Amino acid dipepetide frequency for Pasteurella multocida (strain Pm70)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.28AlaAla: 6.28 ± 0.144
1.069AlaCys: 1.069 ± 0.052
4.27AlaAsp: 4.27 ± 0.084
6.032AlaGlu: 6.032 ± 0.115
3.681AlaPhe: 3.681 ± 0.077
5.578AlaGly: 5.578 ± 0.106
1.685AlaHis: 1.685 ± 0.052
6.238AlaIle: 6.238 ± 0.111
5.713AlaLys: 5.713 ± 0.115
10.532AlaLeu: 10.532 ± 0.147
2.399AlaMet: 2.399 ± 0.07
3.522AlaAsn: 3.522 ± 0.093
2.675AlaPro: 2.675 ± 0.065
4.462AlaGln: 4.462 ± 0.091
3.563AlaArg: 3.563 ± 0.087
4.329AlaSer: 4.329 ± 0.101
4.476AlaThr: 4.476 ± 0.101
5.887AlaVal: 5.887 ± 0.114
0.909AlaTrp: 0.909 ± 0.039
2.519AlaTyr: 2.519 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.912CysAla: 0.912 ± 0.041
0.211CysCys: 0.211 ± 0.02
0.672CysAsp: 0.672 ± 0.036
0.618CysGlu: 0.618 ± 0.036
0.522CysPhe: 0.522 ± 0.027
0.99CysGly: 0.99 ± 0.042
0.339CysHis: 0.339 ± 0.028
0.648CysIle: 0.648 ± 0.033
0.421CysLys: 0.421 ± 0.026
1.192CysLeu: 1.192 ± 0.051
0.175CysMet: 0.175 ± 0.017
0.309CysAsn: 0.309 ± 0.022
0.459CysPro: 0.459 ± 0.032
0.576CysGln: 0.576 ± 0.031
0.499CysArg: 0.499 ± 0.025
0.613CysSer: 0.613 ± 0.031
0.505CysThr: 0.505 ± 0.031
0.717CysVal: 0.717 ± 0.035
0.133CysTrp: 0.133 ± 0.012
0.37CysTyr: 0.37 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
3.72AspAla: 3.72 ± 0.082
0.601AspCys: 0.601 ± 0.036
2.243AspAsp: 2.243 ± 0.072
3.414AspGlu: 3.414 ± 0.076
2.395AspPhe: 2.395 ± 0.066
2.993AspGly: 2.993 ± 0.105
1.077AspHis: 1.077 ± 0.054
3.701AspIle: 3.701 ± 0.077
3.111AspLys: 3.111 ± 0.08
5.241AspLeu: 5.241 ± 0.098
1.164AspMet: 1.164 ± 0.04
2.218AspAsn: 2.218 ± 0.07
2.177AspPro: 2.177 ± 0.062
1.717AspGln: 1.717 ± 0.049
2.138AspArg: 2.138 ± 0.064
2.389AspSer: 2.389 ± 0.064
2.191AspThr: 2.191 ± 0.054
3.653AspVal: 3.653 ± 0.08
0.759AspTrp: 0.759 ± 0.034
2.168AspTyr: 2.168 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
4.627GluAla: 4.627 ± 0.094
0.43GluCys: 0.43 ± 0.026
2.552GluAsp: 2.552 ± 0.076
3.836GluGlu: 3.836 ± 0.097
2.195GluPhe: 2.195 ± 0.057
3.492GluGly: 3.492 ± 0.082
1.439GluHis: 1.439 ± 0.048
4.513GluIle: 4.513 ± 0.088
5.308GluLys: 5.308 ± 0.104
6.119GluLeu: 6.119 ± 0.114
1.807GluMet: 1.807 ± 0.056
3.333GluAsn: 3.333 ± 0.074
1.808GluPro: 1.808 ± 0.049
4.091GluGln: 4.091 ± 0.096
3.117GluArg: 3.117 ± 0.085
2.871GluSer: 2.871 ± 0.078
3.129GluThr: 3.129 ± 0.074
3.959GluVal: 3.959 ± 0.092
0.72GluTrp: 0.72 ± 0.032
1.669GluTyr: 1.669 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
3.777PheAla: 3.777 ± 0.073
0.597PheCys: 0.597 ± 0.03
2.659PheAsp: 2.659 ± 0.073
2.395PheGlu: 2.395 ± 0.063
2.183PhePhe: 2.183 ± 0.08
3.216PheGly: 3.216 ± 0.079
0.994PheHis: 0.994 ± 0.041
3.267PheIle: 3.267 ± 0.084
2.095PheLys: 2.095 ± 0.064
4.353PheLeu: 4.353 ± 0.101
1.102PheMet: 1.102 ± 0.044
2.147PheAsn: 2.147 ± 0.064
1.535PhePro: 1.535 ± 0.044
1.484PheGln: 1.484 ± 0.05
1.583PheArg: 1.583 ± 0.047
3.27PheSer: 3.27 ± 0.081
2.396PheThr: 2.396 ± 0.079
3.078PheVal: 3.078 ± 0.075
0.57PheTrp: 0.57 ± 0.033
1.559PheTyr: 1.559 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
5.154GlyAla: 5.154 ± 0.103
0.843GlyCys: 0.843 ± 0.039
3.018GlyAsp: 3.018 ± 0.087
4.224GlyGlu: 4.224 ± 0.086
3.189GlyPhe: 3.189 ± 0.074
4.507GlyGly: 4.507 ± 0.114
1.453GlyHis: 1.453 ± 0.046
5.173GlyIle: 5.173 ± 0.101
4.71GlyLys: 4.71 ± 0.093
7.109GlyLeu: 7.109 ± 0.121
1.834GlyMet: 1.834 ± 0.053
2.497GlyAsn: 2.497 ± 0.084
1.309GlyPro: 1.309 ± 0.046
2.612GlyGln: 2.612 ± 0.068
2.813GlyArg: 2.813 ± 0.065
3.432GlySer: 3.432 ± 0.081
3.297GlyThr: 3.297 ± 0.08
4.971GlyVal: 4.971 ± 0.103
0.802GlyTrp: 0.802 ± 0.032
2.558GlyTyr: 2.558 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
1.84HisAla: 1.84 ± 0.056
0.394HisCys: 0.394 ± 0.026
1.098HisAsp: 1.098 ± 0.053
1.045HisGlu: 1.045 ± 0.043
1.409HisPhe: 1.409 ± 0.046
1.453HisGly: 1.453 ± 0.051
0.778HisHis: 0.778 ± 0.044
1.648HisIle: 1.648 ± 0.052
1.143HisLys: 1.143 ± 0.046
2.705HisLeu: 2.705 ± 0.076
0.397HisMet: 0.397 ± 0.024
0.921HisAsn: 0.921 ± 0.037
1.173HisPro: 1.173 ± 0.044
1.381HisGln: 1.381 ± 0.045
1.084HisArg: 1.084 ± 0.042
1.327HisSer: 1.327 ± 0.043
1.158HisThr: 1.158 ± 0.051
1.321HisVal: 1.321 ± 0.045
0.396HisTrp: 0.396 ± 0.026
1.029HisTyr: 1.029 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
7.022IleAla: 7.022 ± 0.122
0.837IleCys: 0.837 ± 0.04
3.795IleAsp: 3.795 ± 0.08
4.432IleGlu: 4.432 ± 0.095
2.731IlePhe: 2.731 ± 0.078
5.115IleGly: 5.115 ± 0.118
1.546IleHis: 1.546 ± 0.049
4.287IleIle: 4.287 ± 0.099
3.638IleLys: 3.638 ± 0.09
6.733IleLeu: 6.733 ± 0.126
1.314IleMet: 1.314 ± 0.046
2.996IleAsn: 2.996 ± 0.075
2.874IlePro: 2.874 ± 0.071
2.99IleGln: 2.99 ± 0.068
2.919IleArg: 2.919 ± 0.079
4.405IleSer: 4.405 ± 0.084
3.728IleThr: 3.728 ± 0.075
4.489IleVal: 4.489 ± 0.091
0.657IleTrp: 0.657 ± 0.037
2.044IleTyr: 2.044 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
5.475LysAla: 5.475 ± 0.127
0.414LysCys: 0.414 ± 0.03
2.751LysAsp: 2.751 ± 0.08
3.801LysGlu: 3.801 ± 0.098
1.792LysPhe: 1.792 ± 0.063
3.783LysGly: 3.783 ± 0.084
1.368LysHis: 1.368 ± 0.05
3.911LysIle: 3.911 ± 0.072
3.839LysLys: 3.839 ± 0.105
5.75LysLeu: 5.75 ± 0.099
1.84LysMet: 1.84 ± 0.057
2.822LysAsn: 2.822 ± 0.084
2.45LysPro: 2.45 ± 0.061
3.419LysGln: 3.419 ± 0.084
2.855LysArg: 2.855 ± 0.07
3.086LysSer: 3.086 ± 0.068
3.459LysThr: 3.459 ± 0.078
4.098LysVal: 4.098 ± 0.088
0.622LysTrp: 0.622 ± 0.029
1.687LysTyr: 1.687 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
10.351LeuAla: 10.351 ± 0.155
1.273LeuCys: 1.273 ± 0.038
5.525LeuAsp: 5.525 ± 0.111
5.888LeuGlu: 5.888 ± 0.114
5.103LeuPhe: 5.103 ± 0.124
7.266LeuGly: 7.266 ± 0.11
2.291LeuHis: 2.291 ± 0.061
6.963LeuIle: 6.963 ± 0.133
5.896LeuLys: 5.896 ± 0.086
11.873LeuLeu: 11.873 ± 0.232
2.608LeuMet: 2.608 ± 0.063
4.89LeuAsn: 4.89 ± 0.098
5.041LeuPro: 5.041 ± 0.11
4.624LeuGln: 4.624 ± 0.117
4.756LeuArg: 4.756 ± 0.095
7.814LeuSer: 7.814 ± 0.12
6.208LeuThr: 6.208 ± 0.099
6.869LeuVal: 6.869 ± 0.117
1.113LeuTrp: 1.113 ± 0.05
2.871LeuTyr: 2.871 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.281MetAla: 2.281 ± 0.063
0.187MetCys: 0.187 ± 0.017
1.009MetAsp: 1.009 ± 0.034
1.06MetGlu: 1.06 ± 0.042
0.892MetPhe: 0.892 ± 0.037
1.619MetGly: 1.619 ± 0.049
0.492MetHis: 0.492 ± 0.03
1.576MetIle: 1.576 ± 0.051
1.625MetLys: 1.625 ± 0.05
2.859MetLeu: 2.859 ± 0.066
0.708MetMet: 0.708 ± 0.037
1.125MetAsn: 1.125 ± 0.042
1.098MetPro: 1.098 ± 0.049
1.3MetGln: 1.3 ± 0.046
1.081MetArg: 1.081 ± 0.039
1.532MetSer: 1.532 ± 0.042
1.552MetThr: 1.552 ± 0.052
1.489MetVal: 1.489 ± 0.051
0.219MetTrp: 0.219 ± 0.02
0.528MetTyr: 0.528 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.666AsnAla: 3.666 ± 0.077
0.391AsnCys: 0.391 ± 0.027
1.912AsnAsp: 1.912 ± 0.056
2.48AsnGlu: 2.48 ± 0.07
1.616AsnPhe: 1.616 ± 0.047
2.723AsnGly: 2.723 ± 0.078
0.972AsnHis: 0.972 ± 0.037
3.162AsnIle: 3.162 ± 0.082
2.63AsnLys: 2.63 ± 0.078
4.518AsnLeu: 4.518 ± 0.077
1.003AsnMet: 1.003 ± 0.04
1.891AsnAsn: 1.891 ± 0.076
2.263AsnPro: 2.263 ± 0.064
2.452AsnGln: 2.452 ± 0.061
1.912AsnArg: 1.912 ± 0.053
2.147AsnSer: 2.147 ± 0.069
2.402AsnThr: 2.402 ± 0.075
3.003AsnVal: 3.003 ± 0.083
0.597AsnTrp: 0.597 ± 0.03
1.489AsnTyr: 1.489 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
3.012ProAla: 3.012 ± 0.073
0.345ProCys: 0.345 ± 0.022
1.928ProAsp: 1.928 ± 0.055
3.101ProGlu: 3.101 ± 0.072
1.966ProPhe: 1.966 ± 0.053
1.591ProGly: 1.591 ± 0.051
1.137ProHis: 1.137 ± 0.042
2.72ProIle: 2.72 ± 0.069
2.126ProLys: 2.126 ± 0.062
4.147ProLeu: 4.147 ± 0.087
0.945ProMet: 0.945 ± 0.037
1.955ProAsn: 1.955 ± 0.054
1.195ProPro: 1.195 ± 0.043
1.816ProGln: 1.816 ± 0.053
1.403ProArg: 1.403 ± 0.046
2.101ProSer: 2.101 ± 0.055
2.45ProThr: 2.45 ± 0.057
2.87ProVal: 2.87 ± 0.072
0.396ProTrp: 0.396 ± 0.025
1.384ProTyr: 1.384 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
4.813GlnAla: 4.813 ± 0.12
0.414GlnCys: 0.414 ± 0.026
2.311GlnAsp: 2.311 ± 0.063
2.546GlnGlu: 2.546 ± 0.065
2.204GlnPhe: 2.204 ± 0.061
3.077GlnGly: 3.077 ± 0.079
1.576GlnHis: 1.576 ± 0.06
3.177GlnIle: 3.177 ± 0.073
2.957GlnLys: 2.957 ± 0.072
5.566GlnLeu: 5.566 ± 0.123
1.048GlnMet: 1.048 ± 0.044
2.044GlnAsn: 2.044 ± 0.065
1.934GlnPro: 1.934 ± 0.061
4.251GlnGln: 4.251 ± 0.128
2.762GlnArg: 2.762 ± 0.076
2.381GlnSer: 2.381 ± 0.063
2.495GlnThr: 2.495 ± 0.069
3.219GlnVal: 3.219 ± 0.077
0.589GlnTrp: 0.589 ± 0.032
1.624GlnTyr: 1.624 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
3.207ArgAla: 3.207 ± 0.068
0.471ArgCys: 0.471 ± 0.028
2.222ArgAsp: 2.222 ± 0.064
2.972ArgGlu: 2.972 ± 0.074
2.33ArgPhe: 2.33 ± 0.062
2.611ArgGly: 2.611 ± 0.066
1.263ArgHis: 1.263 ± 0.045
3.116ArgIle: 3.116 ± 0.071
2.431ArgLys: 2.431 ± 0.069
5.266ArgLeu: 5.266 ± 0.111
0.996ArgMet: 0.996 ± 0.04
1.745ArgAsn: 1.745 ± 0.054
1.526ArgPro: 1.526 ± 0.043
2.432ArgGln: 2.432 ± 0.067
2.083ArgArg: 2.083 ± 0.069
2.252ArgSer: 2.252 ± 0.057
2.14ArgThr: 2.14 ± 0.055
2.975ArgVal: 2.975 ± 0.063
0.576ArgTrp: 0.576 ± 0.03
1.838ArgTyr: 1.838 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
5.38SerAla: 5.38 ± 0.096
0.553SerCys: 0.553 ± 0.03
2.751SerAsp: 2.751 ± 0.071
3.218SerGlu: 3.218 ± 0.093
2.528SerPhe: 2.528 ± 0.076
4.135SerGly: 4.135 ± 0.077
1.435SerHis: 1.435 ± 0.052
3.726SerIle: 3.726 ± 0.074
2.88SerLys: 2.88 ± 0.077
6.344SerLeu: 6.344 ± 0.117
1.311SerMet: 1.311 ± 0.046
2.098SerAsn: 2.098 ± 0.062
2.296SerPro: 2.296 ± 0.061
2.711SerGln: 2.711 ± 0.069
2.488SerArg: 2.488 ± 0.066
3.282SerSer: 3.282 ± 0.087
3.09SerThr: 3.09 ± 0.082
3.813SerVal: 3.813 ± 0.075
0.714SerTrp: 0.714 ± 0.032
1.877SerTyr: 1.877 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
4.557ThrAla: 4.557 ± 0.079
0.489ThrCys: 0.489 ± 0.028
2.573ThrAsp: 2.573 ± 0.064
3.287ThrGlu: 3.287 ± 0.074
2.384ThrPhe: 2.384 ± 0.058
3.899ThrGly: 3.899 ± 0.082
1.373ThrHis: 1.373 ± 0.048
3.269ThrIle: 3.269 ± 0.071
2.573ThrLys: 2.573 ± 0.08
6.541ThrLeu: 6.541 ± 0.099
1.078ThrMet: 1.078 ± 0.039
1.951ThrAsn: 1.951 ± 0.065
2.534ThrPro: 2.534 ± 0.056
2.844ThrGln: 2.844 ± 0.077
2.146ThrArg: 2.146 ± 0.062
2.846ThrSer: 2.846 ± 0.074
2.819ThrThr: 2.819 ± 0.087
3.617ThrVal: 3.617 ± 0.094
0.604ThrTrp: 0.604 ± 0.033
1.601ThrTyr: 1.601 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
6.175ValAla: 6.175 ± 0.12
0.76ValCys: 0.76 ± 0.031
3.483ValAsp: 3.483 ± 0.077
4.653ValGlu: 4.653 ± 0.092
2.841ValPhe: 2.841 ± 0.078
4.608ValGly: 4.608 ± 0.084
1.158ValHis: 1.158 ± 0.043
4.93ValIle: 4.93 ± 0.101
4.106ValLys: 4.106 ± 0.101
7.008ValLeu: 7.008 ± 0.112
1.733ValMet: 1.733 ± 0.065
3.173ValAsn: 3.173 ± 0.069
2.477ValPro: 2.477 ± 0.064
2.557ValGln: 2.557 ± 0.064
2.945ValArg: 2.945 ± 0.071
4.159ValSer: 4.159 ± 0.083
3.459ValThr: 3.459 ± 0.083
4.848ValVal: 4.848 ± 0.086
0.688ValTrp: 0.688 ± 0.032
1.913ValTyr: 1.913 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
0.822TrpAla: 0.822 ± 0.036
0.15TrpCys: 0.15 ± 0.015
0.523TrpAsp: 0.523 ± 0.028
0.516TrpGlu: 0.516 ± 0.026
0.618TrpPhe: 0.618 ± 0.03
0.675TrpGly: 0.675 ± 0.032
0.382TrpHis: 0.382 ± 0.023
0.751TrpIle: 0.751 ± 0.035
0.633TrpLys: 0.633 ± 0.032
1.709TrpLeu: 1.709 ± 0.055
0.21TrpMet: 0.21 ± 0.017
0.426TrpAsn: 0.426 ± 0.027
0.223TrpPro: 0.223 ± 0.019
1.077TrpGln: 1.077 ± 0.049
0.609TrpArg: 0.609 ± 0.034
0.55TrpSer: 0.55 ± 0.028
0.516TrpThr: 0.516 ± 0.027
0.783TrpVal: 0.783 ± 0.032
0.177TrpTrp: 0.177 ± 0.016
0.358TrpTyr: 0.358 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.75TyrAla: 2.75 ± 0.073
0.451TyrCys: 0.451 ± 0.028
1.771TyrAsp: 1.771 ± 0.06
1.499TyrGlu: 1.499 ± 0.048
1.682TyrPhe: 1.682 ± 0.056
2.174TyrGly: 2.174 ± 0.072
0.942TyrHis: 0.942 ± 0.042
1.774TyrIle: 1.774 ± 0.062
1.387TyrLys: 1.387 ± 0.055
3.657TyrLeu: 3.657 ± 0.091
0.561TyrMet: 0.561 ± 0.026
1.168TyrAsn: 1.168 ± 0.04
1.54TyrPro: 1.54 ± 0.049
2.194TyrGln: 2.194 ± 0.063
1.694TyrArg: 1.694 ± 0.054
1.844TyrSer: 1.844 ± 0.059
1.514TyrThr: 1.514 ± 0.047
2.017TyrVal: 2.017 ± 0.059
0.468TyrTrp: 0.468 ± 0.027
1.176TyrTyr: 1.176 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2007 proteins (666911 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski