Amino acid dipepetide frequency for Oxalobacteraceae bacterium OM1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.086AlaAla: 17.086 ± 0.159	1.366AlaCys: 1.366 ± 0.034	6.346AlaAsp: 6.346 ± 0.068	6.701AlaGlu: 6.701 ± 0.083	4.281AlaPhe: 4.281 ± 0.058	9.906AlaGly: 9.906 ± 0.119	2.592AlaHis: 2.592 ± 0.047	5.687AlaIle: 5.687 ± 0.072	4.365AlaLys: 4.365 ± 0.076	13.51AlaLeu: 13.51 ± 0.123	3.437AlaMet: 3.437 ± 0.044	3.253AlaAsn: 3.253 ± 0.052	5.474AlaPro: 5.474 ± 0.084	5.084AlaGln: 5.084 ± 0.072	8.078AlaArg: 8.078 ± 0.085	6.42AlaSer: 6.42 ± 0.076	5.955AlaThr: 5.955 ± 0.072	9.008AlaVal: 9.008 ± 0.086	1.677AlaTrp: 1.677 ± 0.039	2.736AlaTyr: 2.736 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.165CysAla: 1.165 ± 0.032	0.126CysCys: 0.126 ± 0.01	0.538CysAsp: 0.538 ± 0.019	0.484CysGlu: 0.484 ± 0.02	0.33CysPhe: 0.33 ± 0.017	0.988CysGly: 0.988 ± 0.029	0.258CysHis: 0.258 ± 0.014	0.454CysIle: 0.454 ± 0.019	0.265CysLys: 0.265 ± 0.014	0.831CysLeu: 0.831 ± 0.026	0.222CysMet: 0.222 ± 0.015	0.297CysAsn: 0.297 ± 0.016	0.454CysPro: 0.454 ± 0.023	0.229CysGln: 0.229 ± 0.014	0.649CysArg: 0.649 ± 0.025	0.52CysSer: 0.52 ± 0.021	0.495CysThr: 0.495 ± 0.023	0.686CysVal: 0.686 ± 0.019	0.13CysTrp: 0.13 ± 0.01	0.264CysTyr: 0.264 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.143AspAla: 7.143 ± 0.084	0.467AspCys: 0.467 ± 0.019	2.886AspAsp: 2.886 ± 0.055	3.175AspGlu: 3.175 ± 0.057	2.109AspPhe: 2.109 ± 0.042	4.612AspGly: 4.612 ± 0.065	1.088AspHis: 1.088 ± 0.027	2.891AspIle: 2.891 ± 0.05	2.008AspLys: 2.008 ± 0.042	5.185AspLeu: 5.185 ± 0.06	1.35AspMet: 1.35 ± 0.03	1.354AspAsn: 1.354 ± 0.031	2.864AspPro: 2.864 ± 0.051	1.537AspGln: 1.537 ± 0.033	3.414AspArg: 3.414 ± 0.055	2.191AspSer: 2.191 ± 0.039	2.713AspThr: 2.713 ± 0.052	4.28AspVal: 4.28 ± 0.058	0.948AspTrp: 0.948 ± 0.029	1.528AspTyr: 1.528 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	6.638GluAla: 6.638 ± 0.073	0.42GluCys: 0.42 ± 0.02	2.401GluAsp: 2.401 ± 0.039	3.042GluGlu: 3.042 ± 0.061	1.914GluPhe: 1.914 ± 0.04	3.63GluGly: 3.63 ± 0.058	1.424GluHis: 1.424 ± 0.037	2.884GluIle: 2.884 ± 0.055	2.257GluLys: 2.257 ± 0.04	5.85GluLeu: 5.85 ± 0.066	1.361GluMet: 1.361 ± 0.032	1.487GluAsn: 1.487 ± 0.033	2.346GluPro: 2.346 ± 0.047	2.775GluGln: 2.775 ± 0.051	4.935GluArg: 4.935 ± 0.076	2.628GluSer: 2.628 ± 0.042	2.806GluThr: 2.806 ± 0.046	3.832GluVal: 3.832 ± 0.052	0.74GluTrp: 0.74 ± 0.022	1.256GluTyr: 1.256 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.458PheAla: 4.458 ± 0.064	0.44PheCys: 0.44 ± 0.02	2.387PheAsp: 2.387 ± 0.039	2.013PheGlu: 2.013 ± 0.04	1.467PhePhe: 1.467 ± 0.038	3.484PheGly: 3.484 ± 0.062	0.809PheHis: 0.809 ± 0.022	1.779PheIle: 1.779 ± 0.04	1.279PheLys: 1.279 ± 0.031	3.331PheLeu: 3.331 ± 0.048	0.833PheMet: 0.833 ± 0.024	1.259PheAsn: 1.259 ± 0.034	1.612PhePro: 1.612 ± 0.037	1.108PheGln: 1.108 ± 0.026	2.16PheArg: 2.16 ± 0.037	2.3PheSer: 2.3 ± 0.041	2.1PheThr: 2.1 ± 0.041	2.826PheVal: 2.826 ± 0.048	0.519PheTrp: 0.519 ± 0.023	1.026PheTyr: 1.026 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.344GlyAla: 8.344 ± 0.1	0.865GlyCys: 0.865 ± 0.026	3.936GlyAsp: 3.936 ± 0.056	4.145GlyGlu: 4.145 ± 0.058	3.292GlyPhe: 3.292 ± 0.055	6.278GlyGly: 6.278 ± 0.085	1.874GlyHis: 1.874 ± 0.041	4.444GlyIle: 4.444 ± 0.06	3.745GlyLys: 3.745 ± 0.062	7.765GlyLeu: 7.765 ± 0.087	2.527GlyMet: 2.527 ± 0.042	2.431GlyAsn: 2.431 ± 0.048	2.775GlyPro: 2.775 ± 0.047	2.824GlyGln: 2.824 ± 0.049	5.054GlyArg: 5.054 ± 0.06	4.42GlySer: 4.42 ± 0.076	4.865GlyThr: 4.865 ± 0.093	6.188GlyVal: 6.188 ± 0.07	1.258GlyTrp: 1.258 ± 0.032	2.414GlyTyr: 2.414 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	3.165HisAla: 3.165 ± 0.05	0.27HisCys: 0.27 ± 0.014	1.326HisAsp: 1.326 ± 0.032	1.186HisGlu: 1.186 ± 0.033	0.961HisPhe: 0.961 ± 0.027	2.088HisGly: 2.088 ± 0.036	0.662HisHis: 0.662 ± 0.027	1.082HisIle: 1.082 ± 0.03	0.595HisLys: 0.595 ± 0.02	2.142HisLeu: 2.142 ± 0.039	0.566HisMet: 0.566 ± 0.023	0.57HisAsn: 0.57 ± 0.02	1.486HisPro: 1.486 ± 0.035	0.697HisGln: 0.697 ± 0.024	1.523HisArg: 1.523 ± 0.036	1.043HisSer: 1.043 ± 0.031	1.044HisThr: 1.044 ± 0.029	1.73HisVal: 1.73 ± 0.041	0.339HisTrp: 0.339 ± 0.016	0.673HisTyr: 0.673 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.838IleAla: 6.838 ± 0.071	0.422IleCys: 0.422 ± 0.018	3.385IleAsp: 3.385 ± 0.052	3.252IleGlu: 3.252 ± 0.05	1.448IlePhe: 1.448 ± 0.033	4.561IleGly: 4.561 ± 0.058	0.957IleHis: 0.957 ± 0.029	1.832IleIle: 1.832 ± 0.044	1.646IleLys: 1.646 ± 0.043	3.9IleLeu: 3.9 ± 0.059	0.882IleMet: 0.882 ± 0.026	1.515IleAsn: 1.515 ± 0.036	2.267IlePro: 2.267 ± 0.047	1.31IleGln: 1.31 ± 0.032	2.911IleArg: 2.911 ± 0.046	2.505IleSer: 2.505 ± 0.046	2.644IleThr: 2.644 ± 0.05	4.113IleVal: 4.113 ± 0.058	0.507IleTrp: 0.507 ± 0.019	1.043IleTyr: 1.043 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.19LysAla: 4.19 ± 0.069	0.183LysCys: 0.183 ± 0.013	1.937LysAsp: 1.937 ± 0.043	1.927LysGlu: 1.927 ± 0.044	1.084LysPhe: 1.084 ± 0.033	2.502LysGly: 2.502 ± 0.046	0.82LysHis: 0.82 ± 0.025	1.746LysIle: 1.746 ± 0.041	1.627LysLys: 1.627 ± 0.047	3.961LysLeu: 3.961 ± 0.056	0.978LysMet: 0.978 ± 0.027	1.131LysAsn: 1.131 ± 0.027	2.302LysPro: 2.302 ± 0.039	1.559LysGln: 1.559 ± 0.032	2.64LysArg: 2.64 ± 0.047	1.886LysSer: 1.886 ± 0.038	2.191LysThr: 2.191 ± 0.043	2.714LysVal: 2.714 ± 0.051	0.418LysTrp: 0.418 ± 0.018	0.774LysTyr: 0.774 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.614LeuAla: 13.614 ± 0.126	1.031LeuCys: 1.031 ± 0.029	5.706LeuAsp: 5.706 ± 0.068	5.329LeuGlu: 5.329 ± 0.074	3.723LeuPhe: 3.723 ± 0.061	7.894LeuGly: 7.894 ± 0.094	2.502LeuHis: 2.502 ± 0.041	4.441LeuIle: 4.441 ± 0.063	3.831LeuLys: 3.831 ± 0.064	10.767LeuLeu: 10.767 ± 0.12	2.335LeuMet: 2.335 ± 0.045	3.026LeuAsn: 3.026 ± 0.046	5.76LeuPro: 5.76 ± 0.063	4.149LeuGln: 4.149 ± 0.056	7.346LeuArg: 7.346 ± 0.083	5.905LeuSer: 5.905 ± 0.069	5.275LeuThr: 5.275 ± 0.077	7.375LeuVal: 7.375 ± 0.084	1.128LeuTrp: 1.128 ± 0.031	2.355LeuTyr: 2.355 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.815MetAla: 2.815 ± 0.045	0.191MetCys: 0.191 ± 0.012	1.215MetAsp: 1.215 ± 0.03	1.288MetGlu: 1.288 ± 0.032	0.776MetPhe: 0.776 ± 0.023	1.645MetGly: 1.645 ± 0.037	0.601MetHis: 0.601 ± 0.021	1.007MetIle: 1.007 ± 0.028	1.166MetLys: 1.166 ± 0.028	2.833MetLeu: 2.833 ± 0.049	0.659MetMet: 0.659 ± 0.022	0.967MetAsn: 0.967 ± 0.027	1.599MetPro: 1.599 ± 0.035	1.284MetGln: 1.284 ± 0.032	1.867MetArg: 1.867 ± 0.038	1.558MetSer: 1.558 ± 0.038	1.526MetThr: 1.526 ± 0.034	1.692MetVal: 1.692 ± 0.037	0.212MetTrp: 0.212 ± 0.013	0.435MetTyr: 0.435 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.688AsnAla: 3.688 ± 0.059	0.302AsnCys: 0.302 ± 0.016	1.64AsnAsp: 1.64 ± 0.036	1.445AsnGlu: 1.445 ± 0.03	1.077AsnPhe: 1.077 ± 0.03	2.682AsnGly: 2.682 ± 0.051	0.573AsnHis: 0.573 ± 0.023	1.466AsnIle: 1.466 ± 0.031	0.981AsnLys: 0.981 ± 0.028	2.866AsnLeu: 2.866 ± 0.049	0.645AsnMet: 0.645 ± 0.021	0.92AsnAsn: 0.92 ± 0.03	1.855AsnPro: 1.855 ± 0.042	0.954AsnGln: 0.954 ± 0.029	1.864AsnArg: 1.864 ± 0.036	1.279AsnSer: 1.279 ± 0.035	1.568AsnThr: 1.568 ± 0.036	2.375AsnVal: 2.375 ± 0.044	0.42AsnTrp: 0.42 ± 0.019	0.798AsnTyr: 0.798 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.357ProAla: 6.357 ± 0.091	0.359ProCys: 0.359 ± 0.019	3.201ProAsp: 3.201 ± 0.049	3.368ProGlu: 3.368 ± 0.057	1.823ProPhe: 1.823 ± 0.035	4.163ProGly: 4.163 ± 0.065	1.19ProHis: 1.19 ± 0.032	2.013ProIle: 2.013 ± 0.042	1.693ProLys: 1.693 ± 0.044	4.812ProLeu: 4.812 ± 0.067	1.17ProMet: 1.17 ± 0.029	1.495ProAsn: 1.495 ± 0.033	2.304ProPro: 2.304 ± 0.052	2.024ProGln: 2.024 ± 0.041	2.697ProArg: 2.697 ± 0.044	2.622ProSer: 2.622 ± 0.049	2.366ProThr: 2.366 ± 0.046	4.256ProVal: 4.256 ± 0.057	0.638ProTrp: 0.638 ± 0.021	1.239ProTyr: 1.239 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.934GlnAla: 4.934 ± 0.063	0.286GlnCys: 0.286 ± 0.015	1.719GlnAsp: 1.719 ± 0.044	1.888GlnGlu: 1.888 ± 0.04	1.393GlnPhe: 1.393 ± 0.03	2.646GlnGly: 2.646 ± 0.045	1.005GlnHis: 1.005 ± 0.028	1.759GlnIle: 1.759 ± 0.039	1.266GlnLys: 1.266 ± 0.033	4.112GlnLeu: 4.112 ± 0.059	0.986GlnMet: 0.986 ± 0.027	1.029GlnAsn: 1.029 ± 0.028	2.124GlnPro: 2.124 ± 0.042	1.958GlnGln: 1.958 ± 0.049	3.087GlnArg: 3.087 ± 0.052	1.945GlnSer: 1.945 ± 0.041	1.927GlnThr: 1.927 ± 0.044	2.882GlnVal: 2.882 ± 0.05	0.525GlnTrp: 0.525 ± 0.022	0.913GlnTyr: 0.913 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.177ArgAla: 7.177 ± 0.084	0.588ArgCys: 0.588 ± 0.023	3.661ArgAsp: 3.661 ± 0.049	4.101ArgGlu: 4.101 ± 0.065	2.93ArgPhe: 2.93 ± 0.046	4.215ArgGly: 4.215 ± 0.055	1.905ArgHis: 1.905 ± 0.044	3.895ArgIle: 3.895 ± 0.059	2.504ArgLys: 2.504 ± 0.043	7.495ArgLeu: 7.495 ± 0.09	1.966ArgMet: 1.966 ± 0.039	2.109ArgAsn: 2.109 ± 0.04	2.953ArgPro: 2.953 ± 0.052	2.773ArgGln: 2.773 ± 0.054	5.153ArgArg: 5.153 ± 0.077	3.502ArgSer: 3.502 ± 0.055	3.538ArgThr: 3.538 ± 0.051	4.664ArgVal: 4.664 ± 0.067	1.017ArgTrp: 1.017 ± 0.027	2.007ArgTyr: 2.007 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.096SerAla: 6.096 ± 0.091	0.476SerCys: 0.476 ± 0.021	2.796SerAsp: 2.796 ± 0.052	2.638SerGlu: 2.638 ± 0.051	2.178SerPhe: 2.178 ± 0.038	5.042SerGly: 5.042 ± 0.07	1.154SerHis: 1.154 ± 0.026	2.629SerIle: 2.629 ± 0.043	1.773SerLys: 1.773 ± 0.038	5.455SerLeu: 5.455 ± 0.07	1.38SerMet: 1.38 ± 0.032	1.624SerAsn: 1.624 ± 0.037	2.539SerPro: 2.539 ± 0.04	1.791SerGln: 1.791 ± 0.035	3.355SerArg: 3.355 ± 0.048	3.135SerSer: 3.135 ± 0.068	2.908SerThr: 2.908 ± 0.062	3.868SerVal: 3.868 ± 0.062	0.675SerTrp: 0.675 ± 0.023	1.384SerTyr: 1.384 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.167ThrAla: 6.167 ± 0.095	0.435ThrCys: 0.435 ± 0.017	2.633ThrAsp: 2.633 ± 0.049	2.488ThrGlu: 2.488 ± 0.046	1.873ThrPhe: 1.873 ± 0.038	4.862ThrGly: 4.862 ± 0.092	1.174ThrHis: 1.174 ± 0.029	2.528ThrIle: 2.528 ± 0.045	1.496ThrLys: 1.496 ± 0.035	6.232ThrLeu: 6.232 ± 0.066	1.269ThrMet: 1.269 ± 0.034	1.376ThrAsn: 1.376 ± 0.041	3.362ThrPro: 3.362 ± 0.055	1.91ThrGln: 1.91 ± 0.041	3.2ThrArg: 3.2 ± 0.047	2.8ThrSer: 2.8 ± 0.062	3.075ThrThr: 3.075 ± 0.09	4.465ThrVal: 4.465 ± 0.068	0.688ThrTrp: 0.688 ± 0.029	1.31ThrTyr: 1.31 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	9.095ValAla: 9.095 ± 0.094	0.734ValCys: 0.734 ± 0.025	4.055ValAsp: 4.055 ± 0.055	4.263ValGlu: 4.263 ± 0.055	2.913ValPhe: 2.913 ± 0.045	5.265ValGly: 5.265 ± 0.066	1.651ValHis: 1.651 ± 0.038	3.707ValIle: 3.707 ± 0.051	2.769ValLys: 2.769 ± 0.057	7.983ValLeu: 7.983 ± 0.086	1.901ValMet: 1.901 ± 0.034	2.406ValAsn: 2.406 ± 0.044	3.89ValPro: 3.89 ± 0.061	2.761ValGln: 2.761 ± 0.046	5.173ValArg: 5.173 ± 0.063	4.183ValSer: 4.183 ± 0.053	4.294ValThr: 4.294 ± 0.07	6.283ValVal: 6.283 ± 0.077	0.882ValTrp: 0.882 ± 0.028	1.719ValTyr: 1.719 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.064TrpAla: 1.064 ± 0.026	0.157TrpCys: 0.157 ± 0.011	0.604TrpAsp: 0.604 ± 0.023	0.617TrpGlu: 0.617 ± 0.023	0.553TrpPhe: 0.553 ± 0.021	0.828TrpGly: 0.828 ± 0.027	0.387TrpHis: 0.387 ± 0.018	0.693TrpIle: 0.693 ± 0.026	0.511TrpLys: 0.511 ± 0.019	1.797TrpLeu: 1.797 ± 0.047	0.395TrpMet: 0.395 ± 0.017	0.452TrpAsn: 0.452 ± 0.018	0.565TrpPro: 0.565 ± 0.021	0.692TrpGln: 0.692 ± 0.024	1.124TrpArg: 1.124 ± 0.03	0.73TrpSer: 0.73 ± 0.026	0.729TrpThr: 0.729 ± 0.028	0.877TrpVal: 0.877 ± 0.027	0.243TrpTrp: 0.243 ± 0.015	0.329TrpTyr: 0.329 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.928TyrAla: 2.928 ± 0.048	0.269TyrCys: 0.269 ± 0.015	1.37TyrAsp: 1.37 ± 0.035	1.278TyrGlu: 1.278 ± 0.034	1.062TyrPhe: 1.062 ± 0.029	2.154TyrGly: 2.154 ± 0.04	0.524TyrHis: 0.524 ± 0.016	1.002TyrIle: 1.002 ± 0.025	0.791TyrLys: 0.791 ± 0.027	2.665TyrLeu: 2.665 ± 0.044	0.472TyrMet: 0.472 ± 0.02	0.697TyrAsn: 0.697 ± 0.028	1.259TyrPro: 1.259 ± 0.031	0.963TyrGln: 0.963 ± 0.028	1.922TyrArg: 1.922 ± 0.039	1.322TyrSer: 1.322 ± 0.034	1.329TyrThr: 1.329 ± 0.038	1.813TyrVal: 1.813 ± 0.036	0.383TyrTrp: 0.383 ± 0.018	0.73TyrTyr: 0.73 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4547 proteins (1366726 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---