Amino acid dipepetide frequency for Bordetella phage FP1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.769AlaAla: 13.769 ± 1.528
0.854AlaCys: 0.854 ± 0.204
5.87AlaAsp: 5.87 ± 0.554
7.952AlaGlu: 7.952 ± 0.718
3.629AlaPhe: 3.629 ± 0.476
8.912AlaGly: 8.912 ± 0.774
1.921AlaHis: 1.921 ± 0.332
4.803AlaIle: 4.803 ± 0.488
4.696AlaLys: 4.696 ± 0.623
10.62AlaLeu: 10.62 ± 0.862
1.868AlaMet: 1.868 ± 0.343
2.722AlaAsn: 2.722 ± 0.459
4.963AlaPro: 4.963 ± 0.579
4.59AlaGln: 4.59 ± 0.702
8.912AlaArg: 8.912 ± 0.764
4.323AlaSer: 4.323 ± 0.392
5.283AlaThr: 5.283 ± 0.605
7.685AlaVal: 7.685 ± 0.817
2.135AlaTrp: 2.135 ± 0.289
2.828AlaTyr: 2.828 ± 0.47
0.0AlaXaa: 0.0 ± 0.0
Cys
0.801CysAla: 0.801 ± 0.259
0.427CysCys: 0.427 ± 0.157
0.64CysAsp: 0.64 ± 0.182
0.907CysGlu: 0.907 ± 0.279
0.374CysPhe: 0.374 ± 0.187
0.694CysGly: 0.694 ± 0.184
0.48CysHis: 0.48 ± 0.166
0.107CysIle: 0.107 ± 0.074
0.213CysLys: 0.213 ± 0.113
1.174CysLeu: 1.174 ± 0.254
0.0CysMet: 0.0 ± 0.0
0.374CysAsn: 0.374 ± 0.142
0.534CysPro: 0.534 ± 0.177
0.107CysGln: 0.107 ± 0.07
1.121CysArg: 1.121 ± 0.215
0.48CysSer: 0.48 ± 0.152
0.48CysThr: 0.48 ± 0.137
0.64CysVal: 0.64 ± 0.171
0.267CysTrp: 0.267 ± 0.106
0.427CysTyr: 0.427 ± 0.176
0.0CysXaa: 0.0 ± 0.0
Asp
5.817AspAla: 5.817 ± 0.516
0.587AspCys: 0.587 ± 0.174
2.935AspAsp: 2.935 ± 0.478
4.003AspGlu: 4.003 ± 0.427
2.828AspPhe: 2.828 ± 0.441
5.71AspGly: 5.71 ± 0.696
1.494AspHis: 1.494 ± 0.26
2.935AspIle: 2.935 ± 0.391
2.081AspLys: 2.081 ± 0.344
6.991AspLeu: 6.991 ± 0.642
1.334AspMet: 1.334 ± 0.263
1.814AspAsn: 1.814 ± 0.339
4.323AspPro: 4.323 ± 0.447
2.775AspGln: 2.775 ± 0.451
3.789AspArg: 3.789 ± 0.422
2.188AspSer: 2.188 ± 0.317
2.722AspThr: 2.722 ± 0.444
3.736AspVal: 3.736 ± 0.462
1.014AspTrp: 1.014 ± 0.236
1.921AspTyr: 1.921 ± 0.271
0.0AspXaa: 0.0 ± 0.0
Glu
8.058GluAla: 8.058 ± 0.719
0.854GluCys: 0.854 ± 0.24
3.789GluAsp: 3.789 ± 0.41
5.177GluGlu: 5.177 ± 0.489
2.615GluPhe: 2.615 ± 0.385
5.55GluGly: 5.55 ± 0.586
1.227GluHis: 1.227 ± 0.24
2.508GluIle: 2.508 ± 0.395
3.682GluLys: 3.682 ± 0.467
7.311GluLeu: 7.311 ± 0.66
1.494GluMet: 1.494 ± 0.374
2.455GluAsn: 2.455 ± 0.378
3.255GluPro: 3.255 ± 0.428
2.935GluGln: 2.935 ± 0.392
5.23GluArg: 5.23 ± 0.532
2.402GluSer: 2.402 ± 0.431
4.109GluThr: 4.109 ± 0.503
5.604GluVal: 5.604 ± 0.499
1.921GluTrp: 1.921 ± 0.27
1.975GluTyr: 1.975 ± 0.307
0.0GluXaa: 0.0 ± 0.0
Phe
3.469PheAla: 3.469 ± 0.48
0.213PheCys: 0.213 ± 0.119
3.095PheAsp: 3.095 ± 0.476
2.935PheGlu: 2.935 ± 0.398
1.548PhePhe: 1.548 ± 0.306
3.469PheGly: 3.469 ± 0.461
0.587PheHis: 0.587 ± 0.197
1.334PheIle: 1.334 ± 0.279
1.388PheLys: 1.388 ± 0.327
2.668PheLeu: 2.668 ± 0.394
1.067PheMet: 1.067 ± 0.261
1.548PheAsn: 1.548 ± 0.237
1.227PhePro: 1.227 ± 0.271
1.227PheGln: 1.227 ± 0.297
2.935PheArg: 2.935 ± 0.385
1.548PheSer: 1.548 ± 0.246
2.135PheThr: 2.135 ± 0.385
2.295PheVal: 2.295 ± 0.38
0.694PheTrp: 0.694 ± 0.192
0.801PheTyr: 0.801 ± 0.213
0.0PheXaa: 0.0 ± 0.0
Gly
7.311GlyAla: 7.311 ± 0.676
0.694GlyCys: 0.694 ± 0.235
4.536GlyAsp: 4.536 ± 0.448
6.457GlyGlu: 6.457 ± 0.673
3.842GlyPhe: 3.842 ± 0.409
6.724GlyGly: 6.724 ± 0.668
1.067GlyHis: 1.067 ± 0.252
2.935GlyIle: 2.935 ± 0.458
4.003GlyLys: 4.003 ± 0.476
6.991GlyLeu: 6.991 ± 0.662
1.868GlyMet: 1.868 ± 0.325
2.241GlyAsn: 2.241 ± 0.356
3.949GlyPro: 3.949 ± 0.525
2.882GlyGln: 2.882 ± 0.347
5.497GlyArg: 5.497 ± 0.52
3.896GlySer: 3.896 ± 0.452
5.123GlyThr: 5.123 ± 0.506
5.87GlyVal: 5.87 ± 0.544
1.708GlyTrp: 1.708 ± 0.335
2.348GlyTyr: 2.348 ± 0.358
0.0GlyXaa: 0.0 ± 0.0
His
1.494HisAla: 1.494 ± 0.322
0.48HisCys: 0.48 ± 0.164
0.801HisAsp: 0.801 ± 0.21
1.761HisGlu: 1.761 ± 0.271
0.64HisPhe: 0.64 ± 0.182
1.227HisGly: 1.227 ± 0.22
0.32HisHis: 0.32 ± 0.131
1.067HisIle: 1.067 ± 0.208
0.694HisLys: 0.694 ± 0.232
1.121HisLeu: 1.121 ± 0.243
0.427HisMet: 0.427 ± 0.172
0.32HisAsn: 0.32 ± 0.146
1.494HisPro: 1.494 ± 0.289
1.014HisGln: 1.014 ± 0.19
1.388HisArg: 1.388 ± 0.305
0.64HisSer: 0.64 ± 0.184
0.534HisThr: 0.534 ± 0.174
1.441HisVal: 1.441 ± 0.259
0.48HisTrp: 0.48 ± 0.145
0.694HisTyr: 0.694 ± 0.207
0.0HisXaa: 0.0 ± 0.0
Ile
4.856IleAla: 4.856 ± 0.462
0.374IleCys: 0.374 ± 0.17
3.309IleAsp: 3.309 ± 0.471
3.469IleGlu: 3.469 ± 0.368
1.121IlePhe: 1.121 ± 0.215
3.042IleGly: 3.042 ± 0.454
1.014IleHis: 1.014 ± 0.273
1.441IleIle: 1.441 ± 0.308
2.455IleLys: 2.455 ± 0.428
3.149IleLeu: 3.149 ± 0.443
1.121IleMet: 1.121 ± 0.212
2.775IleAsn: 2.775 ± 0.392
1.708IlePro: 1.708 ± 0.28
2.668IleGln: 2.668 ± 0.362
3.042IleArg: 3.042 ± 0.369
1.761IleSer: 1.761 ± 0.305
3.469IleThr: 3.469 ± 0.498
2.828IleVal: 2.828 ± 0.342
0.747IleTrp: 0.747 ± 0.216
1.388IleTyr: 1.388 ± 0.225
0.0IleXaa: 0.0 ± 0.0
Lys
6.297LysAla: 6.297 ± 0.75
0.374LysCys: 0.374 ± 0.145
2.668LysAsp: 2.668 ± 0.363
2.508LysGlu: 2.508 ± 0.365
1.388LysPhe: 1.388 ± 0.263
2.722LysGly: 2.722 ± 0.521
1.121LysHis: 1.121 ± 0.269
1.441LysIle: 1.441 ± 0.277
1.601LysLys: 1.601 ± 0.327
3.629LysLeu: 3.629 ± 0.498
1.174LysMet: 1.174 ± 0.272
1.121LysAsn: 1.121 ± 0.235
2.989LysPro: 2.989 ± 0.503
1.975LysGln: 1.975 ± 0.302
2.775LysArg: 2.775 ± 0.439
2.188LysSer: 2.188 ± 0.338
2.295LysThr: 2.295 ± 0.485
2.989LysVal: 2.989 ± 0.457
0.694LysTrp: 0.694 ± 0.163
1.227LysTyr: 1.227 ± 0.237
0.0LysXaa: 0.0 ± 0.0
Leu
9.179LeuAla: 9.179 ± 0.862
1.067LeuCys: 1.067 ± 0.243
6.084LeuAsp: 6.084 ± 0.528
5.443LeuGlu: 5.443 ± 0.466
2.775LeuPhe: 2.775 ± 0.367
7.045LeuGly: 7.045 ± 0.748
1.708LeuHis: 1.708 ± 0.293
4.643LeuIle: 4.643 ± 0.529
4.323LeuLys: 4.323 ± 0.494
6.564LeuLeu: 6.564 ± 0.846
1.388LeuMet: 1.388 ± 0.311
2.828LeuAsn: 2.828 ± 0.354
5.817LeuPro: 5.817 ± 0.801
3.576LeuGln: 3.576 ± 0.495
6.618LeuArg: 6.618 ± 0.568
4.216LeuSer: 4.216 ± 0.643
5.764LeuThr: 5.764 ± 0.701
5.017LeuVal: 5.017 ± 0.644
1.654LeuTrp: 1.654 ± 0.322
2.402LeuTyr: 2.402 ± 0.429
0.0LeuXaa: 0.0 ± 0.0
Met
2.241MetAla: 2.241 ± 0.38
0.107MetCys: 0.107 ± 0.075
1.441MetAsp: 1.441 ± 0.231
0.961MetGlu: 0.961 ± 0.26
0.48MetPhe: 0.48 ± 0.166
1.121MetGly: 1.121 ± 0.298
0.267MetHis: 0.267 ± 0.104
1.814MetIle: 1.814 ± 0.331
0.961MetLys: 0.961 ± 0.263
1.334MetLeu: 1.334 ± 0.251
0.801MetMet: 0.801 ± 0.238
0.854MetAsn: 0.854 ± 0.179
1.121MetPro: 1.121 ± 0.248
0.213MetGln: 0.213 ± 0.133
1.441MetArg: 1.441 ± 0.24
2.295MetSer: 2.295 ± 0.328
1.388MetThr: 1.388 ± 0.289
1.227MetVal: 1.227 ± 0.269
0.267MetTrp: 0.267 ± 0.137
0.267MetTyr: 0.267 ± 0.124
0.0MetXaa: 0.0 ± 0.0
Asn
4.43AsnAla: 4.43 ± 0.534
0.213AsnCys: 0.213 ± 0.096
1.868AsnAsp: 1.868 ± 0.357
1.975AsnGlu: 1.975 ± 0.397
0.907AsnPhe: 0.907 ± 0.207
3.682AsnGly: 3.682 ± 0.498
0.32AsnHis: 0.32 ± 0.118
1.441AsnIle: 1.441 ± 0.234
1.868AsnLys: 1.868 ± 0.347
2.402AsnLeu: 2.402 ± 0.307
0.534AsnMet: 0.534 ± 0.176
1.281AsnAsn: 1.281 ± 0.378
2.562AsnPro: 2.562 ± 0.36
1.067AsnGln: 1.067 ± 0.234
2.508AsnArg: 2.508 ± 0.347
1.441AsnSer: 1.441 ± 0.348
1.601AsnThr: 1.601 ± 0.332
3.202AsnVal: 3.202 ± 0.452
0.801AsnTrp: 0.801 ± 0.161
1.014AsnTyr: 1.014 ± 0.222
0.0AsnXaa: 0.0 ± 0.0
Pro
5.283ProAla: 5.283 ± 0.578
0.374ProCys: 0.374 ± 0.119
3.095ProAsp: 3.095 ± 0.425
5.017ProGlu: 5.017 ± 0.584
2.402ProPhe: 2.402 ± 0.313
4.483ProGly: 4.483 ± 0.625
0.747ProHis: 0.747 ± 0.199
2.668ProIle: 2.668 ± 0.391
2.508ProLys: 2.508 ± 0.42
4.59ProLeu: 4.59 ± 0.457
0.907ProMet: 0.907 ± 0.178
2.295ProAsn: 2.295 ± 0.421
2.668ProPro: 2.668 ± 0.397
1.761ProGln: 1.761 ± 0.298
2.775ProArg: 2.775 ± 0.442
2.562ProSer: 2.562 ± 0.39
2.722ProThr: 2.722 ± 0.489
3.736ProVal: 3.736 ± 0.486
1.174ProTrp: 1.174 ± 0.275
1.281ProTyr: 1.281 ± 0.272
0.0ProXaa: 0.0 ± 0.0
Gln
4.643GlnAla: 4.643 ± 0.602
0.213GlnCys: 0.213 ± 0.107
2.722GlnAsp: 2.722 ± 0.354
3.095GlnGlu: 3.095 ± 0.42
1.227GlnPhe: 1.227 ± 0.236
2.775GlnGly: 2.775 ± 0.366
0.961GlnHis: 0.961 ± 0.216
2.455GlnIle: 2.455 ± 0.286
1.388GlnLys: 1.388 ± 0.257
3.149GlnLeu: 3.149 ± 0.537
1.334GlnMet: 1.334 ± 0.249
1.227GlnAsn: 1.227 ± 0.224
1.654GlnPro: 1.654 ± 0.352
2.615GlnGln: 2.615 ± 0.772
2.828GlnArg: 2.828 ± 0.339
1.494GlnSer: 1.494 ± 0.219
1.921GlnThr: 1.921 ± 0.362
2.828GlnVal: 2.828 ± 0.424
0.747GlnTrp: 0.747 ± 0.184
0.801GlnTyr: 0.801 ± 0.221
0.0GlnXaa: 0.0 ± 0.0
Arg
9.286ArgAla: 9.286 ± 0.654
0.534ArgCys: 0.534 ± 0.17
4.59ArgAsp: 4.59 ± 0.49
6.511ArgGlu: 6.511 ± 0.639
2.828ArgPhe: 2.828 ± 0.461
4.43ArgGly: 4.43 ± 0.491
1.281ArgHis: 1.281 ± 0.309
2.828ArgIle: 2.828 ± 0.44
2.241ArgLys: 2.241 ± 0.354
7.258ArgLeu: 7.258 ± 0.616
0.801ArgMet: 0.801 ± 0.179
2.882ArgAsn: 2.882 ± 0.362
3.149ArgPro: 3.149 ± 0.497
2.615ArgGln: 2.615 ± 0.354
4.643ArgArg: 4.643 ± 0.577
2.615ArgSer: 2.615 ± 0.471
3.522ArgThr: 3.522 ± 0.489
5.017ArgVal: 5.017 ± 0.582
1.334ArgTrp: 1.334 ± 0.291
2.081ArgTyr: 2.081 ± 0.319
0.0ArgXaa: 0.0 ± 0.0
Ser
4.109SerAla: 4.109 ± 0.555
0.64SerCys: 0.64 ± 0.153
2.882SerAsp: 2.882 ± 0.424
2.348SerGlu: 2.348 ± 0.372
1.761SerPhe: 1.761 ± 0.293
4.91SerGly: 4.91 ± 0.589
0.747SerHis: 0.747 ± 0.166
2.241SerIle: 2.241 ± 0.422
2.828SerLys: 2.828 ± 0.398
3.095SerLeu: 3.095 ± 0.453
1.067SerMet: 1.067 ± 0.236
1.814SerAsn: 1.814 ± 0.288
2.028SerPro: 2.028 ± 0.403
1.868SerGln: 1.868 ± 0.279
2.882SerArg: 2.882 ± 0.34
2.668SerSer: 2.668 ± 0.514
2.508SerThr: 2.508 ± 0.338
3.042SerVal: 3.042 ± 0.456
1.281SerTrp: 1.281 ± 0.288
1.548SerTyr: 1.548 ± 0.255
0.0SerXaa: 0.0 ± 0.0
Thr
5.924ThrAla: 5.924 ± 0.602
0.587ThrCys: 0.587 ± 0.175
3.042ThrAsp: 3.042 ± 0.39
3.576ThrGlu: 3.576 ± 0.457
2.188ThrPhe: 2.188 ± 0.35
5.177ThrGly: 5.177 ± 0.546
0.801ThrHis: 0.801 ± 0.186
2.989ThrIle: 2.989 ± 0.52
2.081ThrLys: 2.081 ± 0.306
4.856ThrLeu: 4.856 ± 0.525
0.854ThrMet: 0.854 ± 0.235
1.601ThrAsn: 1.601 ± 0.315
3.789ThrPro: 3.789 ± 0.504
1.814ThrGln: 1.814 ± 0.255
2.989ThrArg: 2.989 ± 0.37
2.828ThrSer: 2.828 ± 0.508
2.188ThrThr: 2.188 ± 0.354
4.696ThrVal: 4.696 ± 0.626
0.854ThrTrp: 0.854 ± 0.227
1.334ThrTyr: 1.334 ± 0.265
0.0ThrXaa: 0.0 ± 0.0
Val
6.244ValAla: 6.244 ± 0.614
0.907ValCys: 0.907 ± 0.237
4.75ValAsp: 4.75 ± 0.55
4.91ValGlu: 4.91 ± 0.502
2.241ValPhe: 2.241 ± 0.314
4.59ValGly: 4.59 ± 0.448
1.227ValHis: 1.227 ± 0.28
3.469ValIle: 3.469 ± 0.563
2.241ValLys: 2.241 ± 0.339
6.671ValLeu: 6.671 ± 0.68
1.548ValMet: 1.548 ± 0.263
2.882ValAsn: 2.882 ± 0.39
3.682ValPro: 3.682 ± 0.476
2.882ValGln: 2.882 ± 0.481
5.977ValArg: 5.977 ± 0.575
3.789ValSer: 3.789 ± 0.591
4.109ValThr: 4.109 ± 0.54
3.949ValVal: 3.949 ± 0.478
1.548ValTrp: 1.548 ± 0.321
1.761ValTyr: 1.761 ± 0.336
0.0ValXaa: 0.0 ± 0.0
Trp
2.615TrpAla: 2.615 ± 0.319
0.267TrpCys: 0.267 ± 0.136
1.281TrpAsp: 1.281 ± 0.26
1.708TrpGlu: 1.708 ± 0.272
0.694TrpPhe: 0.694 ± 0.201
0.801TrpGly: 0.801 ± 0.201
0.267TrpHis: 0.267 ± 0.1
1.067TrpIle: 1.067 ± 0.228
1.014TrpLys: 1.014 ± 0.243
2.081TrpLeu: 2.081 ± 0.381
0.534TrpMet: 0.534 ± 0.197
0.801TrpAsn: 0.801 ± 0.171
0.64TrpPro: 0.64 ± 0.195
0.587TrpGln: 0.587 ± 0.179
1.174TrpArg: 1.174 ± 0.286
1.388TrpSer: 1.388 ± 0.271
0.907TrpThr: 0.907 ± 0.191
1.494TrpVal: 1.494 ± 0.283
0.267TrpTrp: 0.267 ± 0.118
0.694TrpTyr: 0.694 ± 0.192
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.508TyrAla: 2.508 ± 0.333
0.48TyrCys: 0.48 ± 0.167
1.601TyrAsp: 1.601 ± 0.267
1.441TyrGlu: 1.441 ± 0.294
0.694TyrPhe: 0.694 ± 0.18
2.882TyrGly: 2.882 ± 0.448
0.48TyrHis: 0.48 ± 0.167
1.548TyrIle: 1.548 ± 0.332
0.907TyrLys: 0.907 ± 0.176
2.455TyrLeu: 2.455 ± 0.397
0.427TyrMet: 0.427 ± 0.151
1.281TyrAsn: 1.281 ± 0.251
1.494TyrPro: 1.494 ± 0.349
0.907TyrGln: 0.907 ± 0.18
1.921TyrArg: 1.921 ± 0.381
1.601TyrSer: 1.601 ± 0.335
1.388TyrThr: 1.388 ± 0.286
2.081TyrVal: 2.081 ± 0.333
0.694TyrTrp: 0.694 ± 0.165
0.907TyrTyr: 0.907 ± 0.197
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 80 proteins (18739 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski