Amino acid dipepetide frequency for Rhodococcus phage Takoda

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.303AlaAla: 10.303 ± 1.278
0.711AlaCys: 0.711 ± 0.263
5.471AlaAsp: 5.471 ± 0.604
9.095AlaGlu: 9.095 ± 0.791
3.482AlaPhe: 3.482 ± 0.474
7.745AlaGly: 7.745 ± 0.993
1.421AlaHis: 1.421 ± 0.349
4.761AlaIle: 4.761 ± 0.87
3.553AlaLys: 3.553 ± 0.39
8.668AlaLeu: 8.668 ± 0.942
2.345AlaMet: 2.345 ± 0.374
2.984AlaAsn: 2.984 ± 0.677
4.334AlaPro: 4.334 ± 0.596
3.268AlaGln: 3.268 ± 0.536
5.968AlaArg: 5.968 ± 0.61
5.826AlaSer: 5.826 ± 0.639
5.116AlaThr: 5.116 ± 0.624
7.247AlaVal: 7.247 ± 0.538
1.705AlaTrp: 1.705 ± 0.447
2.416AlaTyr: 2.416 ± 0.415
0.0AlaXaa: 0.0 ± 0.0
Cys
0.426CysAla: 0.426 ± 0.141
0.0CysCys: 0.0 ± 0.0
0.639CysAsp: 0.639 ± 0.198
0.782CysGlu: 0.782 ± 0.256
0.142CysPhe: 0.142 ± 0.096
0.924CysGly: 0.924 ± 0.257
0.142CysHis: 0.142 ± 0.09
0.284CysIle: 0.284 ± 0.131
0.568CysLys: 0.568 ± 0.217
0.355CysLeu: 0.355 ± 0.162
0.071CysMet: 0.071 ± 0.071
0.355CysAsn: 0.355 ± 0.15
0.568CysPro: 0.568 ± 0.222
0.426CysGln: 0.426 ± 0.183
0.426CysArg: 0.426 ± 0.181
0.426CysSer: 0.426 ± 0.18
0.284CysThr: 0.284 ± 0.127
0.711CysVal: 0.711 ± 0.276
0.071CysTrp: 0.071 ± 0.07
0.568CysTyr: 0.568 ± 0.22
0.0CysXaa: 0.0 ± 0.0
Asp
5.968AspAla: 5.968 ± 0.752
0.711AspCys: 0.711 ± 0.218
2.842AspAsp: 2.842 ± 0.459
5.187AspGlu: 5.187 ± 0.778
2.203AspPhe: 2.203 ± 0.414
5.755AspGly: 5.755 ± 0.556
1.847AspHis: 1.847 ± 0.396
1.421AspIle: 1.421 ± 0.295
3.126AspLys: 3.126 ± 0.492
6.324AspLeu: 6.324 ± 0.745
2.132AspMet: 2.132 ± 0.401
2.061AspAsn: 2.061 ± 0.38
4.903AspPro: 4.903 ± 0.709
2.345AspGln: 2.345 ± 0.374
2.984AspArg: 2.984 ± 0.522
3.766AspSer: 3.766 ± 0.401
3.553AspThr: 3.553 ± 0.375
5.329AspVal: 5.329 ± 0.665
1.421AspTrp: 1.421 ± 0.351
2.629AspTyr: 2.629 ± 0.526
0.0AspXaa: 0.0 ± 0.0
Glu
8.1GluAla: 8.1 ± 0.964
0.497GluCys: 0.497 ± 0.175
5.187GluAsp: 5.187 ± 0.71
4.832GluGlu: 4.832 ± 0.793
2.416GluPhe: 2.416 ± 0.427
6.466GluGly: 6.466 ± 0.613
1.563GluHis: 1.563 ± 0.34
4.405GluIle: 4.405 ± 0.65
2.771GluLys: 2.771 ± 0.492
7.39GluLeu: 7.39 ± 0.834
1.279GluMet: 1.279 ± 0.313
2.7GluAsn: 2.7 ± 0.445
2.558GluPro: 2.558 ± 0.521
2.203GluGln: 2.203 ± 0.386
3.979GluArg: 3.979 ± 0.681
3.695GluSer: 3.695 ± 0.539
4.263GluThr: 4.263 ± 0.517
6.182GluVal: 6.182 ± 0.601
1.421GluTrp: 1.421 ± 0.364
2.274GluTyr: 2.274 ± 0.414
0.0GluXaa: 0.0 ± 0.0
Phe
3.411PheAla: 3.411 ± 0.562
0.142PheCys: 0.142 ± 0.101
2.984PheAsp: 2.984 ± 0.496
2.345PheGlu: 2.345 ± 0.321
0.639PhePhe: 0.639 ± 0.192
2.771PheGly: 2.771 ± 0.518
0.853PheHis: 0.853 ± 0.242
1.492PheIle: 1.492 ± 0.303
1.279PheLys: 1.279 ± 0.327
2.842PheLeu: 2.842 ± 0.508
0.782PheMet: 0.782 ± 0.214
1.492PheAsn: 1.492 ± 0.274
1.35PhePro: 1.35 ± 0.301
1.208PheGln: 1.208 ± 0.263
2.274PheArg: 2.274 ± 0.369
2.274PheSer: 2.274 ± 0.381
2.203PheThr: 2.203 ± 0.415
2.7PheVal: 2.7 ± 0.487
0.497PheTrp: 0.497 ± 0.151
0.995PheTyr: 0.995 ± 0.3
0.0PheXaa: 0.0 ± 0.0
Gly
6.608GlyAla: 6.608 ± 0.836
0.711GlyCys: 0.711 ± 0.243
6.466GlyAsp: 6.466 ± 0.678
5.116GlyGlu: 5.116 ± 0.727
4.334GlyPhe: 4.334 ± 0.677
6.253GlyGly: 6.253 ± 0.648
1.918GlyHis: 1.918 ± 0.396
4.263GlyIle: 4.263 ± 0.647
3.837GlyLys: 3.837 ± 0.511
5.684GlyLeu: 5.684 ± 0.805
2.274GlyMet: 2.274 ± 0.707
2.984GlyAsn: 2.984 ± 0.473
3.695GlyPro: 3.695 ± 0.458
3.339GlyGln: 3.339 ± 0.652
4.405GlyArg: 4.405 ± 0.671
5.471GlySer: 5.471 ± 0.904
5.116GlyThr: 5.116 ± 0.631
7.247GlyVal: 7.247 ± 0.816
2.487GlyTrp: 2.487 ± 0.463
3.197GlyTyr: 3.197 ± 0.613
0.0GlyXaa: 0.0 ± 0.0
His
1.705HisAla: 1.705 ± 0.354
0.071HisCys: 0.071 ± 0.064
1.847HisAsp: 1.847 ± 0.452
1.279HisGlu: 1.279 ± 0.34
0.853HisPhe: 0.853 ± 0.24
1.066HisGly: 1.066 ± 0.223
0.426HisHis: 0.426 ± 0.179
1.208HisIle: 1.208 ± 0.325
0.711HisLys: 0.711 ± 0.203
1.563HisLeu: 1.563 ± 0.347
0.568HisMet: 0.568 ± 0.266
0.853HisAsn: 0.853 ± 0.229
1.137HisPro: 1.137 ± 0.288
0.711HisGln: 0.711 ± 0.199
1.918HisArg: 1.918 ± 0.412
0.924HisSer: 0.924 ± 0.411
0.995HisThr: 0.995 ± 0.355
1.279HisVal: 1.279 ± 0.32
0.426HisTrp: 0.426 ± 0.171
1.208HisTyr: 1.208 ± 0.276
0.0HisXaa: 0.0 ± 0.0
Ile
4.974IleAla: 4.974 ± 0.758
0.497IleCys: 0.497 ± 0.238
3.908IleAsp: 3.908 ± 0.493
3.695IleGlu: 3.695 ± 0.586
0.995IlePhe: 0.995 ± 0.253
5.187IleGly: 5.187 ± 0.731
1.137IleHis: 1.137 ± 0.257
1.35IleIle: 1.35 ± 0.318
1.208IleLys: 1.208 ± 0.292
3.482IleLeu: 3.482 ± 0.582
0.711IleMet: 0.711 ± 0.243
1.492IleAsn: 1.492 ± 0.331
2.629IlePro: 2.629 ± 0.442
0.924IleGln: 0.924 ± 0.257
3.624IleArg: 3.624 ± 0.547
1.989IleSer: 1.989 ± 0.367
3.411IleThr: 3.411 ± 0.514
3.197IleVal: 3.197 ± 0.595
0.426IleTrp: 0.426 ± 0.231
1.634IleTyr: 1.634 ± 0.316
0.0IleXaa: 0.0 ± 0.0
Lys
4.547LysAla: 4.547 ± 0.556
0.142LysCys: 0.142 ± 0.107
2.274LysAsp: 2.274 ± 0.336
2.203LysGlu: 2.203 ± 0.326
1.208LysPhe: 1.208 ± 0.338
3.553LysGly: 3.553 ± 0.625
1.208LysHis: 1.208 ± 0.303
1.634LysIle: 1.634 ± 0.325
1.918LysLys: 1.918 ± 0.407
4.405LysLeu: 4.405 ± 0.633
0.924LysMet: 0.924 ± 0.296
1.421LysAsn: 1.421 ± 0.31
1.563LysPro: 1.563 ± 0.399
0.568LysGln: 0.568 ± 0.195
2.274LysArg: 2.274 ± 0.458
1.705LysSer: 1.705 ± 0.315
2.132LysThr: 2.132 ± 0.498
3.482LysVal: 3.482 ± 0.71
0.782LysTrp: 0.782 ± 0.243
1.066LysTyr: 1.066 ± 0.233
0.0LysXaa: 0.0 ± 0.0
Leu
9.237LeuAla: 9.237 ± 0.764
0.782LeuCys: 0.782 ± 0.24
5.755LeuAsp: 5.755 ± 0.754
6.04LeuGlu: 6.04 ± 0.661
2.132LeuPhe: 2.132 ± 0.373
6.892LeuGly: 6.892 ± 1.01
1.776LeuHis: 1.776 ± 0.383
3.339LeuIle: 3.339 ± 0.49
3.339LeuLys: 3.339 ± 0.491
5.897LeuLeu: 5.897 ± 0.666
1.918LeuMet: 1.918 ± 0.492
2.629LeuAsn: 2.629 ± 0.479
4.334LeuPro: 4.334 ± 0.493
2.984LeuGln: 2.984 ± 0.387
5.4LeuArg: 5.4 ± 0.791
6.04LeuSer: 6.04 ± 0.663
6.04LeuThr: 6.04 ± 0.637
6.324LeuVal: 6.324 ± 0.677
1.421LeuTrp: 1.421 ± 0.323
2.487LeuTyr: 2.487 ± 0.369
0.0LeuXaa: 0.0 ± 0.0
Met
2.132MetAla: 2.132 ± 0.343
0.0MetCys: 0.0 ± 0.0
1.279MetAsp: 1.279 ± 0.295
1.563MetGlu: 1.563 ± 0.337
0.995MetPhe: 0.995 ± 0.287
2.132MetGly: 2.132 ± 0.319
0.426MetHis: 0.426 ± 0.171
1.421MetIle: 1.421 ± 0.315
1.066MetLys: 1.066 ± 0.285
2.061MetLeu: 2.061 ± 0.342
0.355MetMet: 0.355 ± 0.15
0.782MetAsn: 0.782 ± 0.219
0.711MetPro: 0.711 ± 0.216
0.426MetGln: 0.426 ± 0.185
1.776MetArg: 1.776 ± 0.402
2.771MetSer: 2.771 ± 0.435
1.918MetThr: 1.918 ± 0.322
1.279MetVal: 1.279 ± 0.244
0.213MetTrp: 0.213 ± 0.119
0.497MetTyr: 0.497 ± 0.196
0.0MetXaa: 0.0 ± 0.0
Asn
3.339AsnAla: 3.339 ± 0.386
0.639AsnCys: 0.639 ± 0.247
2.061AsnAsp: 2.061 ± 0.388
2.274AsnGlu: 2.274 ± 0.402
1.137AsnPhe: 1.137 ± 0.272
4.05AsnGly: 4.05 ± 0.835
0.924AsnHis: 0.924 ± 0.232
1.35AsnIle: 1.35 ± 0.345
1.066AsnLys: 1.066 ± 0.275
2.842AsnLeu: 2.842 ± 0.447
0.924AsnMet: 0.924 ± 0.253
1.563AsnAsn: 1.563 ± 0.356
2.416AsnPro: 2.416 ± 0.389
0.782AsnGln: 0.782 ± 0.204
1.847AsnArg: 1.847 ± 0.468
1.918AsnSer: 1.918 ± 0.302
2.061AsnThr: 2.061 ± 0.53
2.558AsnVal: 2.558 ± 0.44
0.782AsnTrp: 0.782 ± 0.253
0.924AsnTyr: 0.924 ± 0.238
0.0AsnXaa: 0.0 ± 0.0
Pro
4.547ProAla: 4.547 ± 0.532
0.355ProCys: 0.355 ± 0.155
2.913ProAsp: 2.913 ± 0.399
3.695ProGlu: 3.695 ± 0.471
1.421ProPhe: 1.421 ± 0.216
3.979ProGly: 3.979 ± 0.55
0.711ProHis: 0.711 ± 0.231
2.913ProIle: 2.913 ± 0.517
1.35ProLys: 1.35 ± 0.288
3.837ProLeu: 3.837 ± 0.454
1.208ProMet: 1.208 ± 0.254
2.061ProAsn: 2.061 ± 0.435
1.35ProPro: 1.35 ± 0.329
1.563ProGln: 1.563 ± 0.273
2.487ProArg: 2.487 ± 0.508
2.416ProSer: 2.416 ± 0.333
3.766ProThr: 3.766 ± 0.493
3.979ProVal: 3.979 ± 0.552
1.137ProTrp: 1.137 ± 0.252
1.35ProTyr: 1.35 ± 0.27
0.0ProXaa: 0.0 ± 0.0
Gln
3.126GlnAla: 3.126 ± 0.463
0.142GlnCys: 0.142 ± 0.152
2.132GlnAsp: 2.132 ± 0.412
1.776GlnGlu: 1.776 ± 0.375
1.208GlnPhe: 1.208 ± 0.215
2.7GlnGly: 2.7 ± 0.649
0.782GlnHis: 0.782 ± 0.229
1.492GlnIle: 1.492 ± 0.295
0.639GlnLys: 0.639 ± 0.172
2.558GlnLeu: 2.558 ± 0.415
0.782GlnMet: 0.782 ± 0.271
0.639GlnAsn: 0.639 ± 0.233
1.847GlnPro: 1.847 ± 0.373
1.208GlnGln: 1.208 ± 0.327
2.771GlnArg: 2.771 ± 0.417
1.918GlnSer: 1.918 ± 0.309
1.492GlnThr: 1.492 ± 0.321
3.624GlnVal: 3.624 ± 0.643
0.639GlnTrp: 0.639 ± 0.229
0.711GlnTyr: 0.711 ± 0.253
0.0GlnXaa: 0.0 ± 0.0
Arg
4.761ArgAla: 4.761 ± 0.6
1.208ArgCys: 1.208 ± 0.318
4.05ArgAsp: 4.05 ± 0.484
4.903ArgGlu: 4.903 ± 0.739
2.274ArgPhe: 2.274 ± 0.45
3.837ArgGly: 3.837 ± 0.537
0.995ArgHis: 0.995 ± 0.307
2.7ArgIle: 2.7 ± 0.499
3.126ArgLys: 3.126 ± 0.491
5.4ArgLeu: 5.4 ± 0.676
0.853ArgMet: 0.853 ± 0.215
2.274ArgAsn: 2.274 ± 0.361
2.771ArgPro: 2.771 ± 0.456
2.132ArgGln: 2.132 ± 0.411
3.695ArgArg: 3.695 ± 0.536
3.268ArgSer: 3.268 ± 0.401
3.979ArgThr: 3.979 ± 0.519
4.476ArgVal: 4.476 ± 0.473
1.279ArgTrp: 1.279 ± 0.304
1.705ArgTyr: 1.705 ± 0.413
0.0ArgXaa: 0.0 ± 0.0
Ser
5.4SerAla: 5.4 ± 0.641
0.284SerCys: 0.284 ± 0.129
3.979SerAsp: 3.979 ± 0.441
4.05SerGlu: 4.05 ± 0.584
2.487SerPhe: 2.487 ± 0.474
5.755SerGly: 5.755 ± 0.738
1.066SerHis: 1.066 ± 0.234
2.416SerIle: 2.416 ± 0.416
2.132SerLys: 2.132 ± 0.444
5.258SerLeu: 5.258 ± 0.816
1.847SerMet: 1.847 ± 0.396
2.416SerAsn: 2.416 ± 0.365
2.061SerPro: 2.061 ± 0.472
1.634SerGln: 1.634 ± 0.286
3.766SerArg: 3.766 ± 0.493
3.055SerSer: 3.055 ± 0.397
3.482SerThr: 3.482 ± 0.425
4.263SerVal: 4.263 ± 0.593
0.995SerTrp: 0.995 ± 0.262
1.776SerTyr: 1.776 ± 0.319
0.0SerXaa: 0.0 ± 0.0
Thr
5.187ThrAla: 5.187 ± 0.586
0.426ThrCys: 0.426 ± 0.219
3.482ThrAsp: 3.482 ± 0.457
4.547ThrGlu: 4.547 ± 0.651
1.989ThrPhe: 1.989 ± 0.416
5.968ThrGly: 5.968 ± 0.688
1.066ThrHis: 1.066 ± 0.278
3.268ThrIle: 3.268 ± 0.537
2.913ThrLys: 2.913 ± 0.466
5.684ThrLeu: 5.684 ± 0.62
1.208ThrMet: 1.208 ± 0.262
1.705ThrAsn: 1.705 ± 0.462
3.766ThrPro: 3.766 ± 0.481
1.847ThrGln: 1.847 ± 0.374
2.629ThrArg: 2.629 ± 0.384
2.7ThrSer: 2.7 ± 0.411
3.695ThrThr: 3.695 ± 0.624
4.832ThrVal: 4.832 ± 0.512
0.995ThrTrp: 0.995 ± 0.221
2.203ThrTyr: 2.203 ± 0.462
0.0ThrXaa: 0.0 ± 0.0
Val
8.313ValAla: 8.313 ± 0.801
0.639ValCys: 0.639 ± 0.214
5.329ValAsp: 5.329 ± 0.512
6.608ValGlu: 6.608 ± 0.657
2.842ValPhe: 2.842 ± 0.567
5.542ValGly: 5.542 ± 0.652
1.208ValHis: 1.208 ± 0.297
4.121ValIle: 4.121 ± 0.489
3.055ValLys: 3.055 ± 0.457
6.608ValLeu: 6.608 ± 0.713
1.847ValMet: 1.847 ± 0.451
2.984ValAsn: 2.984 ± 0.326
3.553ValPro: 3.553 ± 0.403
2.629ValGln: 2.629 ± 0.508
4.618ValArg: 4.618 ± 0.551
4.903ValSer: 4.903 ± 0.479
4.05ValThr: 4.05 ± 0.489
5.826ValVal: 5.826 ± 0.879
1.137ValTrp: 1.137 ± 0.337
2.132ValTyr: 2.132 ± 0.48
0.0ValXaa: 0.0 ± 0.0
Trp
1.279TrpAla: 1.279 ± 0.303
0.071TrpCys: 0.071 ± 0.082
1.35TrpAsp: 1.35 ± 0.267
1.492TrpGlu: 1.492 ± 0.305
0.853TrpPhe: 0.853 ± 0.227
1.705TrpGly: 1.705 ± 0.442
0.711TrpHis: 0.711 ± 0.223
0.995TrpIle: 0.995 ± 0.262
0.853TrpLys: 0.853 ± 0.223
1.137TrpLeu: 1.137 ± 0.324
0.639TrpMet: 0.639 ± 0.202
0.853TrpAsn: 0.853 ± 0.299
0.639TrpPro: 0.639 ± 0.197
0.782TrpGln: 0.782 ± 0.196
0.355TrpArg: 0.355 ± 0.168
1.137TrpSer: 1.137 ± 0.315
1.208TrpThr: 1.208 ± 0.28
1.35TrpVal: 1.35 ± 0.295
0.355TrpTrp: 0.355 ± 0.2
0.639TrpTyr: 0.639 ± 0.24
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.055TyrAla: 3.055 ± 0.574
0.142TyrCys: 0.142 ± 0.101
2.558TyrAsp: 2.558 ± 0.433
2.7TyrGlu: 2.7 ± 0.421
0.924TyrPhe: 0.924 ± 0.236
3.126TyrGly: 3.126 ± 0.523
0.568TyrHis: 0.568 ± 0.179
1.634TyrIle: 1.634 ± 0.381
0.497TyrLys: 0.497 ± 0.2
2.771TyrLeu: 2.771 ± 0.525
1.066TyrMet: 1.066 ± 0.245
1.208TyrAsn: 1.208 ± 0.319
0.853TyrPro: 0.853 ± 0.236
1.208TyrGln: 1.208 ± 0.264
2.487TyrArg: 2.487 ± 0.462
1.918TyrSer: 1.918 ± 0.419
1.35TyrThr: 1.35 ± 0.358
2.132TyrVal: 2.132 ± 0.421
0.213TyrTrp: 0.213 ± 0.13
0.639TyrTyr: 0.639 ± 0.229
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 67 proteins (14075 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski