Amino acid dipepetide frequency for Defluviitoga tunisiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.518AlaAla: 3.518 ± 0.11
0.381AlaCys: 0.381 ± 0.025
2.363AlaAsp: 2.363 ± 0.059
3.126AlaGlu: 3.126 ± 0.069
2.586AlaPhe: 2.586 ± 0.072
3.659AlaGly: 3.659 ± 0.101
0.781AlaHis: 0.781 ± 0.031
5.113AlaIle: 5.113 ± 0.1
4.273AlaLys: 4.273 ± 0.089
5.629AlaLeu: 5.629 ± 0.116
1.26AlaMet: 1.26 ± 0.049
2.474AlaAsn: 2.474 ± 0.07
1.354AlaPro: 1.354 ± 0.052
1.74AlaGln: 1.74 ± 0.059
2.062AlaArg: 2.062 ± 0.057
3.069AlaSer: 3.069 ± 0.074
2.576AlaThr: 2.576 ± 0.066
3.716AlaVal: 3.716 ± 0.085
0.425AlaTrp: 0.425 ± 0.03
2.094AlaTyr: 2.094 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.344CysAla: 0.344 ± 0.026
0.071CysCys: 0.071 ± 0.011
0.455CysAsp: 0.455 ± 0.028
0.542CysGlu: 0.542 ± 0.036
0.327CysPhe: 0.327 ± 0.023
0.68CysGly: 0.68 ± 0.04
0.14CysHis: 0.14 ± 0.016
0.565CysIle: 0.565 ± 0.03
0.492CysLys: 0.492 ± 0.029
0.563CysLeu: 0.563 ± 0.031
0.138CysMet: 0.138 ± 0.014
0.376CysAsn: 0.376 ± 0.023
0.374CysPro: 0.374 ± 0.029
0.17CysGln: 0.17 ± 0.015
0.239CysArg: 0.239 ± 0.022
0.452CysSer: 0.452 ± 0.031
0.299CysThr: 0.299 ± 0.025
0.415CysVal: 0.415 ± 0.029
0.071CysTrp: 0.071 ± 0.011
0.284CysTyr: 0.284 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
2.602AspAla: 2.602 ± 0.072
0.362AspCys: 0.362 ± 0.024
2.458AspAsp: 2.458 ± 0.065
4.411AspGlu: 4.411 ± 0.088
3.354AspPhe: 3.354 ± 0.074
2.96AspGly: 2.96 ± 0.075
0.607AspHis: 0.607 ± 0.032
5.677AspIle: 5.677 ± 0.104
4.479AspLys: 4.479 ± 0.099
5.69AspLeu: 5.69 ± 0.105
1.06AspMet: 1.06 ± 0.042
2.898AspAsn: 2.898 ± 0.076
2.134AspPro: 2.134 ± 0.073
1.188AspGln: 1.188 ± 0.039
1.66AspArg: 1.66 ± 0.053
3.008AspSer: 3.008 ± 0.081
2.32AspThr: 2.32 ± 0.068
3.588AspVal: 3.588 ± 0.069
0.562AspTrp: 0.562 ± 0.036
2.842AspTyr: 2.842 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
3.887GluAla: 3.887 ± 0.08
0.392GluCys: 0.392 ± 0.029
4.146GluAsp: 4.146 ± 0.098
7.226GluGlu: 7.226 ± 0.119
3.393GluPhe: 3.393 ± 0.095
4.043GluGly: 4.043 ± 0.088
0.966GluHis: 0.966 ± 0.043
8.499GluIle: 8.499 ± 0.132
8.133GluLys: 8.133 ± 0.147
7.364GluLeu: 7.364 ± 0.116
1.866GluMet: 1.866 ± 0.053
5.212GluAsn: 5.212 ± 0.087
2.017GluPro: 2.017 ± 0.06
1.958GluGln: 1.958 ± 0.07
2.727GluArg: 2.727 ± 0.077
3.704GluSer: 3.704 ± 0.087
3.246GluThr: 3.246 ± 0.083
4.796GluVal: 4.796 ± 0.103
0.587GluTrp: 0.587 ± 0.033
3.066GluTyr: 3.066 ± 0.085
0.0GluXaa: 0.0 ± 0.0
Phe
2.466PheAla: 2.466 ± 0.066
0.432PheCys: 0.432 ± 0.027
3.084PheAsp: 3.084 ± 0.071
3.932PheGlu: 3.932 ± 0.081
2.915PhePhe: 2.915 ± 0.081
3.28PheGly: 3.28 ± 0.083
0.751PheHis: 0.751 ± 0.034
4.419PheIle: 4.419 ± 0.094
3.58PheLys: 3.58 ± 0.069
5.486PheLeu: 5.486 ± 0.117
1.133PheMet: 1.133 ± 0.041
2.784PheAsn: 2.784 ± 0.077
1.67PhePro: 1.67 ± 0.046
1.376PheGln: 1.376 ± 0.056
1.409PheArg: 1.409 ± 0.058
4.158PheSer: 4.158 ± 0.096
2.265PheThr: 2.265 ± 0.067
3.354PheVal: 3.354 ± 0.082
0.49PheTrp: 0.49 ± 0.03
2.393PheTyr: 2.393 ± 0.075
0.0PheXaa: 0.0 ± 0.0
Gly
3.57GlyAla: 3.57 ± 0.111
0.552GlyCys: 0.552 ± 0.034
2.988GlyAsp: 2.988 ± 0.079
4.278GlyGlu: 4.278 ± 0.092
3.271GlyPhe: 3.271 ± 0.075
4.15GlyGly: 4.15 ± 0.112
0.962GlyHis: 0.962 ± 0.043
6.406GlyIle: 6.406 ± 0.107
5.06GlyLys: 5.06 ± 0.106
5.559GlyLeu: 5.559 ± 0.111
1.482GlyMet: 1.482 ± 0.053
3.076GlyAsn: 3.076 ± 0.074
1.595GlyPro: 1.595 ± 0.054
1.474GlyGln: 1.474 ± 0.051
2.272GlyArg: 2.272 ± 0.059
3.269GlySer: 3.269 ± 0.075
3.309GlyThr: 3.309 ± 0.08
4.301GlyVal: 4.301 ± 0.1
0.645GlyTrp: 0.645 ± 0.035
3.02GlyTyr: 3.02 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
0.788HisAla: 0.788 ± 0.036
0.133HisCys: 0.133 ± 0.016
0.666HisAsp: 0.666 ± 0.03
0.989HisGlu: 0.989 ± 0.039
0.741HisPhe: 0.741 ± 0.039
0.962HisGly: 0.962 ± 0.043
0.274HisHis: 0.274 ± 0.021
1.286HisIle: 1.286 ± 0.05
0.934HisLys: 0.934 ± 0.04
1.361HisLeu: 1.361 ± 0.048
0.287HisMet: 0.287 ± 0.024
0.738HisAsn: 0.738 ± 0.042
0.856HisPro: 0.856 ± 0.035
0.382HisGln: 0.382 ± 0.027
0.467HisArg: 0.467 ± 0.031
0.872HisSer: 0.872 ± 0.04
0.627HisThr: 0.627 ± 0.028
0.831HisVal: 0.831 ± 0.041
0.131HisTrp: 0.131 ± 0.015
0.656HisTyr: 0.656 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.414IleAla: 5.414 ± 0.113
0.703IleCys: 0.703 ± 0.038
5.798IleAsp: 5.798 ± 0.116
7.639IleGlu: 7.639 ± 0.139
5.105IlePhe: 5.105 ± 0.102
5.7IleGly: 5.7 ± 0.119
1.246IleHis: 1.246 ± 0.049
9.286IleIle: 9.286 ± 0.14
8.1IleLys: 8.1 ± 0.126
8.917IleLeu: 8.917 ± 0.141
1.973IleMet: 1.973 ± 0.064
5.797IleAsn: 5.797 ± 0.114
3.907IlePro: 3.907 ± 0.09
2.345IleGln: 2.345 ± 0.065
3.216IleArg: 3.216 ± 0.064
6.717IleSer: 6.717 ± 0.125
4.673IleThr: 4.673 ± 0.082
6.244IleVal: 6.244 ± 0.098
0.74IleTrp: 0.74 ± 0.045
3.957IleTyr: 3.957 ± 0.078
0.0IleXaa: 0.0 ± 0.0
Lys
4.173LysAla: 4.173 ± 0.086
0.444LysCys: 0.444 ± 0.036
5.198LysAsp: 5.198 ± 0.104
8.153LysGlu: 8.153 ± 0.134
3.212LysPhe: 3.212 ± 0.071
4.766LysGly: 4.766 ± 0.107
1.014LysHis: 1.014 ± 0.042
9.23LysIle: 9.23 ± 0.142
8.191LysLys: 8.191 ± 0.131
7.118LysLeu: 7.118 ± 0.12
2.077LysMet: 2.077 ± 0.057
5.901LysAsn: 5.901 ± 0.11
2.418LysPro: 2.418 ± 0.07
1.984LysGln: 1.984 ± 0.054
3.088LysArg: 3.088 ± 0.071
4.691LysSer: 4.691 ± 0.089
4.135LysThr: 4.135 ± 0.084
5.546LysVal: 5.546 ± 0.113
0.685LysTrp: 0.685 ± 0.039
3.992LysTyr: 3.992 ± 0.076
0.0LysXaa: 0.0 ± 0.0
Leu
5.183LeuAla: 5.183 ± 0.09
0.641LeuCys: 0.641 ± 0.038
5.223LeuAsp: 5.223 ± 0.093
7.53LeuGlu: 7.53 ± 0.123
4.758LeuPhe: 4.758 ± 0.116
6.031LeuGly: 6.031 ± 0.109
1.175LeuHis: 1.175 ± 0.043
8.776LeuIle: 8.776 ± 0.157
9.177LeuLys: 9.177 ± 0.125
8.786LeuLeu: 8.786 ± 0.131
2.056LeuMet: 2.056 ± 0.058
5.948LeuAsn: 5.948 ± 0.108
3.498LeuPro: 3.498 ± 0.075
2.335LeuGln: 2.335 ± 0.061
3.473LeuArg: 3.473 ± 0.085
7.008LeuSer: 7.008 ± 0.12
4.728LeuThr: 4.728 ± 0.094
5.522LeuVal: 5.522 ± 0.097
0.72LeuTrp: 0.72 ± 0.041
3.576LeuTyr: 3.576 ± 0.101
0.0LeuXaa: 0.0 ± 0.0
Met
1.338MetAla: 1.338 ± 0.046
0.16MetCys: 0.16 ± 0.014
1.132MetAsp: 1.132 ± 0.048
1.442MetGlu: 1.442 ± 0.047
1.044MetPhe: 1.044 ± 0.046
1.481MetGly: 1.481 ± 0.055
0.307MetHis: 0.307 ± 0.019
1.956MetIle: 1.956 ± 0.067
2.322MetLys: 2.322 ± 0.061
1.878MetLeu: 1.878 ± 0.056
0.535MetMet: 0.535 ± 0.028
1.467MetAsn: 1.467 ± 0.055
0.794MetPro: 0.794 ± 0.035
0.597MetGln: 0.597 ± 0.032
0.801MetArg: 0.801 ± 0.037
1.452MetSer: 1.452 ± 0.048
1.015MetThr: 1.015 ± 0.045
1.464MetVal: 1.464 ± 0.051
0.183MetTrp: 0.183 ± 0.02
0.786MetTyr: 0.786 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
2.627AsnAla: 2.627 ± 0.064
0.434AsnCys: 0.434 ± 0.033
2.77AsnAsp: 2.77 ± 0.072
4.224AsnGlu: 4.224 ± 0.08
3.191AsnPhe: 3.191 ± 0.085
3.023AsnGly: 3.023 ± 0.082
0.823AsnHis: 0.823 ± 0.04
6.285AsnIle: 6.285 ± 0.113
4.851AsnLys: 4.851 ± 0.102
6.179AsnLeu: 6.179 ± 0.118
1.27AsnMet: 1.27 ± 0.046
3.771AsnAsn: 3.771 ± 0.097
2.405AsnPro: 2.405 ± 0.068
1.594AsnGln: 1.594 ± 0.049
1.823AsnArg: 1.823 ± 0.053
3.754AsnSer: 3.754 ± 0.088
2.503AsnThr: 2.503 ± 0.075
3.698AsnVal: 3.698 ± 0.081
0.573AsnTrp: 0.573 ± 0.03
3.008AsnTyr: 3.008 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
1.519ProAla: 1.519 ± 0.053
0.199ProCys: 0.199 ± 0.019
2.009ProAsp: 2.009 ± 0.057
2.882ProGlu: 2.882 ± 0.07
1.961ProPhe: 1.961 ± 0.054
2.084ProGly: 2.084 ± 0.064
0.623ProHis: 0.623 ± 0.029
3.001ProIle: 3.001 ± 0.075
2.506ProLys: 2.506 ± 0.065
3.232ProLeu: 3.232 ± 0.074
0.63ProMet: 0.63 ± 0.039
1.908ProAsn: 1.908 ± 0.048
1.037ProPro: 1.037 ± 0.043
1.123ProGln: 1.123 ± 0.051
1.002ProArg: 1.002 ± 0.037
2.165ProSer: 2.165 ± 0.058
1.921ProThr: 1.921 ± 0.061
2.436ProVal: 2.436 ± 0.065
0.352ProTrp: 0.352 ± 0.03
1.599ProTyr: 1.599 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
1.442GlnAla: 1.442 ± 0.053
0.131GlnCys: 0.131 ± 0.016
1.462GlnAsp: 1.462 ± 0.048
2.368GlnGlu: 2.368 ± 0.058
1.092GlnPhe: 1.092 ± 0.044
1.433GlnGly: 1.433 ± 0.054
0.336GlnHis: 0.336 ± 0.027
2.779GlnIle: 2.779 ± 0.07
2.558GlnLys: 2.558 ± 0.062
2.401GlnLeu: 2.401 ± 0.067
0.725GlnMet: 0.725 ± 0.034
1.697GlnAsn: 1.697 ± 0.053
0.776GlnPro: 0.776 ± 0.036
0.803GlnGln: 0.803 ± 0.039
1.133GlnArg: 1.133 ± 0.047
1.376GlnSer: 1.376 ± 0.057
1.235GlnThr: 1.235 ± 0.046
1.497GlnVal: 1.497 ± 0.051
0.249GlnTrp: 0.249 ± 0.023
1.067GlnTyr: 1.067 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
1.801ArgAla: 1.801 ± 0.054
0.316ArgCys: 0.316 ± 0.024
1.836ArgAsp: 1.836 ± 0.058
2.629ArgGlu: 2.629 ± 0.07
1.705ArgPhe: 1.705 ± 0.052
2.094ArgGly: 2.094 ± 0.061
0.469ArgHis: 0.469 ± 0.027
3.369ArgIle: 3.369 ± 0.068
3.216ArgLys: 3.216 ± 0.076
3.043ArgLeu: 3.043 ± 0.059
0.922ArgMet: 0.922 ± 0.045
2.039ArgAsn: 2.039 ± 0.062
0.976ArgPro: 0.976 ± 0.037
0.922ArgGln: 0.922 ± 0.041
1.497ArgArg: 1.497 ± 0.052
1.781ArgSer: 1.781 ± 0.052
1.718ArgThr: 1.718 ± 0.056
2.114ArgVal: 2.114 ± 0.065
0.346ArgTrp: 0.346 ± 0.024
1.657ArgTyr: 1.657 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
2.938SerAla: 2.938 ± 0.085
0.455SerCys: 0.455 ± 0.028
2.98SerAsp: 2.98 ± 0.07
4.336SerGlu: 4.336 ± 0.085
3.791SerPhe: 3.791 ± 0.082
4.048SerGly: 4.048 ± 0.092
0.989SerHis: 0.989 ± 0.04
5.778SerIle: 5.778 ± 0.108
5.481SerLys: 5.481 ± 0.095
6.594SerLeu: 6.594 ± 0.11
1.431SerMet: 1.431 ± 0.052
3.43SerAsn: 3.43 ± 0.076
2.087SerPro: 2.087 ± 0.055
1.984SerGln: 1.984 ± 0.066
2.044SerArg: 2.044 ± 0.056
4.243SerSer: 4.243 ± 0.094
3.003SerThr: 3.003 ± 0.074
3.784SerVal: 3.784 ± 0.087
0.608SerTrp: 0.608 ± 0.029
2.76SerTyr: 2.76 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
2.558ThrAla: 2.558 ± 0.064
0.344ThrCys: 0.344 ± 0.027
2.373ThrAsp: 2.373 ± 0.066
2.739ThrGlu: 2.739 ± 0.069
2.634ThrPhe: 2.634 ± 0.069
3.309ThrGly: 3.309 ± 0.086
0.843ThrHis: 0.843 ± 0.035
4.711ThrIle: 4.711 ± 0.096
3.61ThrLys: 3.61 ± 0.086
4.874ThrLeu: 4.874 ± 0.081
0.902ThrMet: 0.902 ± 0.035
2.548ThrAsn: 2.548 ± 0.079
2.031ThrPro: 2.031 ± 0.053
1.32ThrGln: 1.32 ± 0.045
1.592ThrArg: 1.592 ± 0.055
3.069ThrSer: 3.069 ± 0.083
2.516ThrThr: 2.516 ± 0.072
3.126ThrVal: 3.126 ± 0.074
0.41ThrTrp: 0.41 ± 0.029
2.059ThrTyr: 2.059 ± 0.064
0.0ThrXaa: 0.0 ± 0.0
Val
3.385ValAla: 3.385 ± 0.079
0.46ValCys: 0.46 ± 0.029
3.859ValAsp: 3.859 ± 0.075
4.836ValGlu: 4.836 ± 0.097
3.4ValPhe: 3.4 ± 0.08
4.243ValGly: 4.243 ± 0.089
0.896ValHis: 0.896 ± 0.036
5.815ValIle: 5.815 ± 0.103
4.979ValLys: 4.979 ± 0.101
5.891ValLeu: 5.891 ± 0.094
1.293ValMet: 1.293 ± 0.047
3.478ValAsn: 3.478 ± 0.068
2.398ValPro: 2.398 ± 0.063
1.657ValGln: 1.657 ± 0.052
2.164ValArg: 2.164 ± 0.059
4.457ValSer: 4.457 ± 0.101
3.106ValThr: 3.106 ± 0.066
4.517ValVal: 4.517 ± 0.097
0.558ValTrp: 0.558 ± 0.032
2.657ValTyr: 2.657 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.49TrpAla: 0.49 ± 0.032
0.07TrpCys: 0.07 ± 0.011
0.558TrpAsp: 0.558 ± 0.033
0.61TrpGlu: 0.61 ± 0.033
0.391TrpPhe: 0.391 ± 0.026
0.557TrpGly: 0.557 ± 0.035
0.183TrpHis: 0.183 ± 0.018
0.703TrpIle: 0.703 ± 0.039
0.746TrpLys: 0.746 ± 0.04
0.907TrpLeu: 0.907 ± 0.041
0.274TrpMet: 0.274 ± 0.023
0.627TrpAsn: 0.627 ± 0.034
0.246TrpPro: 0.246 ± 0.024
0.312TrpGln: 0.312 ± 0.023
0.334TrpArg: 0.334 ± 0.023
0.504TrpSer: 0.504 ± 0.031
0.389TrpThr: 0.389 ± 0.027
0.494TrpVal: 0.494 ± 0.032
0.146TrpTrp: 0.146 ± 0.017
0.379TrpTyr: 0.379 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.155TyrAla: 2.155 ± 0.061
0.317TyrCys: 0.317 ± 0.023
2.498TyrAsp: 2.498 ± 0.069
3.337TyrGlu: 3.337 ± 0.087
2.508TyrPhe: 2.508 ± 0.064
2.735TyrGly: 2.735 ± 0.074
0.6TyrHis: 0.6 ± 0.035
3.822TyrIle: 3.822 ± 0.084
3.332TyrLys: 3.332 ± 0.093
4.671TyrLeu: 4.671 ± 0.095
0.838TyrMet: 0.838 ± 0.036
2.637TyrAsn: 2.637 ± 0.067
1.617TyrPro: 1.617 ± 0.057
1.296TyrGln: 1.296 ± 0.041
1.446TyrArg: 1.446 ± 0.051
3.013TyrSer: 3.013 ± 0.077
1.984TyrThr: 1.984 ± 0.054
2.607TyrVal: 2.607 ± 0.067
0.437TyrTrp: 0.437 ± 0.029
2.17TyrTyr: 2.17 ± 0.08
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1811 proteins (601742 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski