Amino acid dipepetide frequency for Mycobacterium phage Dante

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.171AlaAla: 14.171 ± 1.696
1.09AlaCys: 1.09 ± 0.275
6.852AlaAsp: 6.852 ± 0.594
7.319AlaGlu: 7.319 ± 0.835
2.595AlaPhe: 2.595 ± 0.405
9.707AlaGly: 9.707 ± 1.3
2.44AlaHis: 2.44 ± 0.4
4.724AlaIle: 4.724 ± 0.595
3.945AlaLys: 3.945 ± 0.45
7.838AlaLeu: 7.838 ± 0.651
2.855AlaMet: 2.855 ± 0.462
2.492AlaAsn: 2.492 ± 0.364
5.45AlaPro: 5.45 ± 0.466
3.789AlaGln: 3.789 ± 0.378
7.682AlaArg: 7.682 ± 0.732
5.969AlaSer: 5.969 ± 0.564
5.969AlaThr: 5.969 ± 0.533
7.475AlaVal: 7.475 ± 0.619
2.699AlaTrp: 2.699 ± 0.343
2.232AlaTyr: 2.232 ± 0.354
0.0AlaXaa: 0.0 ± 0.0
Cys
0.986CysAla: 0.986 ± 0.301
0.104CysCys: 0.104 ± 0.072
1.09CysAsp: 1.09 ± 0.292
1.038CysGlu: 1.038 ± 0.234
0.208CysPhe: 0.208 ± 0.09
2.18CysGly: 2.18 ± 0.544
0.363CysHis: 0.363 ± 0.134
0.104CysIle: 0.104 ± 0.074
0.519CysLys: 0.519 ± 0.175
0.675CysLeu: 0.675 ± 0.226
0.052CysMet: 0.052 ± 0.054
0.519CysAsn: 0.519 ± 0.153
1.35CysPro: 1.35 ± 0.3
0.311CysGln: 0.311 ± 0.125
0.779CysArg: 0.779 ± 0.24
0.882CysSer: 0.882 ± 0.281
0.831CysThr: 0.831 ± 0.245
0.675CysVal: 0.675 ± 0.158
0.26CysTrp: 0.26 ± 0.115
0.156CysTyr: 0.156 ± 0.095
0.0CysXaa: 0.0 ± 0.0
Asp
7.527AspAla: 7.527 ± 0.58
0.831AspCys: 0.831 ± 0.214
4.412AspAsp: 4.412 ± 0.561
3.426AspGlu: 3.426 ± 0.462
1.765AspPhe: 1.765 ± 0.221
5.866AspGly: 5.866 ± 0.556
1.609AspHis: 1.609 ± 0.297
2.595AspIle: 2.595 ± 0.381
1.765AspLys: 1.765 ± 0.269
5.295AspLeu: 5.295 ± 0.48
1.038AspMet: 1.038 ± 0.253
1.505AspAsn: 1.505 ± 0.289
5.035AspPro: 5.035 ± 0.566
2.284AspGln: 2.284 ± 0.323
4.568AspArg: 4.568 ± 0.619
3.374AspSer: 3.374 ± 0.458
4.049AspThr: 4.049 ± 0.516
4.879AspVal: 4.879 ± 0.472
1.35AspTrp: 1.35 ± 0.298
2.18AspTyr: 2.18 ± 0.404
0.0AspXaa: 0.0 ± 0.0
Glu
6.904GluAla: 6.904 ± 0.753
0.986GluCys: 0.986 ± 0.325
3.114GluAsp: 3.114 ± 0.417
2.44GluGlu: 2.44 ± 0.462
1.921GluPhe: 1.921 ± 0.353
3.634GluGly: 3.634 ± 0.421
1.402GluHis: 1.402 ± 0.297
2.543GluIle: 2.543 ± 0.369
2.024GluLys: 2.024 ± 0.297
5.814GluLeu: 5.814 ± 0.667
1.402GluMet: 1.402 ± 0.292
1.972GluAsn: 1.972 ± 0.288
2.699GluPro: 2.699 ± 0.353
2.543GluGln: 2.543 ± 0.328
5.139GluArg: 5.139 ± 0.662
2.751GluSer: 2.751 ± 0.456
4.049GluThr: 4.049 ± 0.606
3.997GluVal: 3.997 ± 0.511
1.246GluTrp: 1.246 ± 0.301
1.972GluTyr: 1.972 ± 0.269
0.0GluXaa: 0.0 ± 0.0
Phe
3.063PheAla: 3.063 ± 0.386
0.26PheCys: 0.26 ± 0.1
2.388PheAsp: 2.388 ± 0.523
1.609PheGlu: 1.609 ± 0.304
0.831PhePhe: 0.831 ± 0.245
3.27PheGly: 3.27 ± 0.571
0.519PheHis: 0.519 ± 0.238
1.298PheIle: 1.298 ± 0.336
1.038PheLys: 1.038 ± 0.255
1.817PheLeu: 1.817 ± 0.267
0.675PheMet: 0.675 ± 0.174
1.246PheAsn: 1.246 ± 0.31
1.505PhePro: 1.505 ± 0.287
1.402PheGln: 1.402 ± 0.293
1.661PheArg: 1.661 ± 0.241
1.35PheSer: 1.35 ± 0.271
2.128PheThr: 2.128 ± 0.313
2.128PheVal: 2.128 ± 0.292
0.831PheTrp: 0.831 ± 0.218
0.779PheTyr: 0.779 ± 0.242
0.0PheXaa: 0.0 ± 0.0
Gly
9.188GlyAla: 9.188 ± 0.974
1.298GlyCys: 1.298 ± 0.324
5.658GlyAsp: 5.658 ± 0.587
4.205GlyGlu: 4.205 ± 0.48
2.44GlyPhe: 2.44 ± 0.399
9.914GlyGly: 9.914 ± 1.844
1.921GlyHis: 1.921 ± 0.319
3.634GlyIle: 3.634 ± 0.48
2.647GlyLys: 2.647 ± 0.336
6.333GlyLeu: 6.333 ± 0.568
2.336GlyMet: 2.336 ± 0.433
3.27GlyAsn: 3.27 ± 0.407
4.205GlyPro: 4.205 ± 0.653
2.492GlyGln: 2.492 ± 0.523
5.762GlyArg: 5.762 ± 0.746
5.866GlySer: 5.866 ± 0.72
5.658GlyThr: 5.658 ± 0.915
6.229GlyVal: 6.229 ± 0.589
2.076GlyTrp: 2.076 ± 0.362
2.388GlyTyr: 2.388 ± 0.384
0.0GlyXaa: 0.0 ± 0.0
His
2.128HisAla: 2.128 ± 0.367
0.415HisCys: 0.415 ± 0.177
0.882HisAsp: 0.882 ± 0.209
1.609HisGlu: 1.609 ± 0.293
0.571HisPhe: 0.571 ± 0.142
2.18HisGly: 2.18 ± 0.328
1.038HisHis: 1.038 ± 0.293
1.402HisIle: 1.402 ± 0.315
1.038HisLys: 1.038 ± 0.245
1.609HisLeu: 1.609 ± 0.297
0.363HisMet: 0.363 ± 0.11
0.882HisAsn: 0.882 ± 0.19
1.713HisPro: 1.713 ± 0.297
0.727HisGln: 0.727 ± 0.202
2.336HisArg: 2.336 ± 0.411
0.727HisSer: 0.727 ± 0.17
1.557HisThr: 1.557 ± 0.307
1.557HisVal: 1.557 ± 0.291
0.467HisTrp: 0.467 ± 0.154
0.831HisTyr: 0.831 ± 0.201
0.0HisXaa: 0.0 ± 0.0
Ile
4.568IleAla: 4.568 ± 0.508
0.519IleCys: 0.519 ± 0.22
3.582IleAsp: 3.582 ± 0.52
3.478IleGlu: 3.478 ± 0.408
0.882IlePhe: 0.882 ± 0.243
4.101IleGly: 4.101 ± 0.408
1.557IleHis: 1.557 ± 0.309
1.194IleIle: 1.194 ± 0.27
0.934IleLys: 0.934 ± 0.238
2.492IleLeu: 2.492 ± 0.39
0.363IleMet: 0.363 ± 0.126
1.713IleAsn: 1.713 ± 0.279
2.492IlePro: 2.492 ± 0.357
1.609IleGln: 1.609 ± 0.275
2.336IleArg: 2.336 ± 0.372
2.232IleSer: 2.232 ± 0.435
3.322IleThr: 3.322 ± 0.427
3.114IleVal: 3.114 ± 0.395
0.779IleTrp: 0.779 ± 0.192
0.727IleTyr: 0.727 ± 0.154
0.0IleXaa: 0.0 ± 0.0
Lys
3.582LysAla: 3.582 ± 0.561
0.415LysCys: 0.415 ± 0.177
1.661LysAsp: 1.661 ± 0.304
1.609LysGlu: 1.609 ± 0.245
1.35LysPhe: 1.35 ± 0.216
2.543LysGly: 2.543 ± 0.355
1.09LysHis: 1.09 ± 0.287
0.727LysIle: 0.727 ± 0.241
1.246LysLys: 1.246 ± 0.34
2.284LysLeu: 2.284 ± 0.394
0.519LysMet: 0.519 ± 0.138
0.882LysAsn: 0.882 ± 0.23
2.336LysPro: 2.336 ± 0.288
1.869LysGln: 1.869 ± 0.234
2.543LysArg: 2.543 ± 0.437
2.128LysSer: 2.128 ± 0.344
2.18LysThr: 2.18 ± 0.377
2.336LysVal: 2.336 ± 0.403
1.142LysTrp: 1.142 ± 0.284
0.675LysTyr: 0.675 ± 0.197
0.0LysXaa: 0.0 ± 0.0
Leu
7.994LeuAla: 7.994 ± 0.827
0.675LeuCys: 0.675 ± 0.274
5.139LeuAsp: 5.139 ± 0.523
3.945LeuGlu: 3.945 ± 0.453
2.543LeuPhe: 2.543 ± 0.337
5.035LeuGly: 5.035 ± 0.655
1.35LeuHis: 1.35 ± 0.332
3.063LeuIle: 3.063 ± 0.531
2.024LeuLys: 2.024 ± 0.312
4.36LeuLeu: 4.36 ± 0.51
1.609LeuMet: 1.609 ± 0.283
2.647LeuAsn: 2.647 ± 0.406
5.917LeuPro: 5.917 ± 0.649
2.855LeuGln: 2.855 ± 0.436
4.827LeuArg: 4.827 ± 0.596
4.775LeuSer: 4.775 ± 0.49
5.502LeuThr: 5.502 ± 0.576
4.724LeuVal: 4.724 ± 0.481
1.35LeuTrp: 1.35 ± 0.275
1.972LeuTyr: 1.972 ± 0.361
0.0LeuXaa: 0.0 ± 0.0
Met
2.076MetAla: 2.076 ± 0.321
0.208MetCys: 0.208 ± 0.13
1.298MetAsp: 1.298 ± 0.276
0.831MetGlu: 0.831 ± 0.19
0.623MetPhe: 0.623 ± 0.201
1.817MetGly: 1.817 ± 0.277
0.415MetHis: 0.415 ± 0.164
0.727MetIle: 0.727 ± 0.201
0.727MetLys: 0.727 ± 0.18
2.024MetLeu: 2.024 ± 0.327
0.467MetMet: 0.467 ± 0.192
0.831MetAsn: 0.831 ± 0.198
1.35MetPro: 1.35 ± 0.239
0.571MetGln: 0.571 ± 0.166
1.35MetArg: 1.35 ± 0.258
2.751MetSer: 2.751 ± 0.438
2.492MetThr: 2.492 ± 0.317
1.298MetVal: 1.298 ± 0.321
0.363MetTrp: 0.363 ± 0.136
0.26MetTyr: 0.26 ± 0.112
0.0MetXaa: 0.0 ± 0.0
Asn
3.426AsnAla: 3.426 ± 0.412
0.415AsnCys: 0.415 ± 0.125
1.817AsnAsp: 1.817 ± 0.315
1.869AsnGlu: 1.869 ± 0.327
0.675AsnPhe: 0.675 ± 0.231
3.841AsnGly: 3.841 ± 0.533
0.882AsnHis: 0.882 ± 0.255
1.661AsnIle: 1.661 ± 0.437
0.831AsnLys: 0.831 ± 0.204
2.336AsnLeu: 2.336 ± 0.406
0.675AsnMet: 0.675 ± 0.138
1.661AsnAsn: 1.661 ± 0.346
2.543AsnPro: 2.543 ± 0.329
0.986AsnGln: 0.986 ± 0.276
2.44AsnArg: 2.44 ± 0.329
1.402AsnSer: 1.402 ± 0.255
2.076AsnThr: 2.076 ± 0.338
1.869AsnVal: 1.869 ± 0.291
0.467AsnTrp: 0.467 ± 0.162
0.623AsnTyr: 0.623 ± 0.16
0.0AsnXaa: 0.0 ± 0.0
Pro
6.177ProAla: 6.177 ± 0.632
0.779ProCys: 0.779 ± 0.19
4.568ProAsp: 4.568 ± 0.497
4.36ProGlu: 4.36 ± 0.429
1.921ProPhe: 1.921 ± 0.32
6.748ProGly: 6.748 ± 0.724
1.505ProHis: 1.505 ± 0.3
2.284ProIle: 2.284 ± 0.38
2.18ProLys: 2.18 ± 0.389
4.568ProLeu: 4.568 ± 0.515
1.246ProMet: 1.246 ± 0.266
1.869ProAsn: 1.869 ± 0.299
4.153ProPro: 4.153 ± 0.546
2.284ProGln: 2.284 ± 0.379
3.53ProArg: 3.53 ± 0.545
3.166ProSer: 3.166 ± 0.416
3.322ProThr: 3.322 ± 0.497
4.983ProVal: 4.983 ± 0.526
1.09ProTrp: 1.09 ± 0.277
1.298ProTyr: 1.298 ± 0.272
0.0ProXaa: 0.0 ± 0.0
Gln
4.153GlnAla: 4.153 ± 0.57
0.467GlnCys: 0.467 ± 0.146
1.609GlnAsp: 1.609 ± 0.233
1.661GlnGlu: 1.661 ± 0.275
1.09GlnPhe: 1.09 ± 0.21
2.492GlnGly: 2.492 ± 0.437
1.038GlnHis: 1.038 ± 0.239
1.557GlnIle: 1.557 ± 0.28
1.35GlnLys: 1.35 ± 0.222
3.114GlnLeu: 3.114 ± 0.435
0.727GlnMet: 0.727 ± 0.179
0.882GlnAsn: 0.882 ± 0.261
2.855GlnPro: 2.855 ± 0.453
1.194GlnGln: 1.194 ± 0.292
2.803GlnArg: 2.803 ± 0.415
2.647GlnSer: 2.647 ± 0.413
1.972GlnThr: 1.972 ± 0.33
2.284GlnVal: 2.284 ± 0.353
0.571GlnTrp: 0.571 ± 0.16
0.934GlnTyr: 0.934 ± 0.251
0.0GlnXaa: 0.0 ± 0.0
Arg
7.423ArgAla: 7.423 ± 0.725
1.298ArgCys: 1.298 ± 0.386
4.983ArgAsp: 4.983 ± 0.596
4.931ArgGlu: 4.931 ± 0.61
2.336ArgPhe: 2.336 ± 0.43
3.841ArgGly: 3.841 ± 0.49
1.557ArgHis: 1.557 ± 0.327
3.893ArgIle: 3.893 ± 0.506
2.647ArgLys: 2.647 ± 0.357
5.035ArgLeu: 5.035 ± 0.635
2.699ArgMet: 2.699 ± 0.387
2.543ArgAsn: 2.543 ± 0.417
3.945ArgPro: 3.945 ± 0.53
1.869ArgGln: 1.869 ± 0.309
5.969ArgArg: 5.969 ± 0.898
3.634ArgSer: 3.634 ± 0.509
3.166ArgThr: 3.166 ± 0.48
5.087ArgVal: 5.087 ± 0.613
2.44ArgTrp: 2.44 ± 0.442
2.024ArgTyr: 2.024 ± 0.317
0.0ArgXaa: 0.0 ± 0.0
Ser
5.45SerAla: 5.45 ± 0.813
0.519SerCys: 0.519 ± 0.203
3.945SerAsp: 3.945 ± 0.531
2.855SerGlu: 2.855 ± 0.423
2.128SerPhe: 2.128 ± 0.435
5.71SerGly: 5.71 ± 0.824
1.298SerHis: 1.298 ± 0.238
2.595SerIle: 2.595 ± 0.392
2.388SerLys: 2.388 ± 0.349
4.101SerLeu: 4.101 ± 0.495
1.298SerMet: 1.298 ± 0.235
2.024SerAsn: 2.024 ± 0.316
3.582SerPro: 3.582 ± 0.389
2.024SerGln: 2.024 ± 0.314
3.685SerArg: 3.685 ± 0.416
4.049SerSer: 4.049 ± 0.668
3.374SerThr: 3.374 ± 0.397
4.775SerVal: 4.775 ± 0.441
1.142SerTrp: 1.142 ± 0.232
1.557SerTyr: 1.557 ± 0.233
0.0SerXaa: 0.0 ± 0.0
Thr
6.904ThrAla: 6.904 ± 0.55
0.934ThrCys: 0.934 ± 0.294
3.789ThrAsp: 3.789 ± 0.513
4.205ThrGlu: 4.205 ± 0.399
1.869ThrPhe: 1.869 ± 0.345
6.177ThrGly: 6.177 ± 0.706
1.505ThrHis: 1.505 ± 0.282
3.27ThrIle: 3.27 ± 0.432
2.076ThrLys: 2.076 ± 0.387
3.997ThrLeu: 3.997 ± 0.416
1.609ThrMet: 1.609 ± 0.302
1.869ThrAsn: 1.869 ± 0.357
4.205ThrPro: 4.205 ± 0.468
1.765ThrGln: 1.765 ± 0.31
3.737ThrArg: 3.737 ± 0.486
3.634ThrSer: 3.634 ± 0.453
4.775ThrThr: 4.775 ± 0.788
5.554ThrVal: 5.554 ± 0.557
1.246ThrTrp: 1.246 ± 0.277
1.765ThrTyr: 1.765 ± 0.296
0.0ThrXaa: 0.0 ± 0.0
Val
7.371ValAla: 7.371 ± 0.503
1.35ValCys: 1.35 ± 0.266
5.346ValAsp: 5.346 ± 0.481
4.36ValGlu: 4.36 ± 0.51
2.336ValPhe: 2.336 ± 0.415
5.45ValGly: 5.45 ± 0.685
1.609ValHis: 1.609 ± 0.327
2.751ValIle: 2.751 ± 0.414
2.44ValLys: 2.44 ± 0.375
5.191ValLeu: 5.191 ± 0.564
1.453ValMet: 1.453 ± 0.268
2.336ValAsn: 2.336 ± 0.352
4.516ValPro: 4.516 ± 0.448
2.803ValGln: 2.803 ± 0.373
5.45ValArg: 5.45 ± 0.674
4.516ValSer: 4.516 ± 0.485
5.035ValThr: 5.035 ± 0.574
5.866ValVal: 5.866 ± 0.638
1.402ValTrp: 1.402 ± 0.28
1.35ValTyr: 1.35 ± 0.297
0.0ValXaa: 0.0 ± 0.0
Trp
1.972TrpAla: 1.972 ± 0.318
0.208TrpCys: 0.208 ± 0.091
1.402TrpAsp: 1.402 ± 0.252
0.934TrpGlu: 0.934 ± 0.31
0.882TrpPhe: 0.882 ± 0.218
1.038TrpGly: 1.038 ± 0.245
0.675TrpHis: 0.675 ± 0.181
1.038TrpIle: 1.038 ± 0.221
0.623TrpLys: 0.623 ± 0.144
1.453TrpLeu: 1.453 ± 0.309
0.779TrpMet: 0.779 ± 0.168
0.675TrpAsn: 0.675 ± 0.186
0.882TrpPro: 0.882 ± 0.224
1.142TrpGln: 1.142 ± 0.265
2.388TrpArg: 2.388 ± 0.444
1.35TrpSer: 1.35 ± 0.268
1.609TrpThr: 1.609 ± 0.253
2.076TrpVal: 2.076 ± 0.417
0.986TrpTrp: 0.986 ± 0.202
0.311TrpTyr: 0.311 ± 0.137
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.232TyrAla: 2.232 ± 0.339
0.311TyrCys: 0.311 ± 0.127
1.817TyrAsp: 1.817 ± 0.372
1.869TyrGlu: 1.869 ± 0.317
0.831TyrPhe: 0.831 ± 0.205
1.972TyrGly: 1.972 ± 0.365
0.26TyrHis: 0.26 ± 0.092
0.934TyrIle: 0.934 ± 0.202
0.675TyrLys: 0.675 ± 0.188
1.972TyrLeu: 1.972 ± 0.436
0.26TyrMet: 0.26 ± 0.132
0.675TyrAsn: 0.675 ± 0.194
1.298TyrPro: 1.298 ± 0.252
0.934TyrGln: 0.934 ± 0.221
2.336TyrArg: 2.336 ± 0.379
1.298TyrSer: 1.298 ± 0.272
1.817TyrThr: 1.817 ± 0.286
2.024TyrVal: 2.024 ± 0.272
0.519TyrTrp: 0.519 ± 0.176
0.467TyrTyr: 0.467 ± 0.128
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 105 proteins (19266 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski