Amino acid dipepetide frequency for Sulfuriferula multivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.409AlaAla: 14.409 ± 0.171	1.204AlaCys: 1.204 ± 0.037	5.898AlaAsp: 5.898 ± 0.078	6.349AlaGlu: 6.349 ± 0.09	3.659AlaPhe: 3.659 ± 0.059	9.162AlaGly: 9.162 ± 0.118	2.768AlaHis: 2.768 ± 0.058	5.747AlaIle: 5.747 ± 0.075	4.063AlaLys: 4.063 ± 0.075	13.379AlaLeu: 13.379 ± 0.15	3.171AlaMet: 3.171 ± 0.052	3.233AlaAsn: 3.233 ± 0.072	4.499AlaPro: 4.499 ± 0.077	5.205AlaGln: 5.205 ± 0.085	7.253AlaArg: 7.253 ± 0.092	5.896AlaSer: 5.896 ± 0.082	5.441AlaThr: 5.441 ± 0.076	7.695AlaVal: 7.695 ± 0.102	1.601AlaTrp: 1.601 ± 0.048	2.772AlaTyr: 2.772 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.002CysAla: 1.002 ± 0.035	0.137CysCys: 0.137 ± 0.011	0.519CysAsp: 0.519 ± 0.021	0.526CysGlu: 0.526 ± 0.026	0.324CysPhe: 0.324 ± 0.019	0.969CysGly: 0.969 ± 0.037	0.32CysHis: 0.32 ± 0.017	0.431CysIle: 0.431 ± 0.023	0.29CysLys: 0.29 ± 0.016	0.824CysLeu: 0.824 ± 0.027	0.217CysMet: 0.217 ± 0.016	0.298CysAsn: 0.298 ± 0.017	0.526CysPro: 0.526 ± 0.026	0.293CysGln: 0.293 ± 0.016	0.583CysArg: 0.583 ± 0.025	0.475CysSer: 0.475 ± 0.019	0.456CysThr: 0.456 ± 0.021	0.667CysVal: 0.667 ± 0.027	0.098CysTrp: 0.098 ± 0.01	0.263CysTyr: 0.263 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	6.284AspAla: 6.284 ± 0.09	0.486AspCys: 0.486 ± 0.022	2.66AspAsp: 2.66 ± 0.058	3.15AspGlu: 3.15 ± 0.065	2.355AspPhe: 2.355 ± 0.05	3.985AspGly: 3.985 ± 0.077	1.19AspHis: 1.19 ± 0.033	3.115AspIle: 3.115 ± 0.057	2.202AspLys: 2.202 ± 0.052	5.319AspLeu: 5.319 ± 0.073	1.48AspMet: 1.48 ± 0.037	1.68AspAsn: 1.68 ± 0.04	2.671AspPro: 2.671 ± 0.053	1.812AspGln: 1.812 ± 0.045	2.83AspArg: 2.83 ± 0.052	2.748AspSer: 2.748 ± 0.053	2.877AspThr: 2.877 ± 0.062	3.643AspVal: 3.643 ± 0.063	0.951AspTrp: 0.951 ± 0.031	1.83AspTyr: 1.83 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.19GluAla: 6.19 ± 0.083	0.433GluCys: 0.433 ± 0.021	2.336GluAsp: 2.336 ± 0.05	2.597GluGlu: 2.597 ± 0.063	1.945GluPhe: 1.945 ± 0.046	3.207GluGly: 3.207 ± 0.059	1.442GluHis: 1.442 ± 0.041	3.507GluIle: 3.507 ± 0.066	2.492GluLys: 2.492 ± 0.051	5.898GluLeu: 5.898 ± 0.081	1.577GluMet: 1.577 ± 0.038	1.868GluAsn: 1.868 ± 0.045	2.088GluPro: 2.088 ± 0.047	2.77GluGln: 2.77 ± 0.052	3.919GluArg: 3.919 ± 0.073	2.645GluSer: 2.645 ± 0.061	3.11GluThr: 3.11 ± 0.059	3.809GluVal: 3.809 ± 0.068	0.747GluTrp: 0.747 ± 0.029	1.438GluTyr: 1.438 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.895PheAla: 3.895 ± 0.063	0.357PheCys: 0.357 ± 0.017	2.447PheAsp: 2.447 ± 0.046	2.042PheGlu: 2.042 ± 0.041	1.509PhePhe: 1.509 ± 0.043	3.29PheGly: 3.29 ± 0.065	0.868PheHis: 0.868 ± 0.026	2.0PheIle: 2.0 ± 0.048	1.364PheLys: 1.364 ± 0.036	3.387PheLeu: 3.387 ± 0.06	0.949PheMet: 0.949 ± 0.03	1.379PheAsn: 1.379 ± 0.039	1.578PhePro: 1.578 ± 0.04	1.14PheGln: 1.14 ± 0.032	1.924PheArg: 1.924 ± 0.044	2.485PheSer: 2.485 ± 0.057	1.94PheThr: 1.94 ± 0.036	2.681PheVal: 2.681 ± 0.054	0.539PheTrp: 0.539 ± 0.027	1.094PheTyr: 1.094 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	7.465GlyAla: 7.465 ± 0.109	0.92GlyCys: 0.92 ± 0.031	3.718GlyAsp: 3.718 ± 0.072	4.226GlyGlu: 4.226 ± 0.071	3.26GlyPhe: 3.26 ± 0.068	5.739GlyGly: 5.739 ± 0.105	1.933GlyHis: 1.933 ± 0.044	4.558GlyIle: 4.558 ± 0.068	3.831GlyLys: 3.831 ± 0.064	8.129GlyLeu: 8.129 ± 0.088	2.522GlyMet: 2.522 ± 0.054	2.728GlyAsn: 2.728 ± 0.091	2.033GlyPro: 2.033 ± 0.045	3.021GlyGln: 3.021 ± 0.056	4.494GlyArg: 4.494 ± 0.072	4.315GlySer: 4.315 ± 0.089	3.91GlyThr: 3.91 ± 0.088	5.992GlyVal: 5.992 ± 0.092	1.231GlyTrp: 1.231 ± 0.039	2.473GlyTyr: 2.473 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.903HisAla: 2.903 ± 0.06	0.319HisCys: 0.319 ± 0.016	1.384HisAsp: 1.384 ± 0.036	1.29HisGlu: 1.29 ± 0.032	1.128HisPhe: 1.128 ± 0.034	2.166HisGly: 2.166 ± 0.049	0.777HisHis: 0.777 ± 0.031	1.352HisIle: 1.352 ± 0.036	0.816HisLys: 0.816 ± 0.03	2.565HisLeu: 2.565 ± 0.049	0.535HisMet: 0.535 ± 0.023	0.731HisAsn: 0.731 ± 0.028	1.595HisPro: 1.595 ± 0.044	0.965HisGln: 0.965 ± 0.034	1.353HisArg: 1.353 ± 0.037	1.249HisSer: 1.249 ± 0.035	1.313HisThr: 1.313 ± 0.038	1.486HisVal: 1.486 ± 0.039	0.4HisTrp: 0.4 ± 0.019	0.904HisTyr: 0.904 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.599IleAla: 6.599 ± 0.076	0.514IleCys: 0.514 ± 0.026	3.129IleAsp: 3.129 ± 0.061	3.408IleGlu: 3.408 ± 0.062	1.753IlePhe: 1.753 ± 0.044	4.417IleGly: 4.417 ± 0.07	1.373IleHis: 1.373 ± 0.035	2.5IleIle: 2.5 ± 0.055	2.17IleLys: 2.17 ± 0.048	4.939IleLeu: 4.939 ± 0.077	1.175IleMet: 1.175 ± 0.036	2.002IleAsn: 2.002 ± 0.051	2.719IlePro: 2.719 ± 0.049	1.896IleGln: 1.896 ± 0.044	3.067IleArg: 3.067 ± 0.056	3.272IleSer: 3.272 ± 0.053	2.971IleThr: 2.971 ± 0.054	3.876IleVal: 3.876 ± 0.065	0.563IleTrp: 0.563 ± 0.025	1.388IleTyr: 1.388 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.783LysAla: 3.783 ± 0.074	0.225LysCys: 0.225 ± 0.014	1.86LysAsp: 1.86 ± 0.047	1.795LysGlu: 1.795 ± 0.044	1.111LysPhe: 1.111 ± 0.032	2.482LysGly: 2.482 ± 0.059	0.934LysHis: 0.934 ± 0.032	2.365LysIle: 2.365 ± 0.052	1.818LysLys: 1.818 ± 0.059	4.393LysLeu: 4.393 ± 0.069	1.178LysMet: 1.178 ± 0.033	1.496LysAsn: 1.496 ± 0.034	2.32LysPro: 2.32 ± 0.056	1.932LysGln: 1.932 ± 0.044	2.438LysArg: 2.438 ± 0.05	2.156LysSer: 2.156 ± 0.05	2.372LysThr: 2.372 ± 0.049	2.652LysVal: 2.652 ± 0.061	0.469LysTrp: 0.469 ± 0.023	0.954LysTyr: 0.954 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	13.546LeuAla: 13.546 ± 0.163	0.908LeuCys: 0.908 ± 0.032	6.368LeuAsp: 6.368 ± 0.09	5.605LeuGlu: 5.605 ± 0.083	3.931LeuPhe: 3.931 ± 0.079	8.286LeuGly: 8.286 ± 0.1	2.617LeuHis: 2.617 ± 0.057	5.496LeuIle: 5.496 ± 0.083	4.479LeuLys: 4.479 ± 0.075	11.954LeuLeu: 11.954 ± 0.144	2.575LeuMet: 2.575 ± 0.053	3.562LeuAsn: 3.562 ± 0.057	6.149LeuPro: 6.149 ± 0.081	4.145LeuGln: 4.145 ± 0.066	6.768LeuArg: 6.768 ± 0.088	6.579LeuSer: 6.579 ± 0.085	5.893LeuThr: 5.893 ± 0.076	7.373LeuVal: 7.373 ± 0.091	1.315LeuTrp: 1.315 ± 0.041	2.516LeuTyr: 2.516 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.863MetAla: 2.863 ± 0.053	0.165MetCys: 0.165 ± 0.012	1.431MetAsp: 1.431 ± 0.038	1.35MetGlu: 1.35 ± 0.036	0.791MetPhe: 0.791 ± 0.028	1.885MetGly: 1.885 ± 0.044	0.658MetHis: 0.658 ± 0.029	1.271MetIle: 1.271 ± 0.035	1.134MetLys: 1.134 ± 0.035	3.083MetLeu: 3.083 ± 0.064	0.7MetMet: 0.7 ± 0.026	1.04MetAsn: 1.04 ± 0.032	1.454MetPro: 1.454 ± 0.038	1.332MetGln: 1.332 ± 0.035	1.735MetArg: 1.735 ± 0.04	1.6MetSer: 1.6 ± 0.041	1.49MetThr: 1.49 ± 0.043	1.813MetVal: 1.813 ± 0.046	0.183MetTrp: 0.183 ± 0.014	0.472MetTyr: 0.472 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.554AsnAla: 3.554 ± 0.063	0.298AsnCys: 0.298 ± 0.016	1.68AsnAsp: 1.68 ± 0.05	1.519AsnGlu: 1.519 ± 0.038	1.204AsnPhe: 1.204 ± 0.041	2.581AsnGly: 2.581 ± 0.062	0.81AsnHis: 0.81 ± 0.027	1.917AsnIle: 1.917 ± 0.046	1.217AsnLys: 1.217 ± 0.03	3.54AsnLeu: 3.54 ± 0.06	0.803AsnMet: 0.803 ± 0.027	1.097AsnAsn: 1.097 ± 0.045	2.241AsnPro: 2.241 ± 0.049	1.329AsnGln: 1.329 ± 0.041	1.981AsnArg: 1.981 ± 0.043	1.685AsnSer: 1.685 ± 0.043	1.755AsnThr: 1.755 ± 0.052	2.15AsnVal: 2.15 ± 0.053	0.526AsnTrp: 0.526 ± 0.023	0.886AsnTyr: 0.886 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	5.881ProAla: 5.881 ± 0.095	0.362ProCys: 0.362 ± 0.018	3.275ProAsp: 3.275 ± 0.059	3.266ProGlu: 3.266 ± 0.067	1.741ProPhe: 1.741 ± 0.041	4.081ProGly: 4.081 ± 0.069	1.125ProHis: 1.125 ± 0.034	2.236ProIle: 2.236 ± 0.044	1.623ProLys: 1.623 ± 0.044	4.86ProLeu: 4.86 ± 0.069	1.1ProMet: 1.1 ± 0.031	1.437ProAsn: 1.437 ± 0.043	2.131ProPro: 2.131 ± 0.062	1.969ProGln: 1.969 ± 0.042	2.341ProArg: 2.341 ± 0.052	2.324ProSer: 2.324 ± 0.048	2.169ProThr: 2.169 ± 0.049	4.045ProVal: 4.045 ± 0.07	0.646ProTrp: 0.646 ± 0.028	1.336ProTyr: 1.336 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	5.259GlnAla: 5.259 ± 0.078	0.315GlnCys: 0.315 ± 0.017	1.873GlnAsp: 1.873 ± 0.043	1.795GlnGlu: 1.795 ± 0.042	1.388GlnPhe: 1.388 ± 0.032	2.868GlnGly: 2.868 ± 0.051	1.228GlnHis: 1.228 ± 0.034	2.273GlnIle: 2.273 ± 0.042	1.459GlnLys: 1.459 ± 0.04	4.606GlnLeu: 4.606 ± 0.066	1.13GlnMet: 1.13 ± 0.033	1.231GlnAsn: 1.231 ± 0.035	2.212GlnPro: 2.212 ± 0.051	2.172GlnGln: 2.172 ± 0.059	2.951GlnArg: 2.951 ± 0.066	2.148GlnSer: 2.148 ± 0.047	2.233GlnThr: 2.233 ± 0.051	2.952GlnVal: 2.952 ± 0.052	0.536GlnTrp: 0.536 ± 0.024	1.014GlnTyr: 1.014 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.223ArgAla: 6.223 ± 0.084	0.508ArgCys: 0.508 ± 0.021	3.475ArgAsp: 3.475 ± 0.064	3.889ArgGlu: 3.889 ± 0.069	2.629ArgPhe: 2.629 ± 0.047	3.743ArgGly: 3.743 ± 0.068	1.837ArgHis: 1.837 ± 0.047	3.724ArgIle: 3.724 ± 0.059	2.245ArgLys: 2.245 ± 0.053	7.261ArgLeu: 7.261 ± 0.105	1.692ArgMet: 1.692 ± 0.04	2.091ArgAsn: 2.091 ± 0.045	2.477ArgPro: 2.477 ± 0.053	2.721ArgGln: 2.721 ± 0.058	3.999ArgArg: 3.999 ± 0.069	3.028ArgSer: 3.028 ± 0.055	2.711ArgThr: 2.711 ± 0.05	4.283ArgVal: 4.283 ± 0.069	0.896ArgTrp: 0.896 ± 0.03	2.026ArgTyr: 2.026 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.16SerAla: 6.16 ± 0.084	0.532SerCys: 0.532 ± 0.025	2.694SerAsp: 2.694 ± 0.052	2.801SerGlu: 2.801 ± 0.061	2.099SerPhe: 2.099 ± 0.045	5.287SerGly: 5.287 ± 0.082	1.383SerHis: 1.383 ± 0.034	2.902SerIle: 2.902 ± 0.05	1.838SerLys: 1.838 ± 0.049	5.955SerLeu: 5.955 ± 0.077	1.485SerMet: 1.485 ± 0.039	1.744SerAsn: 1.744 ± 0.046	2.562SerPro: 2.562 ± 0.053	2.068SerGln: 2.068 ± 0.044	3.265SerArg: 3.265 ± 0.058	3.038SerSer: 3.038 ± 0.058	2.705SerThr: 2.705 ± 0.057	4.04SerVal: 4.04 ± 0.07	0.734SerTrp: 0.734 ± 0.027	1.42SerTyr: 1.42 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.514ThrAla: 5.514 ± 0.077	0.46ThrCys: 0.46 ± 0.023	2.741ThrAsp: 2.741 ± 0.055	2.543ThrGlu: 2.543 ± 0.053	1.628ThrPhe: 1.628 ± 0.039	4.603ThrGly: 4.603 ± 0.09	1.348ThrHis: 1.348 ± 0.04	2.533ThrIle: 2.533 ± 0.051	1.443ThrLys: 1.443 ± 0.04	6.753ThrLeu: 6.753 ± 0.093	1.144ThrMet: 1.144 ± 0.034	1.399ThrAsn: 1.399 ± 0.043	3.338ThrPro: 3.338 ± 0.059	2.223ThrGln: 2.223 ± 0.046	3.332ThrArg: 3.332 ± 0.057	2.649ThrSer: 2.649 ± 0.059	2.724ThrThr: 2.724 ± 0.052	3.75ThrVal: 3.75 ± 0.061	0.62ThrTrp: 0.62 ± 0.021	1.308ThrTyr: 1.308 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	8.017ValAla: 8.017 ± 0.095	0.637ValCys: 0.637 ± 0.027	3.815ValAsp: 3.815 ± 0.061	4.094ValGlu: 4.094 ± 0.067	2.612ValPhe: 2.612 ± 0.053	4.778ValGly: 4.778 ± 0.067	1.55ValHis: 1.55 ± 0.043	3.885ValIle: 3.885 ± 0.072	2.916ValLys: 2.916 ± 0.06	7.954ValLeu: 7.954 ± 0.103	2.048ValMet: 2.048 ± 0.047	2.445ValAsn: 2.445 ± 0.046	3.312ValPro: 3.312 ± 0.062	2.477ValGln: 2.477 ± 0.046	4.123ValArg: 4.123 ± 0.071	4.311ValSer: 4.311 ± 0.064	3.92ValThr: 3.92 ± 0.062	5.564ValVal: 5.564 ± 0.085	0.958ValTrp: 0.958 ± 0.034	1.786ValTyr: 1.786 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.064TrpAla: 1.064 ± 0.038	0.143TrpCys: 0.143 ± 0.012	0.581TrpAsp: 0.581 ± 0.026	0.605TrpGlu: 0.605 ± 0.023	0.55TrpPhe: 0.55 ± 0.024	0.833TrpGly: 0.833 ± 0.033	0.416TrpHis: 0.416 ± 0.021	0.735TrpIle: 0.735 ± 0.026	0.504TrpLys: 0.504 ± 0.022	2.125TrpLeu: 2.125 ± 0.051	0.399TrpMet: 0.399 ± 0.017	0.461TrpAsn: 0.461 ± 0.02	0.575TrpPro: 0.575 ± 0.022	0.808TrpGln: 0.808 ± 0.032	1.101TrpArg: 1.101 ± 0.035	0.666TrpSer: 0.666 ± 0.024	0.573TrpThr: 0.573 ± 0.025	0.986TrpVal: 0.986 ± 0.032	0.217TrpTrp: 0.217 ± 0.015	0.346TrpTyr: 0.346 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.795TyrAla: 2.795 ± 0.051	0.293TyrCys: 0.293 ± 0.016	1.382TyrAsp: 1.382 ± 0.041	1.169TyrGlu: 1.169 ± 0.036	1.251TyrPhe: 1.251 ± 0.04	2.138TyrGly: 2.138 ± 0.047	0.654TyrHis: 0.654 ± 0.025	1.186TyrIle: 1.186 ± 0.037	0.829TyrLys: 0.829 ± 0.028	3.142TyrLeu: 3.142 ± 0.054	0.569TyrMet: 0.569 ± 0.024	0.853TyrAsn: 0.853 ± 0.034	1.467TyrPro: 1.467 ± 0.036	1.36TyrGln: 1.36 ± 0.043	2.002TyrArg: 2.002 ± 0.047	1.443TyrSer: 1.443 ± 0.035	1.49TyrThr: 1.49 ± 0.043	1.746TyrVal: 1.746 ± 0.033	0.457TyrTrp: 0.457 ± 0.02	0.808TyrTyr: 0.808 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3515 proteins (1063724 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---