Amino acid dipepetide frequency for Achromobacter phage vB_AxyP_19-32_Axy10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.781AlaAla: 9.781 ± 1.88
0.565AlaCys: 0.565 ± 0.198
4.521AlaAsp: 4.521 ± 0.576
6.26AlaGlu: 6.26 ± 0.733
2.434AlaPhe: 2.434 ± 0.325
6.651AlaGly: 6.651 ± 0.713
1.522AlaHis: 1.522 ± 0.273
4.869AlaIle: 4.869 ± 0.538
5.564AlaLys: 5.564 ± 0.695
7.825AlaLeu: 7.825 ± 0.858
2.695AlaMet: 2.695 ± 0.448
4.521AlaAsn: 4.521 ± 0.589
3.913AlaPro: 3.913 ± 0.495
4.782AlaGln: 4.782 ± 0.779
4.565AlaArg: 4.565 ± 0.702
4.956AlaSer: 4.956 ± 0.503
5.738AlaThr: 5.738 ± 0.609
6.912AlaVal: 6.912 ± 1.091
1.261AlaTrp: 1.261 ± 0.216
3.217AlaTyr: 3.217 ± 0.33
0.0AlaXaa: 0.0 ± 0.0
Cys
0.565CysAla: 0.565 ± 0.165
0.174CysCys: 0.174 ± 0.094
0.304CysAsp: 0.304 ± 0.121
0.522CysGlu: 0.522 ± 0.181
0.217CysPhe: 0.217 ± 0.101
0.478CysGly: 0.478 ± 0.137
0.348CysHis: 0.348 ± 0.134
0.348CysIle: 0.348 ± 0.152
0.565CysLys: 0.565 ± 0.19
0.522CysLeu: 0.522 ± 0.159
0.174CysMet: 0.174 ± 0.113
0.391CysAsn: 0.391 ± 0.159
0.348CysPro: 0.348 ± 0.166
0.13CysGln: 0.13 ± 0.079
0.478CysArg: 0.478 ± 0.172
0.391CysSer: 0.391 ± 0.18
0.522CysThr: 0.522 ± 0.169
0.261CysVal: 0.261 ± 0.109
0.174CysTrp: 0.174 ± 0.091
0.043CysTyr: 0.043 ± 0.044
0.0CysXaa: 0.0 ± 0.0
Asp
5.695AspAla: 5.695 ± 0.886
0.304AspCys: 0.304 ± 0.131
2.956AspAsp: 2.956 ± 0.455
2.956AspGlu: 2.956 ± 0.392
2.348AspPhe: 2.348 ± 0.344
4.086AspGly: 4.086 ± 0.391
1.565AspHis: 1.565 ± 0.268
3.347AspIle: 3.347 ± 0.418
3.217AspLys: 3.217 ± 0.404
5.651AspLeu: 5.651 ± 0.457
1.695AspMet: 1.695 ± 0.326
1.913AspAsn: 1.913 ± 0.42
3.826AspPro: 3.826 ± 0.443
2.956AspGln: 2.956 ± 0.368
3.043AspArg: 3.043 ± 0.372
3.043AspSer: 3.043 ± 0.387
3.087AspThr: 3.087 ± 0.39
3.521AspVal: 3.521 ± 0.373
0.869AspTrp: 0.869 ± 0.211
2.348AspTyr: 2.348 ± 0.38
0.0AspXaa: 0.0 ± 0.0
Glu
7.477GluAla: 7.477 ± 0.938
0.304GluCys: 0.304 ± 0.125
3.869GluAsp: 3.869 ± 0.314
5.304GluGlu: 5.304 ± 0.577
2.521GluPhe: 2.521 ± 0.347
4.217GluGly: 4.217 ± 0.421
1.608GluHis: 1.608 ± 0.281
3.608GluIle: 3.608 ± 0.448
3.826GluLys: 3.826 ± 0.595
5.564GluLeu: 5.564 ± 0.549
1.956GluMet: 1.956 ± 0.282
2.087GluAsn: 2.087 ± 0.27
2.608GluPro: 2.608 ± 0.392
3.652GluGln: 3.652 ± 0.385
2.652GluArg: 2.652 ± 0.346
3.087GluSer: 3.087 ± 0.424
2.869GluThr: 2.869 ± 0.293
4.782GluVal: 4.782 ± 0.409
0.956GluTrp: 0.956 ± 0.186
2.13GluTyr: 2.13 ± 0.347
0.0GluXaa: 0.0 ± 0.0
Phe
2.565PheAla: 2.565 ± 0.31
0.391PheCys: 0.391 ± 0.14
2.174PheAsp: 2.174 ± 0.258
1.695PheGlu: 1.695 ± 0.246
1.261PhePhe: 1.261 ± 0.224
2.826PheGly: 2.826 ± 0.364
0.478PheHis: 0.478 ± 0.148
2.13PheIle: 2.13 ± 0.35
2.217PheLys: 2.217 ± 0.355
2.0PheLeu: 2.0 ± 0.316
1.304PheMet: 1.304 ± 0.2
1.782PheAsn: 1.782 ± 0.292
0.956PhePro: 0.956 ± 0.265
1.565PheGln: 1.565 ± 0.187
2.391PheArg: 2.391 ± 0.333
2.261PheSer: 2.261 ± 0.289
2.652PheThr: 2.652 ± 0.422
2.869PheVal: 2.869 ± 0.434
0.522PheTrp: 0.522 ± 0.211
1.217PheTyr: 1.217 ± 0.222
0.0PheXaa: 0.0 ± 0.0
Gly
5.173GlyAla: 5.173 ± 0.6
0.435GlyCys: 0.435 ± 0.144
3.999GlyAsp: 3.999 ± 0.377
4.26GlyGlu: 4.26 ± 0.35
2.391GlyPhe: 2.391 ± 0.393
3.913GlyGly: 3.913 ± 0.594
0.826GlyHis: 0.826 ± 0.234
4.13GlyIle: 4.13 ± 0.351
4.782GlyLys: 4.782 ± 0.626
5.608GlyLeu: 5.608 ± 0.56
3.087GlyMet: 3.087 ± 0.366
3.565GlyAsn: 3.565 ± 0.432
2.0GlyPro: 2.0 ± 0.296
2.695GlyGln: 2.695 ± 0.34
4.26GlyArg: 4.26 ± 0.508
4.434GlySer: 4.434 ± 0.439
4.782GlyThr: 4.782 ± 0.502
4.608GlyVal: 4.608 ± 0.47
1.13GlyTrp: 1.13 ± 0.223
2.869GlyTyr: 2.869 ± 0.309
0.0GlyXaa: 0.0 ± 0.0
His
1.826HisAla: 1.826 ± 0.29
0.304HisCys: 0.304 ± 0.123
0.826HisAsp: 0.826 ± 0.166
1.304HisGlu: 1.304 ± 0.295
0.783HisPhe: 0.783 ± 0.169
1.13HisGly: 1.13 ± 0.322
0.435HisHis: 0.435 ± 0.141
1.0HisIle: 1.0 ± 0.28
1.043HisLys: 1.043 ± 0.24
2.13HisLeu: 2.13 ± 0.347
0.565HisMet: 0.565 ± 0.131
0.696HisAsn: 0.696 ± 0.131
0.956HisPro: 0.956 ± 0.214
0.956HisGln: 0.956 ± 0.209
1.043HisArg: 1.043 ± 0.311
1.087HisSer: 1.087 ± 0.212
0.783HisThr: 0.783 ± 0.15
1.348HisVal: 1.348 ± 0.24
0.391HisTrp: 0.391 ± 0.144
1.261HisTyr: 1.261 ± 0.29
0.0HisXaa: 0.0 ± 0.0
Ile
4.956IleAla: 4.956 ± 0.443
0.391IleCys: 0.391 ± 0.139
3.565IleAsp: 3.565 ± 0.44
3.347IleGlu: 3.347 ± 0.452
1.826IlePhe: 1.826 ± 0.285
3.304IleGly: 3.304 ± 0.446
1.261IleHis: 1.261 ± 0.281
2.869IleIle: 2.869 ± 0.474
3.869IleLys: 3.869 ± 0.476
3.999IleLeu: 3.999 ± 0.463
1.913IleMet: 1.913 ± 0.284
2.695IleAsn: 2.695 ± 0.333
2.913IlePro: 2.913 ± 0.425
2.608IleGln: 2.608 ± 0.301
2.695IleArg: 2.695 ± 0.313
2.565IleSer: 2.565 ± 0.301
3.26IleThr: 3.26 ± 0.379
3.13IleVal: 3.13 ± 0.406
0.783IleTrp: 0.783 ± 0.222
1.869IleTyr: 1.869 ± 0.297
0.0IleXaa: 0.0 ± 0.0
Lys
6.999LysAla: 6.999 ± 0.655
0.174LysCys: 0.174 ± 0.091
3.913LysAsp: 3.913 ± 0.406
4.304LysGlu: 4.304 ± 0.411
1.913LysPhe: 1.913 ± 0.291
3.565LysGly: 3.565 ± 0.439
1.13LysHis: 1.13 ± 0.271
2.956LysIle: 2.956 ± 0.412
4.391LysLys: 4.391 ± 0.6
5.564LysLeu: 5.564 ± 0.597
2.13LysMet: 2.13 ± 0.318
2.695LysAsn: 2.695 ± 0.43
2.956LysPro: 2.956 ± 0.483
2.869LysGln: 2.869 ± 0.324
2.826LysArg: 2.826 ± 0.374
3.217LysSer: 3.217 ± 0.315
3.695LysThr: 3.695 ± 0.417
4.869LysVal: 4.869 ± 0.487
0.869LysTrp: 0.869 ± 0.187
1.782LysTyr: 1.782 ± 0.266
0.0LysXaa: 0.0 ± 0.0
Leu
7.39LeuAla: 7.39 ± 0.877
0.565LeuCys: 0.565 ± 0.187
5.478LeuAsp: 5.478 ± 0.531
5.173LeuGlu: 5.173 ± 0.428
3.304LeuPhe: 3.304 ± 0.355
6.043LeuGly: 6.043 ± 0.501
1.913LeuHis: 1.913 ± 0.321
3.695LeuIle: 3.695 ± 0.336
4.956LeuLys: 4.956 ± 0.523
5.825LeuLeu: 5.825 ± 0.504
2.304LeuMet: 2.304 ± 0.323
4.695LeuAsn: 4.695 ± 0.469
4.434LeuPro: 4.434 ± 0.486
3.043LeuGln: 3.043 ± 0.395
4.173LeuArg: 4.173 ± 0.408
4.521LeuSer: 4.521 ± 0.495
4.869LeuThr: 4.869 ± 0.506
5.304LeuVal: 5.304 ± 0.427
0.869LeuTrp: 0.869 ± 0.211
2.261LeuTyr: 2.261 ± 0.287
0.0LeuXaa: 0.0 ± 0.0
Met
3.26MetAla: 3.26 ± 0.389
0.13MetCys: 0.13 ± 0.07
2.174MetAsp: 2.174 ± 0.233
2.521MetGlu: 2.521 ± 0.318
1.043MetPhe: 1.043 ± 0.218
1.826MetGly: 1.826 ± 0.327
0.696MetHis: 0.696 ± 0.201
1.695MetIle: 1.695 ± 0.207
2.087MetLys: 2.087 ± 0.374
2.608MetLeu: 2.608 ± 0.364
0.913MetMet: 0.913 ± 0.194
1.348MetAsn: 1.348 ± 0.242
1.565MetPro: 1.565 ± 0.225
2.087MetGln: 2.087 ± 0.28
1.695MetArg: 1.695 ± 0.257
2.652MetSer: 2.652 ± 0.326
1.739MetThr: 1.739 ± 0.259
1.869MetVal: 1.869 ± 0.247
0.261MetTrp: 0.261 ± 0.112
0.696MetTyr: 0.696 ± 0.174
0.0MetXaa: 0.0 ± 0.0
Asn
4.086AsnAla: 4.086 ± 0.404
0.391AsnCys: 0.391 ± 0.145
2.304AsnAsp: 2.304 ± 0.364
3.087AsnGlu: 3.087 ± 0.463
1.869AsnPhe: 1.869 ± 0.322
3.478AsnGly: 3.478 ± 0.397
0.869AsnHis: 0.869 ± 0.233
2.434AsnIle: 2.434 ± 0.282
2.478AsnLys: 2.478 ± 0.384
3.565AsnLeu: 3.565 ± 0.391
1.695AsnMet: 1.695 ± 0.302
2.608AsnAsn: 2.608 ± 0.472
3.478AsnPro: 3.478 ± 0.491
2.739AsnGln: 2.739 ± 0.364
2.304AsnArg: 2.304 ± 0.251
2.956AsnSer: 2.956 ± 0.327
2.608AsnThr: 2.608 ± 0.329
2.565AsnVal: 2.565 ± 0.252
0.913AsnTrp: 0.913 ± 0.249
1.608AsnTyr: 1.608 ± 0.248
0.0AsnXaa: 0.0 ± 0.0
Pro
4.26ProAla: 4.26 ± 0.633
0.391ProCys: 0.391 ± 0.155
2.695ProAsp: 2.695 ± 0.365
4.043ProGlu: 4.043 ± 0.47
1.565ProPhe: 1.565 ± 0.249
3.782ProGly: 3.782 ± 0.524
0.348ProHis: 0.348 ± 0.136
2.261ProIle: 2.261 ± 0.361
3.217ProLys: 3.217 ± 0.349
3.087ProLeu: 3.087 ± 0.329
1.348ProMet: 1.348 ± 0.232
2.0ProAsn: 2.0 ± 0.284
2.0ProPro: 2.0 ± 0.297
1.652ProGln: 1.652 ± 0.27
1.913ProArg: 1.913 ± 0.37
2.826ProSer: 2.826 ± 0.321
2.695ProThr: 2.695 ± 0.276
4.13ProVal: 4.13 ± 0.396
0.739ProTrp: 0.739 ± 0.191
1.608ProTyr: 1.608 ± 0.338
0.0ProXaa: 0.0 ± 0.0
Gln
5.391GlnAla: 5.391 ± 0.804
0.13GlnCys: 0.13 ± 0.087
2.565GlnAsp: 2.565 ± 0.31
3.521GlnGlu: 3.521 ± 0.378
1.739GlnPhe: 1.739 ± 0.294
3.347GlnGly: 3.347 ± 0.429
1.043GlnHis: 1.043 ± 0.232
2.913GlnIle: 2.913 ± 0.496
2.782GlnLys: 2.782 ± 0.318
3.173GlnLeu: 3.173 ± 0.379
1.956GlnMet: 1.956 ± 0.343
2.217GlnAsn: 2.217 ± 0.35
1.522GlnPro: 1.522 ± 0.238
2.261GlnGln: 2.261 ± 0.299
2.261GlnArg: 2.261 ± 0.309
2.174GlnSer: 2.174 ± 0.343
2.565GlnThr: 2.565 ± 0.294
3.0GlnVal: 3.0 ± 0.355
0.783GlnTrp: 0.783 ± 0.194
1.695GlnTyr: 1.695 ± 0.262
0.0GlnXaa: 0.0 ± 0.0
Arg
3.782ArgAla: 3.782 ± 0.423
0.391ArgCys: 0.391 ± 0.136
2.739ArgAsp: 2.739 ± 0.408
3.434ArgGlu: 3.434 ± 0.332
2.0ArgPhe: 2.0 ± 0.28
2.695ArgGly: 2.695 ± 0.281
0.826ArgHis: 0.826 ± 0.181
2.348ArgIle: 2.348 ± 0.356
3.478ArgLys: 3.478 ± 0.358
4.695ArgLeu: 4.695 ± 0.485
1.913ArgMet: 1.913 ± 0.238
2.565ArgAsn: 2.565 ± 0.323
1.652ArgPro: 1.652 ± 0.348
2.478ArgGln: 2.478 ± 0.304
2.739ArgArg: 2.739 ± 0.45
3.347ArgSer: 3.347 ± 0.39
2.826ArgThr: 2.826 ± 0.312
3.652ArgVal: 3.652 ± 0.41
0.869ArgTrp: 0.869 ± 0.228
1.348ArgTyr: 1.348 ± 0.244
0.0ArgXaa: 0.0 ± 0.0
Ser
4.652SerAla: 4.652 ± 0.429
0.478SerCys: 0.478 ± 0.153
3.565SerAsp: 3.565 ± 0.442
2.913SerGlu: 2.913 ± 0.339
2.043SerPhe: 2.043 ± 0.264
3.913SerGly: 3.913 ± 0.459
1.043SerHis: 1.043 ± 0.201
2.913SerIle: 2.913 ± 0.281
3.26SerLys: 3.26 ± 0.384
4.912SerLeu: 4.912 ± 0.536
1.869SerMet: 1.869 ± 0.322
3.26SerAsn: 3.26 ± 0.406
2.434SerPro: 2.434 ± 0.381
2.304SerGln: 2.304 ± 0.31
2.521SerArg: 2.521 ± 0.308
2.826SerSer: 2.826 ± 0.414
4.13SerThr: 4.13 ± 0.408
3.391SerVal: 3.391 ± 0.329
0.956SerTrp: 0.956 ± 0.156
2.217SerTyr: 2.217 ± 0.37
0.0SerXaa: 0.0 ± 0.0
Thr
5.782ThrAla: 5.782 ± 0.598
0.565ThrCys: 0.565 ± 0.191
3.695ThrAsp: 3.695 ± 0.324
3.478ThrGlu: 3.478 ± 0.319
2.217ThrPhe: 2.217 ± 0.384
4.869ThrGly: 4.869 ± 0.408
1.043ThrHis: 1.043 ± 0.273
3.13ThrIle: 3.13 ± 0.514
3.826ThrLys: 3.826 ± 0.503
4.304ThrLeu: 4.304 ± 0.386
1.478ThrMet: 1.478 ± 0.273
2.478ThrAsn: 2.478 ± 0.326
3.478ThrPro: 3.478 ± 0.332
2.782ThrGln: 2.782 ± 0.266
2.652ThrArg: 2.652 ± 0.333
3.391ThrSer: 3.391 ± 0.408
3.217ThrThr: 3.217 ± 0.422
4.13ThrVal: 4.13 ± 0.535
0.783ThrTrp: 0.783 ± 0.264
1.261ThrTyr: 1.261 ± 0.306
0.0ThrXaa: 0.0 ± 0.0
Val
5.695ValAla: 5.695 ± 0.675
0.565ValCys: 0.565 ± 0.233
3.652ValAsp: 3.652 ± 0.329
4.391ValGlu: 4.391 ± 0.433
1.913ValPhe: 1.913 ± 0.321
4.782ValGly: 4.782 ± 0.728
1.478ValHis: 1.478 ± 0.263
4.347ValIle: 4.347 ± 0.597
4.26ValLys: 4.26 ± 0.447
5.521ValLeu: 5.521 ± 0.44
2.521ValMet: 2.521 ± 0.313
3.695ValAsn: 3.695 ± 0.426
3.434ValPro: 3.434 ± 0.467
3.173ValGln: 3.173 ± 0.421
3.217ValArg: 3.217 ± 0.32
3.652ValSer: 3.652 ± 0.336
4.217ValThr: 4.217 ± 0.474
4.825ValVal: 4.825 ± 0.535
1.13ValTrp: 1.13 ± 0.308
2.304ValTyr: 2.304 ± 0.329
0.0ValXaa: 0.0 ± 0.0
Trp
1.13TrpAla: 1.13 ± 0.287
0.174TrpCys: 0.174 ± 0.078
1.087TrpAsp: 1.087 ± 0.343
1.0TrpGlu: 1.0 ± 0.268
0.522TrpPhe: 0.522 ± 0.139
1.348TrpGly: 1.348 ± 0.383
0.435TrpHis: 0.435 ± 0.164
0.913TrpIle: 0.913 ± 0.217
1.087TrpLys: 1.087 ± 0.193
1.304TrpLeu: 1.304 ± 0.29
0.304TrpMet: 0.304 ± 0.13
0.869TrpAsn: 0.869 ± 0.216
0.478TrpPro: 0.478 ± 0.161
0.478TrpGln: 0.478 ± 0.127
0.826TrpArg: 0.826 ± 0.225
0.652TrpSer: 0.652 ± 0.143
0.435TrpThr: 0.435 ± 0.196
1.13TrpVal: 1.13 ± 0.157
0.304TrpTrp: 0.304 ± 0.202
0.565TrpTyr: 0.565 ± 0.203
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.087TyrAla: 2.087 ± 0.273
0.13TyrCys: 0.13 ± 0.079
2.391TyrAsp: 2.391 ± 0.263
1.565TyrGlu: 1.565 ± 0.315
1.348TyrPhe: 1.348 ± 0.295
2.695TyrGly: 2.695 ± 0.455
1.0TyrHis: 1.0 ± 0.276
1.913TyrIle: 1.913 ± 0.306
1.913TyrLys: 1.913 ± 0.284
2.956TyrLeu: 2.956 ± 0.463
1.0TyrMet: 1.0 ± 0.177
1.956TyrAsn: 1.956 ± 0.278
1.608TyrPro: 1.608 ± 0.334
1.826TyrGln: 1.826 ± 0.295
1.522TyrArg: 1.522 ± 0.286
1.565TyrSer: 1.565 ± 0.242
1.869TyrThr: 1.869 ± 0.272
2.478TyrVal: 2.478 ± 0.299
0.478TyrTrp: 0.478 ± 0.119
0.913TyrTyr: 0.913 ± 0.183
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 83 proteins (23004 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski