Amino acid dipepetide frequency for Streptococcus phage Javan527

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.456AlaAla: 4.456 ± 1.23
0.371AlaCys: 0.371 ± 0.184
4.159AlaAsp: 4.159 ± 0.656
5.644AlaGlu: 5.644 ± 0.688
3.268AlaPhe: 3.268 ± 0.635
3.936AlaGly: 3.936 ± 1.146
0.668AlaHis: 0.668 ± 0.217
5.941AlaIle: 5.941 ± 0.978
7.427AlaLys: 7.427 ± 1.076
5.347AlaLeu: 5.347 ± 0.561
2.451AlaMet: 2.451 ± 0.636
3.936AlaAsn: 3.936 ± 0.454
0.965AlaPro: 0.965 ± 0.287
2.896AlaGln: 2.896 ± 0.597
2.822AlaArg: 2.822 ± 0.406
3.936AlaSer: 3.936 ± 1.151
4.902AlaThr: 4.902 ± 0.916
4.753AlaVal: 4.753 ± 1.178
0.743AlaTrp: 0.743 ± 0.251
1.782AlaTyr: 1.782 ± 0.377
0.0AlaXaa: 0.0 ± 0.0
Cys
0.149CysAla: 0.149 ± 0.105
0.074CysCys: 0.074 ± 0.086
0.446CysAsp: 0.446 ± 0.162
0.446CysGlu: 0.446 ± 0.218
0.149CysPhe: 0.149 ± 0.116
0.297CysGly: 0.297 ± 0.163
0.149CysHis: 0.149 ± 0.101
0.223CysIle: 0.223 ± 0.138
0.149CysLys: 0.149 ± 0.112
0.817CysLeu: 0.817 ± 0.23
0.149CysMet: 0.149 ± 0.132
0.074CysAsn: 0.074 ± 0.095
0.074CysPro: 0.074 ± 0.071
0.074CysGln: 0.074 ± 0.086
0.52CysArg: 0.52 ± 0.173
0.223CysSer: 0.223 ± 0.158
0.223CysThr: 0.223 ± 0.132
0.371CysVal: 0.371 ± 0.159
0.074CysTrp: 0.074 ± 0.076
0.371CysTyr: 0.371 ± 0.167
0.0CysXaa: 0.0 ± 0.0
Asp
3.565AspAla: 3.565 ± 0.519
0.594AspCys: 0.594 ± 0.222
3.788AspAsp: 3.788 ± 0.646
4.53AspGlu: 4.53 ± 0.65
3.342AspPhe: 3.342 ± 0.52
4.679AspGly: 4.679 ± 0.664
0.668AspHis: 0.668 ± 0.209
4.456AspIle: 4.456 ± 0.644
6.758AspLys: 6.758 ± 0.692
5.421AspLeu: 5.421 ± 0.677
1.708AspMet: 1.708 ± 0.381
3.565AspAsn: 3.565 ± 0.524
1.114AspPro: 1.114 ± 0.251
1.114AspGln: 1.114 ± 0.31
2.377AspArg: 2.377 ± 0.491
4.159AspSer: 4.159 ± 0.542
3.342AspThr: 3.342 ± 0.577
4.605AspVal: 4.605 ± 0.506
0.743AspTrp: 0.743 ± 0.266
3.268AspTyr: 3.268 ± 0.57
0.0AspXaa: 0.0 ± 0.0
Glu
4.679GluAla: 4.679 ± 0.624
0.223GluCys: 0.223 ± 0.148
3.862GluAsp: 3.862 ± 0.727
6.461GluGlu: 6.461 ± 0.949
3.119GluPhe: 3.119 ± 0.452
3.119GluGly: 3.119 ± 0.421
1.04GluHis: 1.04 ± 0.307
5.793GluIle: 5.793 ± 0.748
6.61GluLys: 6.61 ± 0.73
8.986GluLeu: 8.986 ± 1.019
2.674GluMet: 2.674 ± 0.457
3.416GluAsn: 3.416 ± 0.578
2.154GluPro: 2.154 ± 0.501
3.119GluGln: 3.119 ± 0.488
2.896GluArg: 2.896 ± 0.446
4.307GluSer: 4.307 ± 0.492
4.53GluThr: 4.53 ± 0.74
5.05GluVal: 5.05 ± 0.935
0.668GluTrp: 0.668 ± 0.259
3.639GluTyr: 3.639 ± 0.657
0.0GluXaa: 0.0 ± 0.0
Phe
2.525PheAla: 2.525 ± 0.599
0.223PheCys: 0.223 ± 0.133
3.565PheAsp: 3.565 ± 0.495
3.119PheGlu: 3.119 ± 0.469
0.965PhePhe: 0.965 ± 0.287
3.565PheGly: 3.565 ± 0.609
0.668PheHis: 0.668 ± 0.227
2.079PheIle: 2.079 ± 0.497
3.565PheLys: 3.565 ± 0.467
2.302PheLeu: 2.302 ± 0.387
1.04PheMet: 1.04 ± 0.306
2.228PheAsn: 2.228 ± 0.442
0.743PhePro: 0.743 ± 0.263
1.114PheGln: 1.114 ± 0.335
1.782PheArg: 1.782 ± 0.379
2.896PheSer: 2.896 ± 0.53
1.782PheThr: 1.782 ± 0.328
2.748PheVal: 2.748 ± 0.408
0.52PheTrp: 0.52 ± 0.202
1.337PheTyr: 1.337 ± 0.304
0.0PheXaa: 0.0 ± 0.0
Gly
4.085GlyAla: 4.085 ± 1.372
0.297GlyCys: 0.297 ± 0.18
3.565GlyAsp: 3.565 ± 0.603
3.491GlyGlu: 3.491 ± 0.453
2.377GlyPhe: 2.377 ± 0.541
3.639GlyGly: 3.639 ± 0.687
0.891GlyHis: 0.891 ± 0.261
3.713GlyIle: 3.713 ± 0.773
5.719GlyLys: 5.719 ± 0.627
6.09GlyLeu: 6.09 ± 1.093
2.228GlyMet: 2.228 ± 0.338
3.416GlyAsn: 3.416 ± 0.47
0.668GlyPro: 0.668 ± 0.245
2.525GlyGln: 2.525 ± 0.516
2.302GlyArg: 2.302 ± 0.425
3.119GlySer: 3.119 ± 0.588
4.01GlyThr: 4.01 ± 0.544
4.159GlyVal: 4.159 ± 0.563
0.817GlyTrp: 0.817 ± 0.391
3.045GlyTyr: 3.045 ± 0.62
0.0GlyXaa: 0.0 ± 0.0
His
1.188HisAla: 1.188 ± 0.407
0.074HisCys: 0.074 ± 0.081
0.52HisAsp: 0.52 ± 0.223
1.263HisGlu: 1.263 ± 0.302
0.817HisPhe: 0.817 ± 0.205
0.965HisGly: 0.965 ± 0.233
0.074HisHis: 0.074 ± 0.073
1.114HisIle: 1.114 ± 0.368
0.965HisLys: 0.965 ± 0.253
0.891HisLeu: 0.891 ± 0.271
0.074HisMet: 0.074 ± 0.069
0.817HisAsn: 0.817 ± 0.264
0.446HisPro: 0.446 ± 0.165
1.04HisGln: 1.04 ± 0.266
0.668HisArg: 0.668 ± 0.175
1.188HisSer: 1.188 ± 0.354
0.965HisThr: 0.965 ± 0.222
0.965HisVal: 0.965 ± 0.255
0.223HisTrp: 0.223 ± 0.127
0.52HisTyr: 0.52 ± 0.195
0.0HisXaa: 0.0 ± 0.0
Ile
4.605IleAla: 4.605 ± 0.631
0.297IleCys: 0.297 ± 0.151
5.199IleAsp: 5.199 ± 0.702
4.902IleGlu: 4.902 ± 0.582
1.782IlePhe: 1.782 ± 0.39
4.902IleGly: 4.902 ± 0.649
1.114IleHis: 1.114 ± 0.316
4.679IleIle: 4.679 ± 0.616
6.907IleLys: 6.907 ± 0.801
4.456IleLeu: 4.456 ± 0.567
1.337IleMet: 1.337 ± 0.318
5.496IleAsn: 5.496 ± 0.711
2.228IlePro: 2.228 ± 0.442
2.228IleGln: 2.228 ± 0.356
2.822IleArg: 2.822 ± 0.43
5.05IleSer: 5.05 ± 0.843
5.347IleThr: 5.347 ± 0.536
3.416IleVal: 3.416 ± 0.444
0.594IleTrp: 0.594 ± 0.198
2.674IleTyr: 2.674 ± 0.509
0.0IleXaa: 0.0 ± 0.0
Lys
6.09LysAla: 6.09 ± 0.63
0.297LysCys: 0.297 ± 0.135
4.753LysAsp: 4.753 ± 0.543
7.055LysGlu: 7.055 ± 0.792
3.193LysPhe: 3.193 ± 0.503
3.788LysGly: 3.788 ± 0.576
1.782LysHis: 1.782 ± 0.386
7.798LysIle: 7.798 ± 0.759
7.575LysLys: 7.575 ± 1.01
8.021LysLeu: 8.021 ± 0.818
3.491LysMet: 3.491 ± 0.434
4.902LysAsn: 4.902 ± 0.597
1.56LysPro: 1.56 ± 0.447
5.496LysGln: 5.496 ± 0.712
4.382LysArg: 4.382 ± 0.633
5.941LysSer: 5.941 ± 0.559
5.57LysThr: 5.57 ± 0.561
6.387LysVal: 6.387 ± 0.895
1.114LysTrp: 1.114 ± 0.331
2.451LysTyr: 2.451 ± 0.525
0.0LysXaa: 0.0 ± 0.0
Leu
6.387LeuAla: 6.387 ± 0.851
0.074LeuCys: 0.074 ± 0.076
7.278LeuAsp: 7.278 ± 0.733
8.244LeuGlu: 8.244 ± 0.686
2.525LeuPhe: 2.525 ± 0.438
5.347LeuGly: 5.347 ± 1.002
0.668LeuHis: 0.668 ± 0.208
5.644LeuIle: 5.644 ± 0.857
8.095LeuLys: 8.095 ± 1.124
7.13LeuLeu: 7.13 ± 0.997
2.005LeuMet: 2.005 ± 0.472
4.456LeuAsn: 4.456 ± 0.737
2.302LeuPro: 2.302 ± 0.423
3.491LeuGln: 3.491 ± 0.503
3.639LeuArg: 3.639 ± 0.622
5.347LeuSer: 5.347 ± 0.669
5.496LeuThr: 5.496 ± 0.52
4.976LeuVal: 4.976 ± 0.573
0.446LeuTrp: 0.446 ± 0.16
2.154LeuTyr: 2.154 ± 0.496
0.0LeuXaa: 0.0 ± 0.0
Met
3.639MetAla: 3.639 ± 0.642
0.0MetCys: 0.0 ± 0.0
1.857MetAsp: 1.857 ± 0.392
1.857MetGlu: 1.857 ± 0.382
0.743MetPhe: 0.743 ± 0.264
0.817MetGly: 0.817 ± 0.284
0.297MetHis: 0.297 ± 0.142
1.931MetIle: 1.931 ± 0.316
1.411MetLys: 1.411 ± 0.345
2.377MetLeu: 2.377 ± 0.383
0.891MetMet: 0.891 ± 0.326
0.965MetAsn: 0.965 ± 0.302
0.965MetPro: 0.965 ± 0.246
2.005MetGln: 2.005 ± 0.386
1.634MetArg: 1.634 ± 0.272
1.634MetSer: 1.634 ± 0.311
2.748MetThr: 2.748 ± 0.43
0.965MetVal: 0.965 ± 0.317
0.074MetTrp: 0.074 ± 0.082
0.743MetTyr: 0.743 ± 0.218
0.0MetXaa: 0.0 ± 0.0
Asn
4.233AsnAla: 4.233 ± 0.623
0.371AsnCys: 0.371 ± 0.141
2.525AsnAsp: 2.525 ± 0.426
3.342AsnGlu: 3.342 ± 0.617
2.302AsnPhe: 2.302 ± 0.412
3.862AsnGly: 3.862 ± 0.503
1.337AsnHis: 1.337 ± 0.297
3.788AsnIle: 3.788 ± 0.548
4.307AsnLys: 4.307 ± 0.594
4.456AsnLeu: 4.456 ± 0.47
1.634AsnMet: 1.634 ± 0.423
2.005AsnAsn: 2.005 ± 0.5
2.079AsnPro: 2.079 ± 0.442
2.525AsnGln: 2.525 ± 0.495
2.079AsnArg: 2.079 ± 0.462
3.268AsnSer: 3.268 ± 0.536
2.674AsnThr: 2.674 ± 0.564
2.525AsnVal: 2.525 ± 0.406
0.891AsnTrp: 0.891 ± 0.248
1.931AsnTyr: 1.931 ± 0.407
0.0AsnXaa: 0.0 ± 0.0
Pro
1.188ProAla: 1.188 ± 0.327
0.074ProCys: 0.074 ± 0.076
1.708ProAsp: 1.708 ± 0.373
1.857ProGlu: 1.857 ± 0.391
1.188ProPhe: 1.188 ± 0.397
0.965ProGly: 0.965 ± 0.264
0.52ProHis: 0.52 ± 0.251
1.708ProIle: 1.708 ± 0.376
2.599ProLys: 2.599 ± 0.462
1.56ProLeu: 1.56 ± 0.372
0.594ProMet: 0.594 ± 0.159
0.965ProAsn: 0.965 ± 0.33
0.891ProPro: 0.891 ± 0.276
1.411ProGln: 1.411 ± 0.321
1.263ProArg: 1.263 ± 0.394
1.337ProSer: 1.337 ± 0.288
1.708ProThr: 1.708 ± 0.301
1.56ProVal: 1.56 ± 0.401
0.297ProTrp: 0.297 ± 0.128
0.965ProTyr: 0.965 ± 0.3
0.0ProXaa: 0.0 ± 0.0
Gln
3.788GlnAla: 3.788 ± 0.864
0.297GlnCys: 0.297 ± 0.17
1.931GlnAsp: 1.931 ± 0.346
2.896GlnGlu: 2.896 ± 0.519
1.337GlnPhe: 1.337 ± 0.36
2.896GlnGly: 2.896 ± 0.506
0.371GlnHis: 0.371 ± 0.168
3.119GlnIle: 3.119 ± 0.531
4.605GlnLys: 4.605 ± 0.602
3.639GlnLeu: 3.639 ± 0.519
1.04GlnMet: 1.04 ± 0.283
3.045GlnAsn: 3.045 ± 0.592
1.188GlnPro: 1.188 ± 0.271
2.302GlnGln: 2.302 ± 0.477
1.708GlnArg: 1.708 ± 0.348
3.639GlnSer: 3.639 ± 0.693
2.377GlnThr: 2.377 ± 0.483
2.079GlnVal: 2.079 ± 0.411
0.223GlnTrp: 0.223 ± 0.132
1.188GlnTyr: 1.188 ± 0.281
0.0GlnXaa: 0.0 ± 0.0
Arg
3.119ArgAla: 3.119 ± 0.402
0.223ArgCys: 0.223 ± 0.142
2.005ArgAsp: 2.005 ± 0.359
2.822ArgGlu: 2.822 ± 0.598
1.114ArgPhe: 1.114 ± 0.295
2.228ArgGly: 2.228 ± 0.354
0.668ArgHis: 0.668 ± 0.327
3.639ArgIle: 3.639 ± 0.521
3.713ArgLys: 3.713 ± 0.664
4.456ArgLeu: 4.456 ± 0.484
1.485ArgMet: 1.485 ± 0.319
2.302ArgAsn: 2.302 ± 0.451
0.891ArgPro: 0.891 ± 0.253
1.708ArgGln: 1.708 ± 0.316
2.377ArgArg: 2.377 ± 0.458
1.931ArgSer: 1.931 ± 0.427
1.931ArgThr: 1.931 ± 0.329
2.451ArgVal: 2.451 ± 0.475
0.668ArgTrp: 0.668 ± 0.221
1.931ArgTyr: 1.931 ± 0.436
0.0ArgXaa: 0.0 ± 0.0
Ser
5.05SerAla: 5.05 ± 1.626
0.223SerCys: 0.223 ± 0.143
3.788SerAsp: 3.788 ± 0.469
5.124SerGlu: 5.124 ± 0.598
2.599SerPhe: 2.599 ± 0.441
3.862SerGly: 3.862 ± 0.79
1.04SerHis: 1.04 ± 0.287
4.233SerIle: 4.233 ± 0.602
6.387SerLys: 6.387 ± 0.796
4.53SerLeu: 4.53 ± 0.568
1.485SerMet: 1.485 ± 0.525
3.639SerAsn: 3.639 ± 0.569
0.891SerPro: 0.891 ± 0.198
3.936SerGln: 3.936 ± 0.738
2.079SerArg: 2.079 ± 0.345
4.233SerSer: 4.233 ± 1.059
3.045SerThr: 3.045 ± 0.55
3.936SerVal: 3.936 ± 0.581
0.817SerTrp: 0.817 ± 0.257
2.228SerTyr: 2.228 ± 0.445
0.0SerXaa: 0.0 ± 0.0
Thr
4.827ThrAla: 4.827 ± 0.878
0.297ThrCys: 0.297 ± 0.178
4.605ThrAsp: 4.605 ± 0.618
4.53ThrGlu: 4.53 ± 0.828
3.491ThrPhe: 3.491 ± 0.579
5.124ThrGly: 5.124 ± 0.741
1.04ThrHis: 1.04 ± 0.279
3.936ThrIle: 3.936 ± 0.495
5.867ThrLys: 5.867 ± 0.839
5.941ThrLeu: 5.941 ± 0.668
0.965ThrMet: 0.965 ± 0.232
2.154ThrAsn: 2.154 ± 0.414
2.302ThrPro: 2.302 ± 0.464
2.079ThrGln: 2.079 ± 0.387
1.411ThrArg: 1.411 ± 0.273
3.491ThrSer: 3.491 ± 0.351
4.456ThrThr: 4.456 ± 0.689
4.53ThrVal: 4.53 ± 0.62
0.594ThrTrp: 0.594 ± 0.338
1.634ThrTyr: 1.634 ± 0.427
0.0ThrXaa: 0.0 ± 0.0
Val
4.382ValAla: 4.382 ± 1.03
0.668ValCys: 0.668 ± 0.257
5.124ValAsp: 5.124 ± 0.55
5.719ValGlu: 5.719 ± 0.877
2.451ValPhe: 2.451 ± 0.468
3.936ValGly: 3.936 ± 0.653
0.594ValHis: 0.594 ± 0.187
3.416ValIle: 3.416 ± 0.49
4.53ValLys: 4.53 ± 0.619
4.456ValLeu: 4.456 ± 0.6
1.337ValMet: 1.337 ± 0.406
2.896ValAsn: 2.896 ± 0.375
1.857ValPro: 1.857 ± 0.314
2.005ValGln: 2.005 ± 0.361
2.377ValArg: 2.377 ± 0.478
4.382ValSer: 4.382 ± 0.678
5.124ValThr: 5.124 ± 0.635
4.679ValVal: 4.679 ± 0.592
0.371ValTrp: 0.371 ± 0.147
1.782ValTyr: 1.782 ± 0.438
0.0ValXaa: 0.0 ± 0.0
Trp
0.52TrpAla: 0.52 ± 0.17
0.0TrpCys: 0.0 ± 0.0
0.668TrpAsp: 0.668 ± 0.215
0.743TrpGlu: 0.743 ± 0.203
0.668TrpPhe: 0.668 ± 0.217
0.594TrpGly: 0.594 ± 0.278
0.223TrpHis: 0.223 ± 0.135
0.446TrpIle: 0.446 ± 0.172
1.04TrpLys: 1.04 ± 0.308
1.708TrpLeu: 1.708 ± 0.535
0.52TrpMet: 0.52 ± 0.197
0.52TrpAsn: 0.52 ± 0.204
0.149TrpPro: 0.149 ± 0.105
0.297TrpGln: 0.297 ± 0.136
0.817TrpArg: 0.817 ± 0.243
0.594TrpSer: 0.594 ± 0.195
0.223TrpThr: 0.223 ± 0.123
0.297TrpVal: 0.297 ± 0.142
0.074TrpTrp: 0.074 ± 0.066
0.074TrpTyr: 0.074 ± 0.073
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.931TyrAla: 1.931 ± 0.393
0.371TyrCys: 0.371 ± 0.158
2.451TyrAsp: 2.451 ± 0.506
2.302TyrGlu: 2.302 ± 0.341
1.337TyrPhe: 1.337 ± 0.319
1.634TyrGly: 1.634 ± 0.337
0.965TyrHis: 0.965 ± 0.281
2.377TyrIle: 2.377 ± 0.383
3.491TyrLys: 3.491 ± 0.72
3.119TyrLeu: 3.119 ± 0.558
0.371TyrMet: 0.371 ± 0.175
1.337TyrAsn: 1.337 ± 0.342
0.891TyrPro: 0.891 ± 0.281
2.302TyrGln: 2.302 ± 0.464
1.708TyrArg: 1.708 ± 0.513
2.451TyrSer: 2.451 ± 0.448
2.822TyrThr: 2.822 ± 0.564
1.634TyrVal: 1.634 ± 0.339
0.223TyrTrp: 0.223 ± 0.113
1.56TyrTyr: 1.56 ± 0.374
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 75 proteins (13466 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski