Amino acid dipepetide frequency for Jonquetella anthropi DSM 22815

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.215AlaAla: 13.215 ± 0.244
1.601AlaCys: 1.601 ± 0.07
5.429AlaAsp: 5.429 ± 0.104
6.383AlaGlu: 6.383 ± 0.15
3.985AlaPhe: 3.985 ± 0.088
9.29AlaGly: 9.29 ± 0.185
1.573AlaHis: 1.573 ± 0.058
4.406AlaIle: 4.406 ± 0.102
4.434AlaLys: 4.434 ± 0.115
12.557AlaLeu: 12.557 ± 0.195
2.79AlaMet: 2.79 ± 0.082
2.226AlaAsn: 2.226 ± 0.075
4.095AlaPro: 4.095 ± 0.114
3.881AlaGln: 3.881 ± 0.103
6.165AlaArg: 6.165 ± 0.137
6.56AlaSer: 6.56 ± 0.126
3.749AlaThr: 3.749 ± 0.106
9.288AlaVal: 9.288 ± 0.155
1.285AlaTrp: 1.285 ± 0.053
2.054AlaTyr: 2.054 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
1.385CysAla: 1.385 ± 0.055
0.364CysCys: 0.364 ± 0.031
0.783CysAsp: 0.783 ± 0.04
0.659CysGlu: 0.659 ± 0.039
0.574CysPhe: 0.574 ± 0.038
1.731CysGly: 1.731 ± 0.071
0.35CysHis: 0.35 ± 0.03
0.49CysIle: 0.49 ± 0.036
0.338CysLys: 0.338 ± 0.026
1.577CysLeu: 1.577 ± 0.059
0.312CysMet: 0.312 ± 0.024
0.252CysAsn: 0.252 ± 0.025
0.937CysPro: 0.937 ± 0.046
0.54CysGln: 0.54 ± 0.032
1.267CysArg: 1.267 ± 0.058
1.041CysSer: 1.041 ± 0.046
0.625CysThr: 0.625 ± 0.031
0.959CysVal: 0.959 ± 0.052
0.236CysTrp: 0.236 ± 0.022
0.348CysTyr: 0.348 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
5.18AspAla: 5.18 ± 0.121
0.731AspCys: 0.731 ± 0.037
2.894AspAsp: 2.894 ± 0.083
4.35AspGlu: 4.35 ± 0.113
2.102AspPhe: 2.102 ± 0.064
5.347AspGly: 5.347 ± 0.139
0.869AspHis: 0.869 ± 0.047
2.058AspIle: 2.058 ± 0.068
2.172AspLys: 2.172 ± 0.084
5.955AspLeu: 5.955 ± 0.124
1.345AspMet: 1.345 ± 0.049
1.117AspAsn: 1.117 ± 0.057
2.722AspPro: 2.722 ± 0.084
1.693AspGln: 1.693 ± 0.063
3.799AspArg: 3.799 ± 0.102
2.584AspSer: 2.584 ± 0.08
1.731AspThr: 1.731 ± 0.071
4.616AspVal: 4.616 ± 0.108
0.847AspTrp: 0.847 ± 0.041
1.331AspTyr: 1.331 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
6.546GluAla: 6.546 ± 0.136
0.592GluCys: 0.592 ± 0.037
2.726GluAsp: 2.726 ± 0.081
4.292GluGlu: 4.292 ± 0.123
1.85GluPhe: 1.85 ± 0.064
4.43GluGly: 4.43 ± 0.106
0.881GluHis: 0.881 ± 0.047
3.135GluIle: 3.135 ± 0.082
3.775GluLys: 3.775 ± 0.105
6.812GluLeu: 6.812 ± 0.145
1.723GluMet: 1.723 ± 0.06
2.17GluAsn: 2.17 ± 0.069
2.688GluPro: 2.688 ± 0.079
1.932GluGln: 1.932 ± 0.065
4.458GluArg: 4.458 ± 0.106
3.371GluSer: 3.371 ± 0.09
3.369GluThr: 3.369 ± 0.077
3.441GluVal: 3.441 ± 0.095
0.747GluTrp: 0.747 ± 0.04
1.281GluTyr: 1.281 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.625PheAla: 3.625 ± 0.087
0.735PheCys: 0.735 ± 0.04
2.354PheAsp: 2.354 ± 0.071
1.838PheGlu: 1.838 ± 0.059
1.834PhePhe: 1.834 ± 0.077
3.343PheGly: 3.343 ± 0.098
0.707PheHis: 0.707 ± 0.037
1.962PheIle: 1.962 ± 0.067
1.355PheLys: 1.355 ± 0.05
3.975PheLeu: 3.975 ± 0.118
0.863PheMet: 0.863 ± 0.042
0.987PheAsn: 0.987 ± 0.049
1.812PhePro: 1.812 ± 0.069
1.117PheGln: 1.117 ± 0.042
2.064PheArg: 2.064 ± 0.065
3.057PheSer: 3.057 ± 0.083
1.778PheThr: 1.778 ± 0.059
2.987PheVal: 2.987 ± 0.086
0.621PheTrp: 0.621 ± 0.036
0.983PheTyr: 0.983 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
8.367GlyAla: 8.367 ± 0.154
1.439GlyCys: 1.439 ± 0.061
4.202GlyAsp: 4.202 ± 0.091
4.954GlyGlu: 4.954 ± 0.119
3.349GlyPhe: 3.349 ± 0.083
7.14GlyGly: 7.14 ± 0.162
1.651GlyHis: 1.651 ± 0.064
4.228GlyIle: 4.228 ± 0.101
4.288GlyLys: 4.288 ± 0.108
9.312GlyLeu: 9.312 ± 0.175
2.232GlyMet: 2.232 ± 0.073
2.072GlyAsn: 2.072 ± 0.082
3.155GlyPro: 3.155 ± 0.085
2.983GlyGln: 2.983 ± 0.077
5.911GlyArg: 5.911 ± 0.124
5.14GlySer: 5.14 ± 0.128
4.838GlyThr: 4.838 ± 0.142
6.882GlyVal: 6.882 ± 0.135
1.397GlyTrp: 1.397 ± 0.06
2.254GlyTyr: 2.254 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.353HisAla: 1.353 ± 0.051
0.32HisCys: 0.32 ± 0.024
0.949HisAsp: 0.949 ± 0.053
0.839HisGlu: 0.839 ± 0.044
0.655HisPhe: 0.655 ± 0.036
1.427HisGly: 1.427 ± 0.055
0.394HisHis: 0.394 ± 0.036
0.747HisIle: 0.747 ± 0.042
0.617HisLys: 0.617 ± 0.038
1.804HisLeu: 1.804 ± 0.074
0.434HisMet: 0.434 ± 0.03
0.498HisAsn: 0.498 ± 0.031
1.107HisPro: 1.107 ± 0.047
0.532HisGln: 0.532 ± 0.031
1.041HisArg: 1.041 ± 0.052
0.919HisSer: 0.919 ± 0.045
0.723HisThr: 0.723 ± 0.036
1.121HisVal: 1.121 ± 0.052
0.252HisTrp: 0.252 ± 0.02
0.504HisTyr: 0.504 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
4.99IleAla: 4.99 ± 0.122
0.917IleCys: 0.917 ± 0.046
2.956IleAsp: 2.956 ± 0.076
2.826IleGlu: 2.826 ± 0.083
1.832IlePhe: 1.832 ± 0.067
4.38IleGly: 4.38 ± 0.105
0.829IleHis: 0.829 ± 0.04
2.402IleIle: 2.402 ± 0.082
1.81IleLys: 1.81 ± 0.075
4.582IleLeu: 4.582 ± 0.111
1.047IleMet: 1.047 ± 0.059
1.407IleAsn: 1.407 ± 0.059
2.352IlePro: 2.352 ± 0.062
1.415IleGln: 1.415 ± 0.061
3.031IleArg: 3.031 ± 0.08
3.279IleSer: 3.279 ± 0.095
2.504IleThr: 2.504 ± 0.073
3.971IleVal: 3.971 ± 0.095
0.542IleTrp: 0.542 ± 0.03
1.123IleTyr: 1.123 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
4.88LysAla: 4.88 ± 0.13
0.372LysCys: 0.372 ± 0.031
2.69LysAsp: 2.69 ± 0.09
3.127LysGlu: 3.127 ± 0.082
1.451LysPhe: 1.451 ± 0.065
3.409LysGly: 3.409 ± 0.1
0.506LysHis: 0.506 ± 0.035
2.662LysIle: 2.662 ± 0.093
2.971LysLys: 2.971 ± 0.11
4.196LysLeu: 4.196 ± 0.112
1.285LysMet: 1.285 ± 0.051
1.721LysAsn: 1.721 ± 0.062
1.904LysPro: 1.904 ± 0.077
1.147LysGln: 1.147 ± 0.047
2.618LysArg: 2.618 ± 0.08
2.552LysSer: 2.552 ± 0.072
2.744LysThr: 2.744 ± 0.078
3.193LysVal: 3.193 ± 0.107
0.482LysTrp: 0.482 ± 0.032
1.119LysTyr: 1.119 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
12.743LeuAla: 12.743 ± 0.214
1.745LeuCys: 1.745 ± 0.065
5.395LeuAsp: 5.395 ± 0.104
5.893LeuGlu: 5.893 ± 0.117
3.975LeuPhe: 3.975 ± 0.11
8.928LeuGly: 8.928 ± 0.158
1.547LeuHis: 1.547 ± 0.057
4.968LeuIle: 4.968 ± 0.101
4.952LeuLys: 4.952 ± 0.107
10.525LeuLeu: 10.525 ± 0.24
2.52LeuMet: 2.52 ± 0.075
2.862LeuAsn: 2.862 ± 0.073
5.649LeuPro: 5.649 ± 0.117
3.029LeuGln: 3.029 ± 0.075
6.429LeuArg: 6.429 ± 0.127
8.337LeuSer: 8.337 ± 0.176
6.103LeuThr: 6.103 ± 0.119
7.869LeuVal: 7.869 ± 0.15
1.561LeuTrp: 1.561 ± 0.07
2.316LeuTyr: 2.316 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.956MetAla: 2.956 ± 0.093
0.218MetCys: 0.218 ± 0.023
1.307MetAsp: 1.307 ± 0.049
1.603MetGlu: 1.603 ± 0.068
0.655MetPhe: 0.655 ± 0.039
2.146MetGly: 2.146 ± 0.074
0.274MetHis: 0.274 ± 0.025
1.517MetIle: 1.517 ± 0.064
1.737MetLys: 1.737 ± 0.066
2.142MetLeu: 2.142 ± 0.063
0.611MetMet: 0.611 ± 0.036
1.099MetAsn: 1.099 ± 0.05
1.135MetPro: 1.135 ± 0.052
0.49MetGln: 0.49 ± 0.034
1.325MetArg: 1.325 ± 0.052
1.681MetSer: 1.681 ± 0.055
2.018MetThr: 2.018 ± 0.065
1.834MetVal: 1.834 ± 0.061
0.216MetTrp: 0.216 ± 0.02
0.544MetTyr: 0.544 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
2.53AsnAla: 2.53 ± 0.075
0.44AsnCys: 0.44 ± 0.027
1.541AsnAsp: 1.541 ± 0.049
1.459AsnGlu: 1.459 ± 0.055
0.953AsnPhe: 0.953 ± 0.055
2.422AsnGly: 2.422 ± 0.105
0.422AsnHis: 0.422 ± 0.027
1.281AsnIle: 1.281 ± 0.06
1.119AsnLys: 1.119 ± 0.058
2.924AsnLeu: 2.924 ± 0.076
0.753AsnMet: 0.753 ± 0.038
0.639AsnAsn: 0.639 ± 0.051
1.729AsnPro: 1.729 ± 0.06
0.755AsnGln: 0.755 ± 0.038
1.792AsnArg: 1.792 ± 0.061
1.469AsnSer: 1.469 ± 0.07
1.083AsnThr: 1.083 ± 0.061
2.296AsnVal: 2.296 ± 0.088
0.476AsnTrp: 0.476 ± 0.031
0.833AsnTyr: 0.833 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
5.098ProAla: 5.098 ± 0.117
0.595ProCys: 0.595 ± 0.033
3.109ProAsp: 3.109 ± 0.073
3.743ProGlu: 3.743 ± 0.091
1.936ProPhe: 1.936 ± 0.055
3.745ProGly: 3.745 ± 0.088
0.775ProHis: 0.775 ± 0.041
2.09ProIle: 2.09 ± 0.06
1.926ProLys: 1.926 ± 0.087
5.036ProLeu: 5.036 ± 0.118
1.133ProMet: 1.133 ± 0.053
1.243ProAsn: 1.243 ± 0.049
1.529ProPro: 1.529 ± 0.062
1.82ProGln: 1.82 ± 0.06
2.214ProArg: 2.214 ± 0.061
3.209ProSer: 3.209 ± 0.093
2.166ProThr: 2.166 ± 0.07
4.051ProVal: 4.051 ± 0.095
0.701ProTrp: 0.701 ± 0.041
1.159ProTyr: 1.159 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
3.673GlnAla: 3.673 ± 0.097
0.296GlnCys: 0.296 ± 0.024
1.485GlnAsp: 1.485 ± 0.06
2.07GlnGlu: 2.07 ± 0.062
1.115GlnPhe: 1.115 ± 0.049
2.362GlnGly: 2.362 ± 0.061
0.38GlnHis: 0.38 ± 0.028
1.828GlnIle: 1.828 ± 0.059
1.808GlnLys: 1.808 ± 0.054
3.345GlnLeu: 3.345 ± 0.094
1.005GlnMet: 1.005 ± 0.046
0.971GlnAsn: 0.971 ± 0.047
1.409GlnPro: 1.409 ± 0.063
0.979GlnGln: 0.979 ± 0.044
1.802GlnArg: 1.802 ± 0.072
2.042GlnSer: 2.042 ± 0.067
1.777GlnThr: 1.777 ± 0.054
2.57GlnVal: 2.57 ± 0.072
0.508GlnTrp: 0.508 ± 0.031
0.783GlnTyr: 0.783 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
5.743ArgAla: 5.743 ± 0.116
0.835ArgCys: 0.835 ± 0.043
2.946ArgAsp: 2.946 ± 0.085
3.617ArgGlu: 3.617 ± 0.092
2.552ArgPhe: 2.552 ± 0.07
4.74ArgGly: 4.74 ± 0.117
1.271ArgHis: 1.271 ± 0.05
3.173ArgIle: 3.173 ± 0.089
2.468ArgLys: 2.468 ± 0.08
7.939ArgLeu: 7.939 ± 0.156
1.647ArgMet: 1.647 ± 0.056
1.511ArgAsn: 1.511 ± 0.057
3.013ArgPro: 3.013 ± 0.087
2.706ArgGln: 2.706 ± 0.074
5.711ArgArg: 5.711 ± 0.127
3.739ArgSer: 3.739 ± 0.095
2.987ArgThr: 2.987 ± 0.08
4.254ArgVal: 4.254 ± 0.09
1.081ArgTrp: 1.081 ± 0.05
1.693ArgTyr: 1.693 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
6.195SerAla: 6.195 ± 0.111
1.101SerCys: 1.101 ± 0.046
3.623SerAsp: 3.623 ± 0.08
3.409SerGlu: 3.409 ± 0.104
2.768SerPhe: 2.768 ± 0.062
6.503SerGly: 6.503 ± 0.14
1.069SerHis: 1.069 ± 0.048
2.952SerIle: 2.952 ± 0.074
2.198SerLys: 2.198 ± 0.075
7.196SerLeu: 7.196 ± 0.152
1.733SerMet: 1.733 ± 0.057
1.331SerAsn: 1.331 ± 0.065
3.163SerPro: 3.163 ± 0.087
2.12SerGln: 2.12 ± 0.059
4.194SerArg: 4.194 ± 0.098
4.5SerSer: 4.5 ± 0.093
2.472SerThr: 2.472 ± 0.084
5.21SerVal: 5.21 ± 0.106
1.061SerTrp: 1.061 ± 0.051
1.535SerTyr: 1.535 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
5.503ThrAla: 5.503 ± 0.104
0.667ThrCys: 0.667 ± 0.042
2.746ThrAsp: 2.746 ± 0.095
2.79ThrGlu: 2.79 ± 0.083
1.904ThrPhe: 1.904 ± 0.061
4.722ThrGly: 4.722 ± 0.12
0.785ThrHis: 0.785 ± 0.038
2.48ThrIle: 2.48 ± 0.077
1.782ThrLys: 1.782 ± 0.067
5.182ThrLeu: 5.182 ± 0.102
1.111ThrMet: 1.111 ± 0.05
1.297ThrAsn: 1.297 ± 0.076
2.963ThrPro: 2.963 ± 0.076
1.229ThrGln: 1.229 ± 0.044
2.306ThrArg: 2.306 ± 0.06
3.089ThrSer: 3.089 ± 0.083
2.446ThrThr: 2.446 ± 0.101
4.992ThrVal: 4.992 ± 0.118
0.564ThrTrp: 0.564 ± 0.034
1.283ThrTyr: 1.283 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
7.602ValAla: 7.602 ± 0.149
1.177ValCys: 1.177 ± 0.054
4.049ValAsp: 4.049 ± 0.111
4.266ValGlu: 4.266 ± 0.1
2.989ValPhe: 2.989 ± 0.094
6.097ValGly: 6.097 ± 0.12
1.225ValHis: 1.225 ± 0.052
4.174ValIle: 4.174 ± 0.105
3.659ValLys: 3.659 ± 0.105
8.169ValLeu: 8.169 ± 0.146
2.076ValMet: 2.076 ± 0.07
2.214ValAsn: 2.214 ± 0.093
4.137ValPro: 4.137 ± 0.097
2.414ValGln: 2.414 ± 0.068
4.736ValArg: 4.736 ± 0.108
5.497ValSer: 5.497 ± 0.105
4.91ValThr: 4.91 ± 0.121
6.365ValVal: 6.365 ± 0.135
0.949ValTrp: 0.949 ± 0.04
1.653ValTyr: 1.653 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
1.305TrpAla: 1.305 ± 0.052
0.22TrpCys: 0.22 ± 0.02
0.691TrpAsp: 0.691 ± 0.042
0.801TrpGlu: 0.801 ± 0.041
0.516TrpPhe: 0.516 ± 0.037
1.513TrpGly: 1.513 ± 0.062
0.288TrpHis: 0.288 ± 0.026
0.621TrpIle: 0.621 ± 0.037
0.695TrpLys: 0.695 ± 0.039
1.635TrpLeu: 1.635 ± 0.058
0.318TrpMet: 0.318 ± 0.024
0.566TrpAsn: 0.566 ± 0.034
0.665TrpPro: 0.665 ± 0.042
0.54TrpGln: 0.54 ± 0.038
0.963TrpArg: 0.963 ± 0.044
0.771TrpSer: 0.771 ± 0.042
0.651TrpThr: 0.651 ± 0.041
0.825TrpVal: 0.825 ± 0.042
0.178TrpTrp: 0.178 ± 0.019
0.316TrpTyr: 0.316 ± 0.037
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.078TyrAla: 2.078 ± 0.059
0.402TyrCys: 0.402 ± 0.031
1.569TyrAsp: 1.569 ± 0.055
1.301TyrGlu: 1.301 ± 0.052
1.005TyrPhe: 1.005 ± 0.047
2.12TyrGly: 2.12 ± 0.066
0.442TyrHis: 0.442 ± 0.03
1.019TyrIle: 1.019 ± 0.052
0.921TyrLys: 0.921 ± 0.051
2.482TyrLeu: 2.482 ± 0.071
0.568TyrMet: 0.568 ± 0.038
0.733TyrAsn: 0.733 ± 0.044
1.115TyrPro: 1.115 ± 0.046
0.887TyrGln: 0.887 ± 0.039
1.798TyrArg: 1.798 ± 0.056
1.493TyrSer: 1.493 ± 0.061
1.167TyrThr: 1.167 ± 0.055
1.635TyrVal: 1.635 ± 0.057
0.376TyrTrp: 0.376 ± 0.031
0.745TyrTyr: 0.745 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1508 proteins (500423 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski