Amino acid dipepetide frequency for Shrew coronavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.249AlaAla: 3.249 ± 1.166
1.324AlaCys: 1.324 ± 0.507
2.166AlaAsp: 2.166 ± 0.55
2.287AlaGlu: 2.287 ± 0.748
2.287AlaPhe: 2.287 ± 1.216
3.37AlaGly: 3.37 ± 0.762
0.842AlaHis: 0.842 ± 0.459
3.129AlaIle: 3.129 ± 0.757
3.731AlaLys: 3.731 ± 1.081
4.092AlaLeu: 4.092 ± 1.218
1.805AlaMet: 1.805 ± 0.949
2.648AlaAsn: 2.648 ± 0.87
2.287AlaPro: 2.287 ± 0.559
2.166AlaGln: 2.166 ± 0.728
2.287AlaArg: 2.287 ± 0.37
3.009AlaSer: 3.009 ± 0.637
3.249AlaThr: 3.249 ± 0.658
5.897AlaVal: 5.897 ± 1.492
0.241AlaTrp: 0.241 ± 0.131
1.926AlaTyr: 1.926 ± 0.439
0.0AlaXaa: 0.0 ± 0.0
Cys
2.046CysAla: 2.046 ± 0.647
2.166CysCys: 2.166 ± 1.219
2.527CysAsp: 2.527 ± 0.828
0.963CysGlu: 0.963 ± 0.329
3.009CysPhe: 3.009 ± 0.892
2.768CysGly: 2.768 ± 0.892
0.481CysHis: 0.481 ± 0.419
1.565CysIle: 1.565 ± 0.503
2.046CysLys: 2.046 ± 0.879
1.805CysLeu: 1.805 ± 0.906
0.481CysMet: 0.481 ± 0.176
2.648CysAsn: 2.648 ± 0.646
0.602CysPro: 0.602 ± 0.328
0.602CysGln: 0.602 ± 0.194
0.602CysArg: 0.602 ± 0.328
2.166CysSer: 2.166 ± 0.688
2.648CysThr: 2.648 ± 0.704
4.694CysVal: 4.694 ± 1.03
0.722CysTrp: 0.722 ± 0.393
1.805CysTyr: 1.805 ± 0.758
0.0CysXaa: 0.0 ± 0.0
Asp
2.648AspAla: 2.648 ± 0.88
2.287AspCys: 2.287 ± 0.832
3.972AspAsp: 3.972 ± 0.675
1.926AspGlu: 1.926 ± 0.964
2.768AspPhe: 2.768 ± 1.274
4.453AspGly: 4.453 ± 1.673
0.963AspHis: 0.963 ± 0.271
2.527AspIle: 2.527 ± 0.5
3.009AspLys: 3.009 ± 0.766
5.777AspLeu: 5.777 ± 1.007
0.842AspMet: 0.842 ± 0.459
4.453AspAsn: 4.453 ± 1.605
2.046AspPro: 2.046 ± 0.428
1.805AspGln: 1.805 ± 1.627
1.685AspArg: 1.685 ± 1.224
3.129AspSer: 3.129 ± 0.947
3.49AspThr: 3.49 ± 1.005
6.74AspVal: 6.74 ± 2.139
0.602AspTrp: 0.602 ± 0.328
3.731AspTyr: 3.731 ± 1.266
0.0AspXaa: 0.0 ± 0.0
Glu
2.407GluAla: 2.407 ± 0.582
1.083GluCys: 1.083 ± 0.386
1.926GluAsp: 1.926 ± 0.822
3.851GluGlu: 3.851 ± 0.929
2.166GluPhe: 2.166 ± 1.103
1.444GluGly: 1.444 ± 0.611
0.963GluHis: 0.963 ± 0.524
1.565GluIle: 1.565 ± 0.953
3.249GluLys: 3.249 ± 0.718
2.768GluLeu: 2.768 ± 1.052
0.722GluMet: 0.722 ± 0.393
2.648GluAsn: 2.648 ± 0.559
1.204GluPro: 1.204 ± 0.446
2.287GluGln: 2.287 ± 1.425
1.204GluArg: 1.204 ± 0.387
2.407GluSer: 2.407 ± 0.582
2.527GluThr: 2.527 ± 0.513
3.37GluVal: 3.37 ± 1.677
0.361GluTrp: 0.361 ± 0.619
0.963GluTyr: 0.963 ± 0.524
0.0GluXaa: 0.0 ± 0.0
Phe
2.166PheAla: 2.166 ± 0.986
2.648PheCys: 2.648 ± 0.88
4.694PheAsp: 4.694 ± 1.152
2.527PheGlu: 2.527 ± 0.704
2.527PhePhe: 2.527 ± 0.681
3.129PheGly: 3.129 ± 1.688
0.241PheHis: 0.241 ± 0.655
2.768PheIle: 2.768 ± 1.406
3.49PheLys: 3.49 ± 1.214
3.37PheLeu: 3.37 ± 1.045
0.722PheMet: 0.722 ± 0.628
3.611PheAsn: 3.611 ± 1.466
0.842PhePro: 0.842 ± 0.389
1.565PheGln: 1.565 ± 0.852
0.963PheArg: 0.963 ± 0.271
3.611PheSer: 3.611 ± 1.018
3.731PheThr: 3.731 ± 0.892
5.536PheVal: 5.536 ± 1.953
0.963PheTrp: 0.963 ± 0.494
2.888PheTyr: 2.888 ± 0.66
0.0PheXaa: 0.0 ± 0.0
Gly
1.685GlyAla: 1.685 ± 0.704
2.407GlyCys: 2.407 ± 1.293
4.453GlyAsp: 4.453 ± 1.075
2.166GlyGlu: 2.166 ± 0.691
3.972GlyPhe: 3.972 ± 1.258
3.37GlyGly: 3.37 ± 0.834
0.722GlyHis: 0.722 ± 0.229
2.648GlyIle: 2.648 ± 1.001
4.212GlyLys: 4.212 ± 1.591
4.694GlyLeu: 4.694 ± 1.202
1.083GlyMet: 1.083 ± 0.873
2.888GlyAsn: 2.888 ± 0.821
1.685GlyPro: 1.685 ± 0.458
1.204GlyGln: 1.204 ± 0.315
1.204GlyArg: 1.204 ± 0.387
5.055GlySer: 5.055 ± 1.239
3.37GlyThr: 3.37 ± 1.622
6.86GlyVal: 6.86 ± 0.836
0.602GlyTrp: 0.602 ± 0.194
2.888GlyTyr: 2.888 ± 0.908
0.0GlyXaa: 0.0 ± 0.0
His
1.204HisAla: 1.204 ± 0.656
0.842HisCys: 0.842 ± 0.597
0.963HisAsp: 0.963 ± 0.524
0.481HisGlu: 0.481 ± 0.262
0.963HisPhe: 0.963 ± 0.552
1.083HisGly: 1.083 ± 0.273
0.481HisHis: 0.481 ± 0.262
0.842HisIle: 0.842 ± 0.352
1.083HisLys: 1.083 ± 0.273
1.324HisLeu: 1.324 ± 0.721
0.481HisMet: 0.481 ± 0.602
0.963HisAsn: 0.963 ± 0.752
0.722HisPro: 0.722 ± 0.576
0.361HisGln: 0.361 ± 0.182
0.241HisArg: 0.241 ± 0.131
1.204HisSer: 1.204 ± 0.656
1.565HisThr: 1.565 ± 0.713
1.805HisVal: 1.805 ± 0.391
0.241HisTrp: 0.241 ± 0.497
0.722HisTyr: 0.722 ± 0.229
0.0HisXaa: 0.0 ± 0.0
Ile
2.768IleAla: 2.768 ± 0.892
1.324IleCys: 1.324 ± 0.419
2.166IleAsp: 2.166 ± 0.773
1.685IleGlu: 1.685 ± 0.675
2.166IlePhe: 2.166 ± 0.519
2.648IleGly: 2.648 ± 0.559
0.722IleHis: 0.722 ± 0.645
2.888IleIle: 2.888 ± 2.622
3.731IleLys: 3.731 ± 0.781
4.453IleLeu: 4.453 ± 1.545
1.805IleMet: 1.805 ± 0.604
2.527IleAsn: 2.527 ± 3.083
1.565IlePro: 1.565 ± 1.192
1.685IleGln: 1.685 ± 0.405
0.241IleArg: 0.241 ± 0.885
3.129IleSer: 3.129 ± 1.496
3.611IleThr: 3.611 ± 1.227
6.379IleVal: 6.379 ± 1.247
0.481IleTrp: 0.481 ± 0.609
2.648IleTyr: 2.648 ± 0.946
0.0IleXaa: 0.0 ± 0.0
Lys
3.37LysAla: 3.37 ± 0.769
2.648LysCys: 2.648 ± 1.209
4.814LysAsp: 4.814 ± 1.439
2.888LysGlu: 2.888 ± 1.814
3.129LysPhe: 3.129 ± 1.188
4.092LysGly: 4.092 ± 1.457
2.046LysHis: 2.046 ± 0.428
3.49LysIle: 3.49 ± 0.88
3.37LysLys: 3.37 ± 1.316
6.98LysLeu: 6.98 ± 1.642
1.083LysMet: 1.083 ± 0.622
3.611LysAsn: 3.611 ± 1.138
3.249LysPro: 3.249 ± 0.596
2.648LysGln: 2.648 ± 1.034
2.046LysArg: 2.046 ± 1.088
4.212LysSer: 4.212 ± 1.315
4.934LysThr: 4.934 ± 0.465
4.694LysVal: 4.694 ± 1.29
0.842LysTrp: 0.842 ± 0.276
3.37LysTyr: 3.37 ± 1.08
0.0LysXaa: 0.0 ± 0.0
Leu
4.573LeuAla: 4.573 ± 0.957
3.129LeuCys: 3.129 ± 0.674
4.333LeuAsp: 4.333 ± 1.592
3.972LeuGlu: 3.972 ± 1.194
3.129LeuPhe: 3.129 ± 0.607
4.573LeuGly: 4.573 ± 0.602
1.685LeuHis: 1.685 ± 0.556
2.648LeuIle: 2.648 ± 1.374
5.657LeuLys: 5.657 ± 2.003
8.064LeuLeu: 8.064 ± 2.436
1.444LeuMet: 1.444 ± 0.978
6.258LeuAsn: 6.258 ± 1.648
2.888LeuPro: 2.888 ± 1.149
4.934LeuGln: 4.934 ± 1.205
2.648LeuArg: 2.648 ± 1.207
6.138LeuSer: 6.138 ± 1.806
5.055LeuThr: 5.055 ± 0.872
6.86LeuVal: 6.86 ± 1.348
1.926LeuTrp: 1.926 ± 0.456
4.573LeuTyr: 4.573 ± 1.09
0.0LeuXaa: 0.0 ± 0.0
Met
1.083MetAla: 1.083 ± 0.364
1.083MetCys: 1.083 ± 0.59
0.481MetAsp: 0.481 ± 0.708
0.722MetGlu: 0.722 ± 0.368
1.083MetPhe: 1.083 ± 0.386
0.602MetGly: 0.602 ± 0.328
0.602MetHis: 0.602 ± 0.328
0.963MetIle: 0.963 ± 0.352
0.722MetLys: 0.722 ± 0.229
2.768MetLeu: 2.768 ± 0.251
0.842MetMet: 0.842 ± 0.276
0.602MetAsn: 0.602 ± 0.328
1.083MetPro: 1.083 ± 0.273
0.722MetGln: 0.722 ± 0.628
0.12MetArg: 0.12 ± 0.066
2.287MetSer: 2.287 ± 1.169
1.565MetThr: 1.565 ± 0.424
2.287MetVal: 2.287 ± 0.605
0.12MetTrp: 0.12 ± 0.672
1.444MetTyr: 1.444 ± 0.549
0.0MetXaa: 0.0 ± 0.0
Asn
4.212AsnAla: 4.212 ± 1.383
1.805AsnCys: 1.805 ± 0.638
2.407AsnAsp: 2.407 ± 1.461
1.444AsnGlu: 1.444 ± 0.433
3.129AsnPhe: 3.129 ± 1.454
4.333AsnGly: 4.333 ± 2.079
0.602AsnHis: 0.602 ± 0.194
3.37AsnIle: 3.37 ± 1.653
4.092AsnLys: 4.092 ± 0.59
6.379AsnLeu: 6.379 ± 1.004
2.166AsnMet: 2.166 ± 1.166
3.972AsnAsn: 3.972 ± 1.305
2.407AsnPro: 2.407 ± 0.876
1.805AsnGln: 1.805 ± 0.581
1.324AsnArg: 1.324 ± 0.419
4.694AsnSer: 4.694 ± 1.505
5.536AsnThr: 5.536 ± 2.798
5.416AsnVal: 5.416 ± 1.547
1.083AsnTrp: 1.083 ± 0.622
2.407AsnTyr: 2.407 ± 2.013
0.0AsnXaa: 0.0 ± 0.0
Pro
2.046ProAla: 2.046 ± 0.662
1.444ProCys: 1.444 ± 0.459
2.166ProAsp: 2.166 ± 0.539
1.926ProGlu: 1.926 ± 0.569
1.685ProPhe: 1.685 ± 0.824
2.527ProGly: 2.527 ± 0.507
0.963ProHis: 0.963 ± 0.271
2.287ProIle: 2.287 ± 0.631
1.805ProLys: 1.805 ± 0.636
2.888ProLeu: 2.888 ± 1.247
0.241ProMet: 0.241 ± 0.131
1.204ProAsn: 1.204 ± 0.482
1.204ProPro: 1.204 ± 0.532
1.926ProGln: 1.926 ± 1.58
1.565ProArg: 1.565 ± 0.86
2.768ProSer: 2.768 ± 1.592
2.768ProThr: 2.768 ± 0.838
3.611ProVal: 3.611 ± 1.207
0.481ProTrp: 0.481 ± 0.419
1.324ProTyr: 1.324 ± 0.721
0.0ProXaa: 0.0 ± 0.0
Gln
1.926GlnAla: 1.926 ± 0.447
1.324GlnCys: 1.324 ± 0.773
1.565GlnAsp: 1.565 ± 0.532
1.083GlnGlu: 1.083 ± 0.917
2.407GlnPhe: 2.407 ± 0.694
1.685GlnGly: 1.685 ± 0.778
1.083GlnHis: 1.083 ± 0.695
1.565GlnIle: 1.565 ± 0.655
1.805GlnLys: 1.805 ± 1.489
2.768GlnLeu: 2.768 ± 0.997
0.963GlnMet: 0.963 ± 0.391
2.046GlnAsn: 2.046 ± 0.883
1.565GlnPro: 1.565 ± 1.481
2.166GlnGln: 2.166 ± 1.471
1.685GlnArg: 1.685 ± 1.088
2.407GlnSer: 2.407 ± 0.975
3.731GlnThr: 3.731 ± 1.074
1.926GlnVal: 1.926 ± 0.567
0.481GlnTrp: 0.481 ± 0.176
0.842GlnTyr: 0.842 ± 0.439
0.0GlnXaa: 0.0 ± 0.0
Arg
1.083ArgAla: 1.083 ± 0.712
1.083ArgCys: 1.083 ± 0.59
1.204ArgAsp: 1.204 ± 1.974
0.722ArgGlu: 0.722 ± 0.393
1.805ArgPhe: 1.805 ± 0.622
1.685ArgGly: 1.685 ± 0.556
0.481ArgHis: 0.481 ± 0.262
1.324ArgIle: 1.324 ± 0.563
1.565ArgLys: 1.565 ± 0.407
2.648ArgLeu: 2.648 ± 1.13
0.481ArgMet: 0.481 ± 0.262
1.805ArgAsn: 1.805 ± 0.391
0.842ArgPro: 0.842 ± 0.389
0.842ArgGln: 0.842 ± 1.158
1.204ArgArg: 1.204 ± 0.686
2.768ArgSer: 2.768 ± 3.416
1.565ArgThr: 1.565 ± 1.738
3.009ArgVal: 3.009 ± 1.717
0.361ArgTrp: 0.361 ± 0.182
1.324ArgTyr: 1.324 ± 0.526
0.0ArgXaa: 0.0 ± 0.0
Ser
3.009SerAla: 3.009 ± 0.637
2.046SerCys: 2.046 ± 0.849
4.092SerAsp: 4.092 ± 1.032
2.648SerGlu: 2.648 ± 0.708
3.49SerPhe: 3.49 ± 0.911
4.333SerGly: 4.333 ± 0.823
1.444SerHis: 1.444 ± 0.541
2.166SerIle: 2.166 ± 0.436
5.175SerLys: 5.175 ± 3.234
6.379SerLeu: 6.379 ± 1.745
2.166SerMet: 2.166 ± 0.728
4.934SerAsn: 4.934 ± 2.793
1.926SerPro: 1.926 ± 0.388
1.444SerGln: 1.444 ± 1.472
1.926SerArg: 1.926 ± 3.086
5.295SerSer: 5.295 ± 1.045
4.814SerThr: 4.814 ± 0.741
8.425SerVal: 8.425 ± 1.197
1.204SerTrp: 1.204 ± 0.98
2.648SerTyr: 2.648 ± 0.839
0.0SerXaa: 0.0 ± 0.0
Thr
3.009ThrAla: 3.009 ± 1.032
1.324ThrCys: 1.324 ± 0.5
3.249ThrAsp: 3.249 ± 1.234
1.926ThrGlu: 1.926 ± 0.822
3.972ThrPhe: 3.972 ± 1.826
3.731ThrGly: 3.731 ± 0.919
1.083ThrHis: 1.083 ± 0.59
5.657ThrIle: 5.657 ± 2.93
3.972ThrLys: 3.972 ± 1.716
5.897ThrLeu: 5.897 ± 1.116
1.324ThrMet: 1.324 ± 0.321
3.611ThrAsn: 3.611 ± 2.847
4.092ThrPro: 4.092 ± 1.171
2.768ThrGln: 2.768 ± 1.558
3.009ThrArg: 3.009 ± 0.44
5.055ThrSer: 5.055 ± 0.84
5.897ThrThr: 5.897 ± 1.423
6.74ThrVal: 6.74 ± 1.165
0.963ThrTrp: 0.963 ± 0.391
3.37ThrTyr: 3.37 ± 1.104
0.0ThrXaa: 0.0 ± 0.0
Val
6.499ValAla: 6.499 ± 1.197
4.453ValCys: 4.453 ± 1.568
7.702ValAsp: 7.702 ± 1.483
3.611ValGlu: 3.611 ± 1.444
4.573ValPhe: 4.573 ± 1.464
3.731ValGly: 3.731 ± 1.271
1.083ValHis: 1.083 ± 0.364
4.333ValIle: 4.333 ± 1.707
9.267ValLys: 9.267 ± 1.662
7.702ValLeu: 7.702 ± 2.558
1.204ValMet: 1.204 ± 0.673
7.462ValAsn: 7.462 ± 2.014
4.092ValPro: 4.092 ± 0.598
2.888ValGln: 2.888 ± 0.921
2.287ValArg: 2.287 ± 1.215
7.462ValSer: 7.462 ± 1.092
6.138ValThr: 6.138 ± 1.924
12.757ValVal: 12.757 ± 1.912
1.324ValTrp: 1.324 ± 0.321
4.333ValTyr: 4.333 ± 1.023
0.0ValXaa: 0.0 ± 0.0
Trp
0.842TrpAla: 0.842 ± 0.389
0.602TrpCys: 0.602 ± 0.194
0.722TrpAsp: 0.722 ± 0.393
0.361TrpGlu: 0.361 ± 0.197
0.963TrpPhe: 0.963 ± 0.42
0.241TrpGly: 0.241 ± 0.209
0.0TrpHis: 0.0 ± 0.0
0.602TrpIle: 0.602 ± 0.592
1.083TrpLys: 1.083 ± 0.458
1.565TrpLeu: 1.565 ± 0.492
0.361TrpMet: 0.361 ± 0.182
1.083TrpAsn: 1.083 ± 0.625
0.722TrpPro: 0.722 ± 0.539
0.361TrpGln: 0.361 ± 0.182
0.241TrpArg: 0.241 ± 0.209
0.842TrpSer: 0.842 ± 1.22
0.602TrpThr: 0.602 ± 0.328
1.685TrpVal: 1.685 ± 0.45
0.361TrpTrp: 0.361 ± 0.371
0.481TrpTyr: 0.481 ± 0.708
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.166TyrAla: 2.166 ± 0.688
1.324TyrCys: 1.324 ± 0.419
3.249TyrAsp: 3.249 ± 1.326
1.926TyrGlu: 1.926 ± 0.704
2.768TyrPhe: 2.768 ± 0.577
3.37TyrGly: 3.37 ± 0.308
1.083TyrHis: 1.083 ± 0.513
2.287TyrIle: 2.287 ± 0.449
4.453TyrLys: 4.453 ± 0.917
2.166TyrLeu: 2.166 ± 0.688
0.842TyrMet: 0.842 ± 0.389
3.611TyrAsn: 3.611 ± 0.838
1.805TyrPro: 1.805 ± 0.758
0.842TyrGln: 0.842 ± 0.595
1.324TyrArg: 1.324 ± 0.676
1.926TyrSer: 1.926 ± 0.612
3.851TyrThr: 3.851 ± 0.239
4.333TyrVal: 4.333 ± 1.248
0.361TyrTrp: 0.361 ± 0.371
2.407TyrTyr: 2.407 ± 0.53
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (8310 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski