Amino acid dipepetide frequency for Vibrio phage phi 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.054AlaAla: 5.054 ± 1.193
0.801AlaCys: 0.801 ± 0.248
3.153AlaAsp: 3.153 ± 0.483
4.954AlaGlu: 4.954 ± 0.564
2.852AlaPhe: 2.852 ± 0.359
3.703AlaGly: 3.703 ± 0.46
0.851AlaHis: 0.851 ± 0.219
4.253AlaIle: 4.253 ± 0.449
5.154AlaLys: 5.154 ± 0.756
5.554AlaLeu: 5.554 ± 0.54
2.052AlaMet: 2.052 ± 0.311
3.653AlaAsn: 3.653 ± 0.478
2.252AlaPro: 2.252 ± 0.357
2.702AlaGln: 2.702 ± 0.41
2.352AlaArg: 2.352 ± 0.387
4.153AlaSer: 4.153 ± 0.462
3.353AlaThr: 3.353 ± 0.354
3.903AlaVal: 3.903 ± 0.386
0.701AlaTrp: 0.701 ± 0.215
2.352AlaTyr: 2.352 ± 0.361
0.0AlaXaa: 0.0 ± 0.0
Cys
0.45CysAla: 0.45 ± 0.203
0.1CysCys: 0.1 ± 0.077
0.6CysAsp: 0.6 ± 0.186
0.35CysGlu: 0.35 ± 0.144
0.35CysPhe: 0.35 ± 0.151
0.3CysGly: 0.3 ± 0.145
0.35CysHis: 0.35 ± 0.16
0.701CysIle: 0.701 ± 0.256
0.951CysLys: 0.951 ± 0.276
0.851CysLeu: 0.851 ± 0.241
0.3CysMet: 0.3 ± 0.129
0.701CysAsn: 0.701 ± 0.238
0.2CysPro: 0.2 ± 0.098
0.1CysGln: 0.1 ± 0.072
0.1CysArg: 0.1 ± 0.076
0.5CysSer: 0.5 ± 0.163
0.901CysThr: 0.901 ± 0.214
0.6CysVal: 0.6 ± 0.214
0.1CysTrp: 0.1 ± 0.085
0.55CysTyr: 0.55 ± 0.207
0.0CysXaa: 0.0 ± 0.0
Asp
2.902AspAla: 2.902 ± 0.485
0.6AspCys: 0.6 ± 0.234
2.802AspAsp: 2.802 ± 0.492
4.353AspGlu: 4.353 ± 0.744
2.152AspPhe: 2.152 ± 0.387
3.303AspGly: 3.303 ± 0.641
0.55AspHis: 0.55 ± 0.16
4.253AspIle: 4.253 ± 0.559
4.954AspLys: 4.954 ± 0.648
4.504AspLeu: 4.504 ± 0.43
1.201AspMet: 1.201 ± 0.246
3.503AspAsn: 3.503 ± 0.411
1.651AspPro: 1.651 ± 0.234
1.351AspGln: 1.351 ± 0.268
2.002AspArg: 2.002 ± 0.348
3.403AspSer: 3.403 ± 0.348
3.953AspThr: 3.953 ± 0.396
3.052AspVal: 3.052 ± 0.318
0.801AspTrp: 0.801 ± 0.221
3.102AspTyr: 3.102 ± 0.436
0.0AspXaa: 0.0 ± 0.0
Glu
5.604GluAla: 5.604 ± 0.738
0.4GluCys: 0.4 ± 0.149
3.253GluAsp: 3.253 ± 0.455
6.505GluGlu: 6.505 ± 0.894
3.853GluPhe: 3.853 ± 0.461
3.203GluGly: 3.203 ± 0.43
1.301GluHis: 1.301 ± 0.272
4.604GluIle: 4.604 ± 0.478
3.703GluLys: 3.703 ± 0.409
7.906GluLeu: 7.906 ± 0.585
1.651GluMet: 1.651 ± 0.277
3.102GluAsn: 3.102 ± 0.401
2.702GluPro: 2.702 ± 0.345
2.552GluGln: 2.552 ± 0.376
2.852GluArg: 2.852 ± 0.384
4.604GluSer: 4.604 ± 0.51
4.053GluThr: 4.053 ± 0.49
5.104GluVal: 5.104 ± 0.553
1.051GluTrp: 1.051 ± 0.216
3.303GluTyr: 3.303 ± 0.4
0.0GluXaa: 0.0 ± 0.0
Phe
2.452PheAla: 2.452 ± 0.405
0.2PheCys: 0.2 ± 0.104
3.002PheAsp: 3.002 ± 0.319
2.152PheGlu: 2.152 ± 0.433
1.701PhePhe: 1.701 ± 0.272
2.152PheGly: 2.152 ± 0.331
0.5PheHis: 0.5 ± 0.156
2.902PheIle: 2.902 ± 0.414
3.853PheLys: 3.853 ± 0.473
2.102PheLeu: 2.102 ± 0.301
1.151PheMet: 1.151 ± 0.234
4.353PheAsn: 4.353 ± 0.554
1.401PhePro: 1.401 ± 0.34
1.351PheGln: 1.351 ± 0.23
1.551PheArg: 1.551 ± 0.299
2.402PheSer: 2.402 ± 0.33
3.253PheThr: 3.253 ± 0.4
2.602PheVal: 2.602 ± 0.356
0.35PheTrp: 0.35 ± 0.154
1.601PheTyr: 1.601 ± 0.357
0.0PheXaa: 0.0 ± 0.0
Gly
3.052GlyAla: 3.052 ± 0.428
0.4GlyCys: 0.4 ± 0.162
2.052GlyAsp: 2.052 ± 0.389
2.802GlyGlu: 2.802 ± 0.385
2.952GlyPhe: 2.952 ± 0.475
3.002GlyGly: 3.002 ± 0.623
1.201GlyHis: 1.201 ± 0.252
3.703GlyIle: 3.703 ± 0.459
4.404GlyLys: 4.404 ± 0.487
4.904GlyLeu: 4.904 ± 0.694
1.851GlyMet: 1.851 ± 0.421
4.053GlyAsn: 4.053 ± 0.408
0.2GlyPro: 0.2 ± 0.108
1.701GlyGln: 1.701 ± 0.298
1.851GlyArg: 1.851 ± 0.251
4.353GlySer: 4.353 ± 0.657
3.403GlyThr: 3.403 ± 0.375
3.753GlyVal: 3.753 ± 0.553
0.751GlyTrp: 0.751 ± 0.245
3.153GlyTyr: 3.153 ± 0.351
0.0GlyXaa: 0.0 ± 0.0
His
1.251HisAla: 1.251 ± 0.27
0.25HisCys: 0.25 ± 0.147
0.6HisAsp: 0.6 ± 0.165
1.151HisGlu: 1.151 ± 0.271
0.801HisPhe: 0.801 ± 0.251
0.5HisGly: 0.5 ± 0.162
0.951HisHis: 0.951 ± 0.286
1.151HisIle: 1.151 ± 0.279
1.601HisLys: 1.601 ± 0.289
1.651HisLeu: 1.651 ± 0.357
0.6HisMet: 0.6 ± 0.177
1.401HisAsn: 1.401 ± 0.267
0.701HisPro: 0.701 ± 0.22
0.3HisGln: 0.3 ± 0.148
1.151HisArg: 1.151 ± 0.251
0.701HisSer: 0.701 ± 0.224
0.751HisThr: 0.751 ± 0.202
1.001HisVal: 1.001 ± 0.233
0.35HisTrp: 0.35 ± 0.137
1.001HisTyr: 1.001 ± 0.239
0.0HisXaa: 0.0 ± 0.0
Ile
4.754IleAla: 4.754 ± 0.463
0.55IleCys: 0.55 ± 0.204
4.704IleAsp: 4.704 ± 0.456
5.104IleGlu: 5.104 ± 0.566
1.551IlePhe: 1.551 ± 0.239
3.703IleGly: 3.703 ± 0.568
1.201IleHis: 1.201 ± 0.246
4.103IleIle: 4.103 ± 0.541
6.355IleLys: 6.355 ± 0.654
5.004IleLeu: 5.004 ± 0.686
1.001IleMet: 1.001 ± 0.174
4.654IleAsn: 4.654 ± 0.476
2.902IlePro: 2.902 ± 0.384
2.652IleGln: 2.652 ± 0.359
3.553IleArg: 3.553 ± 0.438
2.802IleSer: 2.802 ± 0.371
4.854IleThr: 4.854 ± 0.531
3.903IleVal: 3.903 ± 0.454
0.951IleTrp: 0.951 ± 0.293
2.102IleTyr: 2.102 ± 0.349
0.0IleXaa: 0.0 ± 0.0
Lys
5.604LysAla: 5.604 ± 0.574
0.55LysCys: 0.55 ± 0.189
5.004LysAsp: 5.004 ± 0.52
6.205LysGlu: 6.205 ± 0.696
3.052LysPhe: 3.052 ± 0.357
3.653LysGly: 3.653 ± 0.394
1.651LysHis: 1.651 ± 0.284
4.353LysIle: 4.353 ± 0.762
4.353LysLys: 4.353 ± 0.457
9.858LysLeu: 9.858 ± 0.709
2.302LysMet: 2.302 ± 0.41
4.053LysAsn: 4.053 ± 0.482
3.953LysPro: 3.953 ± 0.541
4.604LysGln: 4.604 ± 0.439
3.353LysArg: 3.353 ± 0.429
3.703LysSer: 3.703 ± 0.609
4.454LysThr: 4.454 ± 0.457
5.054LysVal: 5.054 ± 0.503
0.801LysTrp: 0.801 ± 0.202
3.803LysTyr: 3.803 ± 0.44
0.0LysXaa: 0.0 ± 0.0
Leu
5.705LeuAla: 5.705 ± 0.57
0.651LeuCys: 0.651 ± 0.199
6.355LeuAsp: 6.355 ± 0.481
5.655LeuGlu: 5.655 ± 0.641
2.752LeuPhe: 2.752 ± 0.374
5.454LeuGly: 5.454 ± 0.547
2.002LeuHis: 2.002 ± 0.396
6.255LeuIle: 6.255 ± 0.753
7.556LeuLys: 7.556 ± 0.627
7.756LeuLeu: 7.756 ± 0.583
2.552LeuMet: 2.552 ± 0.325
5.855LeuAsn: 5.855 ± 0.562
3.703LeuPro: 3.703 ± 0.476
3.203LeuGln: 3.203 ± 0.404
3.853LeuArg: 3.853 ± 0.491
6.005LeuSer: 6.005 ± 0.532
6.906LeuThr: 6.906 ± 0.655
5.304LeuVal: 5.304 ± 0.61
0.901LeuTrp: 0.901 ± 0.174
3.253LeuTyr: 3.253 ± 0.399
0.0LeuXaa: 0.0 ± 0.0
Met
1.251MetAla: 1.251 ± 0.252
0.25MetCys: 0.25 ± 0.118
1.501MetAsp: 1.501 ± 0.282
1.851MetGlu: 1.851 ± 0.461
1.301MetPhe: 1.301 ± 0.207
1.401MetGly: 1.401 ± 0.285
0.3MetHis: 0.3 ± 0.138
1.351MetIle: 1.351 ± 0.253
3.303MetLys: 3.303 ± 0.498
2.502MetLeu: 2.502 ± 0.332
0.45MetMet: 0.45 ± 0.154
1.751MetAsn: 1.751 ± 0.275
0.951MetPro: 0.951 ± 0.184
1.351MetGln: 1.351 ± 0.252
1.101MetArg: 1.101 ± 0.237
1.902MetSer: 1.902 ± 0.335
0.951MetThr: 0.951 ± 0.206
1.651MetVal: 1.651 ± 0.353
0.1MetTrp: 0.1 ± 0.072
0.651MetTyr: 0.651 ± 0.151
0.0MetXaa: 0.0 ± 0.0
Asn
3.653AsnAla: 3.653 ± 0.397
0.45AsnCys: 0.45 ± 0.162
2.302AsnAsp: 2.302 ± 0.437
3.453AsnGlu: 3.453 ± 0.399
2.002AsnPhe: 2.002 ± 0.276
3.052AsnGly: 3.052 ± 0.477
1.251AsnHis: 1.251 ± 0.294
3.653AsnIle: 3.653 ± 0.424
5.554AsnLys: 5.554 ± 0.591
5.855AsnLeu: 5.855 ± 0.63
2.252AsnMet: 2.252 ± 0.255
3.603AsnAsn: 3.603 ± 0.386
3.853AsnPro: 3.853 ± 0.493
3.953AsnGln: 3.953 ± 0.487
2.552AsnArg: 2.552 ± 0.394
4.554AsnSer: 4.554 ± 0.497
4.854AsnThr: 4.854 ± 0.481
3.203AsnVal: 3.203 ± 0.398
0.701AsnTrp: 0.701 ± 0.229
2.552AsnTyr: 2.552 ± 0.531
0.0AsnXaa: 0.0 ± 0.0
Pro
2.402ProAla: 2.402 ± 0.409
0.5ProCys: 0.5 ± 0.18
2.252ProAsp: 2.252 ± 0.274
3.503ProGlu: 3.503 ± 0.391
1.651ProPhe: 1.651 ± 0.351
0.6ProGly: 0.6 ± 0.139
0.6ProHis: 0.6 ± 0.2
2.752ProIle: 2.752 ± 0.353
3.303ProLys: 3.303 ± 0.436
2.902ProLeu: 2.902 ± 0.473
0.851ProMet: 0.851 ± 0.222
3.052ProAsn: 3.052 ± 0.424
0.5ProPro: 0.5 ± 0.161
0.951ProGln: 0.951 ± 0.245
1.101ProArg: 1.101 ± 0.229
2.752ProSer: 2.752 ± 0.322
2.802ProThr: 2.802 ± 0.349
2.852ProVal: 2.852 ± 0.348
0.35ProTrp: 0.35 ± 0.136
1.301ProTyr: 1.301 ± 0.29
0.0ProXaa: 0.0 ± 0.0
Gln
3.002GlnAla: 3.002 ± 0.417
0.2GlnCys: 0.2 ± 0.124
1.952GlnAsp: 1.952 ± 0.265
3.503GlnGlu: 3.503 ± 0.418
1.751GlnPhe: 1.751 ± 0.306
2.402GlnGly: 2.402 ± 0.31
0.701GlnHis: 0.701 ± 0.197
2.502GlnIle: 2.502 ± 0.321
2.402GlnLys: 2.402 ± 0.336
4.454GlnLeu: 4.454 ± 0.466
1.601GlnMet: 1.601 ± 0.446
1.201GlnAsn: 1.201 ± 0.306
1.351GlnPro: 1.351 ± 0.346
2.152GlnGln: 2.152 ± 0.444
1.751GlnArg: 1.751 ± 0.312
2.202GlnSer: 2.202 ± 0.303
2.602GlnThr: 2.602 ± 0.409
2.802GlnVal: 2.802 ± 0.41
0.45GlnTrp: 0.45 ± 0.12
2.002GlnTyr: 2.002 ± 0.31
0.0GlnXaa: 0.0 ± 0.0
Arg
2.152ArgAla: 2.152 ± 0.353
0.651ArgCys: 0.651 ± 0.204
2.052ArgAsp: 2.052 ± 0.265
2.552ArgGlu: 2.552 ± 0.332
1.551ArgPhe: 1.551 ± 0.263
2.302ArgGly: 2.302 ± 0.306
0.55ArgHis: 0.55 ± 0.174
2.602ArgIle: 2.602 ± 0.312
3.303ArgLys: 3.303 ± 0.412
4.103ArgLeu: 4.103 ± 0.439
0.851ArgMet: 0.851 ± 0.195
2.602ArgAsn: 2.602 ± 0.375
1.251ArgPro: 1.251 ± 0.231
1.451ArgGln: 1.451 ± 0.248
1.451ArgArg: 1.451 ± 0.286
2.152ArgSer: 2.152 ± 0.305
2.702ArgThr: 2.702 ± 0.361
2.702ArgVal: 2.702 ± 0.377
0.5ArgTrp: 0.5 ± 0.198
1.751ArgTyr: 1.751 ± 0.288
0.0ArgXaa: 0.0 ± 0.0
Ser
3.553SerAla: 3.553 ± 0.506
0.35SerCys: 0.35 ± 0.116
4.053SerAsp: 4.053 ± 0.618
4.454SerGlu: 4.454 ± 0.536
2.902SerPhe: 2.902 ± 0.366
4.353SerGly: 4.353 ± 0.528
0.5SerHis: 0.5 ± 0.153
5.054SerIle: 5.054 ± 0.519
5.154SerLys: 5.154 ± 0.538
5.805SerLeu: 5.805 ± 0.507
1.551SerMet: 1.551 ± 0.288
3.653SerAsn: 3.653 ± 0.462
1.952SerPro: 1.952 ± 0.332
1.801SerGln: 1.801 ± 0.275
1.801SerArg: 1.801 ± 0.301
3.052SerSer: 3.052 ± 0.475
4.353SerThr: 4.353 ± 0.468
3.803SerVal: 3.803 ± 0.497
0.751SerTrp: 0.751 ± 0.192
2.052SerTyr: 2.052 ± 0.292
0.0SerXaa: 0.0 ± 0.0
Thr
4.103ThrAla: 4.103 ± 0.494
0.751ThrCys: 0.751 ± 0.218
3.253ThrAsp: 3.253 ± 0.351
4.003ThrGlu: 4.003 ± 0.549
2.702ThrPhe: 2.702 ± 0.29
4.504ThrGly: 4.504 ± 0.388
0.951ThrHis: 0.951 ± 0.236
4.153ThrIle: 4.153 ± 0.491
4.904ThrLys: 4.904 ± 0.472
5.404ThrLeu: 5.404 ± 0.513
1.251ThrMet: 1.251 ± 0.226
4.404ThrAsn: 4.404 ± 0.598
2.902ThrPro: 2.902 ± 0.433
3.253ThrGln: 3.253 ± 0.37
2.052ThrArg: 2.052 ± 0.393
3.753ThrSer: 3.753 ± 0.405
3.953ThrThr: 3.953 ± 0.51
4.954ThrVal: 4.954 ± 0.601
1.001ThrTrp: 1.001 ± 0.251
3.453ThrTyr: 3.453 ± 0.475
0.0ThrXaa: 0.0 ± 0.0
Val
3.853ValAla: 3.853 ± 0.45
0.6ValCys: 0.6 ± 0.228
3.253ValAsp: 3.253 ± 0.45
5.204ValGlu: 5.204 ± 0.537
2.352ValPhe: 2.352 ± 0.309
2.952ValGly: 2.952 ± 0.43
1.201ValHis: 1.201 ± 0.254
4.103ValIle: 4.103 ± 0.454
4.654ValLys: 4.654 ± 0.364
5.054ValLeu: 5.054 ± 0.529
1.301ValMet: 1.301 ± 0.22
4.604ValAsn: 4.604 ± 0.499
2.752ValPro: 2.752 ± 0.429
3.052ValGln: 3.052 ± 0.724
2.952ValArg: 2.952 ± 0.382
4.203ValSer: 4.203 ± 0.708
4.504ValThr: 4.504 ± 0.545
3.653ValVal: 3.653 ± 0.48
0.6ValTrp: 0.6 ± 0.155
2.302ValTyr: 2.302 ± 0.336
0.0ValXaa: 0.0 ± 0.0
Trp
0.751TrpAla: 0.751 ± 0.224
0.2TrpCys: 0.2 ± 0.099
0.45TrpAsp: 0.45 ± 0.162
0.851TrpGlu: 0.851 ± 0.246
1.201TrpPhe: 1.201 ± 0.275
0.701TrpGly: 0.701 ± 0.16
0.3TrpHis: 0.3 ± 0.143
0.901TrpIle: 0.901 ± 0.222
0.851TrpLys: 0.851 ± 0.209
0.951TrpLeu: 0.951 ± 0.25
0.3TrpMet: 0.3 ± 0.128
0.5TrpAsn: 0.5 ± 0.135
0.25TrpPro: 0.25 ± 0.129
0.4TrpGln: 0.4 ± 0.156
0.4TrpArg: 0.4 ± 0.154
0.751TrpSer: 0.751 ± 0.212
0.35TrpThr: 0.35 ± 0.136
0.801TrpVal: 0.801 ± 0.227
0.2TrpTrp: 0.2 ± 0.107
0.751TrpTyr: 0.751 ± 0.211
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.252TyrAla: 2.252 ± 0.321
0.6TyrCys: 0.6 ± 0.189
1.801TyrAsp: 1.801 ± 0.35
2.752TyrGlu: 2.752 ± 0.3
1.601TyrPhe: 1.601 ± 0.349
2.302TyrGly: 2.302 ± 0.291
0.951TyrHis: 0.951 ± 0.279
3.052TyrIle: 3.052 ± 0.579
4.053TyrLys: 4.053 ± 0.421
4.554TyrLeu: 4.554 ± 0.528
0.751TyrMet: 0.751 ± 0.22
2.602TyrAsn: 2.602 ± 0.382
1.551TyrPro: 1.551 ± 0.355
2.102TyrGln: 2.102 ± 0.318
1.451TyrArg: 1.451 ± 0.271
3.002TyrSer: 3.002 ± 0.422
2.752TyrThr: 2.752 ± 0.375
2.452TyrVal: 2.452 ± 0.293
0.45TyrTrp: 0.45 ± 0.179
1.501TyrTyr: 1.501 ± 0.354
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 110 proteins (19985 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski