Amino acid dipepetide frequency for Faecalibacterium prausnitzii L2-6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.642AlaAla: 13.642 ± 0.231	1.585AlaCys: 1.585 ± 0.048	5.942AlaAsp: 5.942 ± 0.088	7.485AlaGlu: 7.485 ± 0.123	3.473AlaPhe: 3.473 ± 0.075	7.432AlaGly: 7.432 ± 0.121	1.739AlaHis: 1.739 ± 0.05	4.972AlaIle: 4.972 ± 0.094	5.168AlaLys: 5.168 ± 0.079	10.145AlaLeu: 10.145 ± 0.165	2.735AlaMet: 2.735 ± 0.057	2.815AlaAsn: 2.815 ± 0.063	3.535AlaPro: 3.535 ± 0.077	3.732AlaGln: 3.732 ± 0.075	4.778AlaArg: 4.778 ± 0.087	4.86AlaSer: 4.86 ± 0.098	3.697AlaThr: 3.697 ± 0.07	7.994AlaVal: 7.994 ± 0.119	0.865AlaTrp: 0.865 ± 0.038	2.785AlaTyr: 2.785 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.677CysAla: 1.677 ± 0.054	0.407CysCys: 0.407 ± 0.024	0.979CysAsp: 0.979 ± 0.036	1.041CysGlu: 1.041 ± 0.036	0.681CysPhe: 0.681 ± 0.032	1.899CysGly: 1.899 ± 0.056	0.323CysHis: 0.323 ± 0.02	0.994CysIle: 0.994 ± 0.041	0.783CysLys: 0.783 ± 0.034	1.295CysLeu: 1.295 ± 0.039	0.409CysMet: 0.409 ± 0.024	0.579CysAsn: 0.579 ± 0.033	0.82CysPro: 0.82 ± 0.034	0.441CysGln: 0.441 ± 0.026	1.025CysArg: 1.025 ± 0.045	0.966CysSer: 0.966 ± 0.035	0.907CysThr: 0.907 ± 0.035	1.187CysVal: 1.187 ± 0.038	0.176CysTrp: 0.176 ± 0.015	0.592CysTyr: 0.592 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	5.841AspAla: 5.841 ± 0.104	1.004AspCys: 1.004 ± 0.036	3.082AspAsp: 3.082 ± 0.073	4.484AspGlu: 4.484 ± 0.096	2.523AspPhe: 2.523 ± 0.06	4.802AspGly: 4.802 ± 0.096	1.012AspHis: 1.012 ± 0.036	3.505AspIle: 3.505 ± 0.061	2.974AspLys: 2.974 ± 0.067	4.812AspLeu: 4.812 ± 0.078	1.505AspMet: 1.505 ± 0.044	1.852AspAsn: 1.852 ± 0.049	2.598AspPro: 2.598 ± 0.055	1.212AspGln: 1.212 ± 0.042	2.504AspArg: 2.504 ± 0.06	2.924AspSer: 2.924 ± 0.067	3.277AspThr: 3.277 ± 0.074	3.92AspVal: 3.92 ± 0.067	0.699AspTrp: 0.699 ± 0.035	2.48AspTyr: 2.48 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	6.518GluAla: 6.518 ± 0.113	0.831GluCys: 0.831 ± 0.035	3.649GluAsp: 3.649 ± 0.067	5.095GluGlu: 5.095 ± 0.105	2.087GluPhe: 2.087 ± 0.05	4.388GluGly: 4.388 ± 0.07	1.374GluHis: 1.374 ± 0.049	3.542GluIle: 3.542 ± 0.078	5.041GluLys: 5.041 ± 0.097	6.99GluLeu: 6.99 ± 0.091	2.195GluMet: 2.195 ± 0.056	3.216GluAsn: 3.216 ± 0.062	2.2GluPro: 2.2 ± 0.063	3.188GluGln: 3.188 ± 0.071	3.566GluArg: 3.566 ± 0.069	3.064GluSer: 3.064 ± 0.064	3.387GluThr: 3.387 ± 0.071	4.209GluVal: 4.209 ± 0.08	0.617GluTrp: 0.617 ± 0.028	2.499GluTyr: 2.499 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	3.656PheAla: 3.656 ± 0.074	0.787PheCys: 0.787 ± 0.029	2.569PheAsp: 2.569 ± 0.053	2.361PheGlu: 2.361 ± 0.062	1.581PhePhe: 1.581 ± 0.049	3.176PheGly: 3.176 ± 0.074	0.769PheHis: 0.769 ± 0.032	2.019PheIle: 2.019 ± 0.054	1.61PheLys: 1.61 ± 0.049	3.437PheLeu: 3.437 ± 0.079	0.913PheMet: 0.913 ± 0.038	1.302PheAsn: 1.302 ± 0.049	1.305PhePro: 1.305 ± 0.046	1.094PheGln: 1.094 ± 0.038	1.871PheArg: 1.871 ± 0.051	2.531PheSer: 2.531 ± 0.064	2.262PheThr: 2.262 ± 0.052	2.736PheVal: 2.736 ± 0.067	0.507PheTrp: 0.507 ± 0.026	1.473PheTyr: 1.473 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	6.325GlyAla: 6.325 ± 0.113	1.582GlyCys: 1.582 ± 0.049	3.682GlyAsp: 3.682 ± 0.072	4.661GlyGlu: 4.661 ± 0.076	3.005GlyPhe: 3.005 ± 0.062	5.996GlyGly: 5.996 ± 0.165	1.376GlyHis: 1.376 ± 0.044	4.931GlyIle: 4.931 ± 0.092	4.791GlyLys: 4.791 ± 0.089	6.682GlyLeu: 6.682 ± 0.107	2.554GlyMet: 2.554 ± 0.059	2.378GlyAsn: 2.378 ± 0.074	1.791GlyPro: 1.791 ± 0.046	2.402GlyGln: 2.402 ± 0.058	4.247GlyArg: 4.247 ± 0.085	4.476GlySer: 4.476 ± 0.093	4.412GlyThr: 4.412 ± 0.074	5.837GlyVal: 5.837 ± 0.105	0.969GlyTrp: 0.969 ± 0.037	2.975GlyTyr: 2.975 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.469HisAla: 1.469 ± 0.046	0.402HisCys: 0.402 ± 0.022	1.041HisAsp: 1.041 ± 0.04	1.074HisGlu: 1.074 ± 0.04	0.816HisPhe: 0.816 ± 0.035	1.412HisGly: 1.412 ± 0.048	0.484HisHis: 0.484 ± 0.031	1.281HisIle: 1.281 ± 0.047	0.949HisLys: 0.949 ± 0.036	1.737HisLeu: 1.737 ± 0.045	0.44HisMet: 0.44 ± 0.026	0.632HisAsn: 0.632 ± 0.028	1.132HisPro: 1.132 ± 0.041	0.573HisGln: 0.573 ± 0.026	0.941HisArg: 0.941 ± 0.04	1.05HisSer: 1.05 ± 0.036	1.186HisThr: 1.186 ± 0.042	1.003HisVal: 1.003 ± 0.035	0.223HisTrp: 0.223 ± 0.016	0.818HisTyr: 0.818 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	5.426IleAla: 5.426 ± 0.09	1.079IleCys: 1.079 ± 0.037	3.357IleAsp: 3.357 ± 0.075	3.452IleGlu: 3.452 ± 0.073	2.009IlePhe: 2.009 ± 0.056	4.145IleGly: 4.145 ± 0.077	1.078IleHis: 1.078 ± 0.036	3.036IleIle: 3.036 ± 0.061	2.516IleLys: 2.516 ± 0.062	5.445IleLeu: 5.445 ± 0.09	1.335IleMet: 1.335 ± 0.044	1.925IleAsn: 1.925 ± 0.052	2.638IlePro: 2.638 ± 0.064	1.838IleGln: 1.838 ± 0.048	3.129IleArg: 3.129 ± 0.06	3.519IleSer: 3.519 ± 0.071	3.494IleThr: 3.494 ± 0.072	4.036IleVal: 4.036 ± 0.079	0.522IleTrp: 0.522 ± 0.028	1.923IleTyr: 1.923 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	5.42LysAla: 5.42 ± 0.084	0.632LysCys: 0.632 ± 0.03	3.035LysAsp: 3.035 ± 0.068	3.884LysGlu: 3.884 ± 0.083	1.555LysPhe: 1.555 ± 0.043	3.704LysGly: 3.704 ± 0.073	0.928LysHis: 0.928 ± 0.03	2.977LysIle: 2.977 ± 0.061	4.115LysLys: 4.115 ± 0.078	5.248LysLeu: 5.248 ± 0.092	1.82LysMet: 1.82 ± 0.055	2.41LysAsn: 2.41 ± 0.053	2.262LysPro: 2.262 ± 0.06	2.174LysGln: 2.174 ± 0.056	2.606LysArg: 2.606 ± 0.052	2.725LysSer: 2.725 ± 0.06	3.254LysThr: 3.254 ± 0.07	3.472LysVal: 3.472 ± 0.076	0.513LysTrp: 0.513 ± 0.025	1.989LysTyr: 1.989 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	9.537LeuAla: 9.537 ± 0.124	2.048LeuCys: 2.048 ± 0.05	5.858LeuAsp: 5.858 ± 0.092	5.767LeuGlu: 5.767 ± 0.095	3.647LeuPhe: 3.647 ± 0.085	6.653LeuGly: 6.653 ± 0.104	1.913LeuHis: 1.913 ± 0.048	4.701LeuIle: 4.701 ± 0.082	4.858LeuLys: 4.858 ± 0.08	9.884LeuLeu: 9.884 ± 0.16	2.761LeuMet: 2.761 ± 0.056	3.488LeuAsn: 3.488 ± 0.07	4.694LeuPro: 4.694 ± 0.083	2.886LeuGln: 2.886 ± 0.059	5.297LeuArg: 5.297 ± 0.085	6.236LeuSer: 6.236 ± 0.095	6.118LeuThr: 6.118 ± 0.097	6.171LeuVal: 6.171 ± 0.102	0.93LeuTrp: 0.93 ± 0.035	3.319LeuTyr: 3.319 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.984MetAla: 2.984 ± 0.06	0.304MetCys: 0.304 ± 0.02	1.666MetAsp: 1.666 ± 0.051	1.998MetGlu: 1.998 ± 0.049	0.828MetPhe: 0.828 ± 0.03	2.165MetGly: 2.165 ± 0.058	0.452MetHis: 0.452 ± 0.029	1.495MetIle: 1.495 ± 0.041	1.981MetLys: 1.981 ± 0.046	2.755MetLeu: 2.755 ± 0.066	0.863MetMet: 0.863 ± 0.037	1.27MetAsn: 1.27 ± 0.046	1.321MetPro: 1.321 ± 0.041	1.168MetGln: 1.168 ± 0.04	1.251MetArg: 1.251 ± 0.039	1.699MetSer: 1.699 ± 0.044	1.825MetThr: 1.825 ± 0.05	1.894MetVal: 1.894 ± 0.05	0.208MetTrp: 0.208 ± 0.018	0.69MetTyr: 0.69 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.557AsnAla: 3.557 ± 0.08	0.571AsnCys: 0.571 ± 0.029	1.899AsnAsp: 1.899 ± 0.051	2.106AsnGlu: 2.106 ± 0.059	1.363AsnPhe: 1.363 ± 0.039	3.193AsnGly: 3.193 ± 0.069	0.651AsnHis: 0.651 ± 0.028	2.479AsnIle: 2.479 ± 0.065	1.729AsnLys: 1.729 ± 0.048	3.152AsnLeu: 3.152 ± 0.065	0.989AsnMet: 0.989 ± 0.036	1.217AsnAsn: 1.217 ± 0.046	1.729AsnPro: 1.729 ± 0.054	1.112AsnGln: 1.112 ± 0.035	1.732AsnArg: 1.732 ± 0.045	1.833AsnSer: 1.833 ± 0.054	2.042AsnThr: 2.042 ± 0.048	2.374AsnVal: 2.374 ± 0.054	0.408AsnTrp: 0.408 ± 0.025	1.44AsnTyr: 1.44 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	4.332ProAla: 4.332 ± 0.097	0.633ProCys: 0.633 ± 0.034	2.905ProAsp: 2.905 ± 0.054	3.966ProGlu: 3.966 ± 0.083	1.588ProPhe: 1.588 ± 0.046	3.065ProGly: 3.065 ± 0.067	0.692ProHis: 0.692 ± 0.033	2.013ProIle: 2.013 ± 0.052	1.937ProLys: 1.937 ± 0.053	3.563ProLeu: 3.563 ± 0.064	1.045ProMet: 1.045 ± 0.042	1.333ProAsn: 1.333 ± 0.043	1.232ProPro: 1.232 ± 0.048	1.39ProGln: 1.39 ± 0.041	1.644ProArg: 1.644 ± 0.047	2.009ProSer: 2.009 ± 0.054	1.923ProThr: 1.923 ± 0.053	3.336ProVal: 3.336 ± 0.066	0.398ProTrp: 0.398 ± 0.023	1.464ProTyr: 1.464 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	2.898GlnAla: 2.898 ± 0.064	0.457GlnCys: 0.457 ± 0.024	1.588GlnAsp: 1.588 ± 0.05	2.256GlnGlu: 2.256 ± 0.063	1.278GlnPhe: 1.278 ± 0.04	2.079GlnGly: 2.079 ± 0.06	0.623GlnHis: 0.623 ± 0.026	1.924GlnIle: 1.924 ± 0.053	2.571GlnLys: 2.571 ± 0.058	3.621GlnLeu: 3.621 ± 0.077	1.257GlnMet: 1.257 ± 0.039	1.576GlnAsn: 1.576 ± 0.044	1.403GlnPro: 1.403 ± 0.042	1.691GlnGln: 1.691 ± 0.061	2.072GlnArg: 2.072 ± 0.06	1.852GlnSer: 1.852 ± 0.045	1.908GlnThr: 1.908 ± 0.05	2.018GlnVal: 2.018 ± 0.046	0.395GlnTrp: 0.395 ± 0.024	1.348GlnTyr: 1.348 ± 0.05	0.0GlnXaa: 0.0 ± 0.0
Arg	4.392ArgAla: 4.392 ± 0.089	0.923ArgCys: 0.923 ± 0.037	2.695ArgAsp: 2.695 ± 0.066	3.677ArgGlu: 3.677 ± 0.07	2.151ArgPhe: 2.151 ± 0.05	3.034ArgGly: 3.034 ± 0.059	0.992ArgHis: 0.992 ± 0.037	3.101ArgIle: 3.101 ± 0.062	2.978ArgLys: 2.978 ± 0.063	4.993ArgLeu: 4.993 ± 0.086	1.74ArgMet: 1.74 ± 0.052	1.781ArgAsn: 1.781 ± 0.052	2.113ArgPro: 2.113 ± 0.047	2.267ArgGln: 2.267 ± 0.059	3.538ArgArg: 3.538 ± 0.075	2.725ArgSer: 2.725 ± 0.063	2.979ArgThr: 2.979 ± 0.064	3.335ArgVal: 3.335 ± 0.064	0.58ArgTrp: 0.58 ± 0.025	2.046ArgTyr: 2.046 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.568SerAla: 5.568 ± 0.081	0.92SerCys: 0.92 ± 0.032	2.955SerAsp: 2.955 ± 0.069	3.321SerGlu: 3.321 ± 0.078	2.435SerPhe: 2.435 ± 0.057	5.083SerGly: 5.083 ± 0.126	1.06SerHis: 1.06 ± 0.036	3.269SerIle: 3.269 ± 0.071	2.475SerLys: 2.475 ± 0.063	4.978SerLeu: 4.978 ± 0.083	1.602SerMet: 1.602 ± 0.047	1.773SerAsn: 1.773 ± 0.056	2.082SerPro: 2.082 ± 0.044	1.758SerGln: 1.758 ± 0.044	3.05SerArg: 3.05 ± 0.063	3.334SerSer: 3.334 ± 0.108	3.133SerThr: 3.133 ± 0.072	4.093SerVal: 4.093 ± 0.076	0.573SerTrp: 0.573 ± 0.029	2.043SerTyr: 2.043 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	6.23ThrAla: 6.23 ± 0.12	0.754ThrCys: 0.754 ± 0.03	3.169ThrAsp: 3.169 ± 0.073	3.433ThrGlu: 3.433 ± 0.072	2.051ThrPhe: 2.051 ± 0.054	4.593ThrGly: 4.593 ± 0.09	1.007ThrHis: 1.007 ± 0.032	3.377ThrIle: 3.377 ± 0.083	2.369ThrLys: 2.369 ± 0.053	5.714ThrLeu: 5.714 ± 0.088	1.471ThrMet: 1.471 ± 0.048	1.721ThrAsn: 1.721 ± 0.048	2.915ThrPro: 2.915 ± 0.06	1.645ThrGln: 1.645 ± 0.045	2.555ThrArg: 2.555 ± 0.058	2.746ThrSer: 2.746 ± 0.066	3.092ThrThr: 3.092 ± 0.067	4.821ThrVal: 4.821 ± 0.097	0.489ThrTrp: 0.489 ± 0.024	1.716ThrTyr: 1.716 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	5.817ValAla: 5.817 ± 0.103	1.464ValCys: 1.464 ± 0.041	3.972ValAsp: 3.972 ± 0.062	4.706ValGlu: 4.706 ± 0.082	2.959ValPhe: 2.959 ± 0.075	4.732ValGly: 4.732 ± 0.077	1.192ValHis: 1.192 ± 0.044	3.909ValIle: 3.909 ± 0.07	3.604ValLys: 3.604 ± 0.068	7.599ValLeu: 7.599 ± 0.109	1.977ValMet: 1.977 ± 0.052	2.361ValAsn: 2.361 ± 0.066	2.924ValPro: 2.924 ± 0.068	2.403ValGln: 2.403 ± 0.055	3.711ValArg: 3.711 ± 0.067	4.501ValSer: 4.501 ± 0.072	4.194ValThr: 4.194 ± 0.088	5.205ValVal: 5.205 ± 0.101	0.768ValTrp: 0.768 ± 0.034	2.405ValTyr: 2.405 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.901TrpAla: 0.901 ± 0.037	0.158TrpCys: 0.158 ± 0.014	0.616TrpAsp: 0.616 ± 0.033	0.699TrpGlu: 0.699 ± 0.032	0.438TrpPhe: 0.438 ± 0.025	0.757TrpGly: 0.757 ± 0.033	0.229TrpHis: 0.229 ± 0.016	0.413TrpIle: 0.413 ± 0.028	0.611TrpLys: 0.611 ± 0.028	1.226TrpLeu: 1.226 ± 0.044	0.345TrpMet: 0.345 ± 0.022	0.469TrpAsn: 0.469 ± 0.028	0.351TrpPro: 0.351 ± 0.019	0.491TrpGln: 0.491 ± 0.025	0.504TrpArg: 0.504 ± 0.025	0.478TrpSer: 0.478 ± 0.024	0.488TrpThr: 0.488 ± 0.022	0.652TrpVal: 0.652 ± 0.03	0.129TrpTrp: 0.129 ± 0.014	0.375TrpTyr: 0.375 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.19TyrAla: 3.19 ± 0.067	0.638TyrCys: 0.638 ± 0.026	2.351TyrAsp: 2.351 ± 0.062	2.191TyrGlu: 2.191 ± 0.044	1.488TyrPhe: 1.488 ± 0.043	2.764TyrGly: 2.764 ± 0.054	0.769TyrHis: 0.769 ± 0.031	1.965TyrIle: 1.965 ± 0.047	1.664TyrLys: 1.664 ± 0.05	3.491TyrLeu: 3.491 ± 0.072	0.86TyrMet: 0.86 ± 0.031	1.477TyrAsn: 1.477 ± 0.048	1.421TyrPro: 1.421 ± 0.039	1.352TyrGln: 1.352 ± 0.047	2.019TyrArg: 2.019 ± 0.049	1.98TyrSer: 1.98 ± 0.052	2.29TyrThr: 2.29 ± 0.056	2.109TyrVal: 2.109 ± 0.049	0.362TyrTrp: 0.362 ± 0.022	1.488TyrTyr: 1.488 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2755 proteins (789465 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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