Amino acid dipepetide frequency for Castellaniella defragrans 65Phen

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.176AlaAla: 20.176 ± 0.208	1.578AlaCys: 1.578 ± 0.046	7.303AlaAsp: 7.303 ± 0.088	6.488AlaGlu: 6.488 ± 0.089	4.005AlaPhe: 4.005 ± 0.063	12.778AlaGly: 12.778 ± 0.124	2.881AlaHis: 2.881 ± 0.059	5.209AlaIle: 5.209 ± 0.081	2.359AlaLys: 2.359 ± 0.057	15.887AlaLeu: 15.887 ± 0.17	3.287AlaMet: 3.287 ± 0.055	2.205AlaAsn: 2.205 ± 0.054	6.878AlaPro: 6.878 ± 0.12	5.56AlaGln: 5.56 ± 0.088	11.702AlaArg: 11.702 ± 0.142	6.171AlaSer: 6.171 ± 0.091	5.009AlaThr: 5.009 ± 0.067	8.97AlaVal: 8.97 ± 0.105	2.34AlaTrp: 2.34 ± 0.059	2.627AlaTyr: 2.627 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.364CysAla: 1.364 ± 0.039	0.162CysCys: 0.162 ± 0.012	0.571CysAsp: 0.571 ± 0.022	0.472CysGlu: 0.472 ± 0.022	0.347CysPhe: 0.347 ± 0.019	1.123CysGly: 1.123 ± 0.033	0.278CysHis: 0.278 ± 0.015	0.404CysIle: 0.404 ± 0.019	0.166CysLys: 0.166 ± 0.012	1.029CysLeu: 1.029 ± 0.032	0.213CysMet: 0.213 ± 0.013	0.218CysAsn: 0.218 ± 0.015	0.588CysPro: 0.588 ± 0.025	0.254CysGln: 0.254 ± 0.014	0.723CysArg: 0.723 ± 0.029	0.449CysSer: 0.449 ± 0.019	0.44CysThr: 0.44 ± 0.023	0.78CysVal: 0.78 ± 0.027	0.139CysTrp: 0.139 ± 0.012	0.199CysTyr: 0.199 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.889AspAla: 7.889 ± 0.103	0.509AspCys: 0.509 ± 0.023	2.783AspAsp: 2.783 ± 0.053	3.406AspGlu: 3.406 ± 0.058	2.041AspPhe: 2.041 ± 0.044	5.028AspGly: 5.028 ± 0.079	1.281AspHis: 1.281 ± 0.033	2.634AspIle: 2.634 ± 0.056	1.251AspLys: 1.251 ± 0.036	5.876AspLeu: 5.876 ± 0.072	1.357AspMet: 1.357 ± 0.033	0.999AspAsn: 0.999 ± 0.03	3.701AspPro: 3.701 ± 0.058	1.872AspGln: 1.872 ± 0.044	4.121AspArg: 4.121 ± 0.06	2.257AspSer: 2.257 ± 0.045	2.755AspThr: 2.755 ± 0.05	3.883AspVal: 3.883 ± 0.057	1.128AspTrp: 1.128 ± 0.032	1.55AspTyr: 1.55 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.891GluAla: 6.891 ± 0.09	0.394GluCys: 0.394 ± 0.019	2.606GluAsp: 2.606 ± 0.055	2.119GluGlu: 2.119 ± 0.047	1.657GluPhe: 1.657 ± 0.036	3.792GluGly: 3.792 ± 0.072	1.351GluHis: 1.351 ± 0.036	2.759GluIle: 2.759 ± 0.057	1.377GluLys: 1.377 ± 0.05	5.275GluLeu: 5.275 ± 0.076	1.059GluMet: 1.059 ± 0.028	1.209GluAsn: 1.209 ± 0.034	2.731GluPro: 2.731 ± 0.062	2.407GluGln: 2.407 ± 0.051	4.884GluArg: 4.884 ± 0.076	2.623GluSer: 2.623 ± 0.045	2.662GluThr: 2.662 ± 0.052	3.431GluVal: 3.431 ± 0.061	0.658GluTrp: 0.658 ± 0.023	1.086GluTyr: 1.086 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.571PheAla: 3.571 ± 0.062	0.355PheCys: 0.355 ± 0.018	2.397PheAsp: 2.397 ± 0.041	1.82PheGlu: 1.82 ± 0.041	1.259PhePhe: 1.259 ± 0.037	3.3PheGly: 3.3 ± 0.053	0.765PheHis: 0.765 ± 0.027	1.526PheIle: 1.526 ± 0.038	0.844PheLys: 0.844 ± 0.028	3.285PheLeu: 3.285 ± 0.059	0.809PheMet: 0.809 ± 0.024	0.911PheAsn: 0.911 ± 0.026	1.564PhePro: 1.564 ± 0.036	1.136PheGln: 1.136 ± 0.031	2.056PheArg: 2.056 ± 0.042	2.086PheSer: 2.086 ± 0.048	1.639PheThr: 1.639 ± 0.042	2.534PheVal: 2.534 ± 0.05	0.549PheTrp: 0.549 ± 0.026	0.866PheTyr: 0.866 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.326GlyAla: 10.326 ± 0.114	0.942GlyCys: 0.942 ± 0.028	4.174GlyAsp: 4.174 ± 0.071	4.412GlyGlu: 4.412 ± 0.071	3.102GlyPhe: 3.102 ± 0.056	7.735GlyGly: 7.735 ± 0.106	2.171GlyHis: 2.171 ± 0.046	4.323GlyIle: 4.323 ± 0.063	2.558GlyLys: 2.558 ± 0.053	10.471GlyLeu: 10.471 ± 0.115	2.398GlyMet: 2.398 ± 0.052	1.786GlyAsn: 1.786 ± 0.043	3.891GlyPro: 3.891 ± 0.074	3.463GlyGln: 3.463 ± 0.063	7.395GlyArg: 7.395 ± 0.098	4.235GlySer: 4.235 ± 0.069	4.464GlyThr: 4.464 ± 0.066	6.501GlyVal: 6.501 ± 0.079	1.576GlyTrp: 1.576 ± 0.044	2.308GlyTyr: 2.308 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	3.173HisAla: 3.173 ± 0.055	0.287HisCys: 0.287 ± 0.016	1.298HisAsp: 1.298 ± 0.036	1.266HisGlu: 1.266 ± 0.034	0.875HisPhe: 0.875 ± 0.03	2.248HisGly: 2.248 ± 0.047	0.642HisHis: 0.642 ± 0.026	0.946HisIle: 0.946 ± 0.03	0.411HisLys: 0.411 ± 0.02	2.259HisLeu: 2.259 ± 0.049	0.48HisMet: 0.48 ± 0.02	0.452HisAsn: 0.452 ± 0.017	1.754HisPro: 1.754 ± 0.043	0.742HisGln: 0.742 ± 0.027	1.738HisArg: 1.738 ± 0.045	0.945HisSer: 0.945 ± 0.031	0.993HisThr: 0.993 ± 0.027	1.607HisVal: 1.607 ± 0.041	0.393HisTrp: 0.393 ± 0.018	0.663HisTyr: 0.663 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.617IleAla: 5.617 ± 0.075	0.386IleCys: 0.386 ± 0.018	3.081IleAsp: 3.081 ± 0.053	3.178IleGlu: 3.178 ± 0.056	1.278IlePhe: 1.278 ± 0.039	4.377IleGly: 4.377 ± 0.073	1.026IleHis: 1.026 ± 0.028	1.628IleIle: 1.628 ± 0.049	1.055IleLys: 1.055 ± 0.03	4.483IleLeu: 4.483 ± 0.075	0.89IleMet: 0.89 ± 0.029	1.156IleAsn: 1.156 ± 0.032	2.368IlePro: 2.368 ± 0.048	1.61IleGln: 1.61 ± 0.042	3.387IleArg: 3.387 ± 0.055	2.193IleSer: 2.193 ± 0.046	2.086IleThr: 2.086 ± 0.048	3.578IleVal: 3.578 ± 0.061	0.522IleTrp: 0.522 ± 0.021	0.918IleTyr: 0.918 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.979LysAla: 2.979 ± 0.066	0.123LysCys: 0.123 ± 0.011	1.274LysAsp: 1.274 ± 0.041	1.128LysGlu: 1.128 ± 0.033	0.7LysPhe: 0.7 ± 0.029	1.849LysGly: 1.849 ± 0.046	0.478LysHis: 0.478 ± 0.021	1.253LysIle: 1.253 ± 0.036	0.89LysLys: 0.89 ± 0.036	2.293LysLeu: 2.293 ± 0.051	0.57LysMet: 0.57 ± 0.024	0.616LysAsn: 0.616 ± 0.022	1.466LysPro: 1.466 ± 0.038	0.865LysGln: 0.865 ± 0.03	1.609LysArg: 1.609 ± 0.037	1.35LysSer: 1.35 ± 0.035	1.453LysThr: 1.453 ± 0.039	1.612LysVal: 1.612 ± 0.049	0.251LysTrp: 0.251 ± 0.014	0.538LysTyr: 0.538 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	16.004LeuAla: 16.004 ± 0.143	1.191LeuCys: 1.191 ± 0.033	7.3LeuAsp: 7.3 ± 0.094	5.42LeuGlu: 5.42 ± 0.079	3.574LeuPhe: 3.574 ± 0.068	9.435LeuGly: 9.435 ± 0.103	2.308LeuHis: 2.308 ± 0.051	4.779LeuIle: 4.779 ± 0.084	2.855LeuLys: 2.855 ± 0.058	11.769LeuLeu: 11.769 ± 0.142	2.6LeuMet: 2.6 ± 0.054	2.553LeuAsn: 2.553 ± 0.049	6.163LeuPro: 6.163 ± 0.076	3.624LeuGln: 3.624 ± 0.062	9.321LeuArg: 9.321 ± 0.096	6.303LeuSer: 6.303 ± 0.087	4.939LeuThr: 4.939 ± 0.071	7.418LeuVal: 7.418 ± 0.088	1.381LeuTrp: 1.381 ± 0.046	2.302LeuTyr: 2.302 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.038MetAla: 3.038 ± 0.054	0.176MetCys: 0.176 ± 0.012	1.233MetAsp: 1.233 ± 0.034	0.974MetGlu: 0.974 ± 0.031	0.664MetPhe: 0.664 ± 0.023	1.882MetGly: 1.882 ± 0.04	0.509MetHis: 0.509 ± 0.023	1.101MetIle: 1.101 ± 0.032	0.8MetLys: 0.8 ± 0.028	2.62MetLeu: 2.62 ± 0.052	0.64MetMet: 0.64 ± 0.024	0.779MetAsn: 0.779 ± 0.026	1.529MetPro: 1.529 ± 0.038	0.908MetGln: 0.908 ± 0.032	1.906MetArg: 1.906 ± 0.048	1.51MetSer: 1.51 ± 0.039	1.424MetThr: 1.424 ± 0.033	1.548MetVal: 1.548 ± 0.037	0.19MetTrp: 0.19 ± 0.015	0.379MetTyr: 0.379 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.646AsnAla: 2.646 ± 0.048	0.205AsnCys: 0.205 ± 0.013	1.08AsnAsp: 1.08 ± 0.034	1.042AsnGlu: 1.042 ± 0.036	0.778AsnPhe: 0.778 ± 0.025	1.912AsnGly: 1.912 ± 0.037	0.47AsnHis: 0.47 ± 0.018	1.084AsnIle: 1.084 ± 0.032	0.499AsnLys: 0.499 ± 0.024	2.436AsnLeu: 2.436 ± 0.049	0.494AsnMet: 0.494 ± 0.022	0.528AsnAsn: 0.528 ± 0.029	1.645AsnPro: 1.645 ± 0.039	0.805AsnGln: 0.805 ± 0.026	1.593AsnArg: 1.593 ± 0.039	0.868AsnSer: 0.868 ± 0.03	1.143AsnThr: 1.143 ± 0.038	1.582AsnVal: 1.582 ± 0.042	0.312AsnTrp: 0.312 ± 0.019	0.561AsnTyr: 0.561 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	8.588ProAla: 8.588 ± 0.128	0.486ProCys: 0.486 ± 0.019	4.153ProAsp: 4.153 ± 0.071	3.62ProGlu: 3.62 ± 0.061	1.681ProPhe: 1.681 ± 0.038	5.462ProGly: 5.462 ± 0.075	1.156ProHis: 1.156 ± 0.033	1.886ProIle: 1.886 ± 0.043	1.138ProLys: 1.138 ± 0.039	5.485ProLeu: 5.485 ± 0.082	1.291ProMet: 1.291 ± 0.035	1.038ProAsn: 1.038 ± 0.031	3.06ProPro: 3.06 ± 0.067	1.877ProGln: 1.877 ± 0.047	3.689ProArg: 3.689 ± 0.057	2.515ProSer: 2.515 ± 0.047	2.117ProThr: 2.117 ± 0.039	4.462ProVal: 4.462 ± 0.059	0.904ProTrp: 0.904 ± 0.031	1.22ProTyr: 1.22 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	6.792GlnAla: 6.792 ± 0.118	0.31GlnCys: 0.31 ± 0.016	2.0GlnAsp: 2.0 ± 0.037	1.624GlnGlu: 1.624 ± 0.042	1.063GlnPhe: 1.063 ± 0.031	3.307GlnGly: 3.307 ± 0.059	0.788GlnHis: 0.788 ± 0.027	1.655GlnIle: 1.655 ± 0.043	0.865GlnLys: 0.865 ± 0.032	3.249GlnLeu: 3.249 ± 0.065	0.854GlnMet: 0.854 ± 0.025	0.725GlnAsn: 0.725 ± 0.028	2.049GlnPro: 2.049 ± 0.042	1.521GlnGln: 1.521 ± 0.045	2.937GlnArg: 2.937 ± 0.055	1.878GlnSer: 1.878 ± 0.045	1.687GlnThr: 1.687 ± 0.04	2.813GlnVal: 2.813 ± 0.057	0.658GlnTrp: 0.658 ± 0.025	0.786GlnTyr: 0.786 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	10.036ArgAla: 10.036 ± 0.122	0.714ArgCys: 0.714 ± 0.029	4.398ArgAsp: 4.398 ± 0.069	4.443ArgGlu: 4.443 ± 0.073	2.689ArgPhe: 2.689 ± 0.043	5.555ArgGly: 5.555 ± 0.076	2.389ArgHis: 2.389 ± 0.05	4.444ArgIle: 4.444 ± 0.065	1.847ArgLys: 1.847 ± 0.049	9.46ArgLeu: 9.46 ± 0.102	2.068ArgMet: 2.068 ± 0.041	1.796ArgAsn: 1.796 ± 0.038	4.427ArgPro: 4.427 ± 0.067	3.518ArgGln: 3.518 ± 0.065	7.159ArgArg: 7.159 ± 0.101	3.388ArgSer: 3.388 ± 0.057	3.793ArgThr: 3.793 ± 0.065	5.483ArgVal: 5.483 ± 0.07	1.299ArgTrp: 1.299 ± 0.034	2.082ArgTyr: 2.082 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	5.949SerAla: 5.949 ± 0.08	0.441SerCys: 0.441 ± 0.019	2.403SerAsp: 2.403 ± 0.047	2.051SerGlu: 2.051 ± 0.045	1.796SerPhe: 1.796 ± 0.04	5.211SerGly: 5.211 ± 0.068	1.099SerHis: 1.099 ± 0.03	2.332SerIle: 2.332 ± 0.051	1.039SerLys: 1.039 ± 0.028	5.73SerLeu: 5.73 ± 0.078	1.328SerMet: 1.328 ± 0.033	1.097SerAsn: 1.097 ± 0.032	2.803SerPro: 2.803 ± 0.047	1.673SerGln: 1.673 ± 0.042	3.827SerArg: 3.827 ± 0.065	2.576SerSer: 2.576 ± 0.054	2.37SerThr: 2.37 ± 0.049	3.557SerVal: 3.557 ± 0.054	0.717SerTrp: 0.717 ± 0.025	1.179SerTyr: 1.179 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.492ThrAla: 5.492 ± 0.07	0.422ThrCys: 0.422 ± 0.021	2.456ThrAsp: 2.456 ± 0.047	2.119ThrGlu: 2.119 ± 0.05	1.542ThrPhe: 1.542 ± 0.039	4.574ThrGly: 4.574 ± 0.065	1.12ThrHis: 1.12 ± 0.029	2.046ThrIle: 2.046 ± 0.047	0.769ThrLys: 0.769 ± 0.031	6.337ThrLeu: 6.337 ± 0.081	0.963ThrMet: 0.963 ± 0.024	0.927ThrAsn: 0.927 ± 0.03	3.164ThrPro: 3.164 ± 0.06	1.631ThrGln: 1.631 ± 0.041	3.478ThrArg: 3.478 ± 0.053	2.064ThrSer: 2.064 ± 0.045	2.168ThrThr: 2.168 ± 0.049	3.75ThrVal: 3.75 ± 0.058	0.634ThrTrp: 0.634 ± 0.026	0.957ThrTyr: 0.957 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.652ValAla: 8.652 ± 0.092	0.791ValCys: 0.791 ± 0.028	3.78ValAsp: 3.78 ± 0.064	3.738ValGlu: 3.738 ± 0.066	2.778ValPhe: 2.778 ± 0.051	5.426ValGly: 5.426 ± 0.079	1.591ValHis: 1.591 ± 0.037	3.214ValIle: 3.214 ± 0.061	1.696ValLys: 1.696 ± 0.048	8.607ValLeu: 8.607 ± 0.096	1.649ValMet: 1.649 ± 0.043	1.749ValAsn: 1.749 ± 0.037	4.031ValPro: 4.031 ± 0.069	2.57ValGln: 2.57 ± 0.049	5.956ValArg: 5.956 ± 0.079	3.911ValSer: 3.911 ± 0.054	3.454ValThr: 3.454 ± 0.058	5.568ValVal: 5.568 ± 0.08	0.961ValTrp: 0.961 ± 0.03	1.594ValTyr: 1.594 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.456TrpAla: 1.456 ± 0.043	0.176TrpCys: 0.176 ± 0.014	0.653TrpAsp: 0.653 ± 0.025	0.547TrpGlu: 0.547 ± 0.025	0.543TrpPhe: 0.543 ± 0.023	1.025TrpGly: 1.025 ± 0.03	0.41TrpHis: 0.41 ± 0.021	0.774TrpIle: 0.774 ± 0.027	0.387TrpLys: 0.387 ± 0.018	2.283TrpLeu: 2.283 ± 0.056	0.423TrpMet: 0.423 ± 0.022	0.434TrpAsn: 0.434 ± 0.018	0.817TrpPro: 0.817 ± 0.032	0.674TrpGln: 0.674 ± 0.029	1.525TrpArg: 1.525 ± 0.039	0.771TrpSer: 0.771 ± 0.029	0.835TrpThr: 0.835 ± 0.027	0.938TrpVal: 0.938 ± 0.031	0.273TrpTrp: 0.273 ± 0.017	0.317TrpTyr: 0.317 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.777TyrAla: 2.777 ± 0.057	0.27TyrCys: 0.27 ± 0.015	1.377TyrAsp: 1.377 ± 0.034	1.104TyrGlu: 1.104 ± 0.033	0.899TyrPhe: 0.899 ± 0.033	2.212TyrGly: 2.212 ± 0.043	0.459TyrHis: 0.459 ± 0.02	0.821TyrIle: 0.821 ± 0.027	0.49TyrLys: 0.49 ± 0.026	2.404TyrLeu: 2.404 ± 0.047	0.438TyrMet: 0.438 ± 0.019	0.504TyrAsn: 0.504 ± 0.022	1.199TyrPro: 1.199 ± 0.034	0.854TyrGln: 0.854 ± 0.034	1.984TyrArg: 1.984 ± 0.043	1.082TyrSer: 1.082 ± 0.033	1.18TyrThr: 1.18 ± 0.031	1.7TyrVal: 1.7 ± 0.04	0.373TyrTrp: 0.373 ± 0.018	0.59TyrTyr: 0.59 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3575 proteins (1162262 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---