Amino acid dipepetide frequency for Aspergillus ellipticus CBS 707.79

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.835AlaAla: 8.835 ± 0.067	1.163AlaCys: 1.163 ± 0.014	4.183AlaAsp: 4.183 ± 0.028	4.89AlaGlu: 4.89 ± 0.038	3.163AlaPhe: 3.163 ± 0.027	5.891AlaGly: 5.891 ± 0.039	1.834AlaHis: 1.834 ± 0.022	4.275AlaIle: 4.275 ± 0.033	3.54AlaLys: 3.54 ± 0.03	7.942AlaLeu: 7.942 ± 0.043	2.008AlaMet: 2.008 ± 0.02	2.774AlaAsn: 2.774 ± 0.026	4.801AlaPro: 4.801 ± 0.041	3.331AlaGln: 3.331 ± 0.028	5.01AlaArg: 5.01 ± 0.032	7.228AlaSer: 7.228 ± 0.046	5.32AlaThr: 5.32 ± 0.038	5.498AlaVal: 5.498 ± 0.037	1.215AlaTrp: 1.215 ± 0.016	2.174AlaTyr: 2.174 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	0.997CysAla: 0.997 ± 0.014	0.283CysCys: 0.283 ± 0.009	0.727CysAsp: 0.727 ± 0.012	0.619CysGlu: 0.619 ± 0.013	0.587CysPhe: 0.587 ± 0.011	0.985CysGly: 0.985 ± 0.015	0.374CysHis: 0.374 ± 0.009	0.738CysIle: 0.738 ± 0.012	0.465CysLys: 0.465 ± 0.01	1.45CysLeu: 1.45 ± 0.018	0.307CysMet: 0.307 ± 0.008	0.439CysAsn: 0.439 ± 0.01	0.744CysPro: 0.744 ± 0.013	0.496CysGln: 0.496 ± 0.01	0.89CysArg: 0.89 ± 0.014	1.038CysSer: 1.038 ± 0.015	0.732CysThr: 0.732 ± 0.012	0.891CysVal: 0.891 ± 0.015	0.221CysTrp: 0.221 ± 0.006	0.387CysTyr: 0.387 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.552AspAla: 4.552 ± 0.03	0.651AspCys: 0.651 ± 0.012	3.89AspAsp: 3.89 ± 0.04	4.131AspGlu: 4.131 ± 0.037	2.115AspPhe: 2.115 ± 0.021	3.984AspGly: 3.984 ± 0.034	1.303AspHis: 1.303 ± 0.015	3.024AspIle: 3.024 ± 0.025	2.08AspLys: 2.08 ± 0.021	5.123AspLeu: 5.123 ± 0.034	1.229AspMet: 1.229 ± 0.013	1.778AspAsn: 1.778 ± 0.02	3.475AspPro: 3.475 ± 0.028	1.889AspGln: 1.889 ± 0.021	3.161AspArg: 3.161 ± 0.026	4.062AspSer: 4.062 ± 0.036	2.957AspThr: 2.957 ± 0.026	3.57AspVal: 3.57 ± 0.03	0.901AspTrp: 0.901 ± 0.014	1.615AspTyr: 1.615 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.094GluAla: 5.094 ± 0.04	0.654GluCys: 0.654 ± 0.012	3.897GluAsp: 3.897 ± 0.035	5.23GluGlu: 5.23 ± 0.052	1.916GluPhe: 1.916 ± 0.018	3.827GluGly: 3.827 ± 0.03	1.319GluHis: 1.319 ± 0.014	2.964GluIle: 2.964 ± 0.023	3.297GluLys: 3.297 ± 0.034	4.953GluLeu: 4.953 ± 0.033	1.457GluMet: 1.457 ± 0.016	2.159GluAsn: 2.159 ± 0.022	2.758GluPro: 2.758 ± 0.034	2.379GluGln: 2.379 ± 0.027	3.806GluArg: 3.806 ± 0.036	4.247GluSer: 4.247 ± 0.032	3.517GluThr: 3.517 ± 0.032	3.467GluVal: 3.467 ± 0.025	0.89GluTrp: 0.89 ± 0.014	1.729GluTyr: 1.729 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.99PheAla: 2.99 ± 0.027	0.604PheCys: 0.604 ± 0.011	2.257PheAsp: 2.257 ± 0.021	2.025PheGlu: 2.025 ± 0.02	1.74PhePhe: 1.74 ± 0.022	2.863PheGly: 2.863 ± 0.027	0.998PheHis: 0.998 ± 0.013	1.833PheIle: 1.833 ± 0.018	1.324PheLys: 1.324 ± 0.015	3.737PheLeu: 3.737 ± 0.029	0.792PheMet: 0.792 ± 0.012	1.377PheAsn: 1.377 ± 0.016	2.096PhePro: 2.096 ± 0.022	1.45PheGln: 1.45 ± 0.015	2.074PheArg: 2.074 ± 0.019	3.089PheSer: 3.089 ± 0.027	2.189PheThr: 2.189 ± 0.02	2.424PheVal: 2.424 ± 0.024	0.661PheTrp: 0.661 ± 0.011	1.157PheTyr: 1.157 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.303GlyAla: 5.303 ± 0.039	0.996GlyCys: 0.996 ± 0.016	3.57GlyAsp: 3.57 ± 0.026	3.734GlyGlu: 3.734 ± 0.027	2.879GlyPhe: 2.879 ± 0.026	5.761GlyGly: 5.761 ± 0.049	1.692GlyHis: 1.692 ± 0.02	3.537GlyIle: 3.537 ± 0.028	3.133GlyLys: 3.133 ± 0.028	6.449GlyLeu: 6.449 ± 0.041	1.663GlyMet: 1.663 ± 0.019	2.394GlyAsn: 2.394 ± 0.025	3.467GlyPro: 3.467 ± 0.027	2.55GlyGln: 2.55 ± 0.024	4.238GlyArg: 4.238 ± 0.029	5.754GlySer: 5.754 ± 0.042	3.942GlyThr: 3.942 ± 0.031	4.605GlyVal: 4.605 ± 0.032	1.268GlyTrp: 1.268 ± 0.017	2.217GlyTyr: 2.217 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	1.94HisAla: 1.94 ± 0.019	0.368HisCys: 0.368 ± 0.009	1.334HisAsp: 1.334 ± 0.019	1.326HisGlu: 1.326 ± 0.015	0.934HisPhe: 0.934 ± 0.014	1.769HisGly: 1.769 ± 0.02	0.987HisHis: 0.987 ± 0.018	1.241HisIle: 1.241 ± 0.016	0.789HisLys: 0.789 ± 0.012	2.436HisLeu: 2.436 ± 0.021	0.512HisMet: 0.512 ± 0.011	0.836HisAsn: 0.836 ± 0.016	1.909HisPro: 1.909 ± 0.018	1.02HisGln: 1.02 ± 0.018	1.704HisArg: 1.704 ± 0.019	1.921HisSer: 1.921 ± 0.021	1.346HisThr: 1.346 ± 0.016	1.441HisVal: 1.441 ± 0.016	0.367HisTrp: 0.367 ± 0.008	0.713HisTyr: 0.713 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.178IleAla: 4.178 ± 0.03	0.827IleCys: 0.827 ± 0.014	2.753IleAsp: 2.753 ± 0.025	2.688IleGlu: 2.688 ± 0.027	2.068IlePhe: 2.068 ± 0.024	3.206IleGly: 3.206 ± 0.029	1.33IleHis: 1.33 ± 0.015	2.597IleIle: 2.597 ± 0.029	1.913IleLys: 1.913 ± 0.022	4.741IleLeu: 4.741 ± 0.039	1.028IleMet: 1.028 ± 0.016	1.741IleAsn: 1.741 ± 0.017	3.239IlePro: 3.239 ± 0.026	1.938IleGln: 1.938 ± 0.017	2.857IleArg: 2.857 ± 0.027	3.871IleSer: 3.871 ± 0.028	2.867IleThr: 2.867 ± 0.025	3.147IleVal: 3.147 ± 0.027	0.743IleTrp: 0.743 ± 0.012	1.502IleTyr: 1.502 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.733LysAla: 3.733 ± 0.033	0.47LysCys: 0.47 ± 0.011	2.424LysAsp: 2.424 ± 0.025	2.941LysGlu: 2.941 ± 0.033	1.302LysPhe: 1.302 ± 0.015	2.691LysGly: 2.691 ± 0.026	1.026LysHis: 1.026 ± 0.014	2.056LysIle: 2.056 ± 0.02	2.801LysLys: 2.801 ± 0.041	3.643LysLeu: 3.643 ± 0.029	0.92LysMet: 0.92 ± 0.011	1.556LysAsn: 1.556 ± 0.021	2.502LysPro: 2.502 ± 0.026	1.683LysGln: 1.683 ± 0.02	3.055LysArg: 3.055 ± 0.029	3.113LysSer: 3.113 ± 0.028	2.554LysThr: 2.554 ± 0.021	2.514LysVal: 2.514 ± 0.023	0.597LysTrp: 0.597 ± 0.011	1.276LysTyr: 1.276 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	8.007LeuAla: 8.007 ± 0.04	1.328LeuCys: 1.328 ± 0.017	5.263LeuAsp: 5.263 ± 0.034	5.391LeuGlu: 5.391 ± 0.038	3.515LeuPhe: 3.515 ± 0.029	6.251LeuGly: 6.251 ± 0.04	2.385LeuHis: 2.385 ± 0.021	4.103LeuIle: 4.103 ± 0.03	3.845LeuLys: 3.845 ± 0.03	8.973LeuLeu: 8.973 ± 0.06	1.848LeuMet: 1.848 ± 0.015	3.133LeuAsn: 3.133 ± 0.027	5.737LeuPro: 5.737 ± 0.034	3.914LeuGln: 3.914 ± 0.032	5.956LeuArg: 5.956 ± 0.037	7.732LeuSer: 7.732 ± 0.042	5.068LeuThr: 5.068 ± 0.032	5.72LeuVal: 5.72 ± 0.044	1.27LeuTrp: 1.27 ± 0.016	2.527LeuTyr: 2.527 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.193MetAla: 2.193 ± 0.019	0.268MetCys: 0.268 ± 0.006	1.259MetAsp: 1.259 ± 0.016	1.298MetGlu: 1.298 ± 0.017	0.763MetPhe: 0.763 ± 0.012	1.556MetGly: 1.556 ± 0.018	0.511MetHis: 0.511 ± 0.01	1.035MetIle: 1.035 ± 0.014	0.945MetLys: 0.945 ± 0.012	1.888MetLeu: 1.888 ± 0.02	0.6MetMet: 0.6 ± 0.012	0.797MetAsn: 0.797 ± 0.012	1.243MetPro: 1.243 ± 0.015	0.862MetGln: 0.862 ± 0.013	1.274MetArg: 1.274 ± 0.014	1.874MetSer: 1.874 ± 0.02	1.32MetThr: 1.32 ± 0.015	1.385MetVal: 1.385 ± 0.016	0.268MetTrp: 0.268 ± 0.007	0.546MetTyr: 0.546 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.933AsnAla: 2.933 ± 0.023	0.451AsnCys: 0.451 ± 0.01	1.811AsnAsp: 1.811 ± 0.017	1.854AsnGlu: 1.854 ± 0.019	1.296AsnPhe: 1.296 ± 0.016	2.714AsnGly: 2.714 ± 0.025	0.862AsnHis: 0.862 ± 0.014	2.006AsnIle: 2.006 ± 0.019	1.32AsnLys: 1.32 ± 0.017	3.177AsnLeu: 3.177 ± 0.026	0.79AsnMet: 0.79 ± 0.015	1.414AsnAsn: 1.414 ± 0.022	2.575AsnPro: 2.575 ± 0.021	1.301AsnGln: 1.301 ± 0.017	1.934AsnArg: 1.934 ± 0.02	2.577AsnSer: 2.577 ± 0.022	2.152AsnThr: 2.152 ± 0.019	2.162AsnVal: 2.162 ± 0.019	0.552AsnTrp: 0.552 ± 0.01	1.05AsnTyr: 1.05 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.424ProAla: 5.424 ± 0.043	0.624ProCys: 0.624 ± 0.01	3.343ProAsp: 3.343 ± 0.026	3.868ProGlu: 3.868 ± 0.031	2.193ProPhe: 2.193 ± 0.022	4.052ProGly: 4.052 ± 0.028	1.462ProHis: 1.462 ± 0.019	2.583ProIle: 2.583 ± 0.023	2.379ProLys: 2.379 ± 0.022	4.977ProLeu: 4.977 ± 0.032	1.1ProMet: 1.1 ± 0.014	2.128ProAsn: 2.128 ± 0.02	5.267ProPro: 5.267 ± 0.07	2.512ProGln: 2.512 ± 0.029	3.64ProArg: 3.64 ± 0.026	6.464ProSer: 6.464 ± 0.048	4.12ProThr: 4.12 ± 0.03	3.792ProVal: 3.792 ± 0.031	0.828ProTrp: 0.828 ± 0.012	1.566ProTyr: 1.566 ± 0.018	0.001ProXaa: 0.001 ± 0.0
Gln	3.401GlnAla: 3.401 ± 0.026	0.477GlnCys: 0.477 ± 0.01	1.989GlnAsp: 1.989 ± 0.02	2.354GlnGlu: 2.354 ± 0.022	1.297GlnPhe: 1.297 ± 0.016	2.433GlnGly: 2.433 ± 0.021	1.064GlnHis: 1.064 ± 0.014	1.929GlnIle: 1.929 ± 0.02	1.861GlnLys: 1.861 ± 0.019	3.504GlnLeu: 3.504 ± 0.029	0.886GlnMet: 0.886 ± 0.016	1.46GlnAsn: 1.46 ± 0.017	2.67GlnPro: 2.67 ± 0.027	2.323GlnGln: 2.323 ± 0.044	2.636GlnArg: 2.636 ± 0.025	3.159GlnSer: 3.159 ± 0.031	2.427GlnThr: 2.427 ± 0.018	2.188GlnVal: 2.188 ± 0.022	0.584GlnTrp: 0.584 ± 0.011	1.164GlnTyr: 1.164 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.833ArgAla: 4.833 ± 0.034	0.825ArgCys: 0.825 ± 0.014	3.361ArgAsp: 3.361 ± 0.027	3.795ArgGlu: 3.795 ± 0.031	2.233ArgPhe: 2.233 ± 0.02	3.907ArgGly: 3.907 ± 0.033	1.636ArgHis: 1.636 ± 0.017	2.918ArgIle: 2.918 ± 0.024	3.204ArgLys: 3.204 ± 0.025	5.743ArgLeu: 5.743 ± 0.034	1.369ArgMet: 1.369 ± 0.018	2.145ArgAsn: 2.145 ± 0.021	3.699ArgPro: 3.699 ± 0.029	2.641ArgGln: 2.641 ± 0.024	5.248ArgArg: 5.248 ± 0.043	4.855ArgSer: 4.855 ± 0.04	3.35ArgThr: 3.35 ± 0.022	3.679ArgVal: 3.679 ± 0.029	0.998ArgTrp: 0.998 ± 0.015	1.746ArgTyr: 1.746 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.676SerAla: 6.676 ± 0.043	0.995SerCys: 0.995 ± 0.015	4.237SerAsp: 4.237 ± 0.038	4.096SerGlu: 4.096 ± 0.033	3.1SerPhe: 3.1 ± 0.026	5.637SerGly: 5.637 ± 0.037	2.074SerHis: 2.074 ± 0.021	4.043SerIle: 4.043 ± 0.03	3.335SerLys: 3.335 ± 0.026	7.615SerLeu: 7.615 ± 0.044	1.745SerMet: 1.745 ± 0.017	2.859SerAsn: 2.859 ± 0.023	5.753SerPro: 5.753 ± 0.047	3.308SerGln: 3.308 ± 0.03	5.116SerArg: 5.116 ± 0.042	8.946SerSer: 8.946 ± 0.08	5.677SerThr: 5.677 ± 0.044	4.739SerVal: 4.739 ± 0.032	1.194SerTrp: 1.194 ± 0.014	2.12SerTyr: 2.12 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.324ThrAla: 5.324 ± 0.034	0.794ThrCys: 0.794 ± 0.013	2.94ThrAsp: 2.94 ± 0.024	3.111ThrGlu: 3.111 ± 0.026	2.225ThrPhe: 2.225 ± 0.021	4.326ThrGly: 4.326 ± 0.036	1.396ThrHis: 1.396 ± 0.017	3.091ThrIle: 3.091 ± 0.024	2.316ThrLys: 2.316 ± 0.023	5.474ThrLeu: 5.474 ± 0.035	1.214ThrMet: 1.214 ± 0.016	2.026ThrAsn: 2.026 ± 0.019	4.443ThrPro: 4.443 ± 0.037	2.113ThrGln: 2.113 ± 0.022	3.225ThrArg: 3.225 ± 0.023	5.262ThrSer: 5.262 ± 0.04	4.66ThrThr: 4.66 ± 0.057	3.895ThrVal: 3.895 ± 0.025	0.877ThrTrp: 0.877 ± 0.014	1.703ThrTyr: 1.703 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.329ValAla: 5.329 ± 0.034	0.927ValCys: 0.927 ± 0.014	3.727ValAsp: 3.727 ± 0.03	3.811ValGlu: 3.811 ± 0.024	2.568ValPhe: 2.568 ± 0.025	4.174ValGly: 4.174 ± 0.035	1.471ValHis: 1.471 ± 0.016	2.993ValIle: 2.993 ± 0.022	2.552ValLys: 2.552 ± 0.022	5.848ValLeu: 5.848 ± 0.036	1.376ValMet: 1.376 ± 0.016	2.15ValAsn: 2.15 ± 0.02	3.68ValPro: 3.68 ± 0.03	2.406ValGln: 2.406 ± 0.023	3.655ValArg: 3.655 ± 0.03	4.829ValSer: 4.829 ± 0.03	3.523ValThr: 3.523 ± 0.027	4.497ValVal: 4.497 ± 0.035	0.935ValTrp: 0.935 ± 0.013	1.836ValTyr: 1.836 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.154TrpAla: 1.154 ± 0.016	0.215TrpCys: 0.215 ± 0.005	0.912TrpAsp: 0.912 ± 0.015	0.865TrpGlu: 0.865 ± 0.013	0.564TrpPhe: 0.564 ± 0.01	0.992TrpGly: 0.992 ± 0.014	0.368TrpHis: 0.368 ± 0.008	0.79TrpIle: 0.79 ± 0.012	0.765TrpLys: 0.765 ± 0.011	1.427TrpLeu: 1.427 ± 0.016	0.396TrpMet: 0.396 ± 0.008	0.652TrpAsn: 0.652 ± 0.011	0.647TrpPro: 0.647 ± 0.011	0.569TrpGln: 0.569 ± 0.009	1.008TrpArg: 1.008 ± 0.013	1.114TrpSer: 1.114 ± 0.017	0.984TrpThr: 0.984 ± 0.017	0.983TrpVal: 0.983 ± 0.014	0.292TrpTrp: 0.292 ± 0.008	0.442TrpTyr: 0.442 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.178TyrAla: 2.178 ± 0.021	0.451TyrCys: 0.451 ± 0.009	1.611TyrAsp: 1.611 ± 0.018	1.531TyrGlu: 1.531 ± 0.018	1.221TyrPhe: 1.221 ± 0.016	2.133TyrGly: 2.133 ± 0.021	0.804TyrHis: 0.804 ± 0.012	1.475TyrIle: 1.475 ± 0.016	0.994TyrLys: 0.994 ± 0.015	2.863TyrLeu: 2.863 ± 0.025	0.645TyrMet: 0.645 ± 0.01	1.114TyrAsn: 1.114 ± 0.016	1.618TyrPro: 1.618 ± 0.021	1.121TyrGln: 1.121 ± 0.014	1.7TyrArg: 1.7 ± 0.017	2.13TyrSer: 2.13 ± 0.021	1.71TyrThr: 1.71 ± 0.021	1.692TyrVal: 1.692 ± 0.017	0.48TyrTrp: 0.48 ± 0.01	1.001TyrTyr: 1.001 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.011XaaXaa: 0.011 ± 0.006

Statistics based on 12861 proteins (5629130 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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