Amino acid dipepetide frequency for Erythrobacter litoralis (strain HTCC2594)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.737AlaAla: 15.737 ± 0.182	1.075AlaCys: 1.075 ± 0.039	7.277AlaAsp: 7.277 ± 0.09	8.431AlaGlu: 8.431 ± 0.11	4.255AlaPhe: 4.255 ± 0.061	10.157AlaGly: 10.157 ± 0.126	2.068AlaHis: 2.068 ± 0.054	6.83AlaIle: 6.83 ± 0.089	4.439AlaLys: 4.439 ± 0.082	12.849AlaLeu: 12.849 ± 0.15	3.858AlaMet: 3.858 ± 0.064	3.173AlaAsn: 3.173 ± 0.073	5.447AlaPro: 5.447 ± 0.087	4.419AlaGln: 4.419 ± 0.087	8.639AlaArg: 8.639 ± 0.124	6.587AlaSer: 6.587 ± 0.101	5.989AlaThr: 5.989 ± 0.099	7.804AlaVal: 7.804 ± 0.091	1.56AlaTrp: 1.56 ± 0.049	2.455AlaTyr: 2.455 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.963CysAla: 0.963 ± 0.032	0.093CysCys: 0.093 ± 0.01	0.616CysAsp: 0.616 ± 0.027	0.526CysGlu: 0.526 ± 0.022	0.303CysPhe: 0.303 ± 0.022	0.912CysGly: 0.912 ± 0.036	0.193CysHis: 0.193 ± 0.016	0.379CysIle: 0.379 ± 0.023	0.201CysLys: 0.201 ± 0.014	0.699CysLeu: 0.699 ± 0.028	0.164CysMet: 0.164 ± 0.015	0.258CysAsn: 0.258 ± 0.018	0.408CysPro: 0.408 ± 0.021	0.219CysGln: 0.219 ± 0.015	0.514CysArg: 0.514 ± 0.024	0.458CysSer: 0.458 ± 0.024	0.411CysThr: 0.411 ± 0.025	0.532CysVal: 0.532 ± 0.025	0.11CysTrp: 0.11 ± 0.01	0.165CysTyr: 0.165 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.483AspAla: 7.483 ± 0.101	0.538AspCys: 0.538 ± 0.022	3.966AspAsp: 3.966 ± 0.096	4.42AspGlu: 4.42 ± 0.071	2.41AspPhe: 2.41 ± 0.055	6.059AspGly: 6.059 ± 0.105	1.329AspHis: 1.329 ± 0.042	3.2AspIle: 3.2 ± 0.065	1.97AspLys: 1.97 ± 0.053	6.011AspLeu: 6.011 ± 0.074	1.577AspMet: 1.577 ± 0.043	1.627AspAsn: 1.627 ± 0.046	3.905AspPro: 3.905 ± 0.066	1.765AspGln: 1.765 ± 0.042	4.676AspArg: 4.676 ± 0.085	2.592AspSer: 2.592 ± 0.055	3.029AspThr: 3.029 ± 0.057	4.06AspVal: 4.06 ± 0.064	1.173AspTrp: 1.173 ± 0.037	1.695AspTyr: 1.695 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	8.576GluAla: 8.576 ± 0.113	0.398GluCys: 0.398 ± 0.02	3.937GluAsp: 3.937 ± 0.07	4.526GluGlu: 4.526 ± 0.092	2.081GluPhe: 2.081 ± 0.051	5.317GluGly: 5.317 ± 0.083	1.293GluHis: 1.293 ± 0.045	3.443GluIle: 3.443 ± 0.067	2.714GluLys: 2.714 ± 0.065	6.103GluLeu: 6.103 ± 0.086	1.702GluMet: 1.702 ± 0.045	1.814GluAsn: 1.814 ± 0.043	3.024GluPro: 3.024 ± 0.067	2.672GluGln: 2.672 ± 0.053	5.583GluArg: 5.583 ± 0.092	2.798GluSer: 2.798 ± 0.056	3.687GluThr: 3.687 ± 0.065	4.187GluVal: 4.187 ± 0.064	0.983GluTrp: 0.983 ± 0.034	1.212GluTyr: 1.212 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.947PheAla: 4.947 ± 0.08	0.327PheCys: 0.327 ± 0.018	2.917PheAsp: 2.917 ± 0.059	2.461PheGlu: 2.461 ± 0.052	1.43PhePhe: 1.43 ± 0.051	3.757PheGly: 3.757 ± 0.073	0.656PheHis: 0.656 ± 0.025	1.578PheIle: 1.578 ± 0.047	0.897PheLys: 0.897 ± 0.028	3.167PheLeu: 3.167 ± 0.057	0.8PheMet: 0.8 ± 0.029	1.025PheAsn: 1.025 ± 0.041	1.517PhePro: 1.517 ± 0.039	0.953PheGln: 0.953 ± 0.035	2.124PheArg: 2.124 ± 0.055	2.099PheSer: 2.099 ± 0.051	2.11PheThr: 2.11 ± 0.045	2.719PheVal: 2.719 ± 0.051	0.543PheTrp: 0.543 ± 0.029	0.965PheTyr: 0.965 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.405GlyAla: 9.405 ± 0.11	0.821GlyCys: 0.821 ± 0.031	5.304GlyAsp: 5.304 ± 0.088	6.027GlyGlu: 6.027 ± 0.08	3.728GlyPhe: 3.728 ± 0.063	7.908GlyGly: 7.908 ± 0.131	1.721GlyHis: 1.721 ± 0.049	4.567GlyIle: 4.567 ± 0.081	3.516GlyLys: 3.516 ± 0.063	8.048GlyLeu: 8.048 ± 0.105	2.417GlyMet: 2.417 ± 0.062	2.441GlyAsn: 2.441 ± 0.06	3.574GlyPro: 3.574 ± 0.064	2.994GlyGln: 2.994 ± 0.056	5.681GlyArg: 5.681 ± 0.075	5.174GlySer: 5.174 ± 0.089	4.954GlyThr: 4.954 ± 0.119	5.91GlyVal: 5.91 ± 0.086	1.554GlyTrp: 1.554 ± 0.048	2.275GlyTyr: 2.275 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.131HisAla: 2.131 ± 0.048	0.246HisCys: 0.246 ± 0.017	1.216HisAsp: 1.216 ± 0.037	1.078HisGlu: 1.078 ± 0.035	0.835HisPhe: 0.835 ± 0.036	1.849HisGly: 1.849 ± 0.045	0.573HisHis: 0.573 ± 0.027	0.872HisIle: 0.872 ± 0.033	0.516HisLys: 0.516 ± 0.024	1.778HisLeu: 1.778 ± 0.053	0.44HisMet: 0.44 ± 0.021	0.474HisAsn: 0.474 ± 0.023	1.247HisPro: 1.247 ± 0.042	0.527HisGln: 0.527 ± 0.024	1.447HisArg: 1.447 ± 0.041	0.962HisSer: 0.962 ± 0.034	0.754HisThr: 0.754 ± 0.027	1.291HisVal: 1.291 ± 0.043	0.34HisTrp: 0.34 ± 0.02	0.575HisTyr: 0.575 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.493IleAla: 7.493 ± 0.087	0.465IleCys: 0.465 ± 0.021	3.956IleAsp: 3.956 ± 0.077	4.058IleGlu: 4.058 ± 0.069	1.601IlePhe: 1.601 ± 0.04	5.199IleGly: 5.199 ± 0.082	0.868IleHis: 0.868 ± 0.029	2.12IleIle: 2.12 ± 0.056	1.354IleLys: 1.354 ± 0.042	3.985IleLeu: 3.985 ± 0.066	0.936IleMet: 0.936 ± 0.034	1.331IleAsn: 1.331 ± 0.041	2.325IlePro: 2.325 ± 0.053	1.213IleGln: 1.213 ± 0.038	3.048IleArg: 3.048 ± 0.055	2.557IleSer: 2.557 ± 0.055	2.644IleThr: 2.644 ± 0.065	3.961IleVal: 3.961 ± 0.073	0.649IleTrp: 0.649 ± 0.027	1.119IleTyr: 1.119 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.195LysAla: 4.195 ± 0.084	0.184LysCys: 0.184 ± 0.013	1.84LysAsp: 1.84 ± 0.052	1.677LysGlu: 1.677 ± 0.039	0.968LysPhe: 0.968 ± 0.036	2.739LysGly: 2.739 ± 0.054	0.701LysHis: 0.701 ± 0.027	1.566LysIle: 1.566 ± 0.045	1.434LysLys: 1.434 ± 0.048	3.516LysLeu: 3.516 ± 0.069	0.835LysMet: 0.835 ± 0.033	0.837LysAsn: 0.837 ± 0.033	1.996LysPro: 1.996 ± 0.041	1.158LysGln: 1.158 ± 0.032	2.574LysArg: 2.574 ± 0.056	1.751LysSer: 1.751 ± 0.043	1.825LysThr: 1.825 ± 0.046	2.329LysVal: 2.329 ± 0.062	0.438LysTrp: 0.438 ± 0.024	0.696LysTyr: 0.696 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	13.413LeuAla: 13.413 ± 0.155	0.72LeuCys: 0.72 ± 0.032	6.366LeuAsp: 6.366 ± 0.095	5.953LeuGlu: 5.953 ± 0.081	3.567LeuPhe: 3.567 ± 0.064	8.126LeuGly: 8.126 ± 0.099	1.719LeuHis: 1.719 ± 0.048	4.369LeuIle: 4.369 ± 0.073	3.109LeuLys: 3.109 ± 0.069	8.87LeuLeu: 8.87 ± 0.137	2.073LeuMet: 2.073 ± 0.058	2.257LeuAsn: 2.257 ± 0.057	5.375LeuPro: 5.375 ± 0.083	2.785LeuGln: 2.785 ± 0.056	6.3LeuArg: 6.3 ± 0.091	5.646LeuSer: 5.646 ± 0.082	5.323LeuThr: 5.323 ± 0.083	7.253LeuVal: 7.253 ± 0.11	1.156LeuTrp: 1.156 ± 0.041	1.889LeuTyr: 1.889 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.294MetAla: 3.294 ± 0.061	0.151MetCys: 0.151 ± 0.013	1.271MetAsp: 1.271 ± 0.035	1.355MetGlu: 1.355 ± 0.037	0.682MetPhe: 0.682 ± 0.028	2.007MetGly: 2.007 ± 0.053	0.468MetHis: 0.468 ± 0.021	1.38MetIle: 1.38 ± 0.038	1.023MetLys: 1.023 ± 0.039	2.587MetLeu: 2.587 ± 0.06	0.67MetMet: 0.67 ± 0.034	0.7MetAsn: 0.7 ± 0.025	1.434MetPro: 1.434 ± 0.043	0.827MetGln: 0.827 ± 0.033	1.786MetArg: 1.786 ± 0.045	1.512MetSer: 1.512 ± 0.039	1.641MetThr: 1.641 ± 0.037	1.582MetVal: 1.582 ± 0.046	0.239MetTrp: 0.239 ± 0.017	0.275MetTyr: 0.275 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.285AsnAla: 3.285 ± 0.063	0.277AsnCys: 0.277 ± 0.018	1.458AsnAsp: 1.458 ± 0.04	1.418AsnGlu: 1.418 ± 0.037	1.051AsnPhe: 1.051 ± 0.041	2.437AsnGly: 2.437 ± 0.06	0.476AsnHis: 0.476 ± 0.023	1.402AsnIle: 1.402 ± 0.039	0.671AsnLys: 0.671 ± 0.029	2.473AsnLeu: 2.473 ± 0.061	0.546AsnMet: 0.546 ± 0.024	0.647AsnAsn: 0.647 ± 0.033	1.848AsnPro: 1.848 ± 0.047	0.742AsnGln: 0.742 ± 0.029	1.91AsnArg: 1.91 ± 0.048	1.3AsnSer: 1.3 ± 0.049	1.3AsnThr: 1.3 ± 0.04	1.92AsnVal: 1.92 ± 0.05	0.432AsnTrp: 0.432 ± 0.023	0.681AsnTyr: 0.681 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.736ProAla: 5.736 ± 0.088	0.302ProCys: 0.302 ± 0.019	3.992ProAsp: 3.992 ± 0.068	4.191ProGlu: 4.191 ± 0.069	1.907ProPhe: 1.907 ± 0.054	4.55ProGly: 4.55 ± 0.074	0.971ProHis: 0.971 ± 0.036	2.425ProIle: 2.425 ± 0.051	1.598ProLys: 1.598 ± 0.042	4.664ProLeu: 4.664 ± 0.067	1.207ProMet: 1.207 ± 0.039	1.248ProAsn: 1.248 ± 0.033	2.613ProPro: 2.613 ± 0.092	1.727ProGln: 1.727 ± 0.046	2.873ProArg: 2.873 ± 0.053	2.644ProSer: 2.644 ± 0.055	2.471ProThr: 2.471 ± 0.059	3.969ProVal: 3.969 ± 0.065	0.643ProTrp: 0.643 ± 0.025	1.098ProTyr: 1.098 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.135GlnAla: 4.135 ± 0.079	0.256GlnCys: 0.256 ± 0.017	1.688GlnAsp: 1.688 ± 0.042	1.647GlnGlu: 1.647 ± 0.046	1.219GlnPhe: 1.219 ± 0.037	2.537GlnGly: 2.537 ± 0.055	0.662GlnHis: 0.662 ± 0.026	1.752GlnIle: 1.752 ± 0.049	0.985GlnLys: 0.985 ± 0.038	3.073GlnLeu: 3.073 ± 0.061	0.89GlnMet: 0.89 ± 0.032	0.782GlnAsn: 0.782 ± 0.028	1.742GlnPro: 1.742 ± 0.051	1.303GlnGln: 1.303 ± 0.044	2.549GlnArg: 2.549 ± 0.056	1.817GlnSer: 1.817 ± 0.047	1.649GlnThr: 1.649 ± 0.041	2.388GlnVal: 2.388 ± 0.048	0.475GlnTrp: 0.475 ± 0.024	0.671GlnTyr: 0.671 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	7.716ArgAla: 7.716 ± 0.098	0.488ArgCys: 0.488 ± 0.023	4.351ArgAsp: 4.351 ± 0.074	4.895ArgGlu: 4.895 ± 0.068	3.014ArgPhe: 3.014 ± 0.063	4.932ArgGly: 4.932 ± 0.083	1.459ArgHis: 1.459 ± 0.049	3.937ArgIle: 3.937 ± 0.062	2.429ArgLys: 2.429 ± 0.057	7.365ArgLeu: 7.365 ± 0.087	1.95ArgMet: 1.95 ± 0.051	1.893ArgAsn: 1.893 ± 0.045	3.108ArgPro: 3.108 ± 0.065	2.365ArgGln: 2.365 ± 0.053	4.876ArgArg: 4.876 ± 0.099	3.633ArgSer: 3.633 ± 0.07	3.229ArgThr: 3.229 ± 0.069	4.425ArgVal: 4.425 ± 0.081	1.084ArgTrp: 1.084 ± 0.041	1.728ArgTyr: 1.728 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.958SerAla: 5.958 ± 0.086	0.405SerCys: 0.405 ± 0.026	3.578SerAsp: 3.578 ± 0.074	3.435SerGlu: 3.435 ± 0.066	2.172SerPhe: 2.172 ± 0.054	5.587SerGly: 5.587 ± 0.093	0.944SerHis: 0.944 ± 0.031	2.636SerIle: 2.636 ± 0.056	1.714SerLys: 1.714 ± 0.047	5.189SerLeu: 5.189 ± 0.072	1.287SerMet: 1.287 ± 0.036	1.516SerAsn: 1.516 ± 0.04	2.668SerPro: 2.668 ± 0.057	1.707SerGln: 1.707 ± 0.047	3.449SerArg: 3.449 ± 0.058	2.881SerSer: 2.881 ± 0.063	2.59SerThr: 2.59 ± 0.066	3.639SerVal: 3.639 ± 0.087	0.788SerTrp: 0.788 ± 0.027	1.263SerTyr: 1.263 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.106ThrAla: 6.106 ± 0.097	0.439ThrCys: 0.439 ± 0.024	3.098ThrAsp: 3.098 ± 0.056	2.841ThrGlu: 2.841 ± 0.054	1.919ThrPhe: 1.919 ± 0.055	5.331ThrGly: 5.331 ± 0.106	0.906ThrHis: 0.906 ± 0.033	2.984ThrIle: 2.984 ± 0.067	1.492ThrLys: 1.492 ± 0.05	5.453ThrLeu: 5.453 ± 0.087	1.193ThrMet: 1.193 ± 0.037	1.307ThrAsn: 1.307 ± 0.043	3.132ThrPro: 3.132 ± 0.056	1.499ThrGln: 1.499 ± 0.042	3.341ThrArg: 3.341 ± 0.059	2.821ThrSer: 2.821 ± 0.065	2.613ThrThr: 2.613 ± 0.074	4.03ThrVal: 4.03 ± 0.07	0.647ThrTrp: 0.647 ± 0.027	1.17ThrTyr: 1.17 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.567ValAla: 8.567 ± 0.093	0.544ValCys: 0.544 ± 0.026	4.32ValAsp: 4.32 ± 0.077	5.047ValGlu: 5.047 ± 0.073	2.377ValPhe: 2.377 ± 0.043	5.511ValGly: 5.511 ± 0.087	1.308ValHis: 1.308 ± 0.039	3.777ValIle: 3.777 ± 0.075	2.14ValLys: 2.14 ± 0.051	6.612ValLeu: 6.612 ± 0.093	1.56ValMet: 1.56 ± 0.05	1.873ValAsn: 1.873 ± 0.051	3.783ValPro: 3.783 ± 0.062	1.979ValGln: 1.979 ± 0.042	4.494ValArg: 4.494 ± 0.082	4.007ValSer: 4.007 ± 0.069	4.257ValThr: 4.257 ± 0.076	5.114ValVal: 5.114 ± 0.092	0.854ValTrp: 0.854 ± 0.032	1.302ValTyr: 1.302 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.356TrpAla: 1.356 ± 0.04	0.139TrpCys: 0.139 ± 0.012	0.781TrpAsp: 0.781 ± 0.027	0.722TrpGlu: 0.722 ± 0.032	0.594TrpPhe: 0.594 ± 0.028	0.995TrpGly: 0.995 ± 0.034	0.361TrpHis: 0.361 ± 0.016	0.723TrpIle: 0.723 ± 0.029	0.478TrpLys: 0.478 ± 0.023	1.752TrpLeu: 1.752 ± 0.051	0.386TrpMet: 0.386 ± 0.023	0.472TrpAsn: 0.472 ± 0.024	0.664TrpPro: 0.664 ± 0.024	0.655TrpGln: 0.655 ± 0.028	1.208TrpArg: 1.208 ± 0.038	0.872TrpSer: 0.872 ± 0.03	0.727TrpThr: 0.727 ± 0.034	0.859TrpVal: 0.859 ± 0.034	0.265TrpTrp: 0.265 ± 0.019	0.308TrpTyr: 0.308 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.551TyrAla: 2.551 ± 0.057	0.254TyrCys: 0.254 ± 0.018	1.554TyrAsp: 1.554 ± 0.044	1.343TyrGlu: 1.343 ± 0.041	0.88TyrPhe: 0.88 ± 0.04	2.108TyrGly: 2.108 ± 0.056	0.474TyrHis: 0.474 ± 0.023	0.941TyrIle: 0.941 ± 0.035	0.578TyrLys: 0.578 ± 0.028	2.076TyrLeu: 2.076 ± 0.054	0.393TyrMet: 0.393 ± 0.021	0.599TyrAsn: 0.599 ± 0.024	1.019TyrPro: 1.019 ± 0.034	0.712TyrGln: 0.712 ± 0.029	1.806TyrArg: 1.806 ± 0.051	1.299TyrSer: 1.299 ± 0.042	1.118TyrThr: 1.118 ± 0.038	1.454TyrVal: 1.454 ± 0.043	0.382TyrTrp: 0.382 ± 0.021	0.617TyrTyr: 0.617 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2999 proteins (928556 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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