Amino acid dipepetide frequency for Schistosoma bovis (Blood fluke)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.372AlaAla: 3.372 ± 0.058	1.016AlaCys: 1.016 ± 0.016	2.167AlaAsp: 2.167 ± 0.024	2.509AlaGlu: 2.509 ± 0.029	1.834AlaPhe: 1.834 ± 0.025	2.082AlaGly: 2.082 ± 0.027	1.049AlaHis: 1.049 ± 0.015	2.845AlaIle: 2.845 ± 0.025	2.42AlaLys: 2.42 ± 0.026	4.354AlaLeu: 4.354 ± 0.04	0.933AlaMet: 0.933 ± 0.013	2.54AlaAsn: 2.54 ± 0.023	1.748AlaPro: 1.748 ± 0.025	1.673AlaGln: 1.673 ± 0.02	2.202AlaArg: 2.202 ± 0.027	4.113AlaSer: 4.113 ± 0.034	2.798AlaThr: 2.798 ± 0.026	2.881AlaVal: 2.881 ± 0.028	0.458AlaTrp: 0.458 ± 0.009	1.576AlaTyr: 1.576 ± 0.02	0.003AlaXaa: 0.003 ± 0.001
Cys	0.871CysAla: 0.871 ± 0.013	0.538CysCys: 0.538 ± 0.013	1.149CysAsp: 1.149 ± 0.017	1.09CysGlu: 1.09 ± 0.015	0.897CysPhe: 0.897 ± 0.012	1.059CysGly: 1.059 ± 0.017	0.64CysHis: 0.64 ± 0.012	1.494CysIle: 1.494 ± 0.017	1.08CysLys: 1.08 ± 0.017	2.412CysLeu: 2.412 ± 0.022	0.368CysMet: 0.368 ± 0.007	1.242CysAsn: 1.242 ± 0.019	1.019CysPro: 1.019 ± 0.019	0.929CysGln: 0.929 ± 0.015	1.063CysArg: 1.063 ± 0.015	2.117CysSer: 2.117 ± 0.024	1.246CysThr: 1.246 ± 0.016	1.08CysVal: 1.08 ± 0.015	0.215CysTrp: 0.215 ± 0.006	0.658CysTyr: 0.658 ± 0.013	0.003CysXaa: 0.003 ± 0.001
Asp	2.16AspAla: 2.16 ± 0.023	1.083AspCys: 1.083 ± 0.016	4.167AspAsp: 4.167 ± 0.054	3.722AspGlu: 3.722 ± 0.034	2.031AspPhe: 2.031 ± 0.019	2.512AspGly: 2.512 ± 0.044	1.554AspHis: 1.554 ± 0.021	3.56AspIle: 3.56 ± 0.029	2.88AspLys: 2.88 ± 0.027	4.94AspLeu: 4.94 ± 0.037	0.993AspMet: 0.993 ± 0.013	3.906AspAsn: 3.906 ± 0.039	2.283AspPro: 2.283 ± 0.024	2.112AspGln: 2.112 ± 0.019	2.311AspArg: 2.311 ± 0.024	4.85AspSer: 4.85 ± 0.035	2.651AspThr: 2.651 ± 0.022	2.896AspVal: 2.896 ± 0.025	0.571AspTrp: 0.571 ± 0.012	1.951AspTyr: 1.951 ± 0.02	0.005AspXaa: 0.005 ± 0.001
Glu	2.866GluAla: 2.866 ± 0.031	1.112GluCys: 1.112 ± 0.016	2.914GluAsp: 2.914 ± 0.03	3.981GluGlu: 3.981 ± 0.044	2.184GluPhe: 2.184 ± 0.021	1.774GluGly: 1.774 ± 0.025	1.405GluHis: 1.405 ± 0.015	3.718GluIle: 3.718 ± 0.026	3.654GluLys: 3.654 ± 0.034	5.831GluLeu: 5.831 ± 0.044	1.258GluMet: 1.258 ± 0.016	3.993GluAsn: 3.993 ± 0.031	1.783GluPro: 1.783 ± 0.026	2.573GluGln: 2.573 ± 0.026	2.714GluArg: 2.714 ± 0.031	4.692GluSer: 4.692 ± 0.035	3.153GluThr: 3.153 ± 0.027	2.81GluVal: 2.81 ± 0.027	0.531GluTrp: 0.531 ± 0.012	1.854GluTyr: 1.854 ± 0.017	0.007GluXaa: 0.007 ± 0.001
Phe	1.638PheAla: 1.638 ± 0.02	0.883PheCys: 0.883 ± 0.013	2.126PheAsp: 2.126 ± 0.022	1.911PheGlu: 1.911 ± 0.017	1.405PhePhe: 1.405 ± 0.02	1.956PheGly: 1.956 ± 0.025	1.231PheHis: 1.231 ± 0.014	3.039PheIle: 3.039 ± 0.032	1.913PheLys: 1.913 ± 0.022	3.6PheLeu: 3.6 ± 0.032	0.825PheMet: 0.825 ± 0.011	2.725PheAsn: 2.725 ± 0.026	1.724PhePro: 1.724 ± 0.019	1.525PheGln: 1.525 ± 0.017	1.783PheArg: 1.783 ± 0.021	3.652PheSer: 3.652 ± 0.029	2.516PheThr: 2.516 ± 0.024	2.14PheVal: 2.14 ± 0.02	0.407PheTrp: 0.407 ± 0.01	1.451PheTyr: 1.451 ± 0.018	0.005PheXaa: 0.005 ± 0.001
Gly	1.95GlyAla: 1.95 ± 0.024	0.952GlyCys: 0.952 ± 0.014	2.292GlyAsp: 2.292 ± 0.041	2.183GlyGlu: 2.183 ± 0.046	1.855GlyPhe: 1.855 ± 0.021	2.603GlyGly: 2.603 ± 0.038	1.194GlyHis: 1.194 ± 0.018	2.947GlyIle: 2.947 ± 0.031	2.346GlyLys: 2.346 ± 0.027	4.355GlyLeu: 4.355 ± 0.041	0.824GlyMet: 0.824 ± 0.014	2.484GlyAsn: 2.484 ± 0.024	1.821GlyPro: 1.821 ± 0.065	1.723GlyGln: 1.723 ± 0.021	2.341GlyArg: 2.341 ± 0.027	4.156GlySer: 4.156 ± 0.041	2.402GlyThr: 2.402 ± 0.027	2.574GlyVal: 2.574 ± 0.028	0.49GlyTrp: 0.49 ± 0.011	1.618GlyTyr: 1.618 ± 0.02	0.005GlyXaa: 0.005 ± 0.001
His	1.009HisAla: 1.009 ± 0.013	0.693HisCys: 0.693 ± 0.012	1.359HisAsp: 1.359 ± 0.017	1.467HisGlu: 1.467 ± 0.018	1.196HisPhe: 1.196 ± 0.016	1.183HisGly: 1.183 ± 0.015	1.708HisHis: 1.708 ± 0.042	1.855HisIle: 1.855 ± 0.018	1.454HisLys: 1.454 ± 0.018	3.117HisLeu: 3.117 ± 0.025	0.519HisMet: 0.519 ± 0.011	2.001HisAsn: 2.001 ± 0.023	1.414HisPro: 1.414 ± 0.017	1.53HisGln: 1.53 ± 0.02	1.519HisArg: 1.519 ± 0.016	3.165HisSer: 3.165 ± 0.032	1.579HisThr: 1.579 ± 0.018	1.407HisVal: 1.407 ± 0.017	0.3HisTrp: 0.3 ± 0.009	1.091HisTyr: 1.091 ± 0.016	0.006HisXaa: 0.006 ± 0.001
Ile	2.739IleAla: 2.739 ± 0.026	1.48IleCys: 1.48 ± 0.019	3.839IleAsp: 3.839 ± 0.033	3.582IleGlu: 3.582 ± 0.034	2.482IlePhe: 2.482 ± 0.026	2.858IleGly: 2.858 ± 0.031	2.235IleHis: 2.235 ± 0.024	4.762IleIle: 4.762 ± 0.046	3.787IleLys: 3.787 ± 0.028	5.925IleLeu: 5.925 ± 0.045	1.278IleMet: 1.278 ± 0.019	5.288IleAsn: 5.288 ± 0.05	3.513IlePro: 3.513 ± 0.031	3.104IleGln: 3.104 ± 0.028	3.073IleArg: 3.073 ± 0.026	6.506IleSer: 6.506 ± 0.042	4.373IleThr: 4.373 ± 0.031	3.265IleVal: 3.265 ± 0.027	0.653IleTrp: 0.653 ± 0.013	2.301IleTyr: 2.301 ± 0.027	0.011IleXaa: 0.011 ± 0.001
Lys	2.417LysAla: 2.417 ± 0.026	1.235LysCys: 1.235 ± 0.018	2.529LysAsp: 2.529 ± 0.024	3.271LysGlu: 3.271 ± 0.031	2.081LysPhe: 2.081 ± 0.02	1.755LysGly: 1.755 ± 0.039	1.745LysHis: 1.745 ± 0.02	3.43LysIle: 3.43 ± 0.027	3.472LysLys: 3.472 ± 0.032	6.032LysLeu: 6.032 ± 0.042	1.189LysMet: 1.189 ± 0.016	3.401LysAsn: 3.401 ± 0.03	2.579LysPro: 2.579 ± 0.025	3.031LysGln: 3.031 ± 0.028	3.3LysArg: 3.3 ± 0.028	5.815LysSer: 5.815 ± 0.046	3.31LysThr: 3.31 ± 0.028	2.572LysVal: 2.572 ± 0.027	0.561LysTrp: 0.561 ± 0.011	2.027LysTyr: 2.027 ± 0.023	0.007LysXaa: 0.007 ± 0.001
Leu	4.779LeuAla: 4.779 ± 0.041	2.163LeuCys: 2.163 ± 0.023	4.842LeuAsp: 4.842 ± 0.039	4.983LeuGlu: 4.983 ± 0.043	4.033LeuPhe: 4.033 ± 0.035	3.75LeuGly: 3.75 ± 0.038	2.787LeuHis: 2.787 ± 0.027	6.565LeuIle: 6.565 ± 0.052	5.716LeuLys: 5.716 ± 0.043	10.014LeuLeu: 10.014 ± 0.064	1.87LeuMet: 1.87 ± 0.02	6.816LeuAsn: 6.816 ± 0.047	5.102LeuPro: 5.102 ± 0.033	4.069LeuGln: 4.069 ± 0.032	4.803LeuArg: 4.803 ± 0.036	10.004LeuSer: 10.004 ± 0.052	6.033LeuThr: 6.033 ± 0.034	4.718LeuVal: 4.718 ± 0.041	0.957LeuTrp: 0.957 ± 0.016	2.952LeuTyr: 2.952 ± 0.025	0.011LeuXaa: 0.011 ± 0.001
Met	0.965MetAla: 0.965 ± 0.012	0.356MetCys: 0.356 ± 0.007	1.146MetAsp: 1.146 ± 0.015	1.196MetGlu: 1.196 ± 0.016	0.743MetPhe: 0.743 ± 0.014	0.777MetGly: 0.777 ± 0.017	0.501MetHis: 0.501 ± 0.01	1.369MetIle: 1.369 ± 0.018	1.483MetLys: 1.483 ± 0.019	1.721MetLeu: 1.721 ± 0.017	0.483MetMet: 0.483 ± 0.011	1.944MetAsn: 1.944 ± 0.026	0.82MetPro: 0.82 ± 0.013	0.69MetGln: 0.69 ± 0.012	0.874MetArg: 0.874 ± 0.014	1.708MetSer: 1.708 ± 0.017	1.181MetThr: 1.181 ± 0.013	0.917MetVal: 0.917 ± 0.014	0.159MetTrp: 0.159 ± 0.005	0.586MetTyr: 0.586 ± 0.011	0.003MetXaa: 0.003 ± 0.001
Asn	2.503AsnAla: 2.503 ± 0.024	1.372AsnCys: 1.372 ± 0.016	4.461AsnAsp: 4.461 ± 0.038	4.402AsnGlu: 4.402 ± 0.041	2.322AsnPhe: 2.322 ± 0.022	2.945AsnGly: 2.945 ± 0.028	2.443AsnHis: 2.443 ± 0.032	4.718AsnIle: 4.718 ± 0.038	4.09AsnLys: 4.09 ± 0.037	6.207AsnLeu: 6.207 ± 0.041	1.282AsnMet: 1.282 ± 0.016	9.551AsnAsn: 9.551 ± 0.138	2.984AsnPro: 2.984 ± 0.027	3.474AsnGln: 3.474 ± 0.032	2.894AsnArg: 2.894 ± 0.028	7.755AsnSer: 7.755 ± 0.069	4.533AsnThr: 4.533 ± 0.047	3.456AsnVal: 3.456 ± 0.026	0.609AsnTrp: 0.609 ± 0.011	2.531AsnTyr: 2.531 ± 0.029	0.017AsnXaa: 0.017 ± 0.002
Pro	1.801ProAla: 1.801 ± 0.021	0.836ProCys: 0.836 ± 0.013	2.304ProAsp: 2.304 ± 0.028	2.417ProGlu: 2.417 ± 0.022	1.744ProPhe: 1.744 ± 0.02	2.286ProGly: 2.286 ± 0.079	1.145ProHis: 1.145 ± 0.015	3.354ProIle: 3.354 ± 0.026	2.36ProLys: 2.36 ± 0.026	4.047ProLeu: 4.047 ± 0.032	0.839ProMet: 0.839 ± 0.013	3.08ProAsn: 3.08 ± 0.026	3.089ProPro: 3.089 ± 0.05	1.67ProGln: 1.67 ± 0.022	1.872ProArg: 1.872 ± 0.023	5.031ProSer: 5.031 ± 0.045	3.262ProThr: 3.262 ± 0.03	3.041ProVal: 3.041 ± 0.032	0.393ProTrp: 0.393 ± 0.009	1.484ProTyr: 1.484 ± 0.018	0.004ProXaa: 0.004 ± 0.001
Gln	1.851GlnAla: 1.851 ± 0.022	0.889GlnCys: 0.889 ± 0.015	1.546GlnAsp: 1.546 ± 0.017	1.992GlnGlu: 1.992 ± 0.023	1.736GlnPhe: 1.736 ± 0.019	1.223GlnGly: 1.223 ± 0.026	1.381GlnHis: 1.381 ± 0.022	2.933GlnIle: 2.933 ± 0.029	2.319GlnLys: 2.319 ± 0.021	5.178GlnLeu: 5.178 ± 0.039	0.972GlnMet: 0.972 ± 0.014	2.894GlnAsn: 2.894 ± 0.027	2.052GlnPro: 2.052 ± 0.025	3.162GlnGln: 3.162 ± 0.055	2.143GlnArg: 2.143 ± 0.024	4.626GlnSer: 4.626 ± 0.041	2.728GlnThr: 2.728 ± 0.028	1.918GlnVal: 1.918 ± 0.021	0.431GlnTrp: 0.431 ± 0.009	1.49GlnTyr: 1.49 ± 0.017	0.005GlnXaa: 0.005 ± 0.001
Arg	2.151ArgAla: 2.151 ± 0.027	0.997ArgCys: 0.997 ± 0.015	2.073ArgAsp: 2.073 ± 0.023	2.455ArgGlu: 2.455 ± 0.027	1.997ArgPhe: 1.997 ± 0.02	1.965ArgGly: 1.965 ± 0.032	1.449ArgHis: 1.449 ± 0.016	3.234ArgIle: 3.234 ± 0.026	3.077ArgLys: 3.077 ± 0.028	5.471ArgLeu: 5.471 ± 0.04	0.954ArgMet: 0.954 ± 0.015	2.864ArgAsn: 2.864 ± 0.025	2.076ArgPro: 2.076 ± 0.026	2.206ArgGln: 2.206 ± 0.021	3.503ArgArg: 3.503 ± 0.033	4.299ArgSer: 4.299 ± 0.036	2.496ArgThr: 2.496 ± 0.024	2.362ArgVal: 2.362 ± 0.023	0.509ArgTrp: 0.509 ± 0.011	1.596ArgTyr: 1.596 ± 0.015	0.005ArgXaa: 0.005 ± 0.001
Ser	4.044SerAla: 4.044 ± 0.032	2.009SerCys: 2.009 ± 0.023	5.256SerAsp: 5.256 ± 0.039	5.052SerGlu: 5.052 ± 0.039	3.65SerPhe: 3.65 ± 0.028	4.746SerGly: 4.746 ± 0.041	2.662SerHis: 2.662 ± 0.027	6.674SerIle: 6.674 ± 0.052	5.336SerLys: 5.336 ± 0.041	9.326SerLeu: 9.326 ± 0.049	1.956SerMet: 1.956 ± 0.019	8.072SerAsn: 8.072 ± 0.065	4.685SerPro: 4.685 ± 0.042	3.918SerGln: 3.918 ± 0.031	4.3SerArg: 4.3 ± 0.036	15.107SerSer: 15.107 ± 0.173	7.466SerThr: 7.466 ± 0.058	5.808SerVal: 5.808 ± 0.039	0.835SerTrp: 0.835 ± 0.013	2.831SerTyr: 2.831 ± 0.024	0.015SerXaa: 0.015 ± 0.002
Thr	2.911ThrAla: 2.911 ± 0.029	1.269ThrCys: 1.269 ± 0.019	3.466ThrAsp: 3.466 ± 0.027	3.35ThrGlu: 3.35 ± 0.03	2.176ThrPhe: 2.176 ± 0.021	3.055ThrGly: 3.055 ± 0.032	1.479ThrHis: 1.479 ± 0.02	4.301ThrIle: 4.301 ± 0.037	3.219ThrLys: 3.219 ± 0.026	5.234ThrLeu: 5.234 ± 0.037	1.242ThrMet: 1.242 ± 0.017	5.222ThrAsn: 5.222 ± 0.05	2.997ThrPro: 2.997 ± 0.03	2.147ThrGln: 2.147 ± 0.023	2.397ThrArg: 2.397 ± 0.023	7.093ThrSer: 7.093 ± 0.053	6.85ThrThr: 6.85 ± 0.107	3.69ThrVal: 3.69 ± 0.03	0.496ThrTrp: 0.496 ± 0.01	1.816ThrTyr: 1.816 ± 0.021	0.009ThrXaa: 0.009 ± 0.001
Val	2.665ValAla: 2.665 ± 0.028	1.29ValCys: 1.29 ± 0.018	3.129ValAsp: 3.129 ± 0.029	2.906ValGlu: 2.906 ± 0.029	2.059ValPhe: 2.059 ± 0.022	2.606ValGly: 2.606 ± 0.031	1.529ValHis: 1.529 ± 0.019	3.375ValIle: 3.375 ± 0.029	2.923ValLys: 2.923 ± 0.025	4.57ValLeu: 4.57 ± 0.035	1.009ValMet: 1.009 ± 0.015	3.795ValAsn: 3.795 ± 0.03	2.328ValPro: 2.328 ± 0.024	2.116ValGln: 2.116 ± 0.024	2.391ValArg: 2.391 ± 0.024	4.994ValSer: 4.994 ± 0.036	3.384ValThr: 3.384 ± 0.03	3.133ValVal: 3.133 ± 0.036	0.54ValTrp: 0.54 ± 0.011	1.864ValTyr: 1.864 ± 0.021	0.004ValXaa: 0.004 ± 0.001
Trp	0.412TrpAla: 0.412 ± 0.01	0.226TrpCys: 0.226 ± 0.006	0.528TrpAsp: 0.528 ± 0.01	0.459TrpGlu: 0.459 ± 0.012	0.484TrpPhe: 0.484 ± 0.009	0.347TrpGly: 0.347 ± 0.008	0.26TrpHis: 0.26 ± 0.007	0.78TrpIle: 0.78 ± 0.014	0.583TrpLys: 0.583 ± 0.012	1.118TrpLeu: 1.118 ± 0.017	0.197TrpMet: 0.197 ± 0.006	0.62TrpAsn: 0.62 ± 0.01	0.442TrpPro: 0.442 ± 0.009	0.343TrpGln: 0.343 ± 0.009	0.553TrpArg: 0.553 ± 0.01	0.912TrpSer: 0.912 ± 0.015	0.52TrpThr: 0.52 ± 0.01	0.378TrpVal: 0.378 ± 0.009	0.132TrpTrp: 0.132 ± 0.005	0.329TrpTyr: 0.329 ± 0.008	0.001TrpXaa: 0.001 ± 0.001
Tyr	1.465TyrAla: 1.465 ± 0.018	0.771TyrCys: 0.771 ± 0.011	1.84TyrAsp: 1.84 ± 0.02	1.874TyrGlu: 1.874 ± 0.019	1.538TyrPhe: 1.538 ± 0.019	1.631TyrGly: 1.631 ± 0.021	1.168TyrHis: 1.168 ± 0.016	2.086TyrIle: 2.086 ± 0.023	1.64TyrLys: 1.64 ± 0.019	3.499TyrLeu: 3.499 ± 0.031	0.633TyrMet: 0.633 ± 0.011	2.1TyrAsn: 2.1 ± 0.025	1.599TyrPro: 1.599 ± 0.016	1.467TyrGln: 1.467 ± 0.018	1.7TyrArg: 1.7 ± 0.019	3.138TyrSer: 3.138 ± 0.027	1.928TyrThr: 1.928 ± 0.02	1.56TyrVal: 1.56 ± 0.02	0.373TyrTrp: 0.373 ± 0.009	1.363TyrTyr: 1.363 ± 0.02	0.006TyrXaa: 0.006 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.006XaaAsp: 0.006 ± 0.001	0.006XaaGlu: 0.006 ± 0.001	0.006XaaPhe: 0.006 ± 0.001	0.003XaaGly: 0.003 ± 0.001	0.007XaaHis: 0.007 ± 0.001	0.015XaaIle: 0.015 ± 0.002	0.008XaaLys: 0.008 ± 0.001	0.012XaaLeu: 0.012 ± 0.002	0.003XaaMet: 0.003 ± 0.001	0.012XaaAsn: 0.012 ± 0.002	0.005XaaPro: 0.005 ± 0.001	0.005XaaGln: 0.005 ± 0.001	0.004XaaArg: 0.004 ± 0.001	0.014XaaSer: 0.014 ± 0.002	0.009XaaThr: 0.009 ± 0.001	0.004XaaVal: 0.004 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.007XaaTyr: 0.007 ± 0.001	0.041XaaXaa: 0.041 ± 0.015

Statistics based on 11348 proteins (5570637 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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