Amino acid dipepetide frequency for Mycoplasma mucosicanis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.258AlaAla: 3.258 ± 0.119
0.353AlaCys: 0.353 ± 0.036
2.609AlaAsp: 2.609 ± 0.106
2.869AlaGlu: 2.869 ± 0.133
2.803AlaPhe: 2.803 ± 0.117
2.633AlaGly: 2.633 ± 0.137
1.083AlaHis: 1.083 ± 0.078
5.218AlaIle: 5.218 ± 0.164
6.387AlaLys: 6.387 ± 0.167
5.952AlaLeu: 5.952 ± 0.161
0.978AlaMet: 0.978 ± 0.061
3.941AlaAsn: 3.941 ± 0.115
1.444AlaPro: 1.444 ± 0.086
2.951AlaGln: 2.951 ± 0.129
2.334AlaArg: 2.334 ± 0.102
3.883AlaSer: 3.883 ± 0.146
3.18AlaThr: 3.18 ± 0.118
2.753AlaVal: 2.753 ± 0.129
0.466AlaTrp: 0.466 ± 0.047
1.984AlaTyr: 1.984 ± 0.087
0.0AlaXaa: 0.0 ± 0.0
Cys
0.4CysAla: 0.4 ± 0.045
0.054CysCys: 0.054 ± 0.017
0.346CysAsp: 0.346 ± 0.038
0.322CysGlu: 0.322 ± 0.037
0.377CysPhe: 0.377 ± 0.042
0.33CysGly: 0.33 ± 0.035
0.132CysHis: 0.132 ± 0.026
0.384CysIle: 0.384 ± 0.045
0.45CysLys: 0.45 ± 0.043
0.602CysLeu: 0.602 ± 0.059
0.082CysMet: 0.082 ± 0.018
0.291CysAsn: 0.291 ± 0.038
0.19CysPro: 0.19 ± 0.033
0.163CysGln: 0.163 ± 0.024
0.171CysArg: 0.171 ± 0.029
0.528CysSer: 0.528 ± 0.046
0.268CysThr: 0.268 ± 0.033
0.431CysVal: 0.431 ± 0.047
0.074CysTrp: 0.074 ± 0.018
0.233CysTyr: 0.233 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
3.564AspAla: 3.564 ± 0.166
0.214AspCys: 0.214 ± 0.031
3.079AspAsp: 3.079 ± 0.136
4.951AspGlu: 4.951 ± 0.176
3.588AspPhe: 3.588 ± 0.141
2.57AspGly: 2.57 ± 0.117
0.835AspHis: 0.835 ± 0.05
4.857AspIle: 4.857 ± 0.161
6.504AspLys: 6.504 ± 0.254
5.572AspLeu: 5.572 ± 0.176
0.656AspMet: 0.656 ± 0.053
3.759AspAsn: 3.759 ± 0.145
1.565AspPro: 1.565 ± 0.066
1.984AspGln: 1.984 ± 0.11
1.475AspArg: 1.475 ± 0.091
3.561AspSer: 3.561 ± 0.138
2.671AspThr: 2.671 ± 0.108
3.623AspVal: 3.623 ± 0.126
0.602AspTrp: 0.602 ± 0.055
2.516AspTyr: 2.516 ± 0.115
0.0AspXaa: 0.0 ± 0.0
Glu
3.848GluAla: 3.848 ± 0.168
0.287GluCys: 0.287 ± 0.033
2.982GluAsp: 2.982 ± 0.117
4.306GluGlu: 4.306 ± 0.177
3.836GluPhe: 3.836 ± 0.133
2.644GluGly: 2.644 ± 0.105
1.196GluHis: 1.196 ± 0.068
6.577GluIle: 6.577 ± 0.195
6.989GluLys: 6.989 ± 0.187
7.288GluLeu: 7.288 ± 0.221
1.239GluMet: 1.239 ± 0.081
4.869GluAsn: 4.869 ± 0.13
1.611GluPro: 1.611 ± 0.096
3.351GluGln: 3.351 ± 0.156
1.747GluArg: 1.747 ± 0.084
3.324GluSer: 3.324 ± 0.12
2.974GluThr: 2.974 ± 0.115
3.588GluVal: 3.588 ± 0.138
0.563GluTrp: 0.563 ± 0.05
3.001GluTyr: 3.001 ± 0.138
0.0GluXaa: 0.0 ± 0.0
Phe
3.176PheAla: 3.176 ± 0.139
0.349PheCys: 0.349 ± 0.033
3.809PheAsp: 3.809 ± 0.117
3.669PheGlu: 3.669 ± 0.132
2.415PhePhe: 2.415 ± 0.124
2.598PheGly: 2.598 ± 0.104
0.594PheHis: 0.594 ± 0.053
4.997PheIle: 4.997 ± 0.186
5.09PheLys: 5.09 ± 0.155
4.279PheLeu: 4.279 ± 0.161
0.835PheMet: 0.835 ± 0.061
4.089PheAsn: 4.089 ± 0.134
1.118PhePro: 1.118 ± 0.076
1.246PheGln: 1.246 ± 0.082
1.518PheArg: 1.518 ± 0.079
3.995PheSer: 3.995 ± 0.157
2.64PheThr: 2.64 ± 0.1
3.374PheVal: 3.374 ± 0.142
0.493PheTrp: 0.493 ± 0.045
2.066PheTyr: 2.066 ± 0.122
0.0PheXaa: 0.0 ± 0.0
Gly
2.873GlyAla: 2.873 ± 0.109
0.353GlyCys: 0.353 ± 0.038
2.543GlyAsp: 2.543 ± 0.108
2.508GlyGlu: 2.508 ± 0.113
2.78GlyPhe: 2.78 ± 0.101
2.869GlyGly: 2.869 ± 0.157
0.924GlyHis: 0.924 ± 0.068
4.275GlyIle: 4.275 ± 0.163
4.182GlyLys: 4.182 ± 0.159
4.267GlyLeu: 4.267 ± 0.151
0.955GlyMet: 0.955 ± 0.073
2.295GlyAsn: 2.295 ± 0.101
0.967GlyPro: 0.967 ± 0.072
1.755GlyGln: 1.755 ± 0.094
1.639GlyArg: 1.639 ± 0.096
3.145GlySer: 3.145 ± 0.123
2.477GlyThr: 2.477 ± 0.112
3.304GlyVal: 3.304 ± 0.126
0.509GlyTrp: 0.509 ± 0.048
2.085GlyTyr: 2.085 ± 0.096
0.0GlyXaa: 0.0 ± 0.0
His
0.858HisAla: 0.858 ± 0.07
0.14HisCys: 0.14 ± 0.026
0.881HisAsp: 0.881 ± 0.055
1.114HisGlu: 1.114 ± 0.064
0.905HisPhe: 0.905 ± 0.056
0.905HisGly: 0.905 ± 0.07
0.384HisHis: 0.384 ± 0.049
1.472HisIle: 1.472 ± 0.072
1.697HisLys: 1.697 ± 0.086
1.518HisLeu: 1.518 ± 0.075
0.276HisMet: 0.276 ± 0.033
1.258HisAsn: 1.258 ± 0.078
0.571HisPro: 0.571 ± 0.056
0.629HisGln: 0.629 ± 0.049
0.485HisArg: 0.485 ± 0.045
1.18HisSer: 1.18 ± 0.071
0.823HisThr: 0.823 ± 0.06
0.66HisVal: 0.66 ± 0.061
0.225HisTrp: 0.225 ± 0.028
0.815HisTyr: 0.815 ± 0.06
0.0HisXaa: 0.0 ± 0.0
Ile
5.673IleAla: 5.673 ± 0.16
0.629IleCys: 0.629 ± 0.059
6.601IleAsp: 6.601 ± 0.186
6.682IleGlu: 6.682 ± 0.179
4.547IlePhe: 4.547 ± 0.171
4.193IleGly: 4.193 ± 0.168
1.242IleHis: 1.242 ± 0.082
7.366IleIle: 7.366 ± 0.253
9.171IleLys: 9.171 ± 0.199
7.206IleLeu: 7.206 ± 0.209
1.347IleMet: 1.347 ± 0.077
7.172IleAsn: 7.172 ± 0.209
2.582IlePro: 2.582 ± 0.117
2.59IleGln: 2.59 ± 0.103
2.493IleArg: 2.493 ± 0.106
6.449IleSer: 6.449 ± 0.147
4.5IleThr: 4.5 ± 0.127
5.308IleVal: 5.308 ± 0.159
0.691IleTrp: 0.691 ± 0.053
3.23IleTyr: 3.23 ± 0.131
0.0IleXaa: 0.0 ± 0.0
Lys
5.079LysAla: 5.079 ± 0.208
0.45LysCys: 0.45 ± 0.047
6.313LysAsp: 6.313 ± 0.219
7.195LysGlu: 7.195 ± 0.233
4.57LysPhe: 4.57 ± 0.131
3.898LysGly: 3.898 ± 0.135
1.868LysHis: 1.868 ± 0.092
9.723LysIle: 9.723 ± 0.2
8.694LysLys: 8.694 ± 0.225
9.497LysLeu: 9.497 ± 0.239
2.24LysMet: 2.24 ± 0.111
8.468LysAsn: 8.468 ± 0.192
2.664LysPro: 2.664 ± 0.107
4.263LysGln: 4.263 ± 0.146
3.153LysArg: 3.153 ± 0.118
6.034LysSer: 6.034 ± 0.173
5.77LysThr: 5.77 ± 0.147
5.25LysVal: 5.25 ± 0.179
0.971LysTrp: 0.971 ± 0.065
4.718LysTyr: 4.718 ± 0.146
0.0LysXaa: 0.0 ± 0.0
Leu
5.591LeuAla: 5.591 ± 0.163
0.664LeuCys: 0.664 ± 0.06
5.789LeuAsp: 5.789 ± 0.199
6.08LeuGlu: 6.08 ± 0.177
4.624LeuPhe: 4.624 ± 0.186
4.395LeuGly: 4.395 ± 0.163
1.503LeuHis: 1.503 ± 0.082
8.492LeuIle: 8.492 ± 0.227
9.459LeuLys: 9.459 ± 0.215
8.433LeuLeu: 8.433 ± 0.236
1.441LeuMet: 1.441 ± 0.069
7.571LeuAsn: 7.571 ± 0.208
2.834LeuPro: 2.834 ± 0.13
2.815LeuGln: 2.815 ± 0.109
3.106LeuArg: 3.106 ± 0.106
7.234LeuSer: 7.234 ± 0.189
4.551LeuThr: 4.551 ± 0.14
5.649LeuVal: 5.649 ± 0.162
0.831LeuTrp: 0.831 ± 0.048
2.924LeuTyr: 2.924 ± 0.115
0.0LeuXaa: 0.0 ± 0.0
Met
0.944MetAla: 0.944 ± 0.064
0.144MetCys: 0.144 ± 0.027
0.796MetAsp: 0.796 ± 0.063
0.788MetGlu: 0.788 ± 0.059
1.013MetPhe: 1.013 ± 0.072
0.544MetGly: 0.544 ± 0.053
0.381MetHis: 0.381 ± 0.039
1.382MetIle: 1.382 ± 0.084
1.708MetLys: 1.708 ± 0.089
1.724MetLeu: 1.724 ± 0.102
0.365MetMet: 0.365 ± 0.044
1.25MetAsn: 1.25 ± 0.079
0.637MetPro: 0.637 ± 0.053
0.788MetGln: 0.788 ± 0.058
0.676MetArg: 0.676 ± 0.051
1.347MetSer: 1.347 ± 0.074
0.749MetThr: 0.749 ± 0.06
0.858MetVal: 0.858 ± 0.059
0.132MetTrp: 0.132 ± 0.026
0.45MetTyr: 0.45 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
3.929AsnAla: 3.929 ± 0.129
0.318AsnCys: 0.318 ± 0.038
4.477AsnAsp: 4.477 ± 0.165
5.215AsnGlu: 5.215 ± 0.165
3.627AsnPhe: 3.627 ± 0.142
3.285AsnGly: 3.285 ± 0.11
1.029AsnHis: 1.029 ± 0.066
6.574AsnIle: 6.574 ± 0.218
8.259AsnLys: 8.259 ± 0.203
6.344AsnLeu: 6.344 ± 0.162
1.138AsnMet: 1.138 ± 0.076
5.816AsnAsn: 5.816 ± 0.245
2.252AsnPro: 2.252 ± 0.112
2.664AsnGln: 2.664 ± 0.112
2.035AsnArg: 2.035 ± 0.095
5.094AsnSer: 5.094 ± 0.165
3.759AsnThr: 3.759 ± 0.139
3.995AsnVal: 3.995 ± 0.114
0.726AsnTrp: 0.726 ± 0.047
2.889AsnTyr: 2.889 ± 0.124
0.0AsnXaa: 0.0 ± 0.0
Pro
1.386ProAla: 1.386 ± 0.081
0.155ProCys: 0.155 ± 0.025
1.417ProAsp: 1.417 ± 0.077
1.945ProGlu: 1.945 ± 0.091
1.503ProPhe: 1.503 ± 0.078
1.425ProGly: 1.425 ± 0.084
0.575ProHis: 0.575 ± 0.046
2.221ProIle: 2.221 ± 0.109
2.664ProLys: 2.664 ± 0.111
2.617ProLeu: 2.617 ± 0.117
0.4ProMet: 0.4 ± 0.042
2.093ProAsn: 2.093 ± 0.097
0.613ProPro: 0.613 ± 0.061
1.266ProGln: 1.266 ± 0.085
0.835ProArg: 0.835 ± 0.06
1.887ProSer: 1.887 ± 0.088
1.654ProThr: 1.654 ± 0.09
1.437ProVal: 1.437 ± 0.08
0.264ProTrp: 0.264 ± 0.036
1.204ProTyr: 1.204 ± 0.071
0.0ProXaa: 0.0 ± 0.0
Gln
2.252GlnAla: 2.252 ± 0.126
0.198GlnCys: 0.198 ± 0.03
1.875GlnAsp: 1.875 ± 0.095
2.112GlnGlu: 2.112 ± 0.119
1.518GlnPhe: 1.518 ± 0.092
1.681GlnGly: 1.681 ± 0.087
0.664GlnHis: 0.664 ± 0.055
3.65GlnIle: 3.65 ± 0.131
4.741GlnLys: 4.741 ± 0.16
3.192GlnLeu: 3.192 ± 0.128
0.672GlnMet: 0.672 ± 0.046
3.518GlnAsn: 3.518 ± 0.151
0.967GlnPro: 0.967 ± 0.073
1.798GlnGln: 1.798 ± 0.115
1.507GlnArg: 1.507 ± 0.08
2.411GlnSer: 2.411 ± 0.114
1.79GlnThr: 1.79 ± 0.096
1.697GlnVal: 1.697 ± 0.07
0.349GlnTrp: 0.349 ± 0.038
1.569GlnTyr: 1.569 ± 0.079
0.0GlnXaa: 0.0 ± 0.0
Arg
1.778ArgAla: 1.778 ± 0.094
0.144ArgCys: 0.144 ± 0.024
1.771ArgAsp: 1.771 ± 0.104
2.186ArgGlu: 2.186 ± 0.098
1.802ArgPhe: 1.802 ± 0.086
1.475ArgGly: 1.475 ± 0.085
0.567ArgHis: 0.567 ± 0.052
2.85ArgIle: 2.85 ± 0.105
2.85ArgLys: 2.85 ± 0.112
3.013ArgLeu: 3.013 ± 0.107
0.598ArgMet: 0.598 ± 0.056
2.011ArgAsn: 2.011 ± 0.092
0.955ArgPro: 0.955 ± 0.064
1.258ArgGln: 1.258 ± 0.081
1.301ArgArg: 1.301 ± 0.065
1.98ArgSer: 1.98 ± 0.088
1.561ArgThr: 1.561 ± 0.073
2.05ArgVal: 2.05 ± 0.102
0.264ArgTrp: 0.264 ± 0.029
1.386ArgTyr: 1.386 ± 0.078
0.0ArgXaa: 0.0 ± 0.0
Ser
3.39SerAla: 3.39 ± 0.148
0.388SerCys: 0.388 ± 0.035
3.7SerAsp: 3.7 ± 0.148
3.879SerGlu: 3.879 ± 0.144
3.592SerPhe: 3.592 ± 0.157
3.444SerGly: 3.444 ± 0.137
1.138SerHis: 1.138 ± 0.07
6.216SerIle: 6.216 ± 0.182
7.082SerLys: 7.082 ± 0.187
7.156SerLeu: 7.156 ± 0.178
0.881SerMet: 0.881 ± 0.061
4.756SerAsn: 4.756 ± 0.158
1.685SerPro: 1.685 ± 0.079
2.683SerGln: 2.683 ± 0.11
2.283SerArg: 2.283 ± 0.094
5.052SerSer: 5.052 ± 0.174
3.821SerThr: 3.821 ± 0.13
3.984SerVal: 3.984 ± 0.125
0.551SerTrp: 0.551 ± 0.053
2.508SerTyr: 2.508 ± 0.108
0.0SerXaa: 0.0 ± 0.0
Thr
2.318ThrAla: 2.318 ± 0.078
0.268ThrCys: 0.268 ± 0.036
2.489ThrAsp: 2.489 ± 0.107
2.629ThrGlu: 2.629 ± 0.097
2.846ThrPhe: 2.846 ± 0.101
2.446ThrGly: 2.446 ± 0.116
1.161ThrHis: 1.161 ± 0.068
4.597ThrIle: 4.597 ± 0.132
5.269ThrLys: 5.269 ± 0.171
5.308ThrLeu: 5.308 ± 0.135
0.703ThrMet: 0.703 ± 0.061
3.541ThrAsn: 3.541 ± 0.15
1.965ThrPro: 1.965 ± 0.098
2.334ThrGln: 2.334 ± 0.103
1.677ThrArg: 1.677 ± 0.074
3.432ThrSer: 3.432 ± 0.128
2.955ThrThr: 2.955 ± 0.132
2.361ThrVal: 2.361 ± 0.113
0.388ThrTrp: 0.388 ± 0.038
2.035ThrTyr: 2.035 ± 0.092
0.0ThrXaa: 0.0 ± 0.0
Val
3.832ValAla: 3.832 ± 0.137
0.353ValCys: 0.353 ± 0.039
3.63ValAsp: 3.63 ± 0.123
4.201ValGlu: 4.201 ± 0.164
3.133ValPhe: 3.133 ± 0.123
3.04ValGly: 3.04 ± 0.118
0.831ValHis: 0.831 ± 0.064
4.776ValIle: 4.776 ± 0.153
5.067ValLys: 5.067 ± 0.143
5.347ValLeu: 5.347 ± 0.176
1.072ValMet: 1.072 ± 0.08
3.467ValAsn: 3.467 ± 0.119
1.646ValPro: 1.646 ± 0.086
1.992ValGln: 1.992 ± 0.087
1.689ValArg: 1.689 ± 0.085
4.252ValSer: 4.252 ± 0.129
2.167ValThr: 2.167 ± 0.105
4.003ValVal: 4.003 ± 0.167
0.454ValTrp: 0.454 ± 0.044
2.12ValTyr: 2.12 ± 0.104
0.0ValXaa: 0.0 ± 0.0
Trp
0.52TrpAla: 0.52 ± 0.046
0.066TrpCys: 0.066 ± 0.018
0.528TrpAsp: 0.528 ± 0.046
0.641TrpGlu: 0.641 ± 0.048
0.594TrpPhe: 0.594 ± 0.054
0.458TrpGly: 0.458 ± 0.045
0.097TrpHis: 0.097 ± 0.019
0.858TrpIle: 0.858 ± 0.06
0.753TrpLys: 0.753 ± 0.056
0.909TrpLeu: 0.909 ± 0.059
0.206TrpMet: 0.206 ± 0.029
0.602TrpAsn: 0.602 ± 0.049
0.295TrpPro: 0.295 ± 0.03
0.303TrpGln: 0.303 ± 0.036
0.315TrpArg: 0.315 ± 0.035
0.598TrpSer: 0.598 ± 0.056
0.439TrpThr: 0.439 ± 0.056
0.594TrpVal: 0.594 ± 0.052
0.124TrpTrp: 0.124 ± 0.021
0.349TrpTyr: 0.349 ± 0.036
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.411TyrAla: 2.411 ± 0.104
0.299TyrCys: 0.299 ± 0.039
2.508TyrAsp: 2.508 ± 0.113
2.928TyrGlu: 2.928 ± 0.104
2.279TyrPhe: 2.279 ± 0.105
1.872TyrGly: 1.872 ± 0.095
0.594TyrHis: 0.594 ± 0.052
3.188TyrIle: 3.188 ± 0.135
3.801TyrLys: 3.801 ± 0.134
3.762TyrLeu: 3.762 ± 0.112
0.59TyrMet: 0.59 ± 0.049
2.656TyrAsn: 2.656 ± 0.102
0.998TyrPro: 0.998 ± 0.069
1.328TyrGln: 1.328 ± 0.067
1.367TyrArg: 1.367 ± 0.07
2.803TyrSer: 2.803 ± 0.121
1.972TyrThr: 1.972 ± 0.082
2.155TyrVal: 2.155 ± 0.086
0.571TyrTrp: 0.571 ± 0.053
1.456TyrTyr: 1.456 ± 0.089
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 686 proteins (257547 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski