708 ± 0.04
0.619AsnMet: 0.619 ± 0.021
0.743AsnAsn: 0.743 ± 0.024
1.83AsnPro: 1.83 ± 0.037
0.765AsnGln: 0.765 ± 0.021
1.97AsnArg: 1.97 ± 0.034
1.255AsnSer: 1.255 ± 0.032
1.281AsnThr: 1.281 ± 0.03
1.908AsnVal: 1.908 ± 0.037
0.438AsnTrp: 0.438 ± 0.018
0.67AsnTyr: 0.67 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
6.201ProAla: 6.201 ± 0.081
0.271ProCys: 0.271 ± 0.012
3.59ProAsp: 3.59 ± 0.055
3.405ProGlu: 3.405 ± 0.051
2.05ProPhe: 2.05 ± 0.034
4.24ProGly: 4.24 ± 0.052
1.128ProHis: 1.128 ± 0.025
2.136ProIle: 2.136 ± 0.036
1.717ProLys: 1.717 ± 0.032
4.924ProLeu: 4.924 ± 0.054
1.199ProMet: 1.199 ± 0.025
1.231ProAsn: 1.231 ± 0.029
2.273ProPro: 2.273 ± 0.054
1.887ProGln: 1.887 ± 0.035
2.755ProArg: 2.755 ± 0.049
2.671ProSer: 2.671 ± 0.041
2.261ProThr: 2.261 ± 0.04
4.448ProVal: 4.448 ± 0.057
0.626ProTrp: 0.626 ± 0.021
1.22ProTyr: 1.22 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
4.196GlnAla: 4.196 ± 0.058
0.167GlnCys: 0.167 ± 0.01
1.528GlnAsp: 1.528 ± 0.032
1.549GlnGlu: 1.549 ± 0.032
1.097GlnPhe: 1.097 ± 0.027
2.401GlnGly: 2.401 ± 0.039
0.629GlnHis: 0.629 ± 0.02
1.86GlnIle: 1.86 ± 0.034
1.188GlnLys: 1.188 ± 0.027
2.913GlnLeu: 2.913 ± 0.044
0.959GlnMet: 0.959 ± 0.026
0.92GlnAsn: 0.92 ± 0.024
1.896GlnPro: 1.896 ± 0.038
1.413GlnGln: 1.413 ± 0.035
2.39GlnArg: 2.39 ± 0.039
1.889GlnSer: 1.889 ± 0.034
1.9GlnThr: 1.9 ± 0.03
2.266GlnVal: 2.266 ± 0.036
0.374GlnTrp: 0.374 ± 0.016
0.566GlnTyr: 0.566 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
7.614ArgAla: 7.614 ± 0.081
0.428ArgCys: 0.428 ± 0.017
3.974ArgAsp: 3.974 ± 0.054
3.968ArgGlu: 3.968 ± 0.05
2.998ArgPhe: 2.998 ± 0.044
4.468ArgGly: 4.468 ± 0.056
1.916ArgHis: 1.916 ± 0.036
4.134ArgIle: 4.134 ± 0.058
2.319ArgLys: 2.319 ± 0.043
8.256ArgLeu: 8.256 ± 0.093
2.001ArgMet: 2.001 ± 0.036
1.919ArgAsn: 1.919 ± 0.037
3.517ArgPro: 3.517 ± 0.056
2.957ArgGln: 2.957 ± 0.042
5.804ArgArg: 5.804 ± 0.069
3.689ArgSer: 3.689 ± 0.045
3.42ArgThr: 3.42 ± 0.046
4.467ArgVal: 4.467 ± 0.053
0.872ArgTrp: 0.872 ± 0.022
1.742ArgTyr: 1.742 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.483SerAla: 6.483 ± 0.07
0.358SerCys: 0.358 ± 0.016
2.976SerAsp: 2.976 ± 0.046
2.828SerGlu: 2.828 ± 0.049
2.426SerPhe: 2.426 ± 0.041
5.628SerGly: 5.628 ± 0.071
1.159SerHis: 1.159 ± 0.027
3.04SerIle: 3.04 ± 0.054
1.574SerLys: 1.574 ± 0.038
6.129SerLeu: 6.129 ± 0.075
1.367SerMet: 1.367 ± 0.029
1.401SerAsn: 1.401 ± 0.029
2.792SerPro: 2.792 ± 0.046
1.72SerGln: 1.72 ± 0.034
3.864SerArg: 3.864 ± 0.053
3.176SerSer: 3.176 ± 0.051
2.872SerThr: 2.872 ± 0.049
4.3SerVal: 4.3 ± 0.055
0.73SerTrp: 0.73 ± 0.02
1.322SerTyr: 1.322 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
6.48ThrAla: 6.48 ± 0.06
0.411ThrCys: 0.411 ± 0.017
2.85ThrAsp: 2.85 ± 0.039
2.676ThrGlu: 2.676 ± 0.045
2.104ThrPhe: 2.104 ± 0.037
5.201ThrGly: 5.201 ± 0.063
1.044ThrHis: 1.044 ± 0.027
3.076ThrIle: 3.076 ± 0.043
1.44ThrLys: 1.44 ± 0.031
6.134ThrLeu: 6.134 ± 0.066
1.219ThrMet: 1.219 ± 0.026
1.265ThrAsn: 1.265 ± 0.032
3.063ThrPro: 3.063 ± 0.043
1.443ThrGln: 1.443 ± 0.031
3.337ThrArg: 3.337 ± 0.054
2.829ThrSer: 2.829 ± 0.048
2.885ThrThr: 2.885 ± 0.056
4.549ThrVal: 4.549 ± 0.056
0.63ThrTrp: 0.63 ± 0.021
1.247ThrTyr: 1.247 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
8.898ValAla: 8.898 ± 0.084
0.59ValCys: 0.59 ± 0.02
3.936ValAsp: 3.936 ± 0.05
4.445ValGlu: 4.445 ± 0.058
2.795ValPhe: 2.795 ± 0.04
5.142ValGly: 5.142 ± 0.059
1.342ValHis: 1.342 ± 0.029
4.268ValIle: 4.268 ± 0.053
2.391ValLys: 2.391 ± 0.04
7.57ValLeu: 7.57 ± 0.08
1.999ValMet: 1.999 ± 0.039
2.053ValAsn: 2.053 ± 0.041
3.661ValPro: 3.661 ± 0.05
2.053ValGln: 2.053 ± 0.036
4.727ValArg: 4.727 ± 0.053
4.788ValSer: 4.788 ± 0.054
4.743ValThr: 4.743 ± 0.062
5.812ValVal: 5.812 ± 0.065
0.866ValTrp: 0.866 ± 0.024
1.484ValTyr: 1.484 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.112TrpAla: 1.112 ± 0.028
0.124TrpCys: 0.124 ± 0.009
0.595TrpAsp: 0.595 ± 0.022
0.535TrpGlu: 0.535 ± 0.02
0.534TrpPhe: 0.534 ± 0.02
0.815TrpGly: 0.815 ± 0.026
0.31TrpHis: 0.31 ± 0.013
0.635TrpIle: 0.635 ± 0.021
0.482TrpLys: 0.482 ± 0.019
1.611TrpLeu: 1.611 ± 0.035
0.355TrpMet: 0.355 ± 0.016
0.469TrpAsn: 0.469 ± 0.018
0.645TrpPro: 0.645 ± 0.02
0.624TrpGln: 0.624 ± 0.021
1.049TrpArg: 1.049 ± 0.027
0.808TrpSer: 0.808 ± 0.025
0.712TrpThr: 0.712 ± 0.022
0.709TrpVal: 0.709 ± 0.022
0.212TrpTrp: 0.212 ± 0.011
0.293TrpTyr: 0.293 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.475TyrAla: 2.475 ± 0.041
0.2TyrCys: 0.2 ± 0.011
1.385TyrAsp: 1.385 ± 0.034
1.155TyrGlu: 1.155 ± 0.029
0.928TyrPhe: 0.928 ± 0.024
2.112TyrGly: 2.112 ± 0.038
0.458TyrHis: 0.458 ± 0.019
0.91TyrIle: 0.91 ± 0.023
0.605TyrLys: 0.605 ± 0.02
2.353TyrLeu: 2.353 ± 0.04
0.451TyrMet: 0.451 ± 0.015
0.614TyrAsn: 0.614 ± 0.018
1.142TyrPro: 1.142 ± 0.028
0.739TyrGln: 0.739 ± 0.024
1.829TyrArg: 1.829 ± 0.036
1.212TyrSer: 1.212 ± 0.032
1.098TyrThr: 1.098 ± 0.028
1.619TyrVal: 1.619 ± 0.033
0.36TyrTrp: 0.36 ± 0.018
0.594TyrTyr: 0.594 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5046 proteins (1624162 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski