Amino acid dipepetide frequency for Diplodia corticola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.182AlaAla: 13.182 ± 0.088	1.141AlaCys: 1.141 ± 0.017	5.175AlaAsp: 5.175 ± 0.039	5.793AlaGlu: 5.793 ± 0.046	3.336AlaPhe: 3.336 ± 0.027	7.157AlaGly: 7.157 ± 0.049	2.061AlaHis: 2.061 ± 0.021	3.923AlaIle: 3.923 ± 0.033	4.112AlaLys: 4.112 ± 0.034	8.465AlaLeu: 8.465 ± 0.062	2.058AlaMet: 2.058 ± 0.021	3.099AlaAsn: 3.099 ± 0.026	5.946AlaPro: 5.946 ± 0.06	3.651AlaGln: 3.651 ± 0.031	5.786AlaArg: 5.786 ± 0.037	8.14AlaSer: 8.14 ± 0.051	5.991AlaThr: 5.991 ± 0.042	6.275AlaVal: 6.275 ± 0.045	1.339AlaTrp: 1.339 ± 0.02	2.31AlaTyr: 2.31 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	1.023CysAla: 1.023 ± 0.012	0.242CysCys: 0.242 ± 0.008	0.63CysAsp: 0.63 ± 0.012	0.578CysGlu: 0.578 ± 0.011	0.496CysPhe: 0.496 ± 0.009	0.962CysGly: 0.962 ± 0.013	0.291CysHis: 0.291 ± 0.008	0.6CysIle: 0.6 ± 0.01	0.446CysLys: 0.446 ± 0.011	1.104CysLeu: 1.104 ± 0.016	0.25CysMet: 0.25 ± 0.006	0.391CysAsn: 0.391 ± 0.008	0.637CysPro: 0.637 ± 0.012	0.391CysGln: 0.391 ± 0.009	0.721CysArg: 0.721 ± 0.012	0.851CysSer: 0.851 ± 0.014	0.669CysThr: 0.669 ± 0.012	0.811CysVal: 0.811 ± 0.012	0.202CysTrp: 0.202 ± 0.006	0.331CysTyr: 0.331 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.795AspAla: 5.795 ± 0.038	0.619AspCys: 0.619 ± 0.012	5.197AspAsp: 5.197 ± 0.059	4.749AspGlu: 4.749 ± 0.043	2.214AspPhe: 2.214 ± 0.024	4.708AspGly: 4.708 ± 0.038	1.232AspHis: 1.232 ± 0.016	2.538AspIle: 2.538 ± 0.024	2.218AspLys: 2.218 ± 0.028	4.686AspLeu: 4.686 ± 0.032	1.224AspMet: 1.224 ± 0.016	1.743AspAsn: 1.743 ± 0.02	3.432AspPro: 3.432 ± 0.029	1.808AspGln: 1.808 ± 0.02	3.127AspArg: 3.127 ± 0.029	3.981AspSer: 3.981 ± 0.035	2.867AspThr: 2.867 ± 0.03	4.001AspVal: 4.001 ± 0.031	0.888AspTrp: 0.888 ± 0.013	1.562AspTyr: 1.562 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.751GluAla: 5.751 ± 0.044	0.598GluCys: 0.598 ± 0.012	4.256GluAsp: 4.256 ± 0.04	5.886GluGlu: 5.886 ± 0.066	1.723GluPhe: 1.723 ± 0.018	4.282GluGly: 4.282 ± 0.034	1.437GluHis: 1.437 ± 0.016	2.524GluIle: 2.524 ± 0.023	3.638GluLys: 3.638 ± 0.037	5.059GluLeu: 5.059 ± 0.036	1.46GluMet: 1.46 ± 0.02	1.999GluAsn: 1.999 ± 0.022	2.84GluPro: 2.84 ± 0.038	2.535GluGln: 2.535 ± 0.029	4.414GluArg: 4.414 ± 0.036	3.892GluSer: 3.892 ± 0.038	3.144GluThr: 3.144 ± 0.027	3.563GluVal: 3.563 ± 0.027	0.921GluTrp: 0.921 ± 0.013	1.531GluTyr: 1.531 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.321PheAla: 3.321 ± 0.029	0.513PheCys: 0.513 ± 0.01	2.268PheAsp: 2.268 ± 0.021	2.034PheGlu: 2.034 ± 0.02	1.565PhePhe: 1.565 ± 0.02	2.842PheGly: 2.842 ± 0.032	0.854PheHis: 0.854 ± 0.014	1.473PheIle: 1.473 ± 0.018	1.331PheLys: 1.331 ± 0.018	3.178PheLeu: 3.178 ± 0.028	0.703PheMet: 0.703 ± 0.012	1.297PheAsn: 1.297 ± 0.019	1.88PhePro: 1.88 ± 0.016	1.228PheGln: 1.228 ± 0.017	1.866PheArg: 1.866 ± 0.021	2.776PheSer: 2.776 ± 0.021	2.009PheThr: 2.009 ± 0.022	2.408PheVal: 2.408 ± 0.023	0.626PheTrp: 0.626 ± 0.011	1.026PheTyr: 1.026 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	6.672GlyAla: 6.672 ± 0.046	0.891GlyCys: 0.891 ± 0.014	4.047GlyAsp: 4.047 ± 0.03	4.304GlyGlu: 4.304 ± 0.033	2.786GlyPhe: 2.786 ± 0.024	8.171GlyGly: 8.171 ± 0.083	1.682GlyHis: 1.682 ± 0.019	3.085GlyIle: 3.085 ± 0.027	3.338GlyLys: 3.338 ± 0.031	6.039GlyLeu: 6.039 ± 0.057	1.657GlyMet: 1.657 ± 0.02	2.422GlyAsn: 2.422 ± 0.026	3.537GlyPro: 3.537 ± 0.033	2.46GlyGln: 2.46 ± 0.021	4.58GlyArg: 4.58 ± 0.037	6.1GlySer: 6.1 ± 0.055	4.051GlyThr: 4.051 ± 0.033	4.804GlyVal: 4.804 ± 0.039	1.273GlyTrp: 1.273 ± 0.017	2.045GlyTyr: 2.045 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	2.197HisAla: 2.197 ± 0.019	0.317HisCys: 0.317 ± 0.008	1.388HisAsp: 1.388 ± 0.015	1.33HisGlu: 1.33 ± 0.017	0.895HisPhe: 0.895 ± 0.013	1.797HisGly: 1.797 ± 0.023	1.141HisHis: 1.141 ± 0.022	1.001HisIle: 1.001 ± 0.014	0.838HisLys: 0.838 ± 0.014	2.165HisLeu: 2.165 ± 0.023	0.464HisMet: 0.464 ± 0.01	0.785HisAsn: 0.785 ± 0.013	1.797HisPro: 1.797 ± 0.02	1.053HisGln: 1.053 ± 0.016	1.62HisArg: 1.62 ± 0.02	1.787HisSer: 1.787 ± 0.019	1.251HisThr: 1.251 ± 0.016	1.491HisVal: 1.491 ± 0.016	0.338HisTrp: 0.338 ± 0.007	0.667HisTyr: 0.667 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	3.871IleAla: 3.871 ± 0.031	0.608IleCys: 0.608 ± 0.011	2.479IleAsp: 2.479 ± 0.022	2.393IleGlu: 2.393 ± 0.026	1.622IlePhe: 1.622 ± 0.019	2.747IleGly: 2.747 ± 0.026	1.008IleHis: 1.008 ± 0.014	1.908IleIle: 1.908 ± 0.021	1.83IleLys: 1.83 ± 0.021	3.7IleLeu: 3.7 ± 0.03	0.858IleMet: 0.858 ± 0.012	1.528IleAsn: 1.528 ± 0.017	2.652IlePro: 2.652 ± 0.023	1.535IleGln: 1.535 ± 0.019	2.443IleArg: 2.443 ± 0.023	3.145IleSer: 3.145 ± 0.025	2.466IleThr: 2.466 ± 0.024	2.806IleVal: 2.806 ± 0.025	0.614IleTrp: 0.614 ± 0.012	1.147IleTyr: 1.147 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.201LysAla: 4.201 ± 0.033	0.434LysCys: 0.434 ± 0.009	2.623LysAsp: 2.623 ± 0.029	3.201LysGlu: 3.201 ± 0.034	1.278LysPhe: 1.278 ± 0.019	2.908LysGly: 2.908 ± 0.027	1.096LysHis: 1.096 ± 0.015	1.82LysIle: 1.82 ± 0.021	3.324LysLys: 3.324 ± 0.05	3.644LysLeu: 3.644 ± 0.034	0.932LysMet: 0.932 ± 0.013	1.529LysAsn: 1.529 ± 0.017	2.643LysPro: 2.643 ± 0.036	1.75LysGln: 1.75 ± 0.021	3.4LysArg: 3.4 ± 0.034	3.052LysSer: 3.052 ± 0.029	2.581LysThr: 2.581 ± 0.023	2.541LysVal: 2.541 ± 0.027	0.6LysTrp: 0.6 ± 0.011	1.162LysTyr: 1.162 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.355LeuAla: 8.355 ± 0.054	1.133LeuCys: 1.133 ± 0.016	5.03LeuAsp: 5.03 ± 0.033	5.092LeuGlu: 5.092 ± 0.04	3.134LeuPhe: 3.134 ± 0.027	5.789LeuGly: 5.789 ± 0.046	2.246LeuHis: 2.246 ± 0.02	3.253LeuIle: 3.253 ± 0.031	3.708LeuLys: 3.708 ± 0.032	8.04LeuLeu: 8.04 ± 0.062	1.619LeuMet: 1.619 ± 0.017	2.843LeuAsn: 2.843 ± 0.025	5.635LeuPro: 5.635 ± 0.089	3.498LeuGln: 3.498 ± 0.03	5.833LeuArg: 5.833 ± 0.046	6.771LeuSer: 6.771 ± 0.041	4.582LeuThr: 4.582 ± 0.032	5.327LeuVal: 5.327 ± 0.039	1.175LeuTrp: 1.175 ± 0.016	2.167LeuTyr: 2.167 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.268MetAla: 2.268 ± 0.023	0.225MetCys: 0.225 ± 0.008	1.25MetAsp: 1.25 ± 0.015	1.213MetGlu: 1.213 ± 0.015	0.694MetPhe: 0.694 ± 0.01	1.457MetGly: 1.457 ± 0.017	0.485MetHis: 0.485 ± 0.01	0.807MetIle: 0.807 ± 0.012	0.899MetLys: 0.899 ± 0.014	1.789MetLeu: 1.789 ± 0.02	0.533MetMet: 0.533 ± 0.01	0.685MetAsn: 0.685 ± 0.011	1.306MetPro: 1.306 ± 0.018	0.829MetGln: 0.829 ± 0.013	1.321MetArg: 1.321 ± 0.014	1.679MetSer: 1.679 ± 0.017	1.202MetThr: 1.202 ± 0.016	1.274MetVal: 1.274 ± 0.015	0.269MetTrp: 0.269 ± 0.007	0.481MetTyr: 0.481 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.236AsnAla: 3.236 ± 0.025	0.38AsnCys: 0.38 ± 0.009	1.892AsnAsp: 1.892 ± 0.021	1.807AsnGlu: 1.807 ± 0.022	1.223AsnPhe: 1.223 ± 0.014	2.932AsnGly: 2.932 ± 0.027	0.814AsnHis: 0.814 ± 0.013	1.666AsnIle: 1.666 ± 0.017	1.394AsnLys: 1.394 ± 0.017	2.821AsnLeu: 2.821 ± 0.026	0.747AsnMet: 0.747 ± 0.012	1.583AsnAsn: 1.583 ± 0.026	2.306AsnPro: 2.306 ± 0.023	1.17AsnGln: 1.17 ± 0.015	1.764AsnArg: 1.764 ± 0.021	2.496AsnSer: 2.496 ± 0.025	2.051AsnThr: 2.051 ± 0.024	2.194AsnVal: 2.194 ± 0.025	0.503AsnTrp: 0.503 ± 0.01	0.923AsnTyr: 0.923 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	6.713ProAla: 6.713 ± 0.063	0.493ProCys: 0.493 ± 0.01	3.407ProAsp: 3.407 ± 0.027	3.654ProGlu: 3.654 ± 0.038	2.037ProPhe: 2.037 ± 0.021	4.195ProGly: 4.195 ± 0.042	1.546ProHis: 1.546 ± 0.02	2.191ProIle: 2.191 ± 0.022	2.514ProLys: 2.514 ± 0.028	4.882ProLeu: 4.882 ± 0.03	1.052ProMet: 1.052 ± 0.016	2.053ProAsn: 2.053 ± 0.022	6.584ProPro: 6.584 ± 0.1	2.62ProGln: 2.62 ± 0.035	3.683ProArg: 3.683 ± 0.033	6.445ProSer: 6.445 ± 0.073	4.316ProThr: 4.316 ± 0.044	3.684ProVal: 3.684 ± 0.03	0.741ProTrp: 0.741 ± 0.012	1.49ProTyr: 1.49 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.537GlnAla: 3.537 ± 0.029	0.41GlnCys: 0.41 ± 0.01	2.004GlnAsp: 2.004 ± 0.02	2.25GlnGlu: 2.25 ± 0.025	1.114GlnPhe: 1.114 ± 0.016	2.229GlnGly: 2.229 ± 0.021	1.233GlnHis: 1.233 ± 0.017	1.563GlnIle: 1.563 ± 0.018	1.822GlnLys: 1.822 ± 0.022	3.313GlnLeu: 3.313 ± 0.03	0.842GlnMet: 0.842 ± 0.016	1.377GlnAsn: 1.377 ± 0.017	2.804GlnPro: 2.804 ± 0.037	3.146GlnGln: 3.146 ± 0.06	2.749GlnArg: 2.749 ± 0.026	2.869GlnSer: 2.869 ± 0.027	2.189GlnThr: 2.189 ± 0.02	1.947GlnVal: 1.947 ± 0.02	0.555GlnTrp: 0.555 ± 0.01	1.053GlnTyr: 1.053 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	5.561ArgAla: 5.561 ± 0.039	0.726ArgCys: 0.726 ± 0.013	3.497ArgAsp: 3.497 ± 0.031	4.073ArgGlu: 4.073 ± 0.038	2.123ArgPhe: 2.123 ± 0.022	4.147ArgGly: 4.147 ± 0.036	1.644ArgHis: 1.644 ± 0.019	2.627ArgIle: 2.627 ± 0.024	3.415ArgLys: 3.415 ± 0.031	5.557ArgLeu: 5.557 ± 0.035	1.341ArgMet: 1.341 ± 0.015	2.16ArgAsn: 2.16 ± 0.02	3.821ArgPro: 3.821 ± 0.036	2.603ArgGln: 2.603 ± 0.023	5.827ArgArg: 5.827 ± 0.05	4.757ArgSer: 4.757 ± 0.042	3.388ArgThr: 3.388 ± 0.025	3.568ArgVal: 3.568 ± 0.027	1.04ArgTrp: 1.04 ± 0.012	1.579ArgTyr: 1.579 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	7.715SerAla: 7.715 ± 0.061	0.793SerCys: 0.793 ± 0.013	4.188SerAsp: 4.188 ± 0.031	3.809SerGlu: 3.809 ± 0.037	2.825SerPhe: 2.825 ± 0.024	5.791SerGly: 5.791 ± 0.056	1.816SerHis: 1.816 ± 0.02	3.395SerIle: 3.395 ± 0.026	3.211SerLys: 3.211 ± 0.032	6.567SerLeu: 6.567 ± 0.046	1.565SerMet: 1.565 ± 0.017	2.827SerAsn: 2.827 ± 0.026	5.917SerPro: 5.917 ± 0.055	2.934SerGln: 2.934 ± 0.029	4.798SerArg: 4.798 ± 0.04	9.649SerSer: 9.649 ± 0.096	5.709SerThr: 5.709 ± 0.053	4.465SerVal: 4.465 ± 0.038	1.062SerTrp: 1.062 ± 0.014	1.938SerTyr: 1.938 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	6.05ThrAla: 6.05 ± 0.042	0.697ThrCys: 0.697 ± 0.012	2.844ThrAsp: 2.844 ± 0.023	2.84ThrGlu: 2.84 ± 0.022	2.123ThrPhe: 2.123 ± 0.021	4.195ThrGly: 4.195 ± 0.038	1.312ThrHis: 1.312 ± 0.016	2.682ThrIle: 2.682 ± 0.026	2.332ThrLys: 2.332 ± 0.021	5.009ThrLeu: 5.009 ± 0.034	1.121ThrMet: 1.121 ± 0.015	2.014ThrAsn: 2.014 ± 0.019	4.731ThrPro: 4.731 ± 0.044	1.974ThrGln: 1.974 ± 0.024	3.098ThrArg: 3.098 ± 0.026	5.259ThrSer: 5.259 ± 0.048	5.086ThrThr: 5.086 ± 0.067	3.735ThrVal: 3.735 ± 0.036	0.819ThrTrp: 0.819 ± 0.014	1.535ThrTyr: 1.535 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	5.979ValAla: 5.979 ± 0.038	0.817ValCys: 0.817 ± 0.014	3.884ValAsp: 3.884 ± 0.027	4.151ValGlu: 4.151 ± 0.032	2.393ValPhe: 2.393 ± 0.022	4.566ValGly: 4.566 ± 0.035	1.368ValHis: 1.368 ± 0.015	2.483ValIle: 2.483 ± 0.023	2.662ValLys: 2.662 ± 0.025	5.484ValLeu: 5.484 ± 0.039	1.307ValMet: 1.307 ± 0.015	2.011ValAsn: 2.011 ± 0.022	3.756ValPro: 3.756 ± 0.041	2.3ValGln: 2.3 ± 0.02	3.824ValArg: 3.824 ± 0.029	4.421ValSer: 4.421 ± 0.035	3.383ValThr: 3.383 ± 0.032	4.874ValVal: 4.874 ± 0.052	0.947ValTrp: 0.947 ± 0.014	1.661ValTyr: 1.661 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.24TrpAla: 1.24 ± 0.017	0.207TrpCys: 0.207 ± 0.006	0.902TrpAsp: 0.902 ± 0.013	0.869TrpGlu: 0.869 ± 0.013	0.537TrpPhe: 0.537 ± 0.011	0.988TrpGly: 0.988 ± 0.014	0.369TrpHis: 0.369 ± 0.008	0.676TrpIle: 0.676 ± 0.011	0.726TrpLys: 0.726 ± 0.013	1.333TrpLeu: 1.333 ± 0.016	0.366TrpMet: 0.366 ± 0.008	0.566TrpAsn: 0.566 ± 0.011	0.633TrpPro: 0.633 ± 0.012	0.553TrpGln: 0.553 ± 0.01	1.05TrpArg: 1.05 ± 0.014	1.039TrpSer: 1.039 ± 0.014	0.939TrpThr: 0.939 ± 0.014	0.927TrpVal: 0.927 ± 0.012	0.302TrpTrp: 0.302 ± 0.009	0.422TrpTyr: 0.422 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.274TyrAla: 2.274 ± 0.019	0.381TyrCys: 0.381 ± 0.009	1.628TyrAsp: 1.628 ± 0.016	1.425TyrGlu: 1.425 ± 0.017	1.078TyrPhe: 1.078 ± 0.015	2.082TyrGly: 2.082 ± 0.022	0.688TyrHis: 0.688 ± 0.012	1.144TyrIle: 1.144 ± 0.015	0.962TyrLys: 0.962 ± 0.012	2.391TyrLeu: 2.391 ± 0.022	0.564TyrMet: 0.564 ± 0.011	0.991TyrAsn: 0.991 ± 0.016	1.446TyrPro: 1.446 ± 0.017	0.97TyrGln: 0.97 ± 0.014	1.552TyrArg: 1.552 ± 0.017	1.866TyrSer: 1.866 ± 0.021	1.581TyrThr: 1.581 ± 0.028	1.579TyrVal: 1.579 ± 0.018	0.429TyrTrp: 0.429 ± 0.009	0.891TyrTyr: 0.891 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.022XaaXaa: 0.022 ± 0.011

Statistics based on 10836 proteins (5743668 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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