Amino acid dipepetide frequency for Streptomyces spectabilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.546AlaAla: 23.546 ± 0.15	1.161AlaCys: 1.161 ± 0.024	9.082AlaAsp: 9.082 ± 0.072	8.994AlaGlu: 8.994 ± 0.091	3.638AlaPhe: 3.638 ± 0.038	12.941AlaGly: 12.941 ± 0.09	3.259AlaHis: 3.259 ± 0.035	3.15AlaIle: 3.15 ± 0.036	2.857AlaLys: 2.857 ± 0.052	15.596AlaLeu: 15.596 ± 0.12	2.404AlaMet: 2.404 ± 0.033	1.734AlaAsn: 1.734 ± 0.029	8.0AlaPro: 8.0 ± 0.082	3.685AlaGln: 3.685 ± 0.044	11.396AlaArg: 11.396 ± 0.088	5.774AlaSer: 5.774 ± 0.047	7.023AlaThr: 7.023 ± 0.055	12.762AlaVal: 12.762 ± 0.091	1.974AlaTrp: 1.974 ± 0.026	2.99AlaTyr: 2.99 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.241CysAla: 1.241 ± 0.026	0.085CysCys: 0.085 ± 0.006	0.472CysAsp: 0.472 ± 0.014	0.389CysGlu: 0.389 ± 0.012	0.233CysPhe: 0.233 ± 0.009	1.0CysGly: 1.0 ± 0.023	0.191CysHis: 0.191 ± 0.009	0.121CysIle: 0.121 ± 0.007	0.117CysLys: 0.117 ± 0.007	0.719CysLeu: 0.719 ± 0.017	0.12CysMet: 0.12 ± 0.007	0.117CysAsn: 0.117 ± 0.007	0.485CysPro: 0.485 ± 0.014	0.154CysGln: 0.154 ± 0.007	0.622CysArg: 0.622 ± 0.017	0.41CysSer: 0.41 ± 0.012	0.469CysThr: 0.469 ± 0.014	0.713CysVal: 0.713 ± 0.017	0.117CysTrp: 0.117 ± 0.007	0.149CysTyr: 0.149 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	8.383AspAla: 8.383 ± 0.067	0.412AspCys: 0.412 ± 0.013	3.82AspAsp: 3.82 ± 0.05	3.917AspGlu: 3.917 ± 0.046	1.679AspPhe: 1.679 ± 0.027	6.691AspGly: 6.691 ± 0.067	1.429AspHis: 1.429 ± 0.024	1.687AspIle: 1.687 ± 0.026	1.276AspLys: 1.276 ± 0.031	6.424AspLeu: 6.424 ± 0.054	0.764AspMet: 0.764 ± 0.015	0.857AspAsn: 0.857 ± 0.018	4.403AspPro: 4.403 ± 0.043	1.474AspGln: 1.474 ± 0.024	5.081AspArg: 5.081 ± 0.057	2.39AspSer: 2.39 ± 0.032	3.251AspThr: 3.251 ± 0.041	5.083AspVal: 5.083 ± 0.05	1.005AspTrp: 1.005 ± 0.023	1.056AspTyr: 1.056 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.409GluAla: 7.409 ± 0.069	0.363GluCys: 0.363 ± 0.013	2.765GluAsp: 2.765 ± 0.034	3.288GluGlu: 3.288 ± 0.049	1.417GluPhe: 1.417 ± 0.024	4.445GluGly: 4.445 ± 0.051	1.537GluHis: 1.537 ± 0.025	1.941GluIle: 1.941 ± 0.034	1.352GluLys: 1.352 ± 0.031	6.896GluLeu: 6.896 ± 0.066	0.793GluMet: 0.793 ± 0.017	0.87GluAsn: 0.87 ± 0.023	3.526GluPro: 3.526 ± 0.037	2.105GluGln: 2.105 ± 0.033	6.036GluArg: 6.036 ± 0.058	2.492GluSer: 2.492 ± 0.035	2.657GluThr: 2.657 ± 0.031	4.389GluVal: 4.389 ± 0.049	0.712GluTrp: 0.712 ± 0.018	1.073GluTyr: 1.073 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.77PheAla: 3.77 ± 0.042	0.262PheCys: 0.262 ± 0.011	2.019PheAsp: 2.019 ± 0.03	1.387PheGlu: 1.387 ± 0.028	0.848PhePhe: 0.848 ± 0.022	3.007PheGly: 3.007 ± 0.039	0.642PheHis: 0.642 ± 0.015	0.661PheIle: 0.661 ± 0.017	0.535PheLys: 0.535 ± 0.017	2.529PheLeu: 2.529 ± 0.039	0.37PheMet: 0.37 ± 0.013	0.519PheAsn: 0.519 ± 0.015	1.385PhePro: 1.385 ± 0.02	0.666PheGln: 0.666 ± 0.016	1.834PheArg: 1.834 ± 0.026	1.353PheSer: 1.353 ± 0.025	1.995PheThr: 1.995 ± 0.031	2.263PheVal: 2.263 ± 0.032	0.417PheTrp: 0.417 ± 0.013	0.533PheTyr: 0.533 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	12.073GlyAla: 12.073 ± 0.083	0.839GlyCys: 0.839 ± 0.019	5.436GlyAsp: 5.436 ± 0.05	5.205GlyGlu: 5.205 ± 0.043	2.841GlyPhe: 2.841 ± 0.038	9.19GlyGly: 9.19 ± 0.081	2.443GlyHis: 2.443 ± 0.032	3.121GlyIle: 3.121 ± 0.042	2.464GlyLys: 2.464 ± 0.049	9.587GlyLeu: 9.587 ± 0.069	1.878GlyMet: 1.878 ± 0.029	1.548GlyAsn: 1.548 ± 0.033	5.458GlyPro: 5.458 ± 0.059	2.608GlyGln: 2.608 ± 0.038	8.017GlyArg: 8.017 ± 0.06	5.133GlySer: 5.133 ± 0.054	6.252GlyThr: 6.252 ± 0.058	7.867GlyVal: 7.867 ± 0.07	1.608GlyTrp: 1.608 ± 0.025	2.191GlyTyr: 2.191 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.939HisAla: 2.939 ± 0.038	0.232HisCys: 0.232 ± 0.009	1.384HisAsp: 1.384 ± 0.024	1.254HisGlu: 1.254 ± 0.023	0.616HisPhe: 0.616 ± 0.015	2.54HisGly: 2.54 ± 0.033	0.718HisHis: 0.718 ± 0.019	0.641HisIle: 0.641 ± 0.015	0.373HisLys: 0.373 ± 0.013	2.501HisLeu: 2.501 ± 0.033	0.324HisMet: 0.324 ± 0.011	0.321HisAsn: 0.321 ± 0.011	1.844HisPro: 1.844 ± 0.031	0.671HisGln: 0.671 ± 0.016	2.156HisArg: 2.156 ± 0.034	0.978HisSer: 0.978 ± 0.021	1.405HisThr: 1.405 ± 0.026	1.846HisVal: 1.846 ± 0.028	0.366HisTrp: 0.366 ± 0.012	0.467HisTyr: 0.467 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.415IleAla: 4.415 ± 0.048	0.255IleCys: 0.255 ± 0.011	1.985IleAsp: 1.985 ± 0.028	1.805IleGlu: 1.805 ± 0.026	0.572IlePhe: 0.572 ± 0.017	3.328IleGly: 3.328 ± 0.039	0.546IleHis: 0.546 ± 0.016	0.717IleIle: 0.717 ± 0.02	0.72IleLys: 0.72 ± 0.017	2.061IleLeu: 2.061 ± 0.034	0.384IleMet: 0.384 ± 0.014	0.592IleAsn: 0.592 ± 0.015	1.514IlePro: 1.514 ± 0.026	0.624IleGln: 0.624 ± 0.016	1.974IleArg: 1.974 ± 0.029	1.5IleSer: 1.5 ± 0.023	1.912IleThr: 1.912 ± 0.029	2.405IleVal: 2.405 ± 0.035	0.321IleTrp: 0.321 ± 0.011	0.442IleTyr: 0.442 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	3.0LysAla: 3.0 ± 0.054	0.115LysCys: 0.115 ± 0.007	1.404LysAsp: 1.404 ± 0.03	1.259LysGlu: 1.259 ± 0.025	0.46LysPhe: 0.46 ± 0.014	1.932LysGly: 1.932 ± 0.038	0.453LysHis: 0.453 ± 0.016	0.756LysIle: 0.756 ± 0.021	0.975LysLys: 0.975 ± 0.035	1.955LysLeu: 1.955 ± 0.033	0.367LysMet: 0.367 ± 0.012	0.495LysAsn: 0.495 ± 0.017	1.406LysPro: 1.406 ± 0.034	0.672LysGln: 0.672 ± 0.018	1.454LysArg: 1.454 ± 0.027	1.153LysSer: 1.153 ± 0.025	1.194LysThr: 1.194 ± 0.024	1.875LysVal: 1.875 ± 0.037	0.276LysTrp: 0.276 ± 0.011	0.431LysTyr: 0.431 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.841LeuAla: 15.841 ± 0.115	0.871LeuCys: 0.871 ± 0.02	6.854LeuAsp: 6.854 ± 0.064	4.457LeuGlu: 4.457 ± 0.047	2.67LeuPhe: 2.67 ± 0.037	9.379LeuGly: 9.379 ± 0.074	2.363LeuHis: 2.363 ± 0.037	3.031LeuIle: 3.031 ± 0.041	2.082LeuLys: 2.082 ± 0.033	11.453LeuLeu: 11.453 ± 0.089	1.57LeuMet: 1.57 ± 0.025	1.603LeuAsn: 1.603 ± 0.028	6.625LeuPro: 6.625 ± 0.065	1.978LeuGln: 1.978 ± 0.027	9.254LeuArg: 9.254 ± 0.063	5.155LeuSer: 5.155 ± 0.05	7.095LeuThr: 7.095 ± 0.057	8.999LeuVal: 8.999 ± 0.07	1.331LeuTrp: 1.331 ± 0.025	1.861LeuTyr: 1.861 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.182MetAla: 2.182 ± 0.033	0.131MetCys: 0.131 ± 0.007	0.874MetAsp: 0.874 ± 0.019	0.698MetGlu: 0.698 ± 0.02	0.421MetPhe: 0.421 ± 0.015	1.224MetGly: 1.224 ± 0.026	0.319MetHis: 0.319 ± 0.011	0.562MetIle: 0.562 ± 0.014	0.394MetLys: 0.394 ± 0.015	1.527MetLeu: 1.527 ± 0.026	0.247MetMet: 0.247 ± 0.011	0.393MetAsn: 0.393 ± 0.013	1.035MetPro: 1.035 ± 0.023	0.385MetGln: 0.385 ± 0.012	1.406MetArg: 1.406 ± 0.023	1.203MetSer: 1.203 ± 0.021	1.412MetThr: 1.412 ± 0.024	1.231MetVal: 1.231 ± 0.021	0.193MetTrp: 0.193 ± 0.009	0.322MetTyr: 0.322 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.024AsnAla: 2.024 ± 0.029	0.149AsnCys: 0.149 ± 0.008	0.895AsnAsp: 0.895 ± 0.018	0.715AsnGlu: 0.715 ± 0.019	0.422AsnPhe: 0.422 ± 0.014	1.719AsnGly: 1.719 ± 0.026	0.352AsnHis: 0.352 ± 0.012	0.553AsnIle: 0.553 ± 0.015	0.397AsnLys: 0.397 ± 0.014	1.482AsnLeu: 1.482 ± 0.026	0.26AsnMet: 0.26 ± 0.01	0.373AsnAsn: 0.373 ± 0.013	1.214AsnPro: 1.214 ± 0.023	0.449AsnGln: 0.449 ± 0.012	1.126AsnArg: 1.126 ± 0.021	0.837AsnSer: 0.837 ± 0.021	0.993AsnThr: 0.993 ± 0.02	1.288AsnVal: 1.288 ± 0.024	0.262AsnTrp: 0.262 ± 0.01	0.379AsnTyr: 0.379 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	8.775ProAla: 8.775 ± 0.079	0.349ProCys: 0.349 ± 0.011	4.654ProAsp: 4.654 ± 0.051	4.324ProGlu: 4.324 ± 0.048	1.52ProPhe: 1.52 ± 0.026	7.014ProGly: 7.014 ± 0.08	1.515ProHis: 1.515 ± 0.026	1.162ProIle: 1.162 ± 0.022	1.252ProLys: 1.252 ± 0.028	5.717ProLeu: 5.717 ± 0.051	0.93ProMet: 0.93 ± 0.019	0.803ProAsn: 0.803 ± 0.018	3.681ProPro: 3.681 ± 0.068	1.789ProGln: 1.789 ± 0.033	4.39ProArg: 4.39 ± 0.05	3.153ProSer: 3.153 ± 0.052	3.071ProThr: 3.071 ± 0.041	5.519ProVal: 5.519 ± 0.051	0.907ProTrp: 0.907 ± 0.021	1.321ProTyr: 1.321 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.573GlnAla: 3.573 ± 0.05	0.155GlnCys: 0.155 ± 0.008	1.448GlnAsp: 1.448 ± 0.028	1.466GlnGlu: 1.466 ± 0.025	0.635GlnPhe: 0.635 ± 0.015	2.301GlnGly: 2.301 ± 0.036	0.641GlnHis: 0.641 ± 0.017	0.92GlnIle: 0.92 ± 0.023	0.565GlnLys: 0.565 ± 0.017	2.984GlnLeu: 2.984 ± 0.036	0.428GlnMet: 0.428 ± 0.013	0.448GlnAsn: 0.448 ± 0.015	1.536GlnPro: 1.536 ± 0.034	1.136GlnGln: 1.136 ± 0.033	2.421GlnArg: 2.421 ± 0.031	1.123GlnSer: 1.123 ± 0.021	1.194GlnThr: 1.194 ± 0.022	2.239GlnVal: 2.239 ± 0.035	0.45GlnTrp: 0.45 ± 0.012	0.537GlnTyr: 0.537 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	11.268ArgAla: 11.268 ± 0.091	0.638ArgCys: 0.638 ± 0.017	4.526ArgAsp: 4.526 ± 0.043	4.888ArgGlu: 4.888 ± 0.052	2.364ArgPhe: 2.364 ± 0.029	6.418ArgGly: 6.418 ± 0.054	2.27ArgHis: 2.27 ± 0.032	2.829ArgIle: 2.829 ± 0.035	1.626ArgLys: 1.626 ± 0.03	9.19ArgLeu: 9.19 ± 0.08	1.666ArgMet: 1.666 ± 0.024	1.238ArgAsn: 1.238 ± 0.023	5.27ArgPro: 5.27 ± 0.053	2.304ArgGln: 2.304 ± 0.028	7.886ArgArg: 7.886 ± 0.075	3.954ArgSer: 3.954 ± 0.04	5.538ArgThr: 5.538 ± 0.053	6.401ArgVal: 6.401 ± 0.052	1.395ArgTrp: 1.395 ± 0.021	1.753ArgTyr: 1.753 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.612SerAla: 6.612 ± 0.057	0.384SerCys: 0.384 ± 0.014	2.545SerAsp: 2.545 ± 0.037	2.203SerGlu: 2.203 ± 0.033	1.509SerPhe: 1.509 ± 0.025	5.94SerGly: 5.94 ± 0.053	1.014SerHis: 1.014 ± 0.019	1.213SerIle: 1.213 ± 0.023	1.002SerLys: 1.002 ± 0.022	4.781SerLeu: 4.781 ± 0.047	0.972SerMet: 0.972 ± 0.021	0.787SerAsn: 0.787 ± 0.019	3.044SerPro: 3.044 ± 0.044	1.15SerGln: 1.15 ± 0.021	3.54SerArg: 3.54 ± 0.036	2.585SerSer: 2.585 ± 0.04	2.827SerThr: 2.827 ± 0.037	4.174SerVal: 4.174 ± 0.038	0.879SerTrp: 0.879 ± 0.018	1.153SerTyr: 1.153 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.98ThrAla: 8.98 ± 0.067	0.405ThrCys: 0.405 ± 0.013	3.468ThrAsp: 3.468 ± 0.034	3.114ThrGlu: 3.114 ± 0.034	1.549ThrPhe: 1.549 ± 0.026	6.696ThrGly: 6.696 ± 0.053	1.221ThrHis: 1.221 ± 0.019	1.466ThrIle: 1.466 ± 0.027	1.188ThrLys: 1.188 ± 0.024	5.666ThrLeu: 5.666 ± 0.055	0.855ThrMet: 0.855 ± 0.018	0.89ThrAsn: 0.89 ± 0.02	4.109ThrPro: 4.109 ± 0.044	1.264ThrGln: 1.264 ± 0.023	3.985ThrArg: 3.985 ± 0.036	3.018ThrSer: 3.018 ± 0.038	3.613ThrThr: 3.613 ± 0.042	5.854ThrVal: 5.854 ± 0.049	0.87ThrTrp: 0.87 ± 0.021	1.374ThrTyr: 1.374 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	11.341ValAla: 11.341 ± 0.08	0.795ValCys: 0.795 ± 0.018	5.182ValAsp: 5.182 ± 0.052	4.688ValGlu: 4.688 ± 0.046	2.483ValPhe: 2.483 ± 0.033	6.67ValGly: 6.67 ± 0.056	1.925ValHis: 1.925 ± 0.029	2.679ValIle: 2.679 ± 0.041	1.713ValLys: 1.713 ± 0.031	9.627ValLeu: 9.627 ± 0.069	1.328ValMet: 1.328 ± 0.022	1.558ValAsn: 1.558 ± 0.023	5.475ValPro: 5.475 ± 0.06	1.931ValGln: 1.931 ± 0.029	7.642ValArg: 7.642 ± 0.064	4.331ValSer: 4.331 ± 0.042	5.642ValThr: 5.642 ± 0.05	8.179ValVal: 8.179 ± 0.073	1.15ValTrp: 1.15 ± 0.021	1.477ValTyr: 1.477 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.697TrpAla: 1.697 ± 0.023	0.158TrpCys: 0.158 ± 0.008	0.819TrpAsp: 0.819 ± 0.018	0.713TrpGlu: 0.713 ± 0.017	0.483TrpPhe: 0.483 ± 0.014	1.089TrpGly: 1.089 ± 0.024	0.364TrpHis: 0.364 ± 0.012	0.483TrpIle: 0.483 ± 0.014	0.356TrpLys: 0.356 ± 0.012	1.79TrpLeu: 1.79 ± 0.029	0.258TrpMet: 0.258 ± 0.01	0.386TrpAsn: 0.386 ± 0.012	0.811TrpPro: 0.811 ± 0.018	0.616TrpGln: 0.616 ± 0.017	1.411TrpArg: 1.411 ± 0.022	0.922TrpSer: 0.922 ± 0.021	0.958TrpThr: 0.958 ± 0.022	0.956TrpVal: 0.956 ± 0.02	0.335TrpTrp: 0.335 ± 0.012	0.335TrpTyr: 0.335 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.896TyrAla: 2.896 ± 0.034	0.168TyrCys: 0.168 ± 0.009	1.45TyrAsp: 1.45 ± 0.025	1.302TyrGlu: 1.302 ± 0.022	0.637TyrPhe: 0.637 ± 0.014	2.232TyrGly: 2.232 ± 0.031	0.374TyrHis: 0.374 ± 0.012	0.38TyrIle: 0.38 ± 0.012	0.387TyrLys: 0.387 ± 0.015	1.987TyrLeu: 1.987 ± 0.029	0.241TyrMet: 0.241 ± 0.009	0.357TyrAsn: 0.357 ± 0.012	1.024TyrPro: 1.024 ± 0.019	0.539TyrGln: 0.539 ± 0.012	1.791TyrArg: 1.791 ± 0.027	0.849TyrSer: 0.849 ± 0.018	1.084TyrThr: 1.084 ± 0.021	1.776TyrVal: 1.776 ± 0.032	0.373TyrTrp: 0.373 ± 0.012	0.436TyrTyr: 0.436 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7680 proteins (2715784 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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