Amino acid dipepetide frequency for Dyadobacter sp. Leaf189

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.52AlaAla: 7.52 ± 0.083	0.641AlaCys: 0.641 ± 0.019	4.543AlaAsp: 4.543 ± 0.05	4.909AlaGlu: 4.909 ± 0.063	4.007AlaPhe: 4.007 ± 0.049	6.514AlaGly: 6.514 ± 0.066	1.334AlaHis: 1.334 ± 0.028	4.878AlaIle: 4.878 ± 0.056	4.313AlaLys: 4.313 ± 0.042	7.537AlaLeu: 7.537 ± 0.08	1.794AlaMet: 1.794 ± 0.034	3.578AlaAsn: 3.578 ± 0.046	2.807AlaPro: 2.807 ± 0.048	3.099AlaGln: 3.099 ± 0.042	3.39AlaArg: 3.39 ± 0.04	4.954AlaSer: 4.954 ± 0.053	4.304AlaThr: 4.304 ± 0.059	5.236AlaVal: 5.236 ± 0.051	0.854AlaTrp: 0.854 ± 0.02	2.805AlaTyr: 2.805 ± 0.04	0.003AlaXaa: 0.003 ± 0.001
Cys	0.506CysAla: 0.506 ± 0.019	0.115CysCys: 0.115 ± 0.009	0.376CysAsp: 0.376 ± 0.015	0.427CysGlu: 0.427 ± 0.014	0.385CysPhe: 0.385 ± 0.016	0.586CysGly: 0.586 ± 0.02	0.194CysHis: 0.194 ± 0.011	0.535CysIle: 0.535 ± 0.02	0.371CysLys: 0.371 ± 0.014	0.647CysLeu: 0.647 ± 0.021	0.174CysMet: 0.174 ± 0.01	0.311CysAsn: 0.311 ± 0.014	0.296CysPro: 0.296 ± 0.013	0.234CysGln: 0.234 ± 0.011	0.315CysArg: 0.315 ± 0.014	0.456CysSer: 0.456 ± 0.016	0.398CysThr: 0.398 ± 0.014	0.443CysVal: 0.443 ± 0.016	0.089CysTrp: 0.089 ± 0.007	0.277CysTyr: 0.277 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.868AspAla: 3.868 ± 0.048	0.334AspCys: 0.334 ± 0.014	2.318AspAsp: 2.318 ± 0.037	3.32AspGlu: 3.32 ± 0.048	3.159AspPhe: 3.159 ± 0.037	3.815AspGly: 3.815 ± 0.061	1.003AspHis: 1.003 ± 0.023	3.709AspIle: 3.709 ± 0.045	3.431AspLys: 3.431 ± 0.05	5.258AspLeu: 5.258 ± 0.051	1.161AspMet: 1.161 ± 0.024	2.452AspAsn: 2.452 ± 0.04	2.399AspPro: 2.399 ± 0.041	2.033AspGln: 2.033 ± 0.033	2.427AspArg: 2.427 ± 0.041	3.062AspSer: 3.062 ± 0.048	2.531AspThr: 2.531 ± 0.039	3.371AspVal: 3.371 ± 0.044	0.85AspTrp: 0.85 ± 0.022	2.314AspTyr: 2.314 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	4.752GluAla: 4.752 ± 0.06	0.333GluCys: 0.333 ± 0.016	2.901GluAsp: 2.901 ± 0.043	4.034GluGlu: 4.034 ± 0.057	2.469GluPhe: 2.469 ± 0.036	3.743GluGly: 3.743 ± 0.044	1.087GluHis: 1.087 ± 0.03	4.404GluIle: 4.404 ± 0.052	4.91GluLys: 4.91 ± 0.057	5.905GluLeu: 5.905 ± 0.066	1.701GluMet: 1.701 ± 0.03	3.432GluAsn: 3.432 ± 0.047	1.956GluPro: 1.956 ± 0.036	2.527GluGln: 2.527 ± 0.038	2.878GluArg: 2.878 ± 0.04	3.324GluSer: 3.324 ± 0.045	3.228GluThr: 3.228 ± 0.045	4.254GluVal: 4.254 ± 0.05	0.81GluTrp: 0.81 ± 0.023	2.099GluTyr: 2.099 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.554PheAla: 3.554 ± 0.056	0.438PheCys: 0.438 ± 0.018	3.008PheAsp: 3.008 ± 0.036	3.039PheGlu: 3.039 ± 0.039	2.399PhePhe: 2.399 ± 0.046	3.613PheGly: 3.613 ± 0.05	0.872PheHis: 0.872 ± 0.024	2.845PheIle: 2.845 ± 0.045	2.746PheLys: 2.746 ± 0.039	4.54PheLeu: 4.54 ± 0.055	1.103PheMet: 1.103 ± 0.027	2.602PheAsn: 2.602 ± 0.041	1.9PhePro: 1.9 ± 0.03	1.712PheGln: 1.712 ± 0.028	2.344PheArg: 2.344 ± 0.036	3.753PheSer: 3.753 ± 0.049	3.045PheThr: 3.045 ± 0.044	3.162PheVal: 3.162 ± 0.039	0.642PheTrp: 0.642 ± 0.019	1.882PheTyr: 1.882 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	5.036GlyAla: 5.036 ± 0.066	0.608GlyCys: 0.608 ± 0.017	3.532GlyAsp: 3.532 ± 0.057	3.814GlyGlu: 3.814 ± 0.045	3.751GlyPhe: 3.751 ± 0.046	5.213GlyGly: 5.213 ± 0.077	1.209GlyHis: 1.209 ± 0.028	5.24GlyIle: 5.24 ± 0.051	5.359GlyLys: 5.359 ± 0.063	6.433GlyLeu: 6.433 ± 0.066	1.795GlyMet: 1.795 ± 0.033	3.698GlyAsn: 3.698 ± 0.056	1.868GlyPro: 1.868 ± 0.033	2.548GlyGln: 2.548 ± 0.039	3.079GlyArg: 3.079 ± 0.047	4.867GlySer: 4.867 ± 0.057	4.458GlyThr: 4.458 ± 0.064	4.645GlyVal: 4.645 ± 0.053	1.042GlyTrp: 1.042 ± 0.026	3.156GlyTyr: 3.156 ± 0.045	0.001GlyXaa: 0.001 ± 0.001
His	1.264HisAla: 1.264 ± 0.028	0.169HisCys: 0.169 ± 0.011	0.882HisAsp: 0.882 ± 0.023	1.037HisGlu: 1.037 ± 0.024	1.189HisPhe: 1.189 ± 0.027	1.151HisGly: 1.151 ± 0.03	0.464HisHis: 0.464 ± 0.016	1.315HisIle: 1.315 ± 0.03	0.874HisLys: 0.874 ± 0.023	1.832HisLeu: 1.832 ± 0.03	0.366HisMet: 0.366 ± 0.014	0.808HisAsn: 0.808 ± 0.019	0.985HisPro: 0.985 ± 0.027	0.715HisGln: 0.715 ± 0.019	0.838HisArg: 0.838 ± 0.021	1.128HisSer: 1.128 ± 0.027	0.957HisThr: 0.957 ± 0.022	1.087HisVal: 1.087 ± 0.025	0.278HisTrp: 0.278 ± 0.012	0.875HisTyr: 0.875 ± 0.026	0.001HisXaa: 0.001 ± 0.001
Ile	5.534IleAla: 5.534 ± 0.063	0.612IleCys: 0.612 ± 0.02	3.704IleAsp: 3.704 ± 0.05	4.1IleGlu: 4.1 ± 0.053	2.938IlePhe: 2.938 ± 0.043	4.659IleGly: 4.659 ± 0.054	1.155IleHis: 1.155 ± 0.023	3.945IleIle: 3.945 ± 0.054	3.625IleLys: 3.625 ± 0.047	5.922IleLeu: 5.922 ± 0.073	1.258IleMet: 1.258 ± 0.028	3.302IleAsn: 3.302 ± 0.046	3.189IlePro: 3.189 ± 0.042	2.27IleGln: 2.27 ± 0.035	3.409IleArg: 3.409 ± 0.048	4.879IleSer: 4.879 ± 0.054	3.948IleThr: 3.948 ± 0.048	4.37IleVal: 4.37 ± 0.066	0.756IleTrp: 0.756 ± 0.023	2.411IleTyr: 2.411 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.888LysAla: 4.888 ± 0.052	0.284LysCys: 0.284 ± 0.013	3.339LysAsp: 3.339 ± 0.047	4.222LysGlu: 4.222 ± 0.055	2.225LysPhe: 2.225 ± 0.034	4.302LysGly: 4.302 ± 0.058	1.091LysHis: 1.091 ± 0.026	4.117LysIle: 4.117 ± 0.048	4.387LysLys: 4.387 ± 0.063	5.611LysLeu: 5.611 ± 0.061	1.698LysMet: 1.698 ± 0.037	3.445LysAsn: 3.445 ± 0.042	2.818LysPro: 2.818 ± 0.049	2.31LysGln: 2.31 ± 0.033	2.691LysArg: 2.691 ± 0.045	4.138LysSer: 4.138 ± 0.046	3.799LysThr: 3.799 ± 0.049	4.157LysVal: 4.157 ± 0.048	0.858LysTrp: 0.858 ± 0.021	2.438LysTyr: 2.438 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	7.684LeuAla: 7.684 ± 0.061	0.689LeuCys: 0.689 ± 0.02	4.833LeuAsp: 4.833 ± 0.052	5.17LeuGlu: 5.17 ± 0.055	4.602LeuPhe: 4.602 ± 0.063	6.179LeuGly: 6.179 ± 0.071	1.826LeuHis: 1.826 ± 0.038	6.199LeuIle: 6.199 ± 0.067	6.124LeuLys: 6.124 ± 0.057	9.55LeuLeu: 9.55 ± 0.101	2.058LeuMet: 2.058 ± 0.033	4.891LeuAsn: 4.891 ± 0.059	4.395LeuPro: 4.395 ± 0.056	3.331LeuGln: 3.331 ± 0.044	4.428LeuArg: 4.428 ± 0.048	6.95LeuSer: 6.95 ± 0.073	5.721LeuThr: 5.721 ± 0.065	5.916LeuVal: 5.916 ± 0.066	0.987LeuTrp: 0.987 ± 0.027	3.157LeuTyr: 3.157 ± 0.044	0.001LeuXaa: 0.001 ± 0.001
Met	1.678MetAla: 1.678 ± 0.033	0.128MetCys: 0.128 ± 0.008	1.233MetAsp: 1.233 ± 0.027	1.408MetGlu: 1.408 ± 0.027	0.813MetPhe: 0.813 ± 0.023	1.555MetGly: 1.555 ± 0.037	0.466MetHis: 0.466 ± 0.017	1.457MetIle: 1.457 ± 0.03	1.858MetLys: 1.858 ± 0.031	2.282MetLeu: 2.282 ± 0.038	0.564MetMet: 0.564 ± 0.018	1.225MetAsn: 1.225 ± 0.025	1.056MetPro: 1.056 ± 0.025	1.053MetGln: 1.053 ± 0.023	1.11MetArg: 1.11 ± 0.024	1.399MetSer: 1.399 ± 0.027	1.133MetThr: 1.133 ± 0.026	1.442MetVal: 1.442 ± 0.032	0.214MetTrp: 0.214 ± 0.01	0.673MetTyr: 0.673 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	4.446AsnAla: 4.446 ± 0.058	0.295AsnCys: 0.295 ± 0.015	2.39AsnAsp: 2.39 ± 0.04	2.896AsnGlu: 2.896 ± 0.04	2.428AsnPhe: 2.428 ± 0.046	3.96AsnGly: 3.96 ± 0.052	0.903AsnHis: 0.903 ± 0.024	3.266AsnIle: 3.266 ± 0.049	2.711AsnLys: 2.711 ± 0.043	4.668AsnLeu: 4.668 ± 0.062	1.088AsnMet: 1.088 ± 0.025	2.616AsnAsn: 2.616 ± 0.044	2.766AsnPro: 2.766 ± 0.042	1.968AsnGln: 1.968 ± 0.032	2.44AsnArg: 2.44 ± 0.037	3.008AsnSer: 3.008 ± 0.05	2.828AsnThr: 2.828 ± 0.041	3.349AsnVal: 3.349 ± 0.048	0.737AsnTrp: 0.737 ± 0.02	2.165AsnTyr: 2.165 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	3.948ProAla: 3.948 ± 0.048	0.207ProCys: 0.207 ± 0.011	2.898ProAsp: 2.898 ± 0.039	3.351ProGlu: 3.351 ± 0.051	2.059ProPhe: 2.059 ± 0.037	3.271ProGly: 3.271 ± 0.047	0.717ProHis: 0.717 ± 0.02	2.265ProIle: 2.265 ± 0.036	2.185ProLys: 2.185 ± 0.036	3.401ProLeu: 3.401 ± 0.049	0.829ProMet: 0.829 ± 0.023	1.896ProAsn: 1.896 ± 0.031	1.176ProPro: 1.176 ± 0.03	1.373ProGln: 1.373 ± 0.03	1.388ProArg: 1.388 ± 0.03	2.378ProSer: 2.378 ± 0.035	2.029ProThr: 2.029 ± 0.035	3.658ProVal: 3.658 ± 0.048	0.463ProTrp: 0.463 ± 0.016	1.511ProTyr: 1.511 ± 0.029	0.001ProXaa: 0.001 ± 0.001
Gln	2.802GlnAla: 2.802 ± 0.039	0.207GlnCys: 0.207 ± 0.012	1.635GlnAsp: 1.635 ± 0.03	2.291GlnGlu: 2.291 ± 0.032	1.771GlnPhe: 1.771 ± 0.03	2.149GlnGly: 2.149 ± 0.041	0.741GlnHis: 0.741 ± 0.021	2.544GlnIle: 2.544 ± 0.037	2.645GlnLys: 2.645 ± 0.048	3.823GlnLeu: 3.823 ± 0.045	0.953GlnMet: 0.953 ± 0.022	2.036GlnAsn: 2.036 ± 0.036	1.583GlnPro: 1.583 ± 0.029	1.843GlnGln: 1.843 ± 0.035	1.687GlnArg: 1.687 ± 0.034	2.34GlnSer: 2.34 ± 0.041	2.146GlnThr: 2.146 ± 0.037	2.59GlnVal: 2.59 ± 0.038	0.509GlnTrp: 0.509 ± 0.017	1.411GlnTyr: 1.411 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	3.019ArgAla: 3.019 ± 0.04	0.252ArgCys: 0.252 ± 0.013	2.321ArgAsp: 2.321 ± 0.037	3.008ArgGlu: 3.008 ± 0.05	2.505ArgPhe: 2.505 ± 0.032	2.562ArgGly: 2.562 ± 0.042	0.808ArgHis: 0.808 ± 0.021	3.584ArgIle: 3.584 ± 0.044	3.209ArgLys: 3.209 ± 0.044	4.417ArgLeu: 4.417 ± 0.062	1.196ArgMet: 1.196 ± 0.026	2.65ArgAsn: 2.65 ± 0.044	1.667ArgPro: 1.667 ± 0.036	1.89ArgGln: 1.89 ± 0.036	2.137ArgArg: 2.137 ± 0.037	2.722ArgSer: 2.722 ± 0.039	2.437ArgThr: 2.437 ± 0.04	2.815ArgVal: 2.815 ± 0.04	0.59ArgTrp: 0.59 ± 0.019	2.018ArgTyr: 2.018 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	4.961SerAla: 4.961 ± 0.063	0.525SerCys: 0.525 ± 0.018	3.416SerAsp: 3.416 ± 0.047	3.916SerGlu: 3.916 ± 0.05	3.538SerPhe: 3.538 ± 0.045	5.356SerGly: 5.356 ± 0.062	1.109SerHis: 1.109 ± 0.027	4.361SerIle: 4.361 ± 0.042	3.778SerLys: 3.778 ± 0.045	6.307SerLeu: 6.307 ± 0.061	1.389SerMet: 1.389 ± 0.023	2.976SerAsn: 2.976 ± 0.05	2.549SerPro: 2.549 ± 0.036	2.341SerGln: 2.341 ± 0.038	3.053SerArg: 3.053 ± 0.046	4.266SerSer: 4.266 ± 0.052	3.455SerThr: 3.455 ± 0.044	4.533SerVal: 4.533 ± 0.051	0.911SerTrp: 0.911 ± 0.026	2.71SerTyr: 2.71 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.643ThrAla: 4.643 ± 0.057	0.341ThrCys: 0.341 ± 0.014	3.253ThrAsp: 3.253 ± 0.038	3.142ThrGlu: 3.142 ± 0.045	2.921ThrPhe: 2.921 ± 0.043	4.914ThrGly: 4.914 ± 0.058	1.012ThrHis: 1.012 ± 0.025	3.793ThrIle: 3.793 ± 0.046	2.887ThrLys: 2.887 ± 0.04	5.283ThrLeu: 5.283 ± 0.06	1.039ThrMet: 1.039 ± 0.028	2.715ThrAsn: 2.715 ± 0.046	2.637ThrPro: 2.637 ± 0.041	1.888ThrGln: 1.888 ± 0.036	2.41ThrArg: 2.41 ± 0.038	3.687ThrSer: 3.687 ± 0.051	3.171ThrThr: 3.171 ± 0.052	3.862ThrVal: 3.862 ± 0.047	0.662ThrTrp: 0.662 ± 0.023	2.291ThrTyr: 2.291 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	5.257ValAla: 5.257 ± 0.057	0.552ValCys: 0.552 ± 0.019	3.396ValAsp: 3.396 ± 0.047	3.79ValGlu: 3.79 ± 0.049	3.328ValPhe: 3.328 ± 0.049	4.188ValGly: 4.188 ± 0.051	1.15ValHis: 1.15 ± 0.028	4.49ValIle: 4.49 ± 0.058	4.208ValLys: 4.208 ± 0.054	6.145ValLeu: 6.145 ± 0.065	1.49ValMet: 1.49 ± 0.028	3.525ValAsn: 3.525 ± 0.053	2.862ValPro: 2.862 ± 0.038	2.247ValGln: 2.247 ± 0.035	3.178ValArg: 3.178 ± 0.044	4.904ValSer: 4.904 ± 0.062	4.148ValThr: 4.148 ± 0.057	4.567ValVal: 4.567 ± 0.062	0.749ValTrp: 0.749 ± 0.021	2.279ValTyr: 2.279 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	0.875TrpAla: 0.875 ± 0.02	0.092TrpCys: 0.092 ± 0.007	0.678TrpAsp: 0.678 ± 0.018	0.774TrpGlu: 0.774 ± 0.022	0.595TrpPhe: 0.595 ± 0.019	0.884TrpGly: 0.884 ± 0.025	0.265TrpHis: 0.265 ± 0.013	0.831TrpIle: 0.831 ± 0.023	0.901TrpLys: 0.901 ± 0.022	1.314TrpLeu: 1.314 ± 0.03	0.347TrpMet: 0.347 ± 0.014	0.699TrpAsn: 0.699 ± 0.021	0.393TrpPro: 0.393 ± 0.016	0.596TrpGln: 0.596 ± 0.018	0.594TrpArg: 0.594 ± 0.017	0.741TrpSer: 0.741 ± 0.022	0.686TrpThr: 0.686 ± 0.022	0.799TrpVal: 0.799 ± 0.025	0.213TrpTrp: 0.213 ± 0.011	0.485TrpTyr: 0.485 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.783TyrAla: 2.783 ± 0.039	0.311TyrCys: 0.311 ± 0.012	2.163TyrAsp: 2.163 ± 0.037	2.099TyrGlu: 2.099 ± 0.036	2.118TyrPhe: 2.118 ± 0.035	2.733TyrGly: 2.733 ± 0.034	0.811TyrHis: 0.811 ± 0.022	2.21TyrIle: 2.21 ± 0.037	2.296TyrLys: 2.296 ± 0.037	3.811TyrLeu: 3.811 ± 0.051	0.744TyrMet: 0.744 ± 0.021	2.073TyrAsn: 2.073 ± 0.04	1.7TyrPro: 1.7 ± 0.03	1.726TyrGln: 1.726 ± 0.035	2.011TyrArg: 2.011 ± 0.037	2.494TyrSer: 2.494 ± 0.039	2.13TyrThr: 2.13 ± 0.037	2.197TyrVal: 2.197 ± 0.039	0.55TyrTrp: 0.55 ± 0.017	1.656TyrTyr: 1.656 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4994 proteins (1823744 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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