Amino acid dipepetide frequency for Candidatus Cyclonatronum proteinivorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.691AlaAla: 8.691 ± 0.125	0.708AlaCys: 0.708 ± 0.027	5.109AlaAsp: 5.109 ± 0.071	6.264AlaGlu: 6.264 ± 0.09	4.349AlaPhe: 4.349 ± 0.068	7.573AlaGly: 7.573 ± 0.108	1.648AlaHis: 1.648 ± 0.044	4.455AlaIle: 4.455 ± 0.081	2.791AlaLys: 2.791 ± 0.067	8.637AlaLeu: 8.637 ± 0.117	1.916AlaMet: 1.916 ± 0.045	2.841AlaAsn: 2.841 ± 0.049	3.168AlaPro: 3.168 ± 0.062	3.635AlaGln: 3.635 ± 0.068	4.742AlaArg: 4.742 ± 0.075	4.934AlaSer: 4.934 ± 0.064	3.868AlaThr: 3.868 ± 0.056	5.816AlaVal: 5.816 ± 0.081	1.118AlaTrp: 1.118 ± 0.03	2.474AlaTyr: 2.474 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.532CysAla: 0.532 ± 0.022	0.126CysCys: 0.126 ± 0.011	0.384CysAsp: 0.384 ± 0.019	0.412CysGlu: 0.412 ± 0.017	0.341CysPhe: 0.341 ± 0.019	0.649CysGly: 0.649 ± 0.026	0.172CysHis: 0.172 ± 0.015	0.408CysIle: 0.408 ± 0.018	0.266CysLys: 0.266 ± 0.014	0.605CysLeu: 0.605 ± 0.026	0.169CysMet: 0.169 ± 0.01	0.26CysAsn: 0.26 ± 0.015	0.34CysPro: 0.34 ± 0.019	0.162CysGln: 0.162 ± 0.01	0.399CysArg: 0.399 ± 0.019	0.482CysSer: 0.482 ± 0.02	0.422CysThr: 0.422 ± 0.02	0.423CysVal: 0.423 ± 0.017	0.08CysTrp: 0.08 ± 0.008	0.211CysTyr: 0.211 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.74AspAla: 4.74 ± 0.063	0.294AspCys: 0.294 ± 0.016	3.246AspAsp: 3.246 ± 0.062	4.391AspGlu: 4.391 ± 0.068	3.377AspPhe: 3.377 ± 0.062	4.475AspGly: 4.475 ± 0.082	0.993AspHis: 0.993 ± 0.033	3.556AspIle: 3.556 ± 0.063	2.014AspLys: 2.014 ± 0.055	5.278AspLeu: 5.278 ± 0.078	1.284AspMet: 1.284 ± 0.037	1.977AspAsn: 1.977 ± 0.05	2.826AspPro: 2.826 ± 0.066	1.83AspGln: 1.83 ± 0.04	3.171AspArg: 3.171 ± 0.058	2.911AspSer: 2.911 ± 0.057	3.072AspThr: 3.072 ± 0.059	3.734AspVal: 3.734 ± 0.063	0.79AspTrp: 0.79 ± 0.028	1.841AspTyr: 1.841 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.725GluAla: 6.725 ± 0.097	0.262GluCys: 0.262 ± 0.015	3.31GluAsp: 3.31 ± 0.057	4.302GluGlu: 4.302 ± 0.073	2.492GluPhe: 2.492 ± 0.051	4.362GluGly: 4.362 ± 0.072	1.339GluHis: 1.339 ± 0.038	4.538GluIle: 4.538 ± 0.066	3.193GluLys: 3.193 ± 0.064	6.943GluLeu: 6.943 ± 0.091	1.722GluMet: 1.722 ± 0.043	3.12GluAsn: 3.12 ± 0.047	2.737GluPro: 2.737 ± 0.067	2.967GluGln: 2.967 ± 0.061	4.061GluArg: 4.061 ± 0.073	3.838GluSer: 3.838 ± 0.057	4.188GluThr: 4.188 ± 0.076	4.502GluVal: 4.502 ± 0.071	0.749GluTrp: 0.749 ± 0.026	1.792GluTyr: 1.792 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.918PheAla: 3.918 ± 0.064	0.373PheCys: 0.373 ± 0.018	3.326PheAsp: 3.326 ± 0.063	3.711PheGlu: 3.711 ± 0.053	2.755PhePhe: 2.755 ± 0.062	4.037PheGly: 4.037 ± 0.07	0.84PheHis: 0.84 ± 0.03	2.885PheIle: 2.885 ± 0.053	1.561PheLys: 1.561 ± 0.046	4.331PheLeu: 4.331 ± 0.063	1.266PheMet: 1.266 ± 0.034	2.272PheAsn: 2.272 ± 0.056	2.04PhePro: 2.04 ± 0.044	1.568PheGln: 1.568 ± 0.037	3.173PheArg: 3.173 ± 0.062	3.974PheSer: 3.974 ± 0.063	3.327PheThr: 3.327 ± 0.063	3.193PheVal: 3.193 ± 0.062	0.713PheTrp: 0.713 ± 0.026	1.587PheTyr: 1.587 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	5.667GlyAla: 5.667 ± 0.089	0.614GlyCys: 0.614 ± 0.024	3.796GlyAsp: 3.796 ± 0.069	4.478GlyGlu: 4.478 ± 0.079	4.378GlyPhe: 4.378 ± 0.072	5.554GlyGly: 5.554 ± 0.122	1.459GlyHis: 1.459 ± 0.037	5.11GlyIle: 5.11 ± 0.075	3.032GlyLys: 3.032 ± 0.068	7.53GlyLeu: 7.53 ± 0.092	2.039GlyMet: 2.039 ± 0.047	3.151GlyAsn: 3.151 ± 0.073	2.219GlyPro: 2.219 ± 0.051	2.626GlyGln: 2.626 ± 0.055	4.12GlyArg: 4.12 ± 0.073	5.097GlySer: 5.097 ± 0.103	4.662GlyThr: 4.662 ± 0.081	4.822GlyVal: 4.822 ± 0.069	1.072GlyTrp: 1.072 ± 0.033	2.558GlyTyr: 2.558 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.672HisAla: 1.672 ± 0.044	0.186HisCys: 0.186 ± 0.013	1.063HisAsp: 1.063 ± 0.032	1.313HisGlu: 1.313 ± 0.037	1.184HisPhe: 1.184 ± 0.032	1.393HisGly: 1.393 ± 0.042	0.624HisHis: 0.624 ± 0.029	1.395HisIle: 1.395 ± 0.038	0.866HisLys: 0.866 ± 0.026	1.987HisLeu: 1.987 ± 0.046	0.394HisMet: 0.394 ± 0.019	0.797HisAsn: 0.797 ± 0.028	1.38HisPro: 1.38 ± 0.037	0.864HisGln: 0.864 ± 0.031	1.148HisArg: 1.148 ± 0.031	1.187HisSer: 1.187 ± 0.035	1.201HisThr: 1.201 ± 0.032	1.151HisVal: 1.151 ± 0.029	0.234HisTrp: 0.234 ± 0.015	0.708HisTyr: 0.708 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.179IleAla: 5.179 ± 0.079	0.46IleCys: 0.46 ± 0.02	3.566IleAsp: 3.566 ± 0.066	4.008IleGlu: 4.008 ± 0.063	2.691IlePhe: 2.691 ± 0.057	4.451IleGly: 4.451 ± 0.074	1.207IleHis: 1.207 ± 0.03	3.731IleIle: 3.731 ± 0.066	2.287IleLys: 2.287 ± 0.049	5.229IleLeu: 5.229 ± 0.093	1.247IleMet: 1.247 ± 0.031	2.544IleAsn: 2.544 ± 0.054	3.273IlePro: 3.273 ± 0.053	2.16IleGln: 2.16 ± 0.044	4.253IleArg: 4.253 ± 0.069	4.619IleSer: 4.619 ± 0.066	4.063IleThr: 4.063 ± 0.058	3.545IleVal: 3.545 ± 0.064	0.656IleTrp: 0.656 ± 0.025	1.781IleTyr: 1.781 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	3.59LysAla: 3.59 ± 0.073	0.208LysCys: 0.208 ± 0.014	1.949LysAsp: 1.949 ± 0.047	2.641LysGlu: 2.641 ± 0.063	1.291LysPhe: 1.291 ± 0.038	2.536LysGly: 2.536 ± 0.061	0.894LysHis: 0.894 ± 0.029	2.456LysIle: 2.456 ± 0.054	2.681LysLys: 2.681 ± 0.067	4.07LysLeu: 4.07 ± 0.076	1.215LysMet: 1.215 ± 0.035	1.709LysAsn: 1.709 ± 0.047	2.155LysPro: 2.155 ± 0.055	1.586LysGln: 1.586 ± 0.049	2.265LysArg: 2.265 ± 0.059	2.489LysSer: 2.489 ± 0.062	2.55LysThr: 2.55 ± 0.058	2.364LysVal: 2.364 ± 0.047	0.463LysTrp: 0.463 ± 0.02	1.13LysTyr: 1.13 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	7.462LeuAla: 7.462 ± 0.087	0.777LeuCys: 0.777 ± 0.031	5.117LeuAsp: 5.117 ± 0.073	6.243LeuGlu: 6.243 ± 0.091	5.047LeuPhe: 5.047 ± 0.076	6.267LeuGly: 6.267 ± 0.088	2.252LeuHis: 2.252 ± 0.052	6.394LeuIle: 6.394 ± 0.095	4.356LeuLys: 4.356 ± 0.083	10.133LeuLeu: 10.133 ± 0.145	2.505LeuMet: 2.505 ± 0.046	4.453LeuAsn: 4.453 ± 0.074	5.064LeuPro: 5.064 ± 0.071	4.042LeuGln: 4.042 ± 0.065	6.277LeuArg: 6.277 ± 0.097	7.42LeuSer: 7.42 ± 0.094	6.108LeuThr: 6.108 ± 0.092	5.585LeuVal: 5.585 ± 0.079	1.059LeuTrp: 1.059 ± 0.037	2.86LeuTyr: 2.86 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.012MetAla: 2.012 ± 0.045	0.145MetCys: 0.145 ± 0.011	1.179MetAsp: 1.179 ± 0.031	1.416MetGlu: 1.416 ± 0.039	0.971MetPhe: 0.971 ± 0.033	1.587MetGly: 1.587 ± 0.038	0.547MetHis: 0.547 ± 0.021	1.429MetIle: 1.429 ± 0.039	1.315MetLys: 1.315 ± 0.039	2.695MetLeu: 2.695 ± 0.056	0.772MetMet: 0.772 ± 0.028	1.162MetAsn: 1.162 ± 0.03	1.256MetPro: 1.256 ± 0.031	1.099MetGln: 1.099 ± 0.03	1.489MetArg: 1.489 ± 0.045	1.609MetSer: 1.609 ± 0.036	1.172MetThr: 1.172 ± 0.031	1.523MetVal: 1.523 ± 0.04	0.184MetTrp: 0.184 ± 0.013	0.615MetTyr: 0.615 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.315AsnAla: 3.315 ± 0.053	0.262AsnCys: 0.262 ± 0.015	2.014AsnAsp: 2.014 ± 0.049	2.487AsnGlu: 2.487 ± 0.044	1.904AsnPhe: 1.904 ± 0.045	3.153AsnGly: 3.153 ± 0.067	0.876AsnHis: 0.876 ± 0.025	2.677AsnIle: 2.677 ± 0.058	1.509AsnLys: 1.509 ± 0.045	4.011AsnLeu: 4.011 ± 0.06	1.054AsnMet: 1.054 ± 0.035	1.761AsnAsn: 1.761 ± 0.055	3.078AsnPro: 3.078 ± 0.06	1.692AsnGln: 1.692 ± 0.045	2.766AsnArg: 2.766 ± 0.051	2.303AsnSer: 2.303 ± 0.054	2.486AsnThr: 2.486 ± 0.055	2.448AsnVal: 2.448 ± 0.053	0.624AsnTrp: 0.624 ± 0.022	1.417AsnTyr: 1.417 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	4.382ProAla: 4.382 ± 0.08	0.246ProCys: 0.246 ± 0.014	3.793ProAsp: 3.793 ± 0.061	4.529ProGlu: 4.529 ± 0.074	2.392ProPhe: 2.392 ± 0.046	3.813ProGly: 3.813 ± 0.081	0.943ProHis: 0.943 ± 0.032	2.021ProIle: 2.021 ± 0.042	1.624ProLys: 1.624 ± 0.048	4.09ProLeu: 4.09 ± 0.064	0.895ProMet: 0.895 ± 0.027	1.876ProAsn: 1.876 ± 0.041	1.71ProPro: 1.71 ± 0.045	1.789ProGln: 1.789 ± 0.043	1.848ProArg: 1.848 ± 0.044	2.336ProSer: 2.336 ± 0.045	1.899ProThr: 1.899 ± 0.041	4.123ProVal: 4.123 ± 0.07	0.511ProTrp: 0.511 ± 0.02	1.345ProTyr: 1.345 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.604GlnAla: 3.604 ± 0.064	0.151GlnCys: 0.151 ± 0.01	1.781GlnAsp: 1.781 ± 0.039	2.313GlnGlu: 2.313 ± 0.047	1.74GlnPhe: 1.74 ± 0.042	2.241GlnGly: 2.241 ± 0.044	0.959GlnHis: 0.959 ± 0.028	2.321GlnIle: 2.321 ± 0.044	1.78GlnLys: 1.78 ± 0.046	4.456GlnLeu: 4.456 ± 0.081	0.883GlnMet: 0.883 ± 0.028	1.831GlnAsn: 1.831 ± 0.041	1.914GlnPro: 1.914 ± 0.045	2.345GlnGln: 2.345 ± 0.073	2.425GlnArg: 2.425 ± 0.049	2.164GlnSer: 2.164 ± 0.046	2.377GlnThr: 2.377 ± 0.045	2.346GlnVal: 2.346 ± 0.047	0.432GlnTrp: 0.432 ± 0.021	1.025GlnTyr: 1.025 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	4.376ArgAla: 4.376 ± 0.069	0.342ArgCys: 0.342 ± 0.018	3.271ArgAsp: 3.271 ± 0.065	4.052ArgGlu: 4.052 ± 0.078	3.586ArgPhe: 3.586 ± 0.067	3.386ArgGly: 3.386 ± 0.058	1.245ArgHis: 1.245 ± 0.036	4.141ArgIle: 4.141 ± 0.063	2.757ArgLys: 2.757 ± 0.059	6.259ArgLeu: 6.259 ± 0.083	1.636ArgMet: 1.636 ± 0.041	2.861ArgAsn: 2.861 ± 0.058	2.322ArgPro: 2.322 ± 0.048	2.422ArgGln: 2.422 ± 0.052	3.295ArgArg: 3.295 ± 0.068	3.45ArgSer: 3.45 ± 0.052	3.158ArgThr: 3.158 ± 0.057	3.781ArgVal: 3.781 ± 0.06	0.734ArgTrp: 0.734 ± 0.029	2.224ArgTyr: 2.224 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	5.358SerAla: 5.358 ± 0.079	0.513SerCys: 0.513 ± 0.023	3.599SerAsp: 3.599 ± 0.062	4.111SerGlu: 4.111 ± 0.067	3.542SerPhe: 3.542 ± 0.067	6.364SerGly: 6.364 ± 0.109	1.122SerHis: 1.122 ± 0.033	3.423SerIle: 3.423 ± 0.051	2.247SerLys: 2.247 ± 0.059	6.212SerLeu: 6.212 ± 0.089	1.421SerMet: 1.421 ± 0.036	2.363SerAsn: 2.363 ± 0.057	2.901SerPro: 2.901 ± 0.049	2.007SerGln: 2.007 ± 0.045	3.814SerArg: 3.814 ± 0.058	3.783SerSer: 3.783 ± 0.067	3.214SerThr: 3.214 ± 0.056	4.465SerVal: 4.465 ± 0.067	0.983SerTrp: 0.983 ± 0.031	2.0SerTyr: 2.0 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.128ThrAla: 5.128 ± 0.077	0.309ThrCys: 0.309 ± 0.018	3.629ThrAsp: 3.629 ± 0.055	3.892ThrGlu: 3.892 ± 0.058	2.908ThrPhe: 2.908 ± 0.061	5.407ThrGly: 5.407 ± 0.079	1.176ThrHis: 1.176 ± 0.031	3.43ThrIle: 3.43 ± 0.059	1.744ThrLys: 1.744 ± 0.042	5.768ThrLeu: 5.768 ± 0.087	1.059ThrMet: 1.059 ± 0.034	2.209ThrAsn: 2.209 ± 0.054	2.887ThrPro: 2.887 ± 0.053	1.997ThrGln: 1.997 ± 0.04	3.041ThrArg: 3.041 ± 0.054	3.209ThrSer: 3.209 ± 0.055	2.982ThrThr: 2.982 ± 0.058	3.853ThrVal: 3.853 ± 0.068	0.664ThrTrp: 0.664 ± 0.026	1.844ThrTyr: 1.844 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	4.991ValAla: 4.991 ± 0.064	0.531ValCys: 0.531 ± 0.021	3.077ValAsp: 3.077 ± 0.059	3.728ValGlu: 3.728 ± 0.052	3.529ValPhe: 3.529 ± 0.054	3.686ValGly: 3.686 ± 0.076	1.367ValHis: 1.367 ± 0.035	4.144ValIle: 4.144 ± 0.065	2.585ValLys: 2.585 ± 0.056	6.658ValLeu: 6.658 ± 0.083	1.71ValMet: 1.71 ± 0.046	2.77ValAsn: 2.77 ± 0.053	3.037ValPro: 3.037 ± 0.06	2.505ValGln: 2.505 ± 0.049	4.077ValArg: 4.077 ± 0.059	4.988ValSer: 4.988 ± 0.077	3.946ValThr: 3.946 ± 0.076	4.356ValVal: 4.356 ± 0.083	0.813ValTrp: 0.813 ± 0.029	2.108ValTyr: 2.108 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.849TrpAla: 0.849 ± 0.028	0.099TrpCys: 0.099 ± 0.01	0.726TrpAsp: 0.726 ± 0.029	0.788TrpGlu: 0.788 ± 0.026	0.689TrpPhe: 0.689 ± 0.025	0.813TrpGly: 0.813 ± 0.03	0.353TrpHis: 0.353 ± 0.02	0.745TrpIle: 0.745 ± 0.029	0.474TrpLys: 0.474 ± 0.022	1.38TrpLeu: 1.38 ± 0.039	0.373TrpMet: 0.373 ± 0.021	0.59TrpAsn: 0.59 ± 0.024	0.423TrpPro: 0.423 ± 0.023	0.653TrpGln: 0.653 ± 0.026	0.734TrpArg: 0.734 ± 0.026	0.729TrpSer: 0.729 ± 0.03	0.637TrpThr: 0.637 ± 0.025	0.778TrpVal: 0.778 ± 0.026	0.173TrpTrp: 0.173 ± 0.013	0.466TrpTyr: 0.466 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.546TyrAla: 2.546 ± 0.042	0.24TyrCys: 0.24 ± 0.016	1.865TyrAsp: 1.865 ± 0.042	2.065TyrGlu: 2.065 ± 0.042	1.683TyrPhe: 1.683 ± 0.037	2.233TyrGly: 2.233 ± 0.044	0.73TyrHis: 0.73 ± 0.027	1.691TyrIle: 1.691 ± 0.041	1.158TyrLys: 1.158 ± 0.037	3.153TyrLeu: 3.153 ± 0.064	0.619TyrMet: 0.619 ± 0.024	1.291TyrAsn: 1.291 ± 0.033	1.434TyrPro: 1.434 ± 0.036	1.137TyrGln: 1.137 ± 0.031	2.199TyrArg: 2.199 ± 0.051	1.921TyrSer: 1.921 ± 0.045	1.802TyrThr: 1.802 ± 0.042	1.799TyrVal: 1.799 ± 0.041	0.421TyrTrp: 0.421 ± 0.02	1.083TyrTyr: 1.083 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3251 proteins (1202591 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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