Amino acid dipepetide frequency for Flavobacterium succinicans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.782AlaAla: 4.782 ± 0.088	0.54AlaCys: 0.54 ± 0.026	3.271AlaAsp: 3.271 ± 0.062	3.897AlaGlu: 3.897 ± 0.081	3.611AlaPhe: 3.611 ± 0.069	4.301AlaGly: 4.301 ± 0.1	1.095AlaHis: 1.095 ± 0.039	5.842AlaIle: 5.842 ± 0.078	5.296AlaLys: 5.296 ± 0.083	6.752AlaLeu: 6.752 ± 0.09	1.612AlaMet: 1.612 ± 0.049	3.945AlaAsn: 3.945 ± 0.077	2.15AlaPro: 2.15 ± 0.054	2.795AlaGln: 2.795 ± 0.056	1.885AlaArg: 1.885 ± 0.049	4.45AlaSer: 4.45 ± 0.072	4.625AlaThr: 4.625 ± 0.098	4.462AlaVal: 4.462 ± 0.072	0.607AlaTrp: 0.607 ± 0.03	2.43AlaTyr: 2.43 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.429CysAla: 0.429 ± 0.023	0.12CysCys: 0.12 ± 0.012	0.416CysAsp: 0.416 ± 0.021	0.45CysGlu: 0.45 ± 0.024	0.469CysPhe: 0.469 ± 0.021	0.606CysGly: 0.606 ± 0.031	0.173CysHis: 0.173 ± 0.015	0.617CysIle: 0.617 ± 0.029	0.459CysLys: 0.459 ± 0.023	0.651CysLeu: 0.651 ± 0.027	0.144CysMet: 0.144 ± 0.015	0.447CysAsn: 0.447 ± 0.026	0.315CysPro: 0.315 ± 0.019	0.262CysGln: 0.262 ± 0.017	0.194CysArg: 0.194 ± 0.015	0.591CysSer: 0.591 ± 0.029	0.458CysThr: 0.458 ± 0.034	0.407CysVal: 0.407 ± 0.019	0.072CysTrp: 0.072 ± 0.008	0.3CysTyr: 0.3 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.791AspAla: 3.791 ± 0.073	0.425AspCys: 0.425 ± 0.024	2.282AspAsp: 2.282 ± 0.056	3.05AspGlu: 3.05 ± 0.064	3.672AspPhe: 3.672 ± 0.062	3.375AspGly: 3.375 ± 0.081	0.764AspHis: 0.764 ± 0.032	3.745AspIle: 3.745 ± 0.068	4.131AspLys: 4.131 ± 0.073	5.074AspLeu: 5.074 ± 0.088	0.95AspMet: 0.95 ± 0.036	2.826AspAsn: 2.826 ± 0.052	1.567AspPro: 1.567 ± 0.046	1.515AspGln: 1.515 ± 0.046	1.671AspArg: 1.671 ± 0.048	2.723AspSer: 2.723 ± 0.061	2.582AspThr: 2.582 ± 0.059	3.321AspVal: 3.321 ± 0.058	0.757AspTrp: 0.757 ± 0.032	2.604AspTyr: 2.604 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	4.507GluAla: 4.507 ± 0.088	0.333GluCys: 0.333 ± 0.02	2.886GluAsp: 2.886 ± 0.054	4.295GluGlu: 4.295 ± 0.083	2.765GluPhe: 2.765 ± 0.056	3.426GluGly: 3.426 ± 0.069	1.029GluHis: 1.029 ± 0.036	5.356GluIle: 5.356 ± 0.094	6.122GluLys: 6.122 ± 0.088	5.673GluLeu: 5.673 ± 0.093	1.581GluMet: 1.581 ± 0.041	4.376GluAsn: 4.376 ± 0.074	1.52GluPro: 1.52 ± 0.038	2.345GluGln: 2.345 ± 0.048	2.251GluArg: 2.251 ± 0.054	3.221GluSer: 3.221 ± 0.058	3.537GluThr: 3.537 ± 0.062	4.189GluVal: 4.189 ± 0.071	0.625GluTrp: 0.625 ± 0.028	2.215GluTyr: 2.215 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.263PheAla: 3.263 ± 0.067	0.492PheCys: 0.492 ± 0.025	3.269PheAsp: 3.269 ± 0.064	3.729PheGlu: 3.729 ± 0.067	3.032PhePhe: 3.032 ± 0.075	3.863PheGly: 3.863 ± 0.072	0.9PheHis: 0.9 ± 0.03	3.822PheIle: 3.822 ± 0.072	3.74PheLys: 3.74 ± 0.074	5.057PheLeu: 5.057 ± 0.09	1.18PheMet: 1.18 ± 0.042	3.1PheAsn: 3.1 ± 0.073	1.868PhePro: 1.868 ± 0.047	1.788PheGln: 1.788 ± 0.041	1.57PheArg: 1.57 ± 0.039	4.103PheSer: 4.103 ± 0.079	3.272PheThr: 3.272 ± 0.067	3.432PheVal: 3.432 ± 0.062	0.633PheTrp: 0.633 ± 0.027	2.245PheTyr: 2.245 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	4.294GlyAla: 4.294 ± 0.088	0.553GlyCys: 0.553 ± 0.028	2.967GlyAsp: 2.967 ± 0.062	3.163GlyGlu: 3.163 ± 0.065	3.704GlyPhe: 3.704 ± 0.068	4.555GlyGly: 4.555 ± 0.114	1.094GlyHis: 1.094 ± 0.032	5.507GlyIle: 5.507 ± 0.09	5.098GlyLys: 5.098 ± 0.089	5.677GlyLeu: 5.677 ± 0.077	1.547GlyMet: 1.547 ± 0.043	3.777GlyAsn: 3.777 ± 0.086	1.274GlyPro: 1.274 ± 0.036	1.973GlyGln: 1.973 ± 0.038	1.867GlyArg: 1.867 ± 0.055	4.106GlySer: 4.106 ± 0.094	4.367GlyThr: 4.367 ± 0.105	4.363GlyVal: 4.363 ± 0.08	0.713GlyTrp: 0.713 ± 0.03	2.746GlyTyr: 2.746 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.897HisAla: 0.897 ± 0.037	0.198HisCys: 0.198 ± 0.018	0.79HisAsp: 0.79 ± 0.026	0.928HisGlu: 0.928 ± 0.032	1.271HisPhe: 1.271 ± 0.044	0.962HisGly: 0.962 ± 0.035	0.487HisHis: 0.487 ± 0.026	1.26HisIle: 1.26 ± 0.045	1.14HisLys: 1.14 ± 0.038	1.813HisLeu: 1.813 ± 0.051	0.244HisMet: 0.244 ± 0.018	0.923HisAsn: 0.923 ± 0.03	0.891HisPro: 0.891 ± 0.033	0.837HisGln: 0.837 ± 0.033	0.588HisArg: 0.588 ± 0.025	1.049HisSer: 1.049 ± 0.034	0.837HisThr: 0.837 ± 0.028	0.816HisVal: 0.816 ± 0.032	0.194HisTrp: 0.194 ± 0.013	0.864HisTyr: 0.864 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.267IleAla: 6.267 ± 0.104	0.63IleCys: 0.63 ± 0.027	4.618IleAsp: 4.618 ± 0.073	5.451IleGlu: 5.451 ± 0.086	3.335IlePhe: 3.335 ± 0.066	5.25IleGly: 5.25 ± 0.078	1.371IleHis: 1.371 ± 0.042	5.802IleIle: 5.802 ± 0.1	5.762IleLys: 5.762 ± 0.072	6.839IleLeu: 6.839 ± 0.09	1.346IleMet: 1.346 ± 0.043	4.576IleAsn: 4.576 ± 0.083	3.444IlePro: 3.444 ± 0.06	3.084IleGln: 3.084 ± 0.06	2.398IleArg: 2.398 ± 0.05	4.983IleSer: 4.983 ± 0.07	4.936IleThr: 4.936 ± 0.081	5.062IleVal: 5.062 ± 0.079	0.67IleTrp: 0.67 ± 0.025	2.614IleTyr: 2.614 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.545LysAla: 5.545 ± 0.093	0.386LysCys: 0.386 ± 0.021	4.229LysAsp: 4.229 ± 0.074	6.09LysGlu: 6.09 ± 0.087	2.985LysPhe: 2.985 ± 0.056	4.728LysGly: 4.728 ± 0.063	1.157LysHis: 1.157 ± 0.036	6.772LysIle: 6.772 ± 0.085	7.362LysLys: 7.362 ± 0.106	6.364LysLeu: 6.364 ± 0.093	2.273LysMet: 2.273 ± 0.048	5.662LysAsn: 5.662 ± 0.101	2.509LysPro: 2.509 ± 0.057	2.784LysGln: 2.784 ± 0.061	2.605LysArg: 2.605 ± 0.055	4.587LysSer: 4.587 ± 0.077	5.019LysThr: 5.019 ± 0.087	4.943LysVal: 4.943 ± 0.088	0.813LysTrp: 0.813 ± 0.034	2.98LysTyr: 2.98 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	6.224LeuAla: 6.224 ± 0.096	0.711LeuCys: 0.711 ± 0.028	4.887LeuAsp: 4.887 ± 0.082	5.684LeuGlu: 5.684 ± 0.099	5.362LeuPhe: 5.362 ± 0.089	5.798LeuGly: 5.798 ± 0.09	1.661LeuHis: 1.661 ± 0.047	6.595LeuIle: 6.595 ± 0.093	7.411LeuLys: 7.411 ± 0.093	9.155LeuLeu: 9.155 ± 0.126	2.06LeuMet: 2.06 ± 0.051	5.582LeuAsn: 5.582 ± 0.08	3.592LeuPro: 3.592 ± 0.052	3.654LeuGln: 3.654 ± 0.068	2.926LeuArg: 2.926 ± 0.054	6.683LeuSer: 6.683 ± 0.096	5.293LeuThr: 5.293 ± 0.096	5.687LeuVal: 5.687 ± 0.071	0.78LeuTrp: 0.78 ± 0.032	3.319LeuTyr: 3.319 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	1.674MetAla: 1.674 ± 0.046	0.128MetCys: 0.128 ± 0.011	1.047MetAsp: 1.047 ± 0.035	1.271MetGlu: 1.271 ± 0.036	0.79MetPhe: 0.79 ± 0.032	1.398MetGly: 1.398 ± 0.044	0.431MetHis: 0.431 ± 0.023	1.632MetIle: 1.632 ± 0.042	2.172MetLys: 2.172 ± 0.049	1.835MetLeu: 1.835 ± 0.045	0.572MetMet: 0.572 ± 0.03	1.402MetAsn: 1.402 ± 0.039	0.814MetPro: 0.814 ± 0.031	0.846MetGln: 0.846 ± 0.027	0.822MetArg: 0.822 ± 0.032	1.361MetSer: 1.361 ± 0.043	1.237MetThr: 1.237 ± 0.037	1.392MetVal: 1.392 ± 0.037	0.161MetTrp: 0.161 ± 0.014	0.735MetTyr: 0.735 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	4.166AsnAla: 4.166 ± 0.061	0.517AsnCys: 0.517 ± 0.029	3.124AsnAsp: 3.124 ± 0.064	3.906AsnGlu: 3.906 ± 0.075	3.219AsnPhe: 3.219 ± 0.07	4.285AsnGly: 4.285 ± 0.103	1.096AsnHis: 1.096 ± 0.034	4.257AsnIle: 4.257 ± 0.075	4.531AsnLys: 4.531 ± 0.074	5.363AsnLeu: 5.363 ± 0.072	1.128AsnMet: 1.128 ± 0.035	3.818AsnAsn: 3.818 ± 0.08	2.968AsnPro: 2.968 ± 0.059	2.542AsnGln: 2.542 ± 0.062	2.05AsnArg: 2.05 ± 0.054	3.911AsnSer: 3.911 ± 0.084	3.72AsnThr: 3.72 ± 0.085	3.588AsnVal: 3.588 ± 0.076	0.828AsnTrp: 0.828 ± 0.032	2.943AsnTyr: 2.943 ± 0.075	0.0AsnXaa: 0.0 ± 0.0
Pro	2.109ProAla: 2.109 ± 0.047	0.227ProCys: 0.227 ± 0.015	1.785ProAsp: 1.785 ± 0.04	2.635ProGlu: 2.635 ± 0.06	2.117ProPhe: 2.117 ± 0.048	1.748ProGly: 1.748 ± 0.053	0.544ProHis: 0.544 ± 0.021	2.933ProIle: 2.933 ± 0.054	2.798ProLys: 2.798 ± 0.057	3.105ProLeu: 3.105 ± 0.061	0.758ProMet: 0.758 ± 0.028	2.47ProAsn: 2.47 ± 0.059	0.731ProPro: 0.731 ± 0.036	1.096ProGln: 1.096 ± 0.027	0.915ProArg: 0.915 ± 0.033	2.394ProSer: 2.394 ± 0.057	2.317ProThr: 2.317 ± 0.06	2.31ProVal: 2.31 ± 0.053	0.33ProTrp: 0.33 ± 0.018	1.367ProTyr: 1.367 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.292GlnAla: 2.292 ± 0.051	0.195GlnCys: 0.195 ± 0.015	1.525GlnAsp: 1.525 ± 0.041	2.464GlnGlu: 2.464 ± 0.054	1.901GlnPhe: 1.901 ± 0.048	1.864GlnGly: 1.864 ± 0.052	0.65GlnHis: 0.65 ± 0.026	2.746GlnIle: 2.746 ± 0.049	3.49GlnLys: 3.49 ± 0.066	3.904GlnLeu: 3.904 ± 0.07	0.882GlnMet: 0.882 ± 0.032	2.559GlnAsn: 2.559 ± 0.054	1.189GlnPro: 1.189 ± 0.043	1.608GlnGln: 1.608 ± 0.044	1.178GlnArg: 1.178 ± 0.037	2.162GlnSer: 2.162 ± 0.046	2.13GlnThr: 2.13 ± 0.046	2.068GlnVal: 2.068 ± 0.044	0.407GlnTrp: 0.407 ± 0.022	1.359GlnTyr: 1.359 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	1.947ArgAla: 1.947 ± 0.05	0.193ArgCys: 0.193 ± 0.016	1.487ArgAsp: 1.487 ± 0.042	1.956ArgGlu: 1.956 ± 0.045	1.853ArgPhe: 1.853 ± 0.049	1.692ArgGly: 1.692 ± 0.045	0.516ArgHis: 0.516 ± 0.025	2.715ArgIle: 2.715 ± 0.065	2.649ArgLys: 2.649 ± 0.055	3.023ArgLeu: 3.023 ± 0.047	0.881ArgMet: 0.881 ± 0.032	2.035ArgAsn: 2.035 ± 0.05	1.017ArgPro: 1.017 ± 0.037	0.971ArgGln: 0.971 ± 0.037	1.078ArgArg: 1.078 ± 0.039	1.764ArgSer: 1.764 ± 0.046	1.7ArgThr: 1.7 ± 0.043	2.036ArgVal: 2.036 ± 0.053	0.393ArgTrp: 0.393 ± 0.02	1.445ArgTyr: 1.445 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.858SerAla: 3.858 ± 0.069	0.66SerCys: 0.66 ± 0.037	3.223SerAsp: 3.223 ± 0.061	3.606SerGlu: 3.606 ± 0.056	4.035SerPhe: 4.035 ± 0.072	4.433SerGly: 4.433 ± 0.092	1.062SerHis: 1.062 ± 0.037	5.153SerIle: 5.153 ± 0.085	5.038SerLys: 5.038 ± 0.078	5.941SerLeu: 5.941 ± 0.089	1.223SerMet: 1.223 ± 0.038	4.048SerAsn: 4.048 ± 0.08	2.173SerPro: 2.173 ± 0.053	2.157SerGln: 2.157 ± 0.051	1.941SerArg: 1.941 ± 0.049	4.342SerSer: 4.342 ± 0.078	3.714SerThr: 3.714 ± 0.085	3.956SerVal: 3.956 ± 0.075	0.69SerTrp: 0.69 ± 0.029	2.729SerTyr: 2.729 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	4.392ThrAla: 4.392 ± 0.111	0.34ThrCys: 0.34 ± 0.021	3.045ThrAsp: 3.045 ± 0.067	3.212ThrGlu: 3.212 ± 0.059	3.326ThrPhe: 3.326 ± 0.063	3.955ThrGly: 3.955 ± 0.093	1.018ThrHis: 1.018 ± 0.035	5.594ThrIle: 5.594 ± 0.079	4.337ThrLys: 4.337 ± 0.067	5.706ThrLeu: 5.706 ± 0.078	1.001ThrMet: 1.001 ± 0.032	3.668ThrAsn: 3.668 ± 0.081	2.738ThrPro: 2.738 ± 0.061	2.196ThrGln: 2.196 ± 0.055	1.582ThrArg: 1.582 ± 0.043	3.882ThrSer: 3.882 ± 0.08	4.317ThrThr: 4.317 ± 0.111	3.913ThrVal: 3.913 ± 0.08	0.559ThrTrp: 0.559 ± 0.028	2.307ThrTyr: 2.307 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	4.776ValAla: 4.776 ± 0.075	0.503ValCys: 0.503 ± 0.024	3.255ValAsp: 3.255 ± 0.054	3.554ValGlu: 3.554 ± 0.07	3.724ValPhe: 3.724 ± 0.067	3.92ValGly: 3.92 ± 0.076	0.984ValHis: 0.984 ± 0.033	4.791ValIle: 4.791 ± 0.076	4.478ValLys: 4.478 ± 0.07	6.336ValLeu: 6.336 ± 0.081	1.328ValMet: 1.328 ± 0.039	3.503ValAsn: 3.503 ± 0.06	2.263ValPro: 2.263 ± 0.051	1.985ValGln: 1.985 ± 0.048	1.959ValArg: 1.959 ± 0.047	4.369ValSer: 4.369 ± 0.074	3.984ValThr: 3.984 ± 0.101	4.58ValVal: 4.58 ± 0.08	0.609ValTrp: 0.609 ± 0.026	2.427ValTyr: 2.427 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.624TrpAla: 0.624 ± 0.031	0.09TrpCys: 0.09 ± 0.01	0.544TrpAsp: 0.544 ± 0.028	0.669TrpGlu: 0.669 ± 0.027	0.58TrpPhe: 0.58 ± 0.027	0.657TrpGly: 0.657 ± 0.027	0.22TrpHis: 0.22 ± 0.016	0.736TrpIle: 0.736 ± 0.032	0.871TrpLys: 0.871 ± 0.035	0.996TrpLeu: 0.996 ± 0.035	0.284TrpMet: 0.284 ± 0.019	0.726TrpAsn: 0.726 ± 0.032	0.22TrpPro: 0.22 ± 0.016	0.454TrpGln: 0.454 ± 0.023	0.371TrpArg: 0.371 ± 0.022	0.661TrpSer: 0.661 ± 0.026	0.553TrpThr: 0.553 ± 0.028	0.596TrpVal: 0.596 ± 0.023	0.152TrpTrp: 0.152 ± 0.017	0.458TrpTyr: 0.458 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.514TyrAla: 2.514 ± 0.051	0.339TyrCys: 0.339 ± 0.019	2.175TyrAsp: 2.175 ± 0.049	2.243TyrGlu: 2.243 ± 0.053	2.605TyrPhe: 2.605 ± 0.06	2.531TyrGly: 2.531 ± 0.062	0.737TyrHis: 0.737 ± 0.03	2.562TyrIle: 2.562 ± 0.048	2.909TyrLys: 2.909 ± 0.059	3.799TyrLeu: 3.799 ± 0.077	0.726TyrMet: 0.726 ± 0.03	2.517TyrAsn: 2.517 ± 0.058	1.444TyrPro: 1.444 ± 0.038	1.681TyrGln: 1.681 ± 0.046	1.501TyrArg: 1.501 ± 0.044	2.638TyrSer: 2.638 ± 0.06	2.49TyrThr: 2.49 ± 0.065	2.207TyrVal: 2.207 ± 0.046	0.471TyrTrp: 0.471 ± 0.024	1.772TyrTyr: 1.772 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2812 proteins (957848 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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