Amino acid dipepetide frequency for Martelella sp. BGMRC2036

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.588AlaAla: 15.588 ± 0.178
0.972AlaCys: 0.972 ± 0.028
6.954AlaAsp: 6.954 ± 0.073
7.577AlaGlu: 7.577 ± 0.102
4.816AlaPhe: 4.816 ± 0.069
10.33AlaGly: 10.33 ± 0.103
2.097AlaHis: 2.097 ± 0.042
7.275AlaIle: 7.275 ± 0.08
3.949AlaLys: 3.949 ± 0.066
13.225AlaLeu: 13.225 ± 0.13
3.693AlaMet: 3.693 ± 0.05
2.887AlaAsn: 2.887 ± 0.051
4.725AlaPro: 4.725 ± 0.076
3.132AlaGln: 3.132 ± 0.055
7.782AlaArg: 7.782 ± 0.109
6.433AlaSer: 6.433 ± 0.08
5.915AlaThr: 5.915 ± 0.073
8.33AlaVal: 8.33 ± 0.089
1.277AlaTrp: 1.277 ± 0.033
2.683AlaTyr: 2.683 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.889CysAla: 0.889 ± 0.028
0.109CysCys: 0.109 ± 0.009
0.534CysAsp: 0.534 ± 0.021
0.438CysGlu: 0.438 ± 0.018
0.339CysPhe: 0.339 ± 0.015
0.919CysGly: 0.919 ± 0.028
0.262CysHis: 0.262 ± 0.014
0.373CysIle: 0.373 ± 0.016
0.185CysLys: 0.185 ± 0.012
0.856CysLeu: 0.856 ± 0.026
0.168CysMet: 0.168 ± 0.009
0.218CysAsn: 0.218 ± 0.012
0.427CysPro: 0.427 ± 0.017
0.226CysGln: 0.226 ± 0.013
0.574CysArg: 0.574 ± 0.02
0.488CysSer: 0.488 ± 0.019
0.382CysThr: 0.382 ± 0.018
0.527CysVal: 0.527 ± 0.02
0.119CysTrp: 0.119 ± 0.009
0.219CysTyr: 0.219 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.442AspAla: 6.442 ± 0.071
0.551AspCys: 0.551 ± 0.021
3.595AspAsp: 3.595 ± 0.064
3.603AspGlu: 3.603 ± 0.054
2.588AspPhe: 2.588 ± 0.044
5.614AspGly: 5.614 ± 0.088
1.334AspHis: 1.334 ± 0.032
3.571AspIle: 3.571 ± 0.053
1.876AspLys: 1.876 ± 0.045
5.839AspLeu: 5.839 ± 0.079
1.743AspMet: 1.743 ± 0.033
1.725AspAsn: 1.725 ± 0.036
3.285AspPro: 3.285 ± 0.051
1.931AspGln: 1.931 ± 0.039
3.987AspArg: 3.987 ± 0.068
2.406AspSer: 2.406 ± 0.05
2.684AspThr: 2.684 ± 0.046
4.043AspVal: 4.043 ± 0.063
0.918AspTrp: 0.918 ± 0.026
1.685AspTyr: 1.685 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.356GluAla: 7.356 ± 0.091
0.343GluCys: 0.343 ± 0.017
3.176GluAsp: 3.176 ± 0.046
3.202GluGlu: 3.202 ± 0.064
1.673GluPhe: 1.673 ± 0.036
4.121GluGly: 4.121 ± 0.059
1.128GluHis: 1.128 ± 0.03
3.826GluIle: 3.826 ± 0.054
2.941GluLys: 2.941 ± 0.055
4.745GluLeu: 4.745 ± 0.074
1.632GluMet: 1.632 ± 0.031
2.16GluAsn: 2.16 ± 0.042
2.525GluPro: 2.525 ± 0.048
1.881GluGln: 1.881 ± 0.038
4.324GluArg: 4.324 ± 0.069
2.235GluSer: 2.235 ± 0.039
3.958GluThr: 3.958 ± 0.057
3.228GluVal: 3.228 ± 0.051
0.633GluTrp: 0.633 ± 0.024
0.995GluTyr: 0.995 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
4.891PheAla: 4.891 ± 0.058
0.409PheCys: 0.409 ± 0.019
2.858PheAsp: 2.858 ± 0.053
2.18PheGlu: 2.18 ± 0.04
1.752PhePhe: 1.752 ± 0.047
3.988PheGly: 3.988 ± 0.059
0.783PheHis: 0.783 ± 0.02
2.125PheIle: 2.125 ± 0.045
1.095PheLys: 1.095 ± 0.031
3.662PheLeu: 3.662 ± 0.057
1.001PheMet: 1.001 ± 0.028
1.242PheAsn: 1.242 ± 0.028
1.714PhePro: 1.714 ± 0.033
1.073PheGln: 1.073 ± 0.032
2.229PheArg: 2.229 ± 0.041
2.995PheSer: 2.995 ± 0.046
2.201PheThr: 2.201 ± 0.046
2.834PheVal: 2.834 ± 0.048
0.565PheTrp: 0.565 ± 0.02
1.048PheTyr: 1.048 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
8.545GlyAla: 8.545 ± 0.107
0.795GlyCys: 0.795 ± 0.022
4.69GlyAsp: 4.69 ± 0.106
4.674GlyGlu: 4.674 ± 0.059
3.982GlyPhe: 3.982 ± 0.058
7.498GlyGly: 7.498 ± 0.385
1.846GlyHis: 1.846 ± 0.04
5.078GlyIle: 5.078 ± 0.071
3.471GlyLys: 3.471 ± 0.05
9.013GlyLeu: 9.013 ± 0.085
2.386GlyMet: 2.386 ± 0.043
2.544GlyAsn: 2.544 ± 0.061
3.209GlyPro: 3.209 ± 0.049
2.759GlyGln: 2.759 ± 0.048
5.497GlyArg: 5.497 ± 0.068
4.876GlySer: 4.876 ± 0.116
4.705GlyThr: 4.705 ± 0.11
5.756GlyVal: 5.756 ± 0.075
1.246GlyTrp: 1.246 ± 0.028
2.389GlyTyr: 2.389 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
2.16HisAla: 2.16 ± 0.04
0.219HisCys: 0.219 ± 0.015
1.301HisAsp: 1.301 ± 0.035
1.04HisGlu: 1.04 ± 0.022
0.979HisPhe: 0.979 ± 0.025
1.825HisGly: 1.825 ± 0.035
0.511HisHis: 0.511 ± 0.024
1.127HisIle: 1.127 ± 0.031
0.54HisLys: 0.54 ± 0.02
1.907HisLeu: 1.907 ± 0.039
0.58HisMet: 0.58 ± 0.02
0.507HisAsn: 0.507 ± 0.019
1.212HisPro: 1.212 ± 0.031
0.585HisGln: 0.585 ± 0.019
1.277HisArg: 1.277 ± 0.031
0.931HisSer: 0.931 ± 0.025
0.759HisThr: 0.759 ± 0.021
1.428HisVal: 1.428 ± 0.034
0.271HisTrp: 0.271 ± 0.014
0.579HisTyr: 0.579 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
8.418IleAla: 8.418 ± 0.08
0.596IleCys: 0.596 ± 0.026
3.993IleAsp: 3.993 ± 0.057
3.532IleGlu: 3.532 ± 0.058
2.285IlePhe: 2.285 ± 0.044
5.491IleGly: 5.491 ± 0.078
0.949IleHis: 0.949 ± 0.027
3.045IleIle: 3.045 ± 0.057
1.551IleLys: 1.551 ± 0.035
5.048IleLeu: 5.048 ± 0.066
1.312IleMet: 1.312 ± 0.029
1.732IleAsn: 1.732 ± 0.034
2.493IlePro: 2.493 ± 0.046
1.177IleGln: 1.177 ± 0.03
3.38IleArg: 3.38 ± 0.049
3.615IleSer: 3.615 ± 0.053
3.222IleThr: 3.222 ± 0.048
4.423IleVal: 4.423 ± 0.061
0.667IleTrp: 0.667 ± 0.023
1.387IleTyr: 1.387 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
4.699LysAla: 4.699 ± 0.069
0.185LysCys: 0.185 ± 0.011
1.883LysAsp: 1.883 ± 0.039
1.594LysGlu: 1.594 ± 0.038
0.912LysPhe: 0.912 ± 0.026
2.842LysGly: 2.842 ± 0.048
0.598LysHis: 0.598 ± 0.02
2.129LysIle: 2.129 ± 0.041
1.521LysLys: 1.521 ± 0.037
3.466LysLeu: 3.466 ± 0.048
0.937LysMet: 0.937 ± 0.03
1.104LysAsn: 1.104 ± 0.029
2.087LysPro: 2.087 ± 0.039
1.093LysGln: 1.093 ± 0.028
2.486LysArg: 2.486 ± 0.045
2.05LysSer: 2.05 ± 0.035
2.379LysThr: 2.379 ± 0.042
2.492LysVal: 2.492 ± 0.05
0.372LysTrp: 0.372 ± 0.018
0.66LysTyr: 0.66 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
12.71LeuAla: 12.71 ± 0.118
0.853LeuCys: 0.853 ± 0.027
5.889LeuAsp: 5.889 ± 0.078
5.319LeuGlu: 5.319 ± 0.071
3.971LeuPhe: 3.971 ± 0.072
7.844LeuGly: 7.844 ± 0.077
1.694LeuHis: 1.694 ± 0.04
5.556LeuIle: 5.556 ± 0.07
4.302LeuLys: 4.302 ± 0.058
8.965LeuLeu: 8.965 ± 0.122
2.719LeuMet: 2.719 ± 0.045
2.821LeuAsn: 2.821 ± 0.041
5.338LeuPro: 5.338 ± 0.067
2.769LeuGln: 2.769 ± 0.047
5.497LeuArg: 5.497 ± 0.072
7.542LeuSer: 7.542 ± 0.078
5.814LeuThr: 5.814 ± 0.08
7.117LeuVal: 7.117 ± 0.087
0.995LeuTrp: 0.995 ± 0.031
2.252LeuTyr: 2.252 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
3.432MetAla: 3.432 ± 0.061
0.143MetCys: 0.143 ± 0.011
1.213MetAsp: 1.213 ± 0.031
1.24MetGlu: 1.24 ± 0.03
0.78MetPhe: 0.78 ± 0.025
1.794MetGly: 1.794 ± 0.036
0.48MetHis: 0.48 ± 0.019
1.774MetIle: 1.774 ± 0.036
1.204MetLys: 1.204 ± 0.035
2.898MetLeu: 2.898 ± 0.044
0.794MetMet: 0.794 ± 0.028
0.913MetAsn: 0.913 ± 0.024
1.601MetPro: 1.601 ± 0.036
0.883MetGln: 0.883 ± 0.024
1.891MetArg: 1.891 ± 0.041
1.818MetSer: 1.818 ± 0.03
2.087MetThr: 2.087 ± 0.034
1.907MetVal: 1.907 ± 0.039
0.208MetTrp: 0.208 ± 0.012
0.328MetTyr: 0.328 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.415AsnAla: 3.415 ± 0.051
0.248AsnCys: 0.248 ± 0.014
1.685AsnAsp: 1.685 ± 0.036
1.355AsnGlu: 1.355 ± 0.029
1.138AsnPhe: 1.138 ± 0.029
2.841AsnGly: 2.841 ± 0.07
0.589AsnHis: 0.589 ± 0.023
1.738AsnIle: 1.738 ± 0.037
0.789AsnLys: 0.789 ± 0.026
2.706AsnLeu: 2.706 ± 0.048
0.804AsnMet: 0.804 ± 0.027
0.861AsnAsn: 0.861 ± 0.026
1.895AsnPro: 1.895 ± 0.044
0.882AsnGln: 0.882 ± 0.027
1.912AsnArg: 1.912 ± 0.043
1.492AsnSer: 1.492 ± 0.041
1.403AsnThr: 1.403 ± 0.036
2.045AsnVal: 2.045 ± 0.04
0.482AsnTrp: 0.482 ± 0.018
0.781AsnTyr: 0.781 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
5.723ProAla: 5.723 ± 0.09
0.317ProCys: 0.317 ± 0.014
3.672ProAsp: 3.672 ± 0.049
3.67ProGlu: 3.67 ± 0.054
2.063ProPhe: 2.063 ± 0.035
4.119ProGly: 4.119 ± 0.053
0.993ProHis: 0.993 ± 0.031
2.2ProIle: 2.2 ± 0.038
1.692ProLys: 1.692 ± 0.042
4.622ProLeu: 4.622 ± 0.061
1.188ProMet: 1.188 ± 0.028
1.265ProAsn: 1.265 ± 0.034
2.102ProPro: 2.102 ± 0.053
1.537ProGln: 1.537 ± 0.035
2.278ProArg: 2.278 ± 0.045
2.626ProSer: 2.626 ± 0.044
2.131ProThr: 2.131 ± 0.041
4.17ProVal: 4.17 ± 0.057
0.564ProTrp: 0.564 ± 0.02
1.292ProTyr: 1.292 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.684GlnAla: 3.684 ± 0.059
0.202GlnCys: 0.202 ± 0.014
1.475GlnAsp: 1.475 ± 0.031
1.388GlnGlu: 1.388 ± 0.035
1.098GlnPhe: 1.098 ± 0.027
2.047GlnGly: 2.047 ± 0.043
0.607GlnHis: 0.607 ± 0.022
1.902GlnIle: 1.902 ± 0.041
1.257GlnLys: 1.257 ± 0.034
2.826GlnLeu: 2.826 ± 0.048
0.962GlnMet: 0.962 ± 0.026
0.983GlnAsn: 0.983 ± 0.029
1.583GlnPro: 1.583 ± 0.031
1.253GlnGln: 1.253 ± 0.037
2.158GlnArg: 2.158 ± 0.052
1.942GlnSer: 1.942 ± 0.059
1.785GlnThr: 1.785 ± 0.042
1.914GlnVal: 1.914 ± 0.033
0.376GlnTrp: 0.376 ± 0.016
0.66GlnTyr: 0.66 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
6.761ArgAla: 6.761 ± 0.082
0.432ArgCys: 0.432 ± 0.02
3.752ArgAsp: 3.752 ± 0.062
3.556ArgGlu: 3.556 ± 0.072
2.901ArgPhe: 2.901 ± 0.053
4.039ArgGly: 4.039 ± 0.058
1.567ArgHis: 1.567 ± 0.034
3.912ArgIle: 3.912 ± 0.057
2.322ArgLys: 2.322 ± 0.04
7.184ArgLeu: 7.184 ± 0.101
1.761ArgMet: 1.761 ± 0.037
1.881ArgAsn: 1.881 ± 0.038
3.052ArgPro: 3.052 ± 0.058
2.623ArgGln: 2.623 ± 0.044
4.699ArgArg: 4.699 ± 0.078
3.437ArgSer: 3.437 ± 0.052
2.765ArgThr: 2.765 ± 0.039
3.924ArgVal: 3.924 ± 0.052
0.793ArgTrp: 0.793 ± 0.022
1.685ArgTyr: 1.685 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.642SerAla: 6.642 ± 0.092
0.442SerCys: 0.442 ± 0.017
3.502SerAsp: 3.502 ± 0.051
3.193SerGlu: 3.193 ± 0.048
2.614SerPhe: 2.614 ± 0.044
6.248SerGly: 6.248 ± 0.119
1.186SerHis: 1.186 ± 0.029
3.103SerIle: 3.103 ± 0.065
1.784SerLys: 1.784 ± 0.039
5.91SerLeu: 5.91 ± 0.07
1.46SerMet: 1.46 ± 0.033
1.55SerAsn: 1.55 ± 0.04
2.7SerPro: 2.7 ± 0.043
1.687SerGln: 1.687 ± 0.038
3.518SerArg: 3.518 ± 0.056
3.427SerSer: 3.427 ± 0.094
2.861SerThr: 2.861 ± 0.064
4.349SerVal: 4.349 ± 0.074
0.76SerTrp: 0.76 ± 0.023
1.483SerTyr: 1.483 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
6.329ThrAla: 6.329 ± 0.073
0.432ThrCys: 0.432 ± 0.016
2.945ThrAsp: 2.945 ± 0.054
2.65ThrGlu: 2.65 ± 0.041
2.129ThrPhe: 2.129 ± 0.041
5.363ThrGly: 5.363 ± 0.081
1.027ThrHis: 1.027 ± 0.027
3.325ThrIle: 3.325 ± 0.061
1.565ThrLys: 1.565 ± 0.035
6.135ThrLeu: 6.135 ± 0.09
1.36ThrMet: 1.36 ± 0.031
1.422ThrAsn: 1.422 ± 0.038
3.044ThrPro: 3.044 ± 0.048
1.328ThrGln: 1.328 ± 0.032
3.053ThrArg: 3.053 ± 0.046
2.984ThrSer: 2.984 ± 0.065
2.971ThrThr: 2.971 ± 0.067
4.536ThrVal: 4.536 ± 0.069
0.575ThrTrp: 0.575 ± 0.022
1.313ThrTyr: 1.313 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
8.362ValAla: 8.362 ± 0.079
0.592ValCys: 0.592 ± 0.022
4.068ValAsp: 4.068 ± 0.05
4.168ValGlu: 4.168 ± 0.063
2.996ValPhe: 2.996 ± 0.042
4.958ValGly: 4.958 ± 0.081
1.243ValHis: 1.243 ± 0.032
4.513ValIle: 4.513 ± 0.061
2.351ValLys: 2.351 ± 0.047
7.075ValLeu: 7.075 ± 0.08
2.048ValMet: 2.048 ± 0.041
2.058ValAsn: 2.058 ± 0.037
3.377ValPro: 3.377 ± 0.046
1.829ValGln: 1.829 ± 0.037
3.823ValArg: 3.823 ± 0.058
4.923ValSer: 4.923 ± 0.068
4.616ValThr: 4.616 ± 0.079
5.207ValVal: 5.207 ± 0.062
0.812ValTrp: 0.812 ± 0.026
1.563ValTyr: 1.563 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.039TrpAla: 1.039 ± 0.027
0.131TrpCys: 0.131 ± 0.008
0.616TrpAsp: 0.616 ± 0.021
0.467TrpGlu: 0.467 ± 0.02
0.556TrpPhe: 0.556 ± 0.019
0.815TrpGly: 0.815 ± 0.025
0.307TrpHis: 0.307 ± 0.013
0.653TrpIle: 0.653 ± 0.025
0.444TrpLys: 0.444 ± 0.019
1.459TrpLeu: 1.459 ± 0.037
0.347TrpMet: 0.347 ± 0.017
0.466TrpAsn: 0.466 ± 0.016
0.651TrpPro: 0.651 ± 0.022
0.611TrpGln: 0.611 ± 0.02
0.938TrpArg: 0.938 ± 0.028
0.811TrpSer: 0.811 ± 0.025
0.671TrpThr: 0.671 ± 0.02
0.719TrpVal: 0.719 ± 0.022
0.212TrpTrp: 0.212 ± 0.014
0.304TrpTyr: 0.304 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.556TyrAla: 2.556 ± 0.049
0.278TyrCys: 0.278 ± 0.014
1.621TyrAsp: 1.621 ± 0.035
1.239TyrGlu: 1.239 ± 0.029
1.071TyrPhe: 1.071 ± 0.027
2.262TyrGly: 2.262 ± 0.046
0.535TyrHis: 0.535 ± 0.02
1.091TyrIle: 1.091 ± 0.023
0.651TyrLys: 0.651 ± 0.02
2.428TyrLeu: 2.428 ± 0.046
0.497TyrMet: 0.497 ± 0.02
0.722TyrAsn: 0.722 ± 0.024
1.204TyrPro: 1.204 ± 0.032
0.84TyrGln: 0.84 ± 0.025
1.741TyrArg: 1.741 ± 0.038
1.384TyrSer: 1.384 ± 0.035
1.179TyrThr: 1.179 ± 0.032
1.633TyrVal: 1.633 ± 0.034
0.374TyrTrp: 0.374 ± 0.015
0.662TyrTyr: 0.662 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4394 proteins (1450704 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski