Amino acid dipepetide frequency for Croceicoccus marinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.725AlaAla: 17.725 ± 0.199	1.093AlaCys: 1.093 ± 0.034	7.749AlaAsp: 7.749 ± 0.085	8.185AlaGlu: 8.185 ± 0.089	4.141AlaPhe: 4.141 ± 0.059	11.164AlaGly: 11.164 ± 0.108	2.275AlaHis: 2.275 ± 0.043	6.844AlaIle: 6.844 ± 0.09	3.626AlaLys: 3.626 ± 0.071	13.555AlaLeu: 13.555 ± 0.138	4.166AlaMet: 4.166 ± 0.071	3.09AlaAsn: 3.09 ± 0.055	5.879AlaPro: 5.879 ± 0.076	4.456AlaGln: 4.456 ± 0.063	9.663AlaArg: 9.663 ± 0.115	6.533AlaSer: 6.533 ± 0.09	5.253AlaThr: 5.253 ± 0.072	8.272AlaVal: 8.272 ± 0.093	1.542AlaTrp: 1.542 ± 0.039	2.41AlaTyr: 2.41 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.006CysAla: 1.006 ± 0.028	0.114CysCys: 0.114 ± 0.01	0.625CysAsp: 0.625 ± 0.025	0.535CysGlu: 0.535 ± 0.021	0.303CysPhe: 0.303 ± 0.018	0.92CysGly: 0.92 ± 0.031	0.243CysHis: 0.243 ± 0.014	0.373CysIle: 0.373 ± 0.02	0.189CysLys: 0.189 ± 0.014	0.722CysLeu: 0.722 ± 0.02	0.161CysMet: 0.161 ± 0.011	0.223CysAsn: 0.223 ± 0.013	0.423CysPro: 0.423 ± 0.019	0.209CysGln: 0.209 ± 0.013	0.623CysArg: 0.623 ± 0.023	0.505CysSer: 0.505 ± 0.02	0.389CysThr: 0.389 ± 0.019	0.563CysVal: 0.563 ± 0.023	0.123CysTrp: 0.123 ± 0.01	0.159CysTyr: 0.159 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.781AspAla: 7.781 ± 0.086	0.57AspCys: 0.57 ± 0.023	3.871AspAsp: 3.871 ± 0.068	4.134AspGlu: 4.134 ± 0.059	2.379AspPhe: 2.379 ± 0.048	5.951AspGly: 5.951 ± 0.077	1.401AspHis: 1.401 ± 0.042	3.153AspIle: 3.153 ± 0.05	1.683AspLys: 1.683 ± 0.04	5.947AspLeu: 5.947 ± 0.078	1.717AspMet: 1.717 ± 0.036	1.549AspAsn: 1.549 ± 0.043	4.136AspPro: 4.136 ± 0.061	1.833AspGln: 1.833 ± 0.039	5.207AspArg: 5.207 ± 0.087	2.567AspSer: 2.567 ± 0.046	2.842AspThr: 2.842 ± 0.052	4.122AspVal: 4.122 ± 0.07	1.191AspTrp: 1.191 ± 0.032	1.707AspTyr: 1.707 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.94GluAla: 7.94 ± 0.109	0.391GluCys: 0.391 ± 0.019	3.545GluAsp: 3.545 ± 0.055	3.678GluGlu: 3.678 ± 0.061	1.866GluPhe: 1.866 ± 0.043	5.033GluGly: 5.033 ± 0.071	1.304GluHis: 1.304 ± 0.032	3.322GluIle: 3.322 ± 0.051	2.091GluLys: 2.091 ± 0.053	5.592GluLeu: 5.592 ± 0.075	1.707GluMet: 1.707 ± 0.041	1.626GluAsn: 1.626 ± 0.041	2.827GluPro: 2.827 ± 0.051	2.433GluGln: 2.433 ± 0.055	5.271GluArg: 5.271 ± 0.076	2.537GluSer: 2.537 ± 0.046	3.344GluThr: 3.344 ± 0.059	3.84GluVal: 3.84 ± 0.063	0.953GluTrp: 0.953 ± 0.028	1.198GluTyr: 1.198 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.889PheAla: 4.889 ± 0.068	0.335PheCys: 0.335 ± 0.017	2.821PheAsp: 2.821 ± 0.057	2.216PheGlu: 2.216 ± 0.049	1.292PhePhe: 1.292 ± 0.035	3.655PheGly: 3.655 ± 0.066	0.785PheHis: 0.785 ± 0.027	1.447PheIle: 1.447 ± 0.036	0.77PheLys: 0.77 ± 0.028	3.137PheLeu: 3.137 ± 0.06	0.824PheMet: 0.824 ± 0.028	0.915PheAsn: 0.915 ± 0.033	1.607PhePro: 1.607 ± 0.04	0.887PheGln: 0.887 ± 0.029	2.248PheArg: 2.248 ± 0.043	2.03PheSer: 2.03 ± 0.04	2.003PheThr: 2.003 ± 0.045	2.626PheVal: 2.626 ± 0.048	0.529PheTrp: 0.529 ± 0.02	0.946PheTyr: 0.946 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.526GlyAla: 9.526 ± 0.113	0.85GlyCys: 0.85 ± 0.028	5.357GlyAsp: 5.357 ± 0.073	5.656GlyGlu: 5.656 ± 0.083	3.707GlyPhe: 3.707 ± 0.055	8.16GlyGly: 8.16 ± 0.117	1.941GlyHis: 1.941 ± 0.04	4.45GlyIle: 4.45 ± 0.068	3.184GlyLys: 3.184 ± 0.061	8.351GlyLeu: 8.351 ± 0.102	2.599GlyMet: 2.599 ± 0.049	2.294GlyAsn: 2.294 ± 0.056	3.782GlyPro: 3.782 ± 0.057	3.044GlyGln: 3.044 ± 0.051	6.269GlyArg: 6.269 ± 0.085	5.307GlySer: 5.307 ± 0.082	4.753GlyThr: 4.753 ± 0.087	5.739GlyVal: 5.739 ± 0.068	1.684GlyTrp: 1.684 ± 0.043	2.232GlyTyr: 2.232 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.462HisAla: 2.462 ± 0.051	0.246HisCys: 0.246 ± 0.014	1.362HisAsp: 1.362 ± 0.036	1.108HisGlu: 1.108 ± 0.034	0.809HisPhe: 0.809 ± 0.025	1.966HisGly: 1.966 ± 0.052	0.608HisHis: 0.608 ± 0.024	0.898HisIle: 0.898 ± 0.028	0.439HisLys: 0.439 ± 0.019	1.924HisLeu: 1.924 ± 0.042	0.448HisMet: 0.448 ± 0.022	0.452HisAsn: 0.452 ± 0.019	1.335HisPro: 1.335 ± 0.036	0.612HisGln: 0.612 ± 0.025	1.524HisArg: 1.524 ± 0.036	0.987HisSer: 0.987 ± 0.027	0.7HisThr: 0.7 ± 0.025	1.51HisVal: 1.51 ± 0.038	0.352HisTrp: 0.352 ± 0.017	0.621HisTyr: 0.621 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.856IleAla: 7.856 ± 0.106	0.513IleCys: 0.513 ± 0.02	4.124IleAsp: 4.124 ± 0.062	3.649IleGlu: 3.649 ± 0.059	1.616IlePhe: 1.616 ± 0.043	5.069IleGly: 5.069 ± 0.069	0.875IleHis: 0.875 ± 0.029	1.983IleIle: 1.983 ± 0.043	1.097IleLys: 1.097 ± 0.033	3.695IleLeu: 3.695 ± 0.053	0.995IleMet: 0.995 ± 0.03	1.271IleAsn: 1.271 ± 0.036	2.298IlePro: 2.298 ± 0.041	1.068IleGln: 1.068 ± 0.03	3.321IleArg: 3.321 ± 0.055	2.639IleSer: 2.639 ± 0.053	2.448IleThr: 2.448 ± 0.054	3.962IleVal: 3.962 ± 0.063	0.657IleTrp: 0.657 ± 0.026	1.068IleTyr: 1.068 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.821LysAla: 3.821 ± 0.073	0.163LysCys: 0.163 ± 0.012	1.587LysAsp: 1.587 ± 0.041	1.339LysGlu: 1.339 ± 0.044	0.804LysPhe: 0.804 ± 0.033	2.438LysGly: 2.438 ± 0.049	0.556LysHis: 0.556 ± 0.023	1.414LysIle: 1.414 ± 0.041	1.049LysLys: 1.049 ± 0.036	2.834LysLeu: 2.834 ± 0.053	0.74LysMet: 0.74 ± 0.027	0.731LysAsn: 0.731 ± 0.026	1.821LysPro: 1.821 ± 0.046	0.937LysGln: 0.937 ± 0.031	2.196LysArg: 2.196 ± 0.05	1.56LysSer: 1.56 ± 0.04	1.595LysThr: 1.595 ± 0.044	1.972LysVal: 1.972 ± 0.047	0.315LysTrp: 0.315 ± 0.015	0.595LysTyr: 0.595 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.032LeuAla: 14.032 ± 0.128	0.779LeuCys: 0.779 ± 0.03	6.291LeuAsp: 6.291 ± 0.093	5.131LeuGlu: 5.131 ± 0.078	3.477LeuPhe: 3.477 ± 0.059	8.121LeuGly: 8.121 ± 0.101	1.767LeuHis: 1.767 ± 0.041	4.518LeuIle: 4.518 ± 0.059	2.908LeuLys: 2.908 ± 0.062	9.098LeuLeu: 9.098 ± 0.111	2.312LeuMet: 2.312 ± 0.047	2.332LeuAsn: 2.332 ± 0.05	5.473LeuPro: 5.473 ± 0.079	2.731LeuGln: 2.731 ± 0.047	6.663LeuArg: 6.663 ± 0.086	6.042LeuSer: 6.042 ± 0.069	5.264LeuThr: 5.264 ± 0.067	7.154LeuVal: 7.154 ± 0.086	1.14LeuTrp: 1.14 ± 0.035	1.93LeuTyr: 1.93 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.538MetAla: 3.538 ± 0.07	0.184MetCys: 0.184 ± 0.011	1.397MetAsp: 1.397 ± 0.037	1.391MetGlu: 1.391 ± 0.035	0.739MetPhe: 0.739 ± 0.025	2.103MetGly: 2.103 ± 0.043	0.531MetHis: 0.531 ± 0.023	1.434MetIle: 1.434 ± 0.036	1.031MetLys: 1.031 ± 0.033	2.792MetLeu: 2.792 ± 0.05	0.739MetMet: 0.739 ± 0.023	0.75MetAsn: 0.75 ± 0.028	1.628MetPro: 1.628 ± 0.041	0.913MetGln: 0.913 ± 0.029	1.967MetArg: 1.967 ± 0.041	1.431MetSer: 1.431 ± 0.033	1.706MetThr: 1.706 ± 0.039	1.719MetVal: 1.719 ± 0.042	0.256MetTrp: 0.256 ± 0.013	0.291MetTyr: 0.291 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.2AsnAla: 3.2 ± 0.053	0.272AsnCys: 0.272 ± 0.018	1.496AsnAsp: 1.496 ± 0.04	1.298AsnGlu: 1.298 ± 0.031	0.943AsnPhe: 0.943 ± 0.034	2.325AsnGly: 2.325 ± 0.052	0.458AsnHis: 0.458 ± 0.022	1.289AsnIle: 1.289 ± 0.036	0.585AsnLys: 0.585 ± 0.025	2.378AsnLeu: 2.378 ± 0.047	0.597AsnMet: 0.597 ± 0.024	0.629AsnAsn: 0.629 ± 0.03	1.781AsnPro: 1.781 ± 0.045	0.59AsnGln: 0.59 ± 0.025	1.97AsnArg: 1.97 ± 0.045	1.345AsnSer: 1.345 ± 0.044	1.205AsnThr: 1.205 ± 0.041	1.85AsnVal: 1.85 ± 0.044	0.445AsnTrp: 0.445 ± 0.02	0.691AsnTyr: 0.691 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.869ProAla: 6.869 ± 0.094	0.373ProCys: 0.373 ± 0.021	4.061ProAsp: 4.061 ± 0.065	3.828ProGlu: 3.828 ± 0.058	2.013ProPhe: 2.013 ± 0.041	4.726ProGly: 4.726 ± 0.056	1.072ProHis: 1.072 ± 0.034	2.348ProIle: 2.348 ± 0.052	1.254ProLys: 1.254 ± 0.04	4.753ProLeu: 4.753 ± 0.062	1.31ProMet: 1.31 ± 0.035	1.238ProAsn: 1.238 ± 0.035	2.71ProPro: 2.71 ± 0.068	1.842ProGln: 1.842 ± 0.041	3.161ProArg: 3.161 ± 0.054	2.709ProSer: 2.709 ± 0.044	2.211ProThr: 2.211 ± 0.045	4.313ProVal: 4.313 ± 0.073	0.669ProTrp: 0.669 ± 0.022	1.081ProTyr: 1.081 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.151GlnAla: 4.151 ± 0.068	0.236GlnCys: 0.236 ± 0.014	1.754GlnAsp: 1.754 ± 0.042	1.496GlnGlu: 1.496 ± 0.035	1.117GlnPhe: 1.117 ± 0.032	2.588GlnGly: 2.588 ± 0.045	0.626GlnHis: 0.626 ± 0.024	1.772GlnIle: 1.772 ± 0.035	0.854GlnLys: 0.854 ± 0.026	3.137GlnLeu: 3.137 ± 0.054	0.913GlnMet: 0.913 ± 0.032	0.794GlnAsn: 0.794 ± 0.027	1.902GlnPro: 1.902 ± 0.046	1.38GlnGln: 1.38 ± 0.041	2.537GlnArg: 2.537 ± 0.046	1.724GlnSer: 1.724 ± 0.033	1.635GlnThr: 1.635 ± 0.037	2.235GlnVal: 2.235 ± 0.045	0.477GlnTrp: 0.477 ± 0.022	0.677GlnTyr: 0.677 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.144ArgAla: 8.144 ± 0.099	0.538ArgCys: 0.538 ± 0.022	4.503ArgAsp: 4.503 ± 0.067	4.786ArgGlu: 4.786 ± 0.081	3.254ArgPhe: 3.254 ± 0.058	5.187ArgGly: 5.187 ± 0.073	1.759ArgHis: 1.759 ± 0.041	4.336ArgIle: 4.336 ± 0.061	2.337ArgLys: 2.337 ± 0.049	8.062ArgLeu: 8.062 ± 0.105	2.087ArgMet: 2.087 ± 0.049	1.873ArgAsn: 1.873 ± 0.046	3.551ArgPro: 3.551 ± 0.068	2.658ArgGln: 2.658 ± 0.047	5.85ArgArg: 5.85 ± 0.094	3.878ArgSer: 3.878 ± 0.067	3.386ArgThr: 3.386 ± 0.057	4.567ArgVal: 4.567 ± 0.073	1.194ArgTrp: 1.194 ± 0.03	1.845ArgTyr: 1.845 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.504SerAla: 6.504 ± 0.086	0.482SerCys: 0.482 ± 0.02	3.409SerAsp: 3.409 ± 0.06	2.966SerGlu: 2.966 ± 0.046	2.196SerPhe: 2.196 ± 0.043	5.613SerGly: 5.613 ± 0.086	1.061SerHis: 1.061 ± 0.029	2.635SerIle: 2.635 ± 0.049	1.399SerLys: 1.399 ± 0.036	5.213SerLeu: 5.213 ± 0.081	1.3SerMet: 1.3 ± 0.033	1.42SerAsn: 1.42 ± 0.038	2.688SerPro: 2.688 ± 0.052	1.606SerGln: 1.606 ± 0.038	3.683SerArg: 3.683 ± 0.06	2.754SerSer: 2.754 ± 0.063	2.444SerThr: 2.444 ± 0.051	3.62SerVal: 3.62 ± 0.056	0.827SerTrp: 0.827 ± 0.031	1.354SerTyr: 1.354 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.885ThrAla: 5.885 ± 0.077	0.368ThrCys: 0.368 ± 0.019	3.118ThrAsp: 3.118 ± 0.059	2.529ThrGlu: 2.529 ± 0.051	1.538ThrPhe: 1.538 ± 0.044	5.436ThrGly: 5.436 ± 0.083	0.92ThrHis: 0.92 ± 0.028	2.819ThrIle: 2.819 ± 0.056	1.12ThrLys: 1.12 ± 0.029	5.15ThrLeu: 5.15 ± 0.083	1.274ThrMet: 1.274 ± 0.034	1.221ThrAsn: 1.221 ± 0.038	2.977ThrPro: 2.977 ± 0.05	1.441ThrGln: 1.441 ± 0.036	3.508ThrArg: 3.508 ± 0.052	2.551ThrSer: 2.551 ± 0.055	2.437ThrThr: 2.437 ± 0.059	3.847ThrVal: 3.847 ± 0.062	0.532ThrTrp: 0.532 ± 0.024	1.042ThrTyr: 1.042 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.492ValAla: 8.492 ± 0.099	0.542ValCys: 0.542 ± 0.021	4.259ValAsp: 4.259 ± 0.065	4.708ValGlu: 4.708 ± 0.064	2.304ValPhe: 2.304 ± 0.045	5.244ValGly: 5.244 ± 0.082	1.304ValHis: 1.304 ± 0.036	3.626ValIle: 3.626 ± 0.054	1.877ValLys: 1.877 ± 0.046	6.939ValLeu: 6.939 ± 0.098	1.799ValMet: 1.799 ± 0.042	1.847ValAsn: 1.847 ± 0.048	4.011ValPro: 4.011 ± 0.062	2.026ValGln: 2.026 ± 0.037	4.778ValArg: 4.778 ± 0.06	3.993ValSer: 3.993 ± 0.068	4.289ValThr: 4.289 ± 0.08	5.02ValVal: 5.02 ± 0.074	0.877ValTrp: 0.877 ± 0.032	1.269ValTyr: 1.269 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.325TrpAla: 1.325 ± 0.031	0.122TrpCys: 0.122 ± 0.011	0.786TrpAsp: 0.786 ± 0.03	0.614TrpGlu: 0.614 ± 0.023	0.57TrpPhe: 0.57 ± 0.023	0.996TrpGly: 0.996 ± 0.029	0.363TrpHis: 0.363 ± 0.02	0.713TrpIle: 0.713 ± 0.028	0.451TrpLys: 0.451 ± 0.023	1.813TrpLeu: 1.813 ± 0.042	0.375TrpMet: 0.375 ± 0.018	0.482TrpAsn: 0.482 ± 0.019	0.694TrpPro: 0.694 ± 0.026	0.685TrpGln: 0.685 ± 0.026	1.367TrpArg: 1.367 ± 0.03	0.889TrpSer: 0.889 ± 0.029	0.774TrpThr: 0.774 ± 0.027	0.791TrpVal: 0.791 ± 0.024	0.268TrpTrp: 0.268 ± 0.018	0.295TrpTyr: 0.295 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.475TyrAla: 2.475 ± 0.043	0.237TyrCys: 0.237 ± 0.015	1.626TyrAsp: 1.626 ± 0.04	1.252TyrGlu: 1.252 ± 0.037	0.893TyrPhe: 0.893 ± 0.031	2.189TyrGly: 2.189 ± 0.051	0.514TyrHis: 0.514 ± 0.02	0.829TyrIle: 0.829 ± 0.03	0.524TyrLys: 0.524 ± 0.021	2.072TyrLeu: 2.072 ± 0.043	0.476TyrMet: 0.476 ± 0.021	0.61TyrAsn: 0.61 ± 0.022	1.02TyrPro: 1.02 ± 0.031	0.654TyrGln: 0.654 ± 0.026	1.987TyrArg: 1.987 ± 0.045	1.197TyrSer: 1.197 ± 0.037	1.033TyrThr: 1.033 ± 0.033	1.481TyrVal: 1.481 ± 0.037	0.34TyrTrp: 0.34 ± 0.018	0.595TyrTyr: 0.595 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3600 proteins (1160639 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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