Amino acid dipepetide frequency for Oryctolagus cuniculus (Rabbit)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.248AlaAla: 7.248 ± 0.036	1.45AlaCys: 1.45 ± 0.01	3.004AlaAsp: 3.004 ± 0.013	4.86AlaGlu: 4.86 ± 0.02	2.644AlaPhe: 2.644 ± 0.013	5.058AlaGly: 5.058 ± 0.023	1.64AlaHis: 1.64 ± 0.009	2.805AlaIle: 2.805 ± 0.012	3.439AlaLys: 3.439 ± 0.015	7.206AlaLeu: 7.206 ± 0.028	1.493AlaMet: 1.493 ± 0.008	2.039AlaAsn: 2.039 ± 0.009	4.454AlaPro: 4.454 ± 0.025	3.335AlaGln: 3.335 ± 0.017	3.899AlaArg: 3.899 ± 0.016	5.887AlaSer: 5.887 ± 0.02	3.522AlaThr: 3.522 ± 0.015	4.916AlaVal: 4.916 ± 0.016	0.861AlaTrp: 0.861 ± 0.007	1.513AlaTyr: 1.513 ± 0.008	0.001AlaXaa: 0.001 ± 0.0
Cys	1.34CysAla: 1.34 ± 0.009	0.656CysCys: 0.656 ± 0.009	0.983CysAsp: 0.983 ± 0.009	1.224CysGlu: 1.224 ± 0.011	0.853CysPhe: 0.853 ± 0.006	1.719CysGly: 1.719 ± 0.016	0.651CysHis: 0.651 ± 0.006	0.939CysIle: 0.939 ± 0.008	1.106CysLys: 1.106 ± 0.009	2.204CysLeu: 2.204 ± 0.011	0.402CysMet: 0.402 ± 0.004	0.796CysAsn: 0.796 ± 0.008	1.481CysPro: 1.481 ± 0.012	1.037CysGln: 1.037 ± 0.009	1.362CysArg: 1.362 ± 0.01	2.085CysSer: 2.085 ± 0.014	1.13CysThr: 1.13 ± 0.008	1.36CysVal: 1.36 ± 0.009	0.348CysTrp: 0.348 ± 0.004	0.562CysTyr: 0.562 ± 0.005	0.0CysXaa: 0.0 ± 0.0
Asp	2.97AspAla: 2.97 ± 0.013	1.047AspCys: 1.047 ± 0.009	2.581AspAsp: 2.581 ± 0.015	3.298AspGlu: 3.298 ± 0.017	2.104AspPhe: 2.104 ± 0.01	3.212AspGly: 3.212 ± 0.018	1.106AspHis: 1.106 ± 0.007	2.522AspIle: 2.522 ± 0.012	2.5AspLys: 2.5 ± 0.012	4.953AspLeu: 4.953 ± 0.017	1.078AspMet: 1.078 ± 0.007	1.653AspAsn: 1.653 ± 0.01	2.884AspPro: 2.884 ± 0.013	1.838AspGln: 1.838 ± 0.01	2.432AspArg: 2.432 ± 0.012	4.109AspSer: 4.109 ± 0.016	2.489AspThr: 2.489 ± 0.011	3.075AspVal: 3.075 ± 0.013	0.609AspTrp: 0.609 ± 0.005	1.438AspTyr: 1.438 ± 0.009	0.001AspXaa: 0.001 ± 0.0
Glu	5.227GluAla: 5.227 ± 0.02	1.363GluCys: 1.363 ± 0.016	4.328GluAsp: 4.328 ± 0.018	7.701GluGlu: 7.701 ± 0.041	2.033GluPhe: 2.033 ± 0.009	4.135GluGly: 4.135 ± 0.016	1.495GluHis: 1.495 ± 0.008	3.198GluIle: 3.198 ± 0.015	5.411GluLys: 5.411 ± 0.028	6.333GluLeu: 6.333 ± 0.028	1.62GluMet: 1.62 ± 0.01	3.111GluAsn: 3.111 ± 0.016	3.216GluPro: 3.216 ± 0.015	3.121GluGln: 3.121 ± 0.017	3.987GluArg: 3.987 ± 0.021	4.334GluSer: 4.334 ± 0.017	3.39GluThr: 3.39 ± 0.015	4.069GluVal: 4.069 ± 0.014	0.696GluTrp: 0.696 ± 0.005	1.551GluTyr: 1.551 ± 0.008	0.001GluXaa: 0.001 ± 0.0
Phe	2.001PheAla: 2.001 ± 0.009	0.95PheCys: 0.95 ± 0.008	1.666PheAsp: 1.666 ± 0.01	1.916PheGlu: 1.916 ± 0.009	1.634PhePhe: 1.634 ± 0.01	2.187PheGly: 2.187 ± 0.014	1.026PheHis: 1.026 ± 0.007	1.828PheIle: 1.828 ± 0.01	1.749PheLys: 1.749 ± 0.01	4.134PheLeu: 4.134 ± 0.017	0.77PheMet: 0.77 ± 0.006	1.386PheAsn: 1.386 ± 0.009	2.039PhePro: 2.039 ± 0.011	1.726PheGln: 1.726 ± 0.01	1.927PheArg: 1.927 ± 0.009	3.411PheSer: 3.411 ± 0.015	2.025PheThr: 2.025 ± 0.01	2.161PheVal: 2.161 ± 0.012	0.49PheTrp: 0.49 ± 0.005	1.199PheTyr: 1.199 ± 0.007	0.0PheXaa: 0.0 ± 0.0
Gly	4.765GlyAla: 4.765 ± 0.022	1.369GlyCys: 1.369 ± 0.01	3.096GlyAsp: 3.096 ± 0.013	4.072GlyGlu: 4.072 ± 0.022	2.406GlyPhe: 2.406 ± 0.013	5.051GlyGly: 5.051 ± 0.026	1.701GlyHis: 1.701 ± 0.01	2.696GlyIle: 2.696 ± 0.013	3.721GlyLys: 3.721 ± 0.019	5.944GlyLeu: 5.944 ± 0.027	1.284GlyMet: 1.284 ± 0.009	2.273GlyAsn: 2.273 ± 0.012	4.286GlyPro: 4.286 ± 0.034	2.808GlyGln: 2.808 ± 0.015	4.047GlyArg: 4.047 ± 0.017	5.819GlySer: 5.819 ± 0.023	3.619GlyThr: 3.619 ± 0.015	3.594GlyVal: 3.594 ± 0.015	0.875GlyTrp: 0.875 ± 0.007	1.677GlyTyr: 1.677 ± 0.01	0.002GlyXaa: 0.002 ± 0.0
His	1.379HisAla: 1.379 ± 0.008	0.749HisCys: 0.749 ± 0.006	0.859HisAsp: 0.859 ± 0.007	1.282HisGlu: 1.282 ± 0.007	1.069HisPhe: 1.069 ± 0.007	1.602HisGly: 1.602 ± 0.01	0.876HisHis: 0.876 ± 0.007	1.263HisIle: 1.263 ± 0.007	1.263HisLys: 1.263 ± 0.009	2.919HisLeu: 2.919 ± 0.012	0.604HisMet: 0.604 ± 0.005	0.826HisAsn: 0.826 ± 0.006	1.681HisPro: 1.681 ± 0.01	1.318HisGln: 1.318 ± 0.012	1.621HisArg: 1.621 ± 0.009	2.316HisSer: 2.316 ± 0.01	1.497HisThr: 1.497 ± 0.014	1.523HisVal: 1.523 ± 0.009	0.346HisTrp: 0.346 ± 0.004	0.775HisTyr: 0.775 ± 0.006	0.0HisXaa: 0.0 ± 0.0
Ile	2.588IleAla: 2.588 ± 0.012	1.048IleCys: 1.048 ± 0.009	2.014IleAsp: 2.014 ± 0.012	2.586IleGlu: 2.586 ± 0.013	1.876IlePhe: 1.876 ± 0.01	2.193IleGly: 2.193 ± 0.011	1.378IleHis: 1.378 ± 0.013	2.355IleIle: 2.355 ± 0.013	2.779IleLys: 2.779 ± 0.015	4.624IleLeu: 4.624 ± 0.017	0.974IleMet: 0.974 ± 0.007	1.896IleAsn: 1.896 ± 0.012	2.624IlePro: 2.624 ± 0.014	2.257IleGln: 2.257 ± 0.011	2.401IleArg: 2.401 ± 0.011	3.607IleSer: 3.607 ± 0.015	2.519IleThr: 2.519 ± 0.012	2.454IleVal: 2.454 ± 0.013	0.503IleTrp: 0.503 ± 0.005	1.417IleTyr: 1.417 ± 0.008	0.0IleXaa: 0.0 ± 0.0
Lys	4.077LysAla: 4.077 ± 0.017	1.103LysCys: 1.103 ± 0.008	3.132LysAsp: 3.132 ± 0.013	5.135LysGlu: 5.135 ± 0.025	1.718LysPhe: 1.718 ± 0.01	3.217LysGly: 3.217 ± 0.017	1.411LysHis: 1.411 ± 0.009	2.867LysIle: 2.867 ± 0.014	4.65LysLys: 4.65 ± 0.026	5.193LysLeu: 5.193 ± 0.018	1.412LysMet: 1.412 ± 0.009	2.413LysAsn: 2.413 ± 0.013	3.093LysPro: 3.093 ± 0.018	2.567LysGln: 2.567 ± 0.014	3.252LysArg: 3.252 ± 0.016	3.93LysSer: 3.93 ± 0.016	3.192LysThr: 3.192 ± 0.014	3.338LysVal: 3.338 ± 0.014	0.618LysTrp: 0.618 ± 0.006	1.528LysTyr: 1.528 ± 0.01	0.0LysXaa: 0.0 ± 0.0
Leu	6.854LeuAla: 6.854 ± 0.024	2.221LeuCys: 2.221 ± 0.012	4.588LeuAsp: 4.588 ± 0.016	7.065LeuGlu: 7.065 ± 0.033	3.434LeuPhe: 3.434 ± 0.016	5.984LeuGly: 5.984 ± 0.021	2.737LeuHis: 2.737 ± 0.01	3.879LeuIle: 3.879 ± 0.017	5.753LeuLys: 5.753 ± 0.022	10.752LeuLeu: 10.752 ± 0.034	1.982LeuMet: 1.982 ± 0.009	3.532LeuAsn: 3.532 ± 0.014	6.191LeuPro: 6.191 ± 0.025	5.729LeuGln: 5.729 ± 0.026	5.987LeuArg: 5.987 ± 0.022	8.079LeuSer: 8.079 ± 0.023	5.037LeuThr: 5.037 ± 0.014	5.431LeuVal: 5.431 ± 0.02	1.186LeuTrp: 1.186 ± 0.008	2.531LeuTyr: 2.531 ± 0.012	0.002LeuXaa: 0.002 ± 0.0
Met	1.86MetAla: 1.86 ± 0.008	0.406MetCys: 0.406 ± 0.004	1.232MetAsp: 1.232 ± 0.007	1.772MetGlu: 1.772 ± 0.011	0.719MetPhe: 0.719 ± 0.006	1.243MetGly: 1.243 ± 0.008	0.449MetHis: 0.449 ± 0.005	0.855MetIle: 0.855 ± 0.006	1.444MetLys: 1.444 ± 0.009	1.94MetLeu: 1.94 ± 0.01	0.56MetMet: 0.56 ± 0.005	0.883MetAsn: 0.883 ± 0.006	1.054MetPro: 1.054 ± 0.009	0.941MetGln: 0.941 ± 0.007	1.028MetArg: 1.028 ± 0.006	1.51MetSer: 1.51 ± 0.008	1.071MetThr: 1.071 ± 0.007	1.318MetVal: 1.318 ± 0.008	0.243MetTrp: 0.243 ± 0.003	0.579MetTyr: 0.579 ± 0.005	0.0MetXaa: 0.0 ± 0.0
Asn	2.057AsnAla: 2.057 ± 0.011	0.823AsnCys: 0.823 ± 0.006	1.485AsnAsp: 1.485 ± 0.01	2.216AsnGlu: 2.216 ± 0.013	1.438AsnPhe: 1.438 ± 0.009	2.344AsnGly: 2.344 ± 0.013	0.928AsnHis: 0.928 ± 0.006	2.14AsnIle: 2.14 ± 0.012	2.254AsnLys: 2.254 ± 0.01	3.693AsnLeu: 3.693 ± 0.015	0.87AsnMet: 0.87 ± 0.006	1.485AsnAsn: 1.485 ± 0.01	2.141AsnPro: 2.141 ± 0.009	1.63AsnGln: 1.63 ± 0.01	1.87AsnArg: 1.87 ± 0.01	3.055AsnSer: 3.055 ± 0.014	1.954AsnThr: 1.954 ± 0.011	2.183AsnVal: 2.183 ± 0.011	0.441AsnTrp: 0.441 ± 0.005	1.126AsnTyr: 1.126 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	5.301ProAla: 5.301 ± 0.028	1.242ProCys: 1.242 ± 0.01	2.756ProAsp: 2.756 ± 0.011	4.403ProGlu: 4.403 ± 0.018	1.93ProPhe: 1.93 ± 0.012	5.508ProGly: 5.508 ± 0.048	1.472ProHis: 1.472 ± 0.011	1.846ProIle: 1.846 ± 0.01	2.83ProLys: 2.83 ± 0.016	5.333ProLeu: 5.333 ± 0.018	1.001ProMet: 1.001 ± 0.008	1.786ProAsn: 1.786 ± 0.01	5.964ProPro: 5.964 ± 0.042	2.846ProGln: 2.846 ± 0.016	3.662ProArg: 3.662 ± 0.019	5.726ProSer: 5.726 ± 0.029	3.012ProThr: 3.012 ± 0.013	3.879ProVal: 3.879 ± 0.016	0.753ProTrp: 0.753 ± 0.007	1.437ProTyr: 1.437 ± 0.011	0.001ProXaa: 0.001 ± 0.0
Gln	3.538GlnAla: 3.538 ± 0.016	0.93GlnCys: 0.93 ± 0.009	2.341GlnAsp: 2.341 ± 0.01	3.878GlnGlu: 3.878 ± 0.023	1.32GlnPhe: 1.32 ± 0.008	2.928GlnGly: 2.928 ± 0.014	1.31GlnHis: 1.31 ± 0.008	1.981GlnIle: 1.981 ± 0.01	2.955GlnLys: 2.955 ± 0.015	4.685GlnLeu: 4.685 ± 0.023	1.092GlnMet: 1.092 ± 0.008	1.79GlnAsn: 1.79 ± 0.011	2.848GlnPro: 2.848 ± 0.018	3.013GlnGln: 3.013 ± 0.025	3.002GlnArg: 3.002 ± 0.016	3.13GlnSer: 3.13 ± 0.014	2.26GlnThr: 2.26 ± 0.009	2.811GlnVal: 2.811 ± 0.012	0.552GlnTrp: 0.552 ± 0.005	1.108GlnTyr: 1.108 ± 0.007	0.001GlnXaa: 0.001 ± 0.0
Arg	4.127ArgAla: 4.127 ± 0.016	1.27ArgCys: 1.27 ± 0.011	2.743ArgAsp: 2.743 ± 0.013	4.059ArgGlu: 4.059 ± 0.022	1.858ArgPhe: 1.858 ± 0.009	3.88ArgGly: 3.88 ± 0.017	1.569ArgHis: 1.569 ± 0.009	2.504ArgIle: 2.504 ± 0.013	3.667ArgLys: 3.667 ± 0.016	5.424ArgLeu: 5.424 ± 0.02	1.196ArgMet: 1.196 ± 0.007	2.137ArgAsn: 2.137 ± 0.012	3.494ArgPro: 3.494 ± 0.017	2.682ArgGln: 2.682 ± 0.013	4.565ArgArg: 4.565 ± 0.022	4.41ArgSer: 4.41 ± 0.022	2.87ArgThr: 2.87 ± 0.013	3.182ArgVal: 3.182 ± 0.013	0.756ArgTrp: 0.756 ± 0.006	1.407ArgTyr: 1.407 ± 0.007	0.002ArgXaa: 0.002 ± 0.0
Ser	5.523SerAla: 5.523 ± 0.02	1.868SerCys: 1.868 ± 0.013	3.825SerAsp: 3.825 ± 0.016	5.089SerGlu: 5.089 ± 0.021	2.999SerPhe: 2.999 ± 0.011	5.598SerGly: 5.598 ± 0.024	2.111SerHis: 2.111 ± 0.011	3.189SerIle: 3.189 ± 0.014	4.02SerLys: 4.02 ± 0.017	8.277SerLeu: 8.277 ± 0.022	1.523SerMet: 1.523 ± 0.009	2.599SerAsn: 2.599 ± 0.014	6.122SerPro: 6.122 ± 0.031	3.864SerGln: 3.864 ± 0.016	4.684SerArg: 4.684 ± 0.021	9.125SerSer: 9.125 ± 0.04	4.425SerThr: 4.425 ± 0.015	4.901SerVal: 4.901 ± 0.018	1.129SerTrp: 1.129 ± 0.008	2.034SerTyr: 2.034 ± 0.012	0.001SerXaa: 0.001 ± 0.0
Thr	3.899ThrAla: 3.899 ± 0.015	1.341ThrCys: 1.341 ± 0.011	2.413ThrAsp: 2.413 ± 0.01	3.508ThrGlu: 3.508 ± 0.015	2.11ThrPhe: 2.11 ± 0.01	3.456ThrGly: 3.456 ± 0.016	1.303ThrHis: 1.303 ± 0.01	2.405ThrIle: 2.405 ± 0.013	2.654ThrLys: 2.654 ± 0.013	5.291ThrLeu: 5.291 ± 0.017	1.085ThrMet: 1.085 ± 0.007	1.68ThrAsn: 1.68 ± 0.008	3.564ThrPro: 3.564 ± 0.019	2.256ThrGln: 2.256 ± 0.01	2.524ThrArg: 2.524 ± 0.013	4.451ThrSer: 4.451 ± 0.018	2.881ThrThr: 2.881 ± 0.016	3.859ThrVal: 3.859 ± 0.015	0.739ThrTrp: 0.739 ± 0.006	1.358ThrTyr: 1.358 ± 0.009	0.001ThrXaa: 0.001 ± 0.0
Val	4.281ValAla: 4.281 ± 0.015	1.471ValCys: 1.471 ± 0.009	2.911ValAsp: 2.911 ± 0.014	3.761ValGlu: 3.761 ± 0.015	2.412ValPhe: 2.412 ± 0.013	3.42ValGly: 3.42 ± 0.014	1.576ValHis: 1.576 ± 0.009	2.88ValIle: 2.88 ± 0.014	3.354ValLys: 3.354 ± 0.014	6.195ValLeu: 6.195 ± 0.02	1.282ValMet: 1.282 ± 0.007	2.231ValAsn: 2.231 ± 0.011	3.712ValPro: 3.712 ± 0.014	2.751ValGln: 2.751 ± 0.013	3.121ValArg: 3.121 ± 0.013	4.909ValSer: 4.909 ± 0.019	3.738ValThr: 3.738 ± 0.016	3.969ValVal: 3.969 ± 0.016	0.719ValTrp: 0.719 ± 0.005	1.608ValTyr: 1.608 ± 0.009	0.001ValXaa: 0.001 ± 0.0
Trp	0.846TrpAla: 0.846 ± 0.006	0.261TrpCys: 0.261 ± 0.003	0.684TrpAsp: 0.684 ± 0.006	0.83TrpGlu: 0.83 ± 0.006	0.448TrpPhe: 0.448 ± 0.004	0.774TrpGly: 0.774 ± 0.008	0.297TrpHis: 0.297 ± 0.004	0.612TrpIle: 0.612 ± 0.006	0.822TrpLys: 0.822 ± 0.005	1.235TrpLeu: 1.235 ± 0.009	0.31TrpMet: 0.31 ± 0.004	0.536TrpAsn: 0.536 ± 0.005	0.586TrpPro: 0.586 ± 0.005	0.535TrpGln: 0.535 ± 0.005	0.832TrpArg: 0.832 ± 0.006	0.885TrpSer: 0.885 ± 0.007	0.666TrpThr: 0.666 ± 0.005	0.721TrpVal: 0.721 ± 0.006	0.209TrpTrp: 0.209 ± 0.003	0.355TrpTyr: 0.355 ± 0.004	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.39TyrAla: 1.39 ± 0.008	0.671TyrCys: 0.671 ± 0.006	1.256TyrAsp: 1.256 ± 0.009	1.662TyrGlu: 1.662 ± 0.01	1.221TyrPhe: 1.221 ± 0.007	1.597TyrGly: 1.597 ± 0.011	0.732TyrHis: 0.732 ± 0.006	1.33TyrIle: 1.33 ± 0.008	1.475TyrLys: 1.475 ± 0.012	2.618TyrLeu: 2.618 ± 0.011	0.572TyrMet: 0.572 ± 0.005	1.078TyrAsn: 1.078 ± 0.007	1.251TyrPro: 1.251 ± 0.008	1.218TyrGln: 1.218 ± 0.007	1.594TyrArg: 1.594 ± 0.01	2.127TyrSer: 2.127 ± 0.01	1.48TyrThr: 1.48 ± 0.009	1.557TyrVal: 1.557 ± 0.009	0.373TyrTrp: 0.373 ± 0.004	0.947TyrTyr: 0.947 ± 0.007	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.002XaaSer: 0.002 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.48XaaXaa: 0.48 ± 0.044

Statistics based on 41549 proteins (24883876 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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