Amino acid dipepetide frequency for Buchnera aphidicola (Cinara tujafilina)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.346AlaAla: 2.346 ± 0.177
0.634AlaCys: 0.634 ± 0.083
1.468AlaAsp: 1.468 ± 0.109
1.807AlaGlu: 1.807 ± 0.155
1.764AlaPhe: 1.764 ± 0.153
2.468AlaGly: 2.468 ± 0.17
0.964AlaHis: 0.964 ± 0.095
4.553AlaIle: 4.553 ± 0.207
3.415AlaLys: 3.415 ± 0.202
4.24AlaLeu: 4.24 ± 0.206
0.921AlaMet: 0.921 ± 0.102
1.877AlaAsn: 1.877 ± 0.137
1.034AlaPro: 1.034 ± 0.085
1.573AlaGln: 1.573 ± 0.12
1.851AlaArg: 1.851 ± 0.147
2.52AlaSer: 2.52 ± 0.151
2.016AlaThr: 2.016 ± 0.13
1.903AlaVal: 1.903 ± 0.14
0.304AlaTrp: 0.304 ± 0.049
1.434AlaTyr: 1.434 ± 0.133
0.0AlaXaa: 0.0 ± 0.0
Cys
0.704CysAla: 0.704 ± 0.077
0.156CysCys: 0.156 ± 0.033
0.591CysAsp: 0.591 ± 0.077
0.382CysGlu: 0.382 ± 0.052
0.773CysPhe: 0.773 ± 0.087
0.973CysGly: 0.973 ± 0.101
0.365CysHis: 0.365 ± 0.066
1.868CysIle: 1.868 ± 0.163
1.13CysLys: 1.13 ± 0.101
1.156CysLeu: 1.156 ± 0.096
0.33CysMet: 0.33 ± 0.053
0.904CysAsn: 0.904 ± 0.102
0.513CysPro: 0.513 ± 0.064
0.417CysGln: 0.417 ± 0.059
0.426CysArg: 0.426 ± 0.066
1.086CysSer: 1.086 ± 0.097
0.669CysThr: 0.669 ± 0.074
0.591CysVal: 0.591 ± 0.062
0.139CysTrp: 0.139 ± 0.042
0.547CysTyr: 0.547 ± 0.069
0.0CysXaa: 0.0 ± 0.0
Asp
1.634AspAla: 1.634 ± 0.113
0.487AspCys: 0.487 ± 0.07
1.338AspAsp: 1.338 ± 0.118
1.46AspGlu: 1.46 ± 0.13
2.389AspPhe: 2.389 ± 0.151
1.894AspGly: 1.894 ± 0.13
0.904AspHis: 0.904 ± 0.08
6.169AspIle: 6.169 ± 0.25
2.928AspLys: 2.928 ± 0.17
4.24AspLeu: 4.24 ± 0.222
0.86AspMet: 0.86 ± 0.09
2.303AspAsn: 2.303 ± 0.142
1.164AspPro: 1.164 ± 0.102
1.269AspGln: 1.269 ± 0.09
1.373AspArg: 1.373 ± 0.112
2.459AspSer: 2.459 ± 0.146
1.894AspThr: 1.894 ± 0.124
2.138AspVal: 2.138 ± 0.194
0.452AspTrp: 0.452 ± 0.063
1.816AspTyr: 1.816 ± 0.133
0.0AspXaa: 0.0 ± 0.0
Glu
1.92GluAla: 1.92 ± 0.153
0.339GluCys: 0.339 ± 0.047
1.547GluAsp: 1.547 ± 0.148
2.077GluGlu: 2.077 ± 0.165
1.755GluPhe: 1.755 ± 0.11
1.851GluGly: 1.851 ± 0.148
0.808GluHis: 0.808 ± 0.09
5.57GluIle: 5.57 ± 0.258
5.848GluLys: 5.848 ± 0.251
4.284GluLeu: 4.284 ± 0.206
1.173GluMet: 1.173 ± 0.112
3.276GluAsn: 3.276 ± 0.159
0.895GluPro: 0.895 ± 0.098
1.46GluGln: 1.46 ± 0.127
1.712GluArg: 1.712 ± 0.14
2.52GluSer: 2.52 ± 0.158
1.842GluThr: 1.842 ± 0.135
1.972GluVal: 1.972 ± 0.149
0.295GluTrp: 0.295 ± 0.053
1.903GluTyr: 1.903 ± 0.136
0.0GluXaa: 0.0 ± 0.0
Phe
1.19PheAla: 1.19 ± 0.104
1.13PheCys: 1.13 ± 0.117
1.859PheAsp: 1.859 ± 0.139
1.651PheGlu: 1.651 ± 0.135
4.518PhePhe: 4.518 ± 0.354
2.807PheGly: 2.807 ± 0.148
1.121PheHis: 1.121 ± 0.106
5.709PheIle: 5.709 ± 0.253
3.962PheLys: 3.962 ± 0.203
7.056PheLeu: 7.056 ± 0.386
1.025PheMet: 1.025 ± 0.087
3.762PheAsn: 3.762 ± 0.221
1.912PhePro: 1.912 ± 0.154
1.799PheGln: 1.799 ± 0.131
1.39PheArg: 1.39 ± 0.118
5.127PheSer: 5.127 ± 0.309
2.129PheThr: 2.129 ± 0.141
1.773PheVal: 1.773 ± 0.136
0.617PheTrp: 0.617 ± 0.083
2.468PheTyr: 2.468 ± 0.187
0.0PheXaa: 0.0 ± 0.0
Gly
2.546GlyAla: 2.546 ± 0.163
0.938GlyCys: 0.938 ± 0.094
2.216GlyAsp: 2.216 ± 0.148
2.111GlyGlu: 2.111 ± 0.148
2.668GlyPhe: 2.668 ± 0.164
3.51GlyGly: 3.51 ± 0.274
1.251GlyHis: 1.251 ± 0.122
6.734GlyIle: 6.734 ± 0.266
4.327GlyLys: 4.327 ± 0.207
4.875GlyLeu: 4.875 ± 0.209
1.269GlyMet: 1.269 ± 0.107
2.572GlyAsn: 2.572 ± 0.173
1.434GlyPro: 1.434 ± 0.11
1.651GlyGln: 1.651 ± 0.118
2.25GlyArg: 2.25 ± 0.164
3.232GlySer: 3.232 ± 0.18
2.772GlyThr: 2.772 ± 0.151
2.85GlyVal: 2.85 ± 0.183
0.53GlyTrp: 0.53 ± 0.071
2.085GlyTyr: 2.085 ± 0.133
0.0GlyXaa: 0.0 ± 0.0
His
1.121HisAla: 1.121 ± 0.081
0.278HisCys: 0.278 ± 0.05
0.912HisAsp: 0.912 ± 0.077
0.808HisGlu: 0.808 ± 0.087
0.973HisPhe: 0.973 ± 0.097
1.373HisGly: 1.373 ± 0.115
0.521HisHis: 0.521 ± 0.068
2.737HisIle: 2.737 ± 0.146
1.79HisLys: 1.79 ± 0.113
2.164HisLeu: 2.164 ± 0.127
0.391HisMet: 0.391 ± 0.052
1.416HisAsn: 1.416 ± 0.109
1.017HisPro: 1.017 ± 0.106
0.843HisGln: 0.843 ± 0.067
0.886HisArg: 0.886 ± 0.089
1.39HisSer: 1.39 ± 0.121
0.999HisThr: 0.999 ± 0.09
1.017HisVal: 1.017 ± 0.106
0.174HisTrp: 0.174 ± 0.037
0.973HisTyr: 0.973 ± 0.097
0.0HisXaa: 0.0 ± 0.0
Ile
5.335IleAla: 5.335 ± 0.234
1.773IleCys: 1.773 ± 0.136
5.422IleAsp: 5.422 ± 0.209
5.431IleGlu: 5.431 ± 0.191
7.151IlePhe: 7.151 ± 0.344
6.117IleGly: 6.117 ± 0.242
2.954IleHis: 2.954 ± 0.154
14.85IleIle: 14.85 ± 0.455
14.015IleLys: 14.015 ± 0.413
13.051IleLeu: 13.051 ± 0.405
2.381IleMet: 2.381 ± 0.135
9.688IleAsn: 9.688 ± 0.279
4.536IlePro: 4.536 ± 0.171
4.692IleGln: 4.692 ± 0.209
4.336IleArg: 4.336 ± 0.223
9.341IleSer: 9.341 ± 0.259
5.717IleThr: 5.717 ± 0.231
4.762IleVal: 4.762 ± 0.195
0.765IleTrp: 0.765 ± 0.091
5.1IleTyr: 5.1 ± 0.245
0.0IleXaa: 0.0 ± 0.0
Lys
2.311LysAla: 2.311 ± 0.167
0.782LysCys: 0.782 ± 0.082
3.51LysAsp: 3.51 ± 0.161
4.77LysGlu: 4.77 ± 0.211
4.475LysPhe: 4.475 ± 0.209
3.198LysGly: 3.198 ± 0.176
1.773LysHis: 1.773 ± 0.13
16.057LysIle: 16.057 ± 0.541
19.968LysLys: 19.968 ± 0.676
8.567LysLeu: 8.567 ± 0.329
2.016LysMet: 2.016 ± 0.12
13.781LysAsn: 13.781 ± 0.453
1.972LysPro: 1.972 ± 0.118
2.407LysGln: 2.407 ± 0.133
3.276LysArg: 3.276 ± 0.189
5.405LysSer: 5.405 ± 0.204
4.649LysThr: 4.649 ± 0.248
3.119LysVal: 3.119 ± 0.163
0.721LysTrp: 0.721 ± 0.073
5.448LysTyr: 5.448 ± 0.251
0.0LysXaa: 0.0 ± 0.0
Leu
3.849LeuAla: 3.849 ± 0.217
1.329LeuCys: 1.329 ± 0.094
4.171LeuAsp: 4.171 ± 0.203
5.109LeuGlu: 5.109 ± 0.22
4.875LeuPhe: 4.875 ± 0.274
5.405LeuGly: 5.405 ± 0.216
2.416LeuHis: 2.416 ± 0.166
10.305LeuIle: 10.305 ± 0.345
11.296LeuLys: 11.296 ± 0.348
10.618LeuLeu: 10.618 ± 0.431
2.094LeuMet: 2.094 ± 0.125
7.638LeuAsn: 7.638 ± 0.253
3.215LeuPro: 3.215 ± 0.158
3.397LeuGln: 3.397 ± 0.17
3.745LeuArg: 3.745 ± 0.197
7.829LeuSer: 7.829 ± 0.263
3.962LeuThr: 3.962 ± 0.176
3.893LeuVal: 3.893 ± 0.21
0.964LeuTrp: 0.964 ± 0.097
4.414LeuTyr: 4.414 ± 0.201
0.0LeuXaa: 0.0 ± 0.0
Met
0.904MetAla: 0.904 ± 0.093
0.226MetCys: 0.226 ± 0.044
0.817MetAsp: 0.817 ± 0.095
0.782MetGlu: 0.782 ± 0.093
0.956MetPhe: 0.956 ± 0.096
1.034MetGly: 1.034 ± 0.1
0.461MetHis: 0.461 ± 0.057
2.277MetIle: 2.277 ± 0.127
2.337MetLys: 2.337 ± 0.136
2.389MetLeu: 2.389 ± 0.137
0.53MetMet: 0.53 ± 0.064
1.877MetAsn: 1.877 ± 0.111
0.799MetPro: 0.799 ± 0.093
0.782MetGln: 0.782 ± 0.077
0.825MetArg: 0.825 ± 0.076
1.303MetSer: 1.303 ± 0.115
0.947MetThr: 0.947 ± 0.087
1.017MetVal: 1.017 ± 0.08
0.174MetTrp: 0.174 ± 0.037
0.799MetTyr: 0.799 ± 0.081
0.0MetXaa: 0.0 ± 0.0
Asn
2.259AsnAla: 2.259 ± 0.146
0.843AsnCys: 0.843 ± 0.086
2.659AsnAsp: 2.659 ± 0.137
2.615AsnGlu: 2.615 ± 0.16
4.727AsnPhe: 4.727 ± 0.224
2.72AsnGly: 2.72 ± 0.167
1.46AsnHis: 1.46 ± 0.103
13.338AsnIle: 13.338 ± 0.394
8.35AsnLys: 8.35 ± 0.293
6.717AsnLeu: 6.717 ± 0.281
1.564AsnMet: 1.564 ± 0.136
7.108AsnAsn: 7.108 ± 0.285
2.138AsnPro: 2.138 ± 0.14
2.72AsnGln: 2.72 ± 0.165
2.164AsnArg: 2.164 ± 0.127
4.588AsnSer: 4.588 ± 0.179
3.623AsnThr: 3.623 ± 0.177
2.98AsnVal: 2.98 ± 0.143
0.495AsnTrp: 0.495 ± 0.073
3.154AsnTyr: 3.154 ± 0.194
0.0AsnXaa: 0.0 ± 0.0
Pro
1.008ProAla: 1.008 ± 0.09
0.356ProCys: 0.356 ± 0.054
1.121ProAsp: 1.121 ± 0.112
1.607ProGlu: 1.607 ± 0.125
1.503ProPhe: 1.503 ± 0.12
2.042ProGly: 2.042 ± 0.147
0.713ProHis: 0.713 ± 0.083
3.719ProIle: 3.719 ± 0.188
2.694ProLys: 2.694 ± 0.162
2.746ProLeu: 2.746 ± 0.147
0.721ProMet: 0.721 ± 0.068
1.981ProAsn: 1.981 ± 0.147
0.782ProPro: 0.782 ± 0.083
0.904ProGln: 0.904 ± 0.074
0.982ProArg: 0.982 ± 0.105
1.79ProSer: 1.79 ± 0.112
1.477ProThr: 1.477 ± 0.12
1.868ProVal: 1.868 ± 0.144
0.295ProTrp: 0.295 ± 0.05
1.329ProTyr: 1.329 ± 0.104
0.0ProXaa: 0.0 ± 0.0
Gln
1.269GlnAla: 1.269 ± 0.102
0.443GlnCys: 0.443 ± 0.06
1.347GlnAsp: 1.347 ± 0.103
2.007GlnGlu: 2.007 ± 0.13
1.408GlnPhe: 1.408 ± 0.111
1.408GlnGly: 1.408 ± 0.113
0.626GlnHis: 0.626 ± 0.075
3.554GlnIle: 3.554 ± 0.187
4.614GlnLys: 4.614 ± 0.2
3.397GlnLeu: 3.397 ± 0.169
0.6GlnMet: 0.6 ± 0.068
2.294GlnAsn: 2.294 ± 0.14
0.834GlnPro: 0.834 ± 0.097
0.869GlnGln: 0.869 ± 0.096
1.034GlnArg: 1.034 ± 0.101
1.972GlnSer: 1.972 ± 0.113
1.303GlnThr: 1.303 ± 0.108
1.39GlnVal: 1.39 ± 0.11
0.33GlnTrp: 0.33 ± 0.065
1.747GlnTyr: 1.747 ± 0.126
0.0GlnXaa: 0.0 ± 0.0
Arg
1.712ArgAla: 1.712 ± 0.143
0.521ArgCys: 0.521 ± 0.074
1.503ArgAsp: 1.503 ± 0.136
1.755ArgGlu: 1.755 ± 0.145
1.92ArgPhe: 1.92 ± 0.132
1.929ArgGly: 1.929 ± 0.152
0.825ArgHis: 0.825 ± 0.089
4.24ArgIle: 4.24 ± 0.212
3.189ArgLys: 3.189 ± 0.172
3.18ArgLeu: 3.18 ± 0.203
0.973ArgMet: 0.973 ± 0.083
2.32ArgAsn: 2.32 ± 0.152
1.017ArgPro: 1.017 ± 0.097
1.077ArgGln: 1.077 ± 0.108
1.66ArgArg: 1.66 ± 0.119
2.294ArgSer: 2.294 ± 0.162
1.79ArgThr: 1.79 ± 0.139
1.903ArgVal: 1.903 ± 0.139
0.269ArgTrp: 0.269 ± 0.054
1.512ArgTyr: 1.512 ± 0.12
0.0ArgXaa: 0.0 ± 0.0
Ser
2.989SerAla: 2.989 ± 0.189
1.051SerCys: 1.051 ± 0.1
2.807SerAsp: 2.807 ± 0.161
2.876SerGlu: 2.876 ± 0.18
3.319SerPhe: 3.319 ± 0.19
4.709SerGly: 4.709 ± 0.22
1.321SerHis: 1.321 ± 0.109
8.663SerIle: 8.663 ± 0.333
5.743SerLys: 5.743 ± 0.198
6.777SerLeu: 6.777 ± 0.258
1.607SerMet: 1.607 ± 0.119
4.119SerAsn: 4.119 ± 0.161
1.694SerPro: 1.694 ± 0.115
1.972SerGln: 1.972 ± 0.122
2.685SerArg: 2.685 ± 0.145
4.614SerSer: 4.614 ± 0.232
2.798SerThr: 2.798 ± 0.175
3.536SerVal: 3.536 ± 0.194
0.739SerTrp: 0.739 ± 0.108
2.641SerTyr: 2.641 ± 0.165
0.0SerXaa: 0.0 ± 0.0
Thr
2.19ThrAla: 2.19 ± 0.139
0.66ThrCys: 0.66 ± 0.083
1.859ThrAsp: 1.859 ± 0.122
2.164ThrGlu: 2.164 ± 0.141
2.094ThrPhe: 2.094 ± 0.151
3.215ThrGly: 3.215 ± 0.181
0.964ThrHis: 0.964 ± 0.102
5.161ThrIle: 5.161 ± 0.218
4.188ThrLys: 4.188 ± 0.216
5.1ThrLeu: 5.1 ± 0.189
0.773ThrMet: 0.773 ± 0.085
3.006ThrAsn: 3.006 ± 0.152
1.781ThrPro: 1.781 ± 0.129
1.46ThrGln: 1.46 ± 0.095
1.547ThrArg: 1.547 ± 0.13
2.624ThrSer: 2.624 ± 0.162
2.155ThrThr: 2.155 ± 0.141
2.389ThrVal: 2.389 ± 0.137
0.391ThrTrp: 0.391 ± 0.059
1.738ThrTyr: 1.738 ± 0.117
0.0ThrXaa: 0.0 ± 0.0
Val
1.859ValAla: 1.859 ± 0.146
0.773ValCys: 0.773 ± 0.084
1.929ValAsp: 1.929 ± 0.141
1.946ValGlu: 1.946 ± 0.152
2.346ValPhe: 2.346 ± 0.159
2.615ValGly: 2.615 ± 0.172
1.051ValHis: 1.051 ± 0.096
5.144ValIle: 5.144 ± 0.228
3.519ValLys: 3.519 ± 0.167
4.814ValLeu: 4.814 ± 0.211
0.852ValMet: 0.852 ± 0.078
2.563ValAsn: 2.563 ± 0.158
1.495ValPro: 1.495 ± 0.121
1.286ValGln: 1.286 ± 0.112
1.651ValArg: 1.651 ± 0.135
3.241ValSer: 3.241 ± 0.172
2.207ValThr: 2.207 ± 0.137
2.138ValVal: 2.138 ± 0.173
0.374ValTrp: 0.374 ± 0.057
1.529ValTyr: 1.529 ± 0.121
0.0ValXaa: 0.0 ± 0.0
Trp
0.243TrpAla: 0.243 ± 0.048
0.182TrpCys: 0.182 ± 0.04
0.278TrpAsp: 0.278 ± 0.047
0.261TrpGlu: 0.261 ± 0.039
0.591TrpPhe: 0.591 ± 0.079
0.374TrpGly: 0.374 ± 0.064
0.156TrpHis: 0.156 ± 0.035
1.208TrpIle: 1.208 ± 0.104
0.808TrpLys: 0.808 ± 0.086
0.912TrpLeu: 0.912 ± 0.109
0.243TrpMet: 0.243 ± 0.043
0.869TrpAsn: 0.869 ± 0.092
0.235TrpPro: 0.235 ± 0.042
0.2TrpGln: 0.2 ± 0.046
0.365TrpArg: 0.365 ± 0.059
0.434TrpSer: 0.434 ± 0.062
0.348TrpThr: 0.348 ± 0.059
0.391TrpVal: 0.391 ± 0.066
0.052TrpTrp: 0.052 ± 0.02
0.365TrpTyr: 0.365 ± 0.065
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.703TyrAla: 1.703 ± 0.116
0.817TyrCys: 0.817 ± 0.097
1.816TyrAsp: 1.816 ± 0.115
1.425TyrGlu: 1.425 ± 0.122
2.798TyrPhe: 2.798 ± 0.183
2.181TyrGly: 2.181 ± 0.114
1.13TyrHis: 1.13 ± 0.095
5.57TyrIle: 5.57 ± 0.248
4.084TyrLys: 4.084 ± 0.233
4.24TyrLeu: 4.24 ± 0.217
0.904TyrMet: 0.904 ± 0.105
2.867TyrAsn: 2.867 ± 0.183
1.173TyrPro: 1.173 ± 0.091
1.668TyrGln: 1.668 ± 0.148
1.434TyrArg: 1.434 ± 0.106
2.893TyrSer: 2.893 ± 0.178
2.164TyrThr: 2.164 ± 0.153
1.703TyrVal: 1.703 ± 0.116
0.434TyrTrp: 0.434 ± 0.06
2.111TyrTyr: 2.111 ± 0.159
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 359 proteins (115088 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski